Synthesis and evaluation of beta-carbolinium cations as new antimalarial agents based on pi-delocalized lipophilic cation (DLC) hypothesis (Publications)
Several beta-carbolines including naturally occurring substances and their corresponding cationic derivatives were synthesized and evaluated for antimalarial (antiplasmodial) activity in vitro and in
Inhibition of <em>Plasmodium falciparum</em> fatty acid biosynthesis: evaluation of FabG, FabZ, and FabI as drug targets for flavonoids (Publications)
After the discovery of a potent natural flavonoid glucoside as a potent inhibitor of FabI, a large flavonoid library was screened against three important enzymes (i.e., FabG, FabZ, and FabI) involved
Synthesis and structure-activity analysis of new phosphonium salts with potent activity against African trypanosomes (Publications)
A series of 73 bisphosphonium salts and 10 monophosphonium salt derivatives were synthesized and tested in vitro against several wild type and resistant lines of Trypanosoma brucei (T. b. rhodesiense
Genome-based health literacy: a new challenge for public health genomics (Publications)
So far health literacy has not been sufficiently discussed in the context of public health genomics. Primarily, not genomic but rather genome-based health information needs to be addressed taking into
Informed choices for attaining the Millennium Development Goals: towards an international cooperative agenda for health-systems research (Publications)
Health systems constraints are impeding the implementation of major global initiatives for health and the attainment of the Millennium Development Goals (MDGs). Research could contribute to overcoming
