Effect of artemether administered alone or in combination with praziquantel to mice infected with <em>Plasmodium berghei </em>or <em>Schistosoma... (Publications)
The artemisinins have become key drugs for the treatment and control of malaria, particularly within artemisinin-based combination therapies. Since the artemisinins also exhibit antischistosomal prope
Effect of praziquantel together with artemether on <em>Schistosoma japonicum </em>parasites of different ages in rabbits (Publications)
The efficacy of combined treatment with praziquantel and artemether against infection with Schistosoma japonicum was tested on infected rabbits, in which 7-to 14-day-old schistosomules and 42-day-old
Selection and reversal of <em>Plasmodium berghei</em> resistance in the mouse model following repeated high doses of artemether (Publications)
Artemether, a derivative of artemisinin, is effectively used for the treatment of malaria without any clinically relevant resistance to date. Artemether has also been developed as an antischistosomal
Tegumental alterations in juvenile <em>Schistosoma haematobium</em> harboured in hamsters following artemether treatment (Publications)
We report the findings of a detailed temporal study on tegumental alterations in juvenile Schistosoma haematobium, induced by artemether, using scanning electron microscopy. Hamsters infected with S.
Advances with the Chinese anthelminthic drug tribendimidine in clinical trials and laboratory investigations (Publications)
The anthelminthic drug tribendimidine has been approved by Chinese authorities for human use in 2004, and a first comprehensive review was published in Acta Tropica in 2005. Here, we summarise further
Analysis of subtelomeric virulence gene families in <em>Plasmodium falciparum</em> by comparative transcriptional profiling (Publications)
The Plasmodium falciparum genome is equipped with several subtelomeric gene families that are implicated in parasite virulence and immune evasion. Members of these families are uniformly positioned wi
An approach to classifying human resources constraints to attaining health-related Millennium Development Goals (Publications)
BACKGROUND: For any wide-ranging effort to scale up health-related priority interventions, human resources for health (HRH) are likely to be a key to success. This study explores constraints related t
<em>Schistosoma japonicum</em>: in vitro effects of artemether combined with haemin depend on cultivation media and appraisal of artemether products... (Publications)
We recently found that the exposure of schistosomes in vitro to artemether plus haemin can lead to parasite death, while exposure to each compound singly had no effect. Since these observations might
