Group | Genetic Epidemiology of Non-Communicable Diseases

The group has established one of the largest chronic disease-related biobanks in Switzerland (The SAPALDIA Biobank). The biobank allows for studies on the genetic background of complex chronic diseases and related subclincial phenotypes, with a special focus on phenotypes related to respiratory and cardiovascular health (i.e. lung function, asthma, COPD, heart rate variability, intima-media thickness and renal function).

In the context of international collaborations and genetics consortia, staff members contribute to and lead large meta-analyses to identify novel disease genes and to understand how they modify susceptibility to lifestyle and environmental factors. Studies on the interaction of inherited genetic and epigenetic susceptibility factors with environmental factors, such as air pollution and noise, are a major focus of the group.

Nicole Probst-Hensch

Nicole Probst-Hensch, Professor, PhD (Pharmacy and Epidemiology), MPH

Beloconi A, Probst-Hensch N, Vounatsou P. Spatio-temporal modelling of changes in air pollution exposure associated to the COVID-19 lockdown measures across Europe. Sci Total Environ. 2021;787:147607. DOI: 10.1016/j.scitotenv.2021.147607

Cerletti P et al. Perceived built environment, health-related quality of life and health care utilization. PLoS One. 2021;16(5):e0251251. DOI: 10.1371/journal.pone.0251251

Lytras T et al. Cumulative occupational exposures and lung function decline in two large general population cohorts. Ann Am Thorac Soc. 2021;18(2):238-246. DOI: 10.1513/AnnalsATS.202002-113OC

Marcon A et al. The coexistence of asthma and COPD: risk factors, clinical history and lung function trajectories. Eur Respir J. 2021(in press). (ALEC). DOI: 10.1183/13993003.04656-2020

Probst-Hensch N et al. Causal effects of body mass index on airflow obstruction and forced mid-expiratory flow: a mendelian randomization study taking interactions and age-specific instruments into consideration toward a life course perspective. Front Public Health. 2021;9:584955. DOI: 10.3389/fpubh.2021.584955