A major role for the <em>Plasmodium falciparum</em> ApiAP2 protein PfSIP2 in chromosome end biology (Publications)
The heterochromatic environment and physical clustering of chromosome ends at the nuclear periphery provide a functional and structural framework for antigenic variation and evolution of subtelomeric
Modelling the cost-effectiveness of mass screening and treatment for reducing <em>Plasmodium falciparum</em> malaria burden (Publications)
BACKGROUND: Past experience and modelling suggest that, in most cases, mass treatment strategies are not likely to succeed in interrupting Plasmodium falciparum malaria transmission. However, this doe
The activities of current antimalarial drugs on the life cycle stages of <em>Plasmodium</em>: a comparative study with human and rodent parasites (Publications)
BACKGROUND: Malaria remains a disease of devastating global impact, killing more than 800,000 people every year-the vast majority being children under the age of 5. While effective therapies are avail
"Pseudo-Beijing": evidence for convergent evolution in the direct repeat region of <em>Mycobacterium tuberculosis</em> (Publications)
BACKGROUND: Mycobacterium tuberculosis has a global population structure consisting of six main phylogenetic lineages associated with specific geographic regions and human populations. One particular
A tool box for operational mosquito larval control: preliminary results and early lessons from the Urban Malaria Control Programme in Dar es Salaam,... (Publications)
BACKGROUND: As the population of Africa rapidly urbanizes, large populations could be protected from malaria by controlling aquatic stages of mosquitoes if cost-effective and scalable implementation s
<em>Plasmodium vivax</em> and mixed infections are associated with severe malaria in children: a prospective cohort study from Papua New Guinea (Publications)
BACKGROUND: Severe malaria (SM) is classically associated with Plasmodium falciparum infection. Little information is available on the contribution of P. vivax to severe disease. There are some epidem
High-resolution genotyping and mapping of recombination and gene conversion in the protozoan <em>Theileria parva</em> using whole genome sequencing (Publications)
ABSTRACT: BACKGROUND: Theileria parva is a tick-borne protozoan parasite, which causes East Coast Fever, a disease of cattle in sub-Saharan Africa. Like Plasmodium falciparum, the parasite undergoes a
Spatial effects of mosquito bednets on child mortality (Publications)
BACKGROUND: Insecticide treated nets (ITN) have been proven to be an effective tool in reducing the burden of malaria. Few randomized clinical trials examined the spatial effect of ITNs on child morta
