Targeting the parasite's DNA with methyltriazenyl purine analogs is a safe, selective and efficacious antitrypanosomal strategy (Publications)
The human and veterinary disease complex known as African trypanosomiasis continues to inflict significant global morbidity, mortality and economic hardship. Drug resistance and toxic side effects of
Malaria eradication and elimination: views on how to translate a vision into reality (Publications)
Although global efforts in the past decade have halved the number of deaths due to malaria, there are still an estimated 219 million cases of malaria a year, causing more than half a million deaths. I
An operational comparative study of quinine and artesunate for the treatment of severe malaria in hospitals and health centres in the Democratic... (Publications)
BACKGROUND: The Democratic Republic of the Congo (DRC) has the highest number of severe malaria cases in the world. In early 2012, the National Malaria Control Programme (NMCP) changed the policy for
AMBITION-cm: intermittent high dose AmBisome on a high dose fluconazole backbone for cryptococcal meningitis induction therapy in sub-Saharan Africa:... (Publications)
BACKGROUND: Cryptococcal meningitis (CM) is a leading cause of mortality among HIV-infected individuals in Africa. Poor outcomes from conventional antifungal therapies, unavailability of flucytosine,
Do holes in long-lasting insecticidal nets compromise their efficacy against pyrethroid resistant <em>Anopheles gambiae</em> and <em>Culex... (Publications)
BACKGROUND: Resistance of malaria vectors to pyrethroids threatens the effectiveness of long-lasting insecticidal nets (LLINs) as a tool for malaria control. Recent experimental hut and observational
Osteopathology and selenium deficiency co-occurring in a population of endangered Patagonian huemul (<em>Hippocamelus bisulcus</em>) (Publications)
BACKGROUND: About 1,000 endangered Patagonian huemul deer (Hippocamelus bisulcus) remain in Chile and 350-500 in Argentina. Most groups (> 100) are not recovering, and prevalence of osteopathology in
The integrated disease surveillance and response system in northern Ghana: challenges to the core and support functions (Publications)
BACKGROUND: The integrated disease surveillance and response (IDSR) strategy was adopted in Ghana over a decade ago, yet gaps still remain in its proper functioning. The objective of this study was to