Antischistosomal versus antiandrogenic properties of aryl hydantoin ro 13-3978 (Publications)
In the early 1980s, the antischistosomal aryl hydantoin Ro 13-3978 (AH01), a close structural analogue of the androgen receptor antagonist nilutamide, was discovered. Administration of 100 mg/kg oral
Synthesis, beta-haematin inhibition, and in vitro antimalarial testing of isocryptolepine analogues: SAR study of indolo[3,2-c]quinolines with various... (Publications)
A series of indolo[3,2-c]quinolines were synthesized by modifying the side chains of the omega-aminoalkylamines at the C6 position and introducing substituents at the C2 position, such as F, Cl, Br, M
Air pollution and nonmalignant respiratory mortality in 16 cohorts within the ESCAPE project (Publications)
Rationale: Prospective cohort studies have shown that chronic exposure to particulate matter and traffic-related air pollution is associated with reduced survival. However, the effects on nonmalignant
Comparison of ambient airborne PM2.5, PM2.5 absorbance and nitrogen dioxide ratios measured in 1999 and 2009 in three areas in Europe (Publications)
Epidemiological studies often use nitrogen dioxide (NO2) or proximity to roads to characterize exposure to more health-relevant pollutants (e.g., fine particles or black carbon aerosol) in vehicle exh
China's sustained drive to eliminate neglected tropical diseases (Publications)
Non-communicable diseases dominate the public health arena in China, yet neglected tropical diseases (NTDs) are still widespread and create a substantial burden. We review the geographical distributio
Synthesis and antiparasitic activity of new bis-arylimidamides: DB766 analogs modfied in the terminal groups (Publications)
Fifteen novel bis-arylimidamide derivatives with various 6-membered (7a-c) and 5-membered (7d-o) heterocyclic rings replacing the terminal pyridyl rings of the lead compound DB766{(2,5-bis[2-i-propoxy
Probing the antimalarial mechanism of artemisinin and OZ277 (arterolane) with nonperoxidic isosteres and nitroxyl radicals (Publications)
Peroxidic antimalarials such as the semisynthetic artemisinins are critically important in the treatment of drug-resistant malaria. Nevertheless, their peroxide bond-dependent mode of action is still