Cinnamoylphenethyl amides from <em>Polygonum hyrcanicum</em> possess anti-trypanosomal activity (Publications)
A methanolic extract from aerial parts of Polygonum hyrcanicum (Polygonaceae) showed high activity against Trypanosoma brucei rhodesiense (IC50 = 3.7 microg/mL). Bioassay-guided fractionation of the e
Comparative genomics reveals multiple genetic backgrounds of human pathogenicity in the <em>Trypanosoma brucei</em> complex (Publications)
The Trypanosoma brucei complex contains a number of subspecies with exceptionally variable life histories, including zoonotic subspecies, which are causative agents of human African trypanosomiasis (H
High prevalence of <em>Ancylostoma ceylanicum</em> hookworm infections in humans, Cambodia, 2012 (Publications)
Ancylostoma ceylanicum, a hookworm of canids and felids in Asia, is becoming the second most common hookworm infecting humans. In 2012, we investigated the prevalence and infection dynamics of and ris
Risk stratification for 1-year mortality in acute heart failure: classification and regression tree analysis (Publications)
BACKGROUND: Simple tools for risk stratification of patients with acute heart failure (AHF) are an unmet clinical need, particularly regarding long-term mortality. METHODS: We prospectively enrolled 6
1,2-substituted 4-(1H)-quinolones: synthesis, antimalarial and antitrypanosomal activities in vitro (Publications)
A diverse array of 4-(1H)-quinolone derivatives bearing substituents at positions 1 and 2 were synthesized and evaluated for antiprotozoal activities against Plasmodium falciparum and Trypanosoma bruc
Mycobacterial lineages causing pulmonary and extrapulmonary tuberculosis, Ethiopia (Publications)
Molecular typing of 964 specimens from patients in Ethiopia with lymph node or pulmonary tuberculosis showed a similar distribution of Mycobacterium tuberculosis strains between the 2 disease manifest
Assessment of dual life stage antiplasmodial activity of British seaweeds (Publications)
Terrestrial plants have proven to be a prolific producer of clinically effective antimalarial drugs, but the antimalarial potential of seaweeds has been little explored. The main aim of this study was
Space and time clustering of mortality in rural South Africa (Agincourt HDSS), 1992-2007 (Publications)
BACKGROUND: Detailed information regarding the spatial and/or spatial-temporal distribution of mortality is required for the efficient implementation and targeting of public health interventions. OBJE
Natural and semisynthetic analogues of manadoperoxide B reveal new structural requirements for trypanocidal activity (Publications)
Chemical analysis of the Indonesian sponge Plakortis cfr. lita afforded two new analogues of the potent trypanocidal agent manadoperoxide B (1), namely 12-isomanadoperoxide B (2) and manadoperoxidic a
