Optimization of the electrophile of chloronitrobenzamide leads active against <em>Trypanosoma brucei</em> (Publications)
We previously reported the phenylchloronitrobenzamides (PCNBs), a novel class of compounds active against the species of trypanosomes that cause Human African Trypanosomiasis (HAT). Herein, we explore
Evidence for diversifying selection in a set of <em>Mycobacterium tuberculosis</em> genes in response to antibiotic- and nonantibiotic-related... (Publications)
Tuberculosis (TB) is a global health problem estimated to kill 1.4 million people per year. Recent advances in the genomics of the causative agents of TB, bacteria known as the Mycobacterium tuberculo
Discovery and structure-activity relationships of pyrrolone antimalarials (Publications)
In the pursuit of new antimalarial leads, a phenotypic screening of various commercially sourced compound libraries was undertaken by the World Health Organisation Programme for Research and Training
Prevalence of active convulsive epilepsy in sub-Saharan Africa and associated risk factors: cross-sectional and case-control studies (Publications)
BACKGROUND: The prevalence of epilepsy in sub-Saharan Africa seems to be higher than in other parts of the world, but estimates vary substantially for unknown reasons. We assessed the prevalence and r
Asthma and allergies: is the farming environment (still) protective in Poland? The GABRIEL Advanced Studies (Publications)
BACKGROUND: Evidence exists that a farming environment in childhood may provide protection against atopic respiratory disease. In the GABRIEL project based in Poland and Alpine regions of Germany, Aus
Collection, verification, sharing and dissemination of data: the CONTRAST experience (Publications)
The scientific community is charged with growing demands regarding the management of project data and outputs and the dissemination of key results to various stakeholders. We discuss experiences and l
Antiprotozoal isoflavan quinones from <em>Abrus precatorius</em> ssp. <em>africanus</em> (Publications)
A library of 206 extracts from selected South African plants was screened in vitro against a panel of protozoan parasites, Plasmodium falciparum, Trypanosoma brucei rhodesiense, and Leishmania donovan
Mbandakamines A and B, unsymmetrically coupled dimeric naphthylisoquinoline alkaloids, from a Congolese <em>Ancistrocladus</em> species (Publications)
Mbandakamines A (1) and B (2), isolated from the leaves of an as yet unidentified Congolese Ancistrocladus species, are the first dimeric naphthylisoquinoline alkaloids with an unsymmetrically coupled
