Ensuring transmission through dynamic host environments: host-pathogen interactions in <em>Plasmodium </em>sexual development (Publications)
A renewed global commitment to malaria elimination lends urgency to understanding the biology of Plasmodium transmission stages. Recent progress toward uncovering the mechanisms underlying Plasmodium
Sex: how malaria parasites get turned on (Publications)
The mechanisms underlying sexual stage switching in Plasmodium spp. have hitherto remained a mystery. However, two recent studies have revealed that an apicomplexan-specific DNA-binding protein is ess
An assay to probe <em>Plasmodium falciparum</em> growth, transmission stage formation and early gametocyte development (Publications)
Conversion from asexual proliferation to sexual differentiation initiates the production of the gametocyte, which is the malaria parasite stage required for human-to-mosquito transmission. This protoc
Infected erythrocyte-derived extracellular vesicles alter vascular function via regulatory Ago2-miRNA complexes in malaria (Publications)
Malaria remains one of the greatest public health challenges worldwide, particularly in sub-Saharan Africa. The clinical outcome of individuals infected with Plasmodium falciparum parasites depends on
Diversity-oriented synthesis yields novel multistage antimalarial inhibitors (Publications)
Antimalarial drugs have thus far been chiefly derived from two sources-natural products and synthetic drug-like compounds. Here we investigate whether antimalarial agents with novel mechanisms of acti
Antimalarial <em>N</em>1,<em>N</em>3-dialkyldioxonaphthoimidazoliums: synthesis, biological activity, and structure-activity relationships (Publications)
Here we report the nanomolar potencies of N (1),N (3)-dialkyldioxonaphthoimidazoliums against asexual forms of sensitive and resistant Plasmodium falciparum. Activity was dependent on the presence of
Impact of a complex gender-transformative intervention on maternal and child health outcomes in the eastern Democratic Republic of Congo: protocol of... (Publications)
BACKGROUND: In the eastern part of the Democratic Republic of Congo (DRC) Village Savings and Loan Associations (VSLAs) programs targeting women are implemented. In the context of the 'Mawe Tatu' prog
Leprosy post-exposure prophylaxis with single-dose rifampicin: toolkit for implementation (Publications)
lNLR, Amsterdam, NetherlandsmPrivate, UKnHealth Services, Dadra and Nagar Haveli, IndiaoNLR, Jakarta, IndonesiapAnti-Leprosy Campaign, Colombo, Sri LankaqUniversidade do Estado de Mato Grosso, Ca ́cer
Correlates and outcomes of low physical activity posttransplant: a systematic review and meta-analysis (Publications)
BACKGROUND: Little is known about associations between low physical activity (PA) and its correlates and outcomes in solid organ transplant recipients. This systematic review with meta-analysis examin
