Exploring a tetrahydroquinoline antimalarial hit from the medicines for malaria pathogen box and the identification of its mode of resistance as... (Publications)
New antimalarial treatments with novel mechanism of action are needed to tackle Plasmodium falciparum infections that are resistant to first-line therapeutics. Here we report the exploration of MMV692
Co-infection of the four major <em>Plasmodium </em>species: effects on densities and gametocyte carriage (Publications)
BACKGROUND: Co-infection of the four major species of human malaria parasite Plasmodium falciparum (Pf), P. vivax (Pv), P. malariae (Pm), and P. ovale sp. (Po) is regularly observed, but there is limi
Modulation of host-parasite interactions with small molecules targeting <em>Schistosoma mansoni </em>microRNAs (Publications)
Parasites use different strategies of communication with their hosts. One communication channel that has been studied in recent years is the use of vesicle microRNAs to influence the host immune syste
The relative impact of interventions on sympatric <em>Plasmodium vivax</em> and <em>Plasmodium falciparum</em> malaria: a systematic review (Publications)
BACKGROUND: In areas with both Plasmodium vivax and Plasmodium falciparum malaria, interventions can reduce the burden of both species but the impact may vary due to their different biology. Knowing t
Effects of animal-assisted psychotherapy incorporating mindfulness and self-compassion in neurorehabilitation: a randomized controlled feasibility... (Publications)
Transdiagnostic psychotherapeutic approaches are increasingly used in neurorehabilitation to address psychological distress. Animal-assistance is thought to increase efficacy. The present study evalua
High-throughput <em>Plasmodium falciparum hrp2</em> and <em>hrp3 </em>gene deletion typing by digital PCR to monitor malaria rapid diagnostic test... (Publications)
Most rapid diagnostic tests for Plasmodium falciparum malaria target the Histidine-Rich Proteins 2 and 3 (HRP2, HRP3). Deletions of the hrp2 and hrp3 genes result in false negative tests and are a thr
Stakeholder perceptions on the deployment of multiple first-line therapies for uncomplicated malaria: a qualitative study in the health district of... (Publications)
BACKGROUND: In Burkina Faso, malaria remains the first cause of medical consultation and hospitalization in health centres. First-line case management of malaria in the country's health facilities is
Efficacy and safety of Shenqisuxin granule for non-ST-segment elevation acute coronary syndrome: study protocol for a randomized, double-blinded,... (Publications)
Introduction: The Chinese herbal compound formula, Shenqisuxin granule (SQSX), promotes neovascularization and prevents in-stent restenosis in modern pharmaceutical studies and is expected to provide
A malaria-free China: global importance and key experience (Publications)
Malaria has a worldwide distribution and is the world's deadliest mosquito-borne disease. The goal of malaria elimination is also reflected in the United Nations Sustainable Development Goals and the
Estimating baseline rates of adverse perinatal and neonatal outcomes using a facility-based surveillance approach: a prospective observational study... (Publications)
Background: Most perinatal and neonatal deaths occur in low- and middle-income countries (LMICs), yet, quality data on burden of adverse outcomes of pregnancy is limited in such countries. Methods: A
