Dramatic decreases of malaria transmission intensities in Ifakara, south-eastern Tanzania since early 2000s (Publications)
BACKGROUND: Ongoing epidemiological transitions across Africa are particularly evident in fast-growing towns, such as Ifakara in the Kilombero valley, south-eastern Tanzania. This town and its environ
Comparative pan-genomic analyses of <em>Orientia tsutsugamushi </em>reveal an exceptional model of bacterial evolution driving genomic diversity (Publications)
Orientia tsutsugamushi, formerly Rickettsia tsutsugamushi, is an obligate intracellular pathogen that causes scrub typhus, an underdiagnosed acute febrile disease with high morbidity. Scrub typhus is
Baseline exposure, antibody subclass, and hepatitis B response differentially affect malaria protective immunity following RTS,S/AS01E vaccination in... (Publications)
BACKGROUND: The RTS,S/AS01E vaccine provides partial protection against malaria in African children, but immune responses have only been partially characterized and do not reliably predict protective
Challenges and lessons from conducting a paediatric clinical trial in sub-Saharan Africa: the case of the praziquantel oral dispersible tablets phase... (Publications)
The importance of implementing paediatric clinical trials for neglected tropical diseases (NTDs) in compliance with the Good Clinical Practices of the International Conference of Harmonisation (ICH-GC
Community and drug distributor perceptions and experiences of mass drug administration for the elimination of lymphatic filariasis: a rapid review of... (Publications)
STUDY OBJECTIVES: This article presents findings from a rapid review of qualitative research conducted to inform decision makers about community and drug distributor perceptions and experiences of mas
Antiplasmodial imidazopyridazines: structure-activity relationship studies lead to the identification of analogues with improved solubility and hERG... (Publications)
3,6-Diarylated imidazopyridazines have recently been shown to possess good in vitro antiplasmodial and in vivo antimalarial activity. However, frontrunner compounds have been associated with poor solu
Cell penetration, herbicidal activity, and <em>in-vivo</em>-toxicity of oligo-arginine derivatives and of novel guanidinium-rich compounds derived... (Publications)
Oligo-arginines are thoroughly studied cell-penetrating peptides (CPPs, Figures 1 and 2). Previous in-vitro investigations with the octaarginine salt of the phosphonate fosmidomycin (herbicide and ant