Nonregistration, discontinuation, and nonpublication of randomized trials: a repeated metaresearch analysis (Publications)
BACKGROUND: We previously found that 25% of 1,017 randomized clinical trials (RCTs) approved between 2000 and 2003 were discontinued prematurely, and 44% remained unpublished at a median of 12 years f
Mental distress and health-related quality of life in <em>gambiense </em>human African trypanosomiasis: a case-control study in the Democratic... (Publications)
BACKGROUND: The extent to which neuropsychiatric sequelae affects the mental health status and quality of life of former gambiense human African trypanosomiasis (gHAT) patients is not known. METHODS:
Competent and deficient provision of childbirth services: a descriptive observational study assessing the quality of intrapartum care in two provinces... (Publications)
BACKGROUND: A majority of women in the Democratic Republic of the Congo (DRC) give birth in a health facility, but maternal and newborn mortality remains high. In rural areas, the quality of facility-
Infection intensity-dependent accuracy of reagent strip for the diagnosis of <em>Schistosoma haematobium </em>and estimation of treatment prevalence... (Publications)
BACKGROUND: Reagent strip to detect microhematuria as a proxy for Schistosoma haematobium infections has been considered an alternative to urine filtration for individual diagnosis and community-based
Population pharmacokinetics of antimalarial naphthoquine in combination with artemisinin in Tanzanian children and adults: dose optimization (Publications)
The combination antimalarial therapy of artemisinin-naphthoquine (ART-NQ) was developed as a single-dose therapy, aiming to improve adherence relative to the multiday schedules of other artemisinin co
Presenting a comprehensive multi-scale evaluation framework for participatory modelling programs: a scoping review (Publications)
INTRODUCTION: Systems modelling and simulation can improve understanding of complex systems to support decision making, better managing system challenges. Advances in technology have facilitated acces
Vaccine hesitancy and HPV vaccine uptake among male and female youth in Switzerland: a cross-sectional study (Publications)
OBJECTIVES: Identifying factors associated with human papillomavirus (HPV) vaccine uptake is essential for designing successful vaccination programmes. We aimed to examine the association between vacc
Metabolic, pharmacokinetic, and activity profile of the liver stage antimalarial (RC-12) (Publications)
The catechol derivative RC-12 (WR 27653) (1) is one of the few non-8-aminoquinolines with good activity against hypnozoites in the gold-standard Plasmodium cynomolgi-rhesus monkey (Macaca mulatta) mod
An evidence synthesis approach for combining different data sources illustrated using entomological efficacy of insecticides for indoor residual... (Publications)
BACKGROUND: Prospective malaria public health interventions are initially tested for entomological impact using standardised experimental hut trials. In some cases, data are collated as aggregated cou
Financially incentivized knowledge assessments to improve provider compliance with treatment guidelines: a cluster-randomized controlled trial (Publications)
BACKGROUND: Despite increasing access to health care, under-5 mortality remains high in many parts of Sub-Saharan Africa. Interventions to improve quality of care have mostly focused on additional tra
