Animal-assisted psychotherapy for pediatric chronic pain: case series of an open pilot study to test initial feasibility and potential efficacy (Publications)
To date, however, AAIs have not been examined in pediatric chronic pain. METHODS: The aim of this open pilot study was to examine the initial feasibility of recruitment and potential efficacy of an an [...] revealed that patients and their parents had a positive attitude towards AAIs. CONCLUSION: Our initial open pilot study is the first to investigate AAIs in the context of pediatric chronic pain. Notably, we
Ultrasononography in managing extrapulmonary tuberculosis: a randomized, controlled, parallel, superiority, open-label trial (Publications)
BACKGROUND: Patients with suspected extrapulmonary tuberculosis are often treated empirically. We hypothesized that extended focused assessment with sonography for human immunodeficiency virus (HIV) a
Efficacy, safety, and palatability of arpraziquantel (L-praziquantel) orodispersible tablets in children aged 3 months to 6 years infected with... (Publications)
arpraziquantel (L-praziquantel) orodispersible tablets for preschool-aged children. METHODS: This open-label, partly randomised, phase 3 study was conducted at two hospitals in Cote d'Ivoire and Kenya
Managing research and surveillance projects in real-time with a novel open-source eManagement tool designed for under-resourced countries (Publications)
is lightweight and uses minimal internet resources. It was designed to be used with the open source software Open Data Kit (ODK). The users can easily configure odk_planner to meet their needs, and the [...] tracked sputum samples, and collected clinical and laboratory data. CONCLUSIONS: The user friendly, open source odk_planner is a simple, but multi-functional, Web-based eManagement tool with add-ons that
Open source drug discovery with the malaria box compound collection for neglected diseases and beyond (Publications)
industry. Open source drug discovery, with sharing of information, is clearly a first step towards overcoming this gap. But the interface could especially be bridged through a scale-up of open sharing of [...] expertise in biological assays involving human pathogens into drug discovery starting points, by providing open access to new families of molecules, and emphasize how a small additional investment made to help
Open source drug discovery: highly potent antimalarial compounds derived from the Tres Cantos arylpyrroles (Publications)
potential starting points for hit-to-lead campaigns. One such public set is explored, employing an open source research mechanism in which all data and ideas were shared in real time, anyone was able to [...] including activity within gametocyte and liver stage assays, but at the cost of low solubility. As an open source research project, unexplored avenues are clearly identified and may be explored further by
Efficacy of single versus four repeated doses of praziquantel agains<em>t Schistosoma mansoni </em>infection in school-aged children from Côte... (Publications)
infection in school-aged children from Cote d'Ivoire, using two different diagnostic tests. METHODS: An open-label, randomized controlled trial was conducted from October 2018 to January 2019. School-aged children
Fixed-dose artesunate-amodiaquine combination vs chloroquine for treatment of uncomplicated blood stage <em>P. vivax</em> infection in the Brazilian... (Publications)
BACKGROUND: Despite increasing evidence of the development of Plasmodium vivax chloroquine (CQ) resistance, there have been no trials comparing its efficacy with that of artemisinin-based combination
Open Malaria : a simulator program for studying malaria epidemiology and the impacts of interventions against malaria [Software] (Publications)
OpenMalaria is an open source C++ program for simulating malaria epidemiology and the impacts on that epidemiology of interventions against malaria. It is based on microsimulations of