1-Aryl-1,2,3,4-tetrahydroisoquinolines as potential antimalarials: synthesis, in vitro antiplasmodial activity and in silico pharmacokinetics... (Publications)
In the present study, twenty-one 1-aryl-6-hydroxy-1,2,3,4-tetrahydroisoquinoline (THIQ) analogues were synthesized by base-catalyzed Pictet-Spengler reaction, and tested in vitro against P. falciparum
Nuclear factor I revealed as family of promoter binding transcription activators (Publications)
ABSTRACT: BACKGROUND: Multiplex experimental assays coupled to computational predictions are being increasingly employed for the simultaneous analysis of many specimens at the genome scale, which quic
Indoloditerpenes from a marine-derived fungal strain of <em>Dichotomomyces cejpii</em> with antagonistic activity at GPR18 and cannabinoid receptors (Publications)
A marine-derived strain of Dichotomomyces cejpii produces the new compounds emindole SB beta-mannoside (1) and 27-O-methylasporyzin C (2), as well as the known indoloditerpenes JBIR-03 (3) and emindol