First generation leishmaniasis vaccines: A review of field efficacy trials (Publications)
First generation candidate vaccines against leishmaniasis, prepared using inactivated whole parasites as their main ingredient, were considered as promising because of their relative ease of productio
The antiprotozoal activity of methylated flavonoids from <em>Ageratum conyzoides</em> L (Publications)
AIM OF THE STUDY: The dichloromethane extract prepared from aerial parts of Ageratum conyzoides L. (Asteraceae), a plant commonly used in folk medicine for a number of illnesses including sleeping sic
Structure-activity-based design of a synthetic malaria peptide eliciting sporozoite inhibitory antibodies in a virosomal formulation (Publications)
The circumsporozoite protein (CSP) of Plasmodium falciparum is a leading candidate antigen for inclusion in a malaria subunit vaccine. We describe here the design of a conformationally constrained syn
Synthesis and antiprotozoal activity of <em>N</em>-alkoxy analogues of the trypanocidal lead compound 4,4'-bis(imidazolinylamino)diphenylamine with... (Publications)
To improve the blood-brain barrier permeability of the trypanocidal lead compound 4,4'-bis(imidazolinylamino)diphenylamine (1), five N-alkoxy analogues were synthesized from bis(4-isothiocyanatophenyl
Preclinical profiling of the immunogenicity of a two-component subunit malaria vaccine candidate based on virosome technology (Publications)
Presentation of synthetic peptides on immunopotentiating reconstituted influenza virosomes is a promising technology for subunit vaccine development. An optimized virosomally delivered peptide represe