Using yeast synthetic lethality to inform drug combination for malaria (Publications)
Combinatorial chemotherapy is necessary for the treatment of malaria. However, finding a suitable partner drug for a new candidate is challenging. Here we develop an algorithm that identifies all of t
Orientia <em>tsutsugamushi</em> is highly susceptible to the RNA polymerase switch region inhibitor corallopyronin a <em>in vitro</em> and<em> in... (Publications)
Scrub typhus is a potentially lethal infection caused by the obligate intracellular bacterium Orientia tsutsugamushi Reports on the emergence of doxycycline-resistant strains highlight the urgent need
The effect of case management and vector-control interventions on space-time patterns of malaria incidence in Uganda (Publications)
BACKGROUND: Electronic reporting of routine health facility data in Uganda began with the adoption of the District Health Information Software System version 2 (DHIS2) in 2011. This has improved healt
Physical activity and dual disease burden among South African primary schoolchildren from disadvantaged neighbourhoods (Publications)
People from low- and middle-income countries still face challenges stemming from parasitic infections. Additionally, non-communicable diseases (NCDs) and their risk factors are rapidly increasing, whi
Anemia in tuberculosis cases and household controls from Tanzania: contribution of disease, coinfections, and the role of hepcidin (Publications)
BACKGROUND: Tuberculosis (TB) induces a systemic inflammatory state affecting iron homeostasis. Patients with TB often have additional comorbidities such as anemia which can result in poorer treat out