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1. Mode of action of action of Artemether/Iumefantirne (Coartem :the sole, fixed, oral ADDC) and its role in combatting multidrug-resistance (Publications)

   Mode of action of action of Artemether/Iumefantirne (Coartem :the sole, fixed, oral ADDC) and its role in combatting multidrug-resistance

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2. Molecular genotyping in a malaria treatment trial in Uganda - unexpected high rate of new infections within 2 weeks after treatment (Publications)

   Molecular genotyping in a malaria treatment trial in Uganda - unexpected high rate of new infections within 2 weeks after treatment

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   Polymerase chain reaction (PCR) genotyping of malaria parasites in drug efficacy trials helps differentiate reinfections from recrudescences. A combination therapy trial of one (n = 115) or three (n =

3. Disentangling the impacts of seasonality, temperature and land cover on the abundance of arboviral mosquito vectors in California using generalized... (Publications)

   Disentangling the impacts of seasonality, temperature and land cover on the abundance of arboviral mosquito vectors in California using generalized additive models

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4. Molecular genotyping to distinguish between recrudescents and new infections in treatment trials of <em>Plasmodium falciparum</em> malaria conducted... (Publications)

   Molecular genotyping to distinguish between recrudescents and new infections in treatment trials of <em>Plasmodium falciparum</em> malaria conducted in Sub-Saharan Africa: adjustment of parasitological outcomes and assessment of genotyping effectiveness.

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5. Screen test: topics in international health: Malaria, 2nd edition. (CD review) (Publications)

   Screen test: topics in international health: Malaria, 2nd edition. (CD review)

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6. Traffic-related pollution and atherosclerosis in European cohorts (ESCAPE study) (Publications)

   Traffic-related pollution and atherosclerosis in European cohorts (ESCAPE study)

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7. Novel inhibitors of Trypanosoma cruzi dihydrofolate reductase (Publications)

   Novel inhibitors of Trypanosoma cruzi dihydrofolate reductase

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   There is an urgent need for the development of new drugs to treat Chagas' disease, which is caused by the protozoan parasite Trypanosoma cruzi. The enzyme dihydrofolate reductase (DHFR) has been a ver

8. Synthesis and testing of 5-benzyl-2,4-diaminopyrimidines as potential inhibitors of leishmanial and trypanosomal dihydrofolate reductase (Publications)

   Synthesis and testing of 5-benzyl-2,4-diaminopyrimidines as potential inhibitors of leishmanial and trypanosomal dihydrofolate reductase

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   Dihydrofolate reductase is a drug target that has not been thoroughly investigated in leishmania and trypanosomes. Work has previously shown that 5-benzyl-2,4-diaminopyrimidines are selective inhibito

9. Quinuclidine derivatives as potential antiparasitics (Publications)

   Quinuclidine derivatives as potential antiparasitics

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   There is an urgent need for the development of new drugs for the treatment of tropical parasitic diseases such as Chagas' disease and leishmaniasis. One potential drug target in the organisms that cau

10. Novel inhibitors of leishmanial dihydrofolate reductase (Publications)

    Novel inhibitors of leishmanial dihydrofolate reductase

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    The program DOCK3.5 was used to search the Cambridge Structural Database for novel inhibitors of Leishmanial dihydrofolate reductase. A number of compounds were obtained and screened against the enzym