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1. Serum vitamin E concentrations at 1 year and risk of atopy, atopic dermatitis, wheezing, and asthma in childhood: the PASTURE study (Publications)

   Serum vitamin E concentrations at 1 year and risk of atopy, atopic dermatitis, wheezing, and asthma in childhood: the PASTURE study

   Relevanz:

   BACKGROUND: Prospective studies investigating the role of serum vitamin E concentrations during early life in the development of childhood allergies and asthma are limited. OBJECTIVE: To study the ass

2. Sialic acid linkage in glycosphingolipids is a molecular correlate for trafficking and delivery of extracellular cargo (Publications)

   Sialic acid linkage in glycosphingolipids is a molecular correlate for trafficking and delivery of extracellular cargo

   Relevanz:

   Gangliosides, glycosphingolipids containing sialic acid moieties, are well known mediators of transmembrane signaling and endocytosis at the plasma membrane. However, little is known about their preci

3. Survey on animal bite injuries and their management to estimate human rabies deaths in N'Djamena, Chad (Publications)

   Survey on animal bite injuries and their management to estimate human rabies deaths in N'Djamena, Chad

   Relevanz:

   OBJECTIVE: To estimate the annual human rabies incidence as a baseline prior to mass dog vaccination campaigns in N'Djaména, Chad. METHODS: Survey of animal bites, involving 50% of all healthcare prov

4. Enantioselective synthesis of encecaline-derived potent antimalarial agents (Publications)

   Enantioselective synthesis of encecaline-derived potent antimalarial agents

   Relevanz:

   The high antiplasmodial activity of racemic benzylamines rac- and rac- stimulated the synthesis of pure enantiomers. Ellman's chiral sulfinamides (S)- and (R)- were used as chiral auxiliaries. Condens

5. Structure-activity-relationship studies around the 2-amino group and pyridine core of antimalarial 3,5-diarylaminopyridines lead to a novel series of... (Publications)

   Structure-activity-relationship studies around the 2-amino group and pyridine core of antimalarial 3,5-diarylaminopyridines lead to a novel series of pyrazine analogues with oral in vivo activity

   Relevanz:

   Replacement of the pyridine core of antimalarial 3,5-diaryl-2-aminopyridines led to the identification of a novel series of pyrazine analogues with potent oral antimalarial activity. However, other ch

6. Toward the development of dual-targeted glyceraldehyde-3-phosphate dehydrogenase/trypanothione reductase inhibitors against <em>Trypanosoma... (Publications)

   Toward the development of dual-targeted glyceraldehyde-3-phosphate dehydrogenase/trypanothione reductase inhibitors against <em>Trypanosoma brucei</em> and <em>Trypanosoma cruzi</em>

   Relevanz:

   A significant improvement in the treatment of trypanosomiases has been achieved with the recent development of nifurtimox-eflornithine combination therapy (NECT). As an alternative to drug combination

7. Deciphering the origin of dengue virus introduced in Madeira, Portugal (Publications)

   Deciphering the origin of dengue virus introduced in Madeira, Portugal

   Relevanz:

8. Investigation of acyclic uridine amide and 5'-amido nucleoside analogues as potential inhibitors of the <em>Plasmodium falciparum</em> dUTPase (Publications)

   Investigation of acyclic uridine amide and 5'-amido nucleoside analogues as potential inhibitors of the <em>Plasmodium falciparum</em> dUTPase

   Relevanz:

   Previously we have shown that trityl and diphenyl deoxyuridine derivatives and their acyclic analogues can inhibit Plasmodium falciparum dUTPase (PfdUTPase). We report the synthesis of conformationall

9. Comparison of performance of land use regression models derived for Catalunya, Spain (Publications)

   Comparison of performance of land use regression models derived for Catalunya, Spain

   Relevanz:

10. Differential virulence and disease progression following <em>Mycobacterium tuberculosis</em> complex infection of the common marmoset (<em>Callithrix... (Publications)

    Differential virulence and disease progression following <em>Mycobacterium tuberculosis</em> complex infection of the common marmoset (<em>Callithrix jacchus</em>)

    Relevanz:

    Existing small-animal models of tuberculosis (TB) rarely develop cavitary disease, limiting their value for assessing the biology and dynamics of this highly important feature of human disease. To dev