Genetic validation of <em>Pf</em>FKBP35 as an antimalarial drug target (Publications)
Plasmodium falciparum accounts for the majority of over 600,000 malaria-associated deaths annually. Parasites resistant to nearly all antimalarials have emerged and the need for drugs with alternative
Community-based type 2 diabetes care by lay village health workers in rural Lesotho: protocol for a cluster-randomized trial within the ComBaCaL... (Publications)
BACKGROUND: Type 2 diabetes (T2D) poses a growing public health burden, especially in low- and middle-income countries (LMICs). Task-shifting to lay village health workers (VHWs) and the use of digita
Baseline liver ultrasound findings in preschool children from the praziquantel in preschoolers trial in Lake Albert, Uganda (Publications)
BACKGROUND: Periportal fibrosis is a late-stage manifestation of chronic infection with Schistosoma mansoni. Praziquantel (PZQ), the only drug available for the treatment of schistosomiasis, has limit
Spatial distributions of diarrheal cases in relation to housing conditions in informal settlements: a cross-sectional study in Abidjan, Côte... (Publications)
In addition to individual practices and access to water, sanitation, and hygiene (WASH) facilities, housing conditions may also be associated with the risk of diarrhea. Our study embraced a broad appr
Comparison of sensitivity and faecal egg counts of mini-FLOTAC using fixed stool samples and Kato-Katz technique for the diagnosis of <em>Schistosoma... (Publications)
Accurate diagnostic tools for human helminthiasis are crucial for improved patient management and evaluation of community-based intervention studies. However, the diagnosis of intestinal schistosomias
Regular family breakfast was associated with children's overweight and parental education: results from the ENERGY cross-sectional study (Publications)
INTRODUCTION: This study aims to assess (i) the prevalence of having regular family breakfast, lunch, dinner (i.e. 5-7days/week together with their family) among 10-12year olds in Europe, (ii) the ass
Discovery and characterization of ACT-451840: an antimalarial drug with a novel mechanism of action (Publications)
More than 40 % of the world's population is at risk of being infected with malaria. Most malaria cases occur in the countries of sub-Saharan Africa, Central and South America, and Asia. Resistance to
Correcting India's chronic shortage of drug inspectors to ensure the production and distribution of safe, high-quality medicines (Publications)
BACKGROUND: Good drug regulation requires an effective system for monitoring and inspection of manufacturing and sales units. In India, despite widespread agreement on this principle, ongoing shortage
Characterization of novel antimalarial compound ACT-451840: preclinical assessment of activity and dose-efficacy modeling (Publications)
BACKGROUND: Artemisinin resistance observed in Southeast Asia threatens the continued use of artemisinin-based combination therapy in endemic countries. Additionally, the diversity of chemical mode of
Ivermectin treatment and sanitation effectively reduce <em>Strongyloides stercoralis</em> infection risk in rural communities in Cambodia (Publications)
BACKGROUND: Strongyloides stercoralis is the only soil-transmitted helminth with the ability to replicate within its host, leading to long-lasting and potentially fatal infections. It is ubiquitous an
