1000 Genomes-based meta-analysis identifies 10 novel loci for kidney function (Publications)
HapMap imputed genome-wide association studies (GWAS) have revealed > 50 loci at which common variants with minor allele frequency > 5% are associated with kidney function. GWAS using more complete re
Associations of novel and traditional vascular biomarkers of arterial stiffness: results of the SAPALDIA 3 cohort study (Publications)
BACKGROUND AND OBJECTIVES: There is a lack of evidence concerning associations between novel parameters of arterial stiffness as cardiovascular risk markers and traditional structural and functional v
Prevalence of renal impairment and its association with cardiovascular risk factors in a general population: results of the Swiss SAPALDIA study (Publications)
BACKGROUND: Impaired renal function is evolving as an independent marker of the risk of cardiovascular morbidity and mortality. Little is known about the prevalence of impaired renal function and its
Relative validation of a food frequency questionnaire to estimate food intake in an adult population (Publications)
Background: Scientifically valid descriptions of dietary intake at population level are crucial for investigating diet effects on health and disease. Food frequency questionnaires (FFQs) are the most
High blood pressure: prevalence and adherence to guidelines in a population-based cohort (Publications)
QUESTIONS UNDER STUDY: High blood pressure, the single leading health risk factor worldwide, contributes greatly to morbidity and mortality. This study aimed to add to the understanding of diagnosed a
Peak flow variability in the SAPALDIA study and its validity in screening for asthma-related conditions (Publications)
We used 3-wk peak expiratory flow (PEF) measurements (twice daily) made in the diary study of the population-based Swiss Study on Air Pollution and Lung Disease in Adults to describe PEF-variability (
SOS2 and ACP1 loci identified through large-scale exome chip analysis regulate kidney development and function (Publications)
Genome-wide association studies have identified > 50 common variants associated with kidney function, but these variants do not fully explain the variation in eGFR. We performed a two-stage meta-analy
Is age at menopause increasing across Europe? Results on age at menopause and determinants from two population-based studies (Publications)
OBJECTIVE: To investigate the variability and determinants of menopause age in two European cohort studies, the European Respiratory Health Survey and the Swiss Air Pollution and Lung Disease in Adult
Improvements in PM10 exposure and reduced rates of respiratory symptoms in a cohort of Swiss adults (SAPALDIA) (Publications)
RATIONALE: Reductions in mortality following improvements in air quality were documented by several studies, and our group found, in an earlier analysis, that decreasing particulate levels attenuate l
