Group | Genetic Epidemiology of Non-Communicable Diseases

The group has established one of the largest chronic disease-related biobanks in Switzerland (The SAPALDIA Biobank). The biobank allows for studies on the genetic background of complex chronic diseases and related subclincial phenotypes, with a special focus on phenotypes related to respiratory and cardiovascular health (i.e. lung function, asthma, COPD, heart rate variability, intima-media thickness and renal function).

In the context of international collaborations and genetics consortia, staff members contribute to and lead large meta-analyses to identify novel disease genes and to understand how they modify susceptibility to lifestyle and environmental factors. Studies on the interaction of inherited genetic and epigenetic susceptibility factors with environmental factors, such as air pollution and noise, are a major focus of the group.

Nicole Probst-Hensch

Nicole Probst-Hensch, Professor, PhD (Pharmacy and Epidemiology), MPH

Carsin A.E et al. Restrictive spirometry pattern is associated with low physical activity levels. A population based international study. Respir Med. 2019;146:116-123. DOI: 10.1016/j.rmed.2018.11.017

Mattli R, Wieser S, Probst-Hensch N, Schmidt-Trucksäss A, Schwenkglenks M. Physical inactivity caused economic burden depends on regional cultural differences. Scand J Med Sci Sports. 2019;29(1):95-104. DOI: 10.1111/sms.13311

Triebner K et al. Exogenous female sex steroids may reduce lung ageing after menopause: a 20-year follow-up study of a general population sample (ECRHS). Maturitas. 2019;120:29-34. DOI: 10.1016/j.maturitas.2018.11.007

Vienneau D et al. Façades, floors and maps – influence of exposure measurement error on the association between transportation noise and myocardial infarction. Environ Int. 2019;123:399-406. DOI: 10.1016/j.envint.2018.12.015

Australian Asthma Genetics Consortium Collaborators et al. Multiancestry association study identifies new asthma risk loci that colocalize with immune-cell enhancer marks. Nat Genet. 2018;50(1):42-53. (AAGC). DOI: 10.1038/s41588-017-0014-7