Panorganismal metabolic response modelling of an experimental <em>Echinostoma caproni </em>infection in the mouse (Publications)
Metabolic profiling of host tissues and biofluids during parasitic infections can reveal new biomarker information and aid the elucidation of mechanisms of disease. The multicompartmental metabolic ef
The changing epidemiology of malaria in Ifakara Town, southern Tanzania (Publications)
Between 1995 and 2000 there were marked changes in the epidemiology of malaria in Ifakara, southern Tanzania. We documented these changes using parasitological and clinical data from a series of commu
The burden of asthma in children: a European perspective (Publications)
Asthma is the most common chronic disease in childhood, imposing a huge burden on the patient, their family and society. It is a worldwide disease with variable expression between countries and betwee
A role for apical membrane antigen 1 during invasion of hepatocytes by <em>Plasmodium falciparum</em> sporozoites (Publications)
Plasmodium sporozoites are transmitted through the bite of infected mosquitoes and invade hepatocytes, as a first and obligatory step of the parasite life cycle in man. Hepatocyte invasion involves pr
Effectiveness of artemether/lumefantrine for the treatment of uncomplicated <em>Plasmodium vivax</em> and <em>P. falciparum</em> malaria in young... (Publications)
Background. Artemisinin combination therapy (ACT) is recommended as treatment for uncomplicated Plasmodium falciparum (Pf) malaria, while chloroquine is still widely used for non-Pf infections. A comm
The economic cost to households of childhood malaria in Papua New Guinea: a focus on intra-country variation (Publications)
BACKGROUND We compare direct and indirect household costs associated with malaria treatment for children
Antiprotozoal activities of new bicyclo[2.2.2]octan-2-imines and esters of bicyclo[2.2.2]octan-2-ols (Publications)
Several bicyclo[2.2.2]octan-2-imines and esters of bicyclo[2.2.2]octan-2-ols were prepared. Their antitrypanosomal and antiplasmodial activities against Trypanosoma brucei rhodesiense (STIB 900) and t