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1. Spiro and dispiro-1,2,4-trioxolanes as antimalarial peroxides: charting a workable structure-activity relationship using simple prototypes (Publications)

   Spiro and dispiro-1,2,4-trioxolanes as antimalarial peroxides: charting a workable structure-activity relationship using simple prototypes

   Relevanz:

   This paper describes the discovery of synthetic 1,2,4-trioxolane antimalarials and how we established a workable structure-activity relationship in the context of physicochemical, biopharmaceutical, a

2. Effect of functional group polarity on the antimalarial activity of spiro and dispiro-1,2,4-trioxolanes (Publications)

   Effect of functional group polarity on the antimalarial activity of spiro and dispiro-1,2,4-trioxolanes

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3. Efficacy of triclosan soap against superficial dermatomycoses: a double-blind clinical trial in 224 primary school-children in Kilombero District,... (Publications)

   Efficacy of triclosan soap against superficial dermatomycoses: a double-blind clinical trial in 224 primary school-children in Kilombero District, Morogoro Region, Tanzania

   Relevanz:

4. State of the art der Prävention, Diagnose und Behandlung der Osteoporose und der nichtmedikamentösen Prävention von Frakturen im Alter (Publications)

   State of the art der Prävention, Diagnose und Behandlung der Osteoporose und der nichtmedikamentösen Prävention von Frakturen im Alter

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5. Moderate to vigorous physical activity and sedentary time and cardiometabolic risk factors in children and adolescents (Publications)

   Moderate to vigorous physical activity and sedentary time and cardiometabolic risk factors in children and adolescents

   Relevanz:

   CONTEXT: Sparse data exist on the combined associations between physical activity and sedentary time with cardiometabolic risk factors in healthy children. OBJECTIVE: To examine the independent and co

6. Field issues related to effectiveness of insecticide-treated nets in Tanzania (Publications)

   Field issues related to effectiveness of insecticide-treated nets in Tanzania

   Relevanz:

   Insecticide-treated nets (ITNs) impregnated with pyrethroid insecticides have become one of the most promising interventions to prevent malaria in highly endemic areas. Despite the large body of exper

7. Praziquantel: mechanisms of action, resistance and new derivatives for schistosomiasis (Publications)

   Praziquantel: mechanisms of action, resistance and new derivatives for schistosomiasis

   Relevanz:

   PURPOSE OF REVIEW: Praziquantel (PZQ) is the only drug being used to treat human schistosomiasis on a large scale. This review focuses on current knowledge about the mechanisms of action of PZQ, prosp

8. Assessment of intensity, prevalence and duration of everyday activities in Swiss school children: a cross-sectional analysis of accelerometer and... (Publications)

   Assessment of intensity, prevalence and duration of everyday activities in Swiss school children: a cross-sectional analysis of accelerometer and diary data

   Relevanz:

   ABSTRACT: BACKGROUND: Appropriately measuring habitual physical activity (PA) in children is a major challenge. Questionnaires and accelerometers are the most widely used instruments but both have wel

9. Identification of a new chemical class of antimalarials (Publications)

   Identification of a new chemical class of antimalarials

   Relevanz:

   The increasing spread of drug-resistant malaria strains underscores the need for new antimalarial agents with novel modes of action (MOAs). Here, we describe a compound representative of a new class o

10. Synthesis of a potent antimalarial agent through natural products conjugation (Publications)

    Synthesis of a potent antimalarial agent through natural products conjugation

    Relevanz:

    Au naturel! (+)-Usnic acid (green) is a weak antimalarial agent, however, in conjugation with known antimalarial scaffolds and drugs, such as dihydroartemisinin (blue), potent activity against the blo