Sequence diversity in the <em>pe_pgrs</em> genes of <em>Mycobacterium tuberculosis</em> is independent of human T cell recognition (Publications)
The Mycobacterium tuberculosis genome includes the large family of pe_pgrs genes, whose functions are unknown. Because of precedents in other pathogens in which gene families showing high sequence var
In silico ionomics segregates parasitic from free-living eukaryotes (Publications)
Ion transporters are fundamental to life. Due to their ancient origin and conservation in sequence, ion transporters are also particularly well suited for comparative genomics of distantly related spe
Impact of geocoding methods on associations between long-term exposure to urban air pollution and lung function (Publications)
BACKGROUND: Errors in address geocodes may impact estimates of the effects of air pollution on health. OBJECTIVE: We investigated the impact of four geocoding techniques on the association between urb
Bromopyrrole alkaloids as lead compounds against protozoan parasites (Publications)
In the present study, 13 bromopyrrole alkaloids, including the oroidin analogs hymenidin (2), dispacamide B (3) and dispacamide D (4), stevensine (5) and spongiacidin B (6), their derivatives lacking
Discovery and evaluation of thiazinoquinones as anti-protozoal agents (Publications)
Pure compound screening has identified the dioxothiazino-quinoline-quinone ascidian metabolite ascidiathiazone A (2) to be a moderate growth inhibitor of Trypanosoma brucei rhodesiense (IC50 3.1 muM)
Ethanolamine phosphoglycerol attachment to eEF1A is not essential for normal growth of <em>Trypanosoma brucei</em> (Publications)
Eukaryotic elongation factor 1A (eEF1A) is the only protein modified by ethanolamine phosphoglycerol (EPG). In mammals and plants, EPG is attached to conserved glutamate residues located in eEF1A doma
Weather and mortality: a 10 year retrospective analysis of the Nouna Health and Demographic Surveillance System, Burkina Faso (Publications)
Background: A growing body of evidence points to the emission of greenhouse gases from human activity as a key factor in climate change. This in turn affects human health and wellbeing through consequ