Characterization of choline uptake in<em> Trypanosoma brucei</em> procyclic and bloodstream forms (Publications)
Choline is an essential nutrient for eukaryotic cells, where it is used as precursor for the synthesis of choline-containing phospholipids, such as phosphatidylcholine (PC). According to published dat
Mobile phone use and the risk of skin cancer: a nationwide cohort study in Denmark (Publications)
The International Agency for Research on Cancer has classified radiofrequency radiation as possibly carcinogenic. Previous studies have focused on intracranial tumors, although the skin receives much
Cynaropicrin targets the trypanothione redox system in <em>Trypanosoma brucei</em> (Publications)
In mice cynaropicrin (CYN) potently inhibits the proliferation of Trypanosoma brucei-the causative agent of Human African Trypanosomiasis-by a so far unknown mechanism. We hypothesized that CYNs ?,?-u
Synthesis and antiprotozoal activity of dicationic 2, 6-diphenylpyrazines and aza-analogues (Publications)
Dicationic 2,6-diphenylpyrazines, aza-analogues and prodrugs were synthesized; evaluated for DNA affinity, activity against Trypanosoma brucei rhodesiense (T. b. r.) and Plasmodium falciparum (P. f.)
Natural product derived antiprotozoal agents: synthesis, biological evaluation, and structure-activity relationships of novel chromene and chromane... (Publications)
Various natural products with the chromane and chromene scaffold exhibit high antiprotozoal activity. The natural product encecalin (7) served as key intermediate for the synthesis of different ethers
Improved characterization of visual evoked potentials in multiple sclerosis by topographic analysis (Publications)
In multiple sclerosis (MS), the combination of visual, somatosensory and motor evoked potentials (EP) has been shown to be highly correlated with the Expanded Disability Severity Scale (EDSS) and to p
Mathematical models of contact patterns between age groups for predicting the spread of infectious diseases (Publications)
The spread of an infectious disease is sensitive to the contact patterns in the population and to precautions people take to reduce the transmission of the disease. We investigate the impact that diff
More than one way to produce protein diversity: duplication and limited alternative splicing of an adhesion molecule gene in basal arthropods (Publications)
Exon duplication and alternative splicing evolved multiple times in metazoa and are of overall importance in shaping genomes and allowing organisms to produce many fold more proteins than there are ge
