Nifurtimox-eflornithine combination therapy for second-stage African <em>Trypanosoma brucei gambiense</em> trypanosomiasis: a multicentre, randomised,... (Publications)
BACKGROUND: Human African trypanosomiasis (HAT; sleeping sickness) caused by Trypanosoma brucei gambiense is a fatal disease. Current treatment options for patients with second-stage disease are toxic
Synthesis, stereoelectronic characterization and antiparasitic activity of new 1-benzenesulfonyl-2-methyl-1,2,3,4-tetrahydroquinolines (Publications)
The synthesis and full 3D structural characterization of nine new 1-benzenesulfonyl-2-methyl-1,2,3,4-tetrahydroquinoline derivatives are reported. These belong to a library whose rationale for the des
Human antibodies to recombinant protein constructs of <em>Plasmodium falciparum</em> Apical Membrane Antigen 1 (AMA1) and their associations with... (Publications)
Serum antibodies from 1071 people in two Kenyan villages were assayed using eight different recombinant Apical Membrane Antigen 1 (AMA1) protein constructs to investigate their role in naturally acqui
Molecular epidemiology of <em>Plasmodium falciparum</em> infections among asymptomatic inhabitans of a holoendemic malarious area in northern Ghana (Publications)
Age dependence of malaria infection was assessed in an age-stratified cluster sample of 308 individuals from Kassena-Nankana District of northern Ghana during June and July 2000. Overall prevalence of
[(eta(6) -praziquantel)Cr(CO)(3)] derivatives with remarkable in vitro anti-schistosomal activity (Publications)
The antischistosomal effect of two [(eta(6) -praziquantel)Cr(CO)(3) ] derivatives 1 and 2 was investigated. The compounds (see figure: Cr purple, N blue, O red) are prepared in a one-step procedure fr
PTEN expression is a strong predictor of survival in mesothelioma patients (Publications)
BACKGROUND: Malignant pleural mesothelioma (MPM) is a highly aggressive tumour with poor prognosis and limited response to therapy. MPM is characterised by complex chromosomal aberrations, including c
A community-randomised evaluation of the effect of IPTi on anti-malarial drug resistance in southern Tanzania (Publications)
Background: Intermittent Preventive Treatment in infants (IPTi) is the administration of sulphadoxine-pyrimethamine (SP) at 2, 3 and 9 months of age to prevent malaria. We investigated the influence o