Characterization of a serine hydrolase targeted by acyl-protein thioesterase inhibitors in <em>Toxoplasma gondii</em> (Publications)
In eukaryotic organisms, cysteine palmitoylation is an important reversible modification that impacts protein targeting, folding, stability, and interactions with partners. Evidence suggests that prot
Diagnosis and treatment of schistosomiasis in children in the era of intensified control (Publications)
In the current era of intensified and integrated control against schistosomiasis and other neglected tropical diseases, there is a need to carefully rethink and take into consideration disease-specifi
Out-of-Africa migration and neolithic coexpansion of <em>Mycobacterium tuberculosis</em> with modern humans (Publications)
Tuberculosis caused 20% of all human deaths in the Western world between the seventeenth and nineteenth centuries and remains a cause of high mortality in developing countries. In analogy to other cro
Challenging sleep homeostasis in narcolepsy-cataplexy: implications for non-REM and REM sleep regulation (Publications)
STUDY OBJECTIVES: We recently proposed insufficient non-rapid eye movement sleep (NREMS) intensity to contribute to disturbed nocturnal sleep in patients with narcolepsy-cataplexy (NC). To test this h
Novel 3-nitro-1H-1,2,4-triazole-based compounds as potential anti-Chagasic drugs: <em>in vivo</em> studies (Publications)
Background: Chagas disease is caused by the parasite Trypanosoma cruzi, is endemic in Latin America and leads to an estimated 14,000 deaths per year and around 100 million people at risk of infection.
Air pollution and childhood leukaemia: a nationwide case-control study in Italy (Publications)
OBJECTIVES: Leukaemia is the most common cancer in children, but its aetiology is still poorly understood. We tested the hypothesis that traffic-related air pollution is associated with paediatric leu
Adenosinergic mechanisms contribute to individual differences in sleep deprivation-induced changes in neurobehavioral function and brain rhythmic... (Publications)
Large individual differences characterize the changes induced by sleep deprivation on neurobehavioral functions and rhythmic brain activity. To investigate adenosinergic mechanisms in these difference
Simple variables predict miserable outcome after intravenous thrombolysis (Publications)
BACKGROUND AND PURPOSE: To test the predictability of miserable outcome amongst ischaemic stroke patients receiving intravenous thrombolysis (IVT) based on a simple variables model (SVM) and to compar
