Assembling a global database of child pneumonia studies to inform WHO pneumonia management algorithm: methodology and applications (Publications)
BACKGROUND: The existing World Health Organization (WHO) pneumonia case management guidelines rely on clinical symptoms and signs for identifying, classifying, and treating pneumonia in children up to
Comparison of model predictions of typhoid conjugate vaccine public health impact and cost-effectiveness (Publications)
Models are useful to inform policy decisions on typhoid conjugate vaccine (TCV) deployment in endemic settings. However, methodological choices can influence model-predicted outcomes. To provide robus
Household-level risk factors for water contamination and antimicrobial resistance in drinking water among households with children under 5 in rural... (Publications)
Household water contamination at point of use depends on human, animal and environmental factors embodying all aspects of a One Health approach. This study investigated the association between househo
Quality of care for postpartum hemorrhage: a direct observation study in referral hospitals in Kenya (Publications)
Postpartum hemorrhage (PPH) is the leading cause of maternal mortality in Kenya. The aim of this study was to measure quality and timeliness of care for PPH in a sample of deliveries in referral hospi
What Africa can do to accelerate and sustain progress against malaria (Publications)
After a longstanding global presence, malaria is now largely non-existent or suppressed in most parts of the world. Today, cases and deaths are primarily concentrated in sub-Saharan Africa. According
Model-informed target product profiles of long-acting-injectables for use as seasonal malaria prevention (Publications)
Seasonal malaria chemoprevention (SMC) has proven highly efficacious in reducing malaria incidence. However, the continued success of SMC is threatened by the spread of resistance against one of its m
Investigation of the effect of structure modification of furamidine on the DNA minor groove binding and antiprotozoal activity (Publications)
New analogs of the antiprotozoal agent Furamidine were prepared utilizing Stille coupling reactions and amidation of the bisnitrile intermediate using lithium bis-trimethylsilylamide. Both the phenyl
Effect of residential relocation on environmental exposures in European cohorts: an exposome-wide approach (Publications)
Residential relocation is increasingly used as a natural experiment in epidemiological studies to assess the health impact of changes in environmental exposures. Since the likelihood of relocation can
Heat-related cardiorespiratory mortality: effect modification by air pollution across 482 cities from 24 countries (Publications)
Background Evidence on the potential interactive effects of heat and ambient air pollution on cause-specific mortality is inconclusive and limited to selected locations. Objectives We investigated the
ePOCT+ and the medAL-<em>suite</em>: development of an electronic clinical decision support algorithm and digital platform for pediatric outpatients... (Publications)
Electronic clinical decision support algorithms (CDSAs) have been developed to address high childhood mortality and inappropriate antibiotic prescription by helping clinicians adhere to guidelines. Pr
