Vaccines for enteric diseases: update on recent developments (Publications)
The 5th International Conference on Vaccines for Enteric Diseases (VED) attracted more than 250 delegates, mainly from industrialized countries. A total of 56 papers were presented and 46 posters were
Swiss registry for patients with cystic fibrosis: design, programming, implementation and first examples of use (Publications)
The Swiss Registry for Cystic Fibrosis (SRCF) was designed to collect demographic, clinical and therapeutic data from patients with cystic fibrosis (CF) in Switzerland. It was designed, programmed and
New 4-aminobicyclo[2.2.2]octane derivatives and their activities against <em>Plasmodium falciparum</em> and <em>Trypanosoma b. rhodesiense</em> (Publications)
A series of new 2-substituted 4-dialkylaminobicyclo[2.2.2]octane derivatives was prepared and the compounds were investigated for their activity against causative organisms of tropical diseases. The t
Synthesis of new esters and oximes with 4-aminobicyclo[2.2.2]octane structure and evaluation of their antitrypanosomal and antiplasmodial activities (Publications)
New 4-amino-6,7-diphenylbicyclo[2.2.2]octane derivatives, esters of bicyclo[2.2.2]octan-2-ols and O-methyl oximes of bicyclo[2.2.2]octan-2-ones were synthesised. Their activities against Trypanosoma b
Synthesis and in vitro antiprotozoal activities of 5-phenyliminobenzo[a]phenoxazine derivatives (Publications)
A series of 5-phenyliminobenzo[a]phenoxazine derivatives were synthesized. The in vitro antiprotozoal activities were evaluated against Plasmodium falciparum K1, Trypanosoma cruzi, Leishmania donovani
A point mutation in codon 76 of <em>pfcrt </em>of <em>P. falciparum </em>is positively selected for by chloroquine treatment in Tanzania (Publications)
This study was undertaken to validate the relevance of Chloroquine (CQ) resistance markers pfcrt(76) and pfmdr1(86) in an endemic area in Tanzania. After treatment with CQ, recrudescence was distingui