Group | Genetic Epidemiology of Non-Communicable Diseases

The group has established one of the largest chronic disease-related biobanks in Switzerland (The SAPALDIA Biobank). The biobank allows for studies on the genetic background of complex chronic diseases and related subclincial phenotypes, with a special focus on phenotypes related to respiratory and cardiovascular health (i.e. lung function, asthma, COPD, heart rate variability, intima-media thickness and renal function).

In the context of international collaborations and genetics consortia, staff members contribute to and lead large meta-analyses to identify novel disease genes and to understand how they modify susceptibility to lifestyle and environmental factors. Studies on the interaction of inherited genetic and epigenetic susceptibility factors with environmental factors, such as air pollution and noise, are a major focus of the group.

Nicole Probst-Hensch

Nicole Probst-Hensch, Professor, PhD (Pharmacy and Epidemiology), MPH

Nguyen T.T.N, Schindler C, Dien T.M, Probst-Hensch N, Perez L, Künzli N. Acute effects of ambient air pollution on lower respiratory infections in Hanoi children: an eight-year time series study. Environ Int. 2018;110:139-148. DOI: 10.1016/j.envint.2017.10.024

Gulliver J et al. Land use regression models for the oxidative potential of fine particles (PM2.5) in five European areas. Environ Res. 2018;160:247-255. DOI: 10.1016/j.envres.2017.10.002

Fuertes E et al. Leisure-time vigorous physical activity is associated with better lung function: the prospective ECRHS study. Thorax. 2018(in press). DOI: 10.1136/thoraxjnl-2017-210947

Valkonen M et al. Microbial characteristics in homes of asthmatic and non-asthmatic adults in the ECRHS cohort. Indoor Air. 2018;28:16-27. DOI: 10.1111/ina.12427

Australian Asthma Genetics Consortium Collaborators et al. Multiancestry association study identifies new asthma risk loci that colocalize with immune-cell enhancer marks. Nat Genet. 2018;50(1):42-53. (AAGC). DOI: 10.1038/s41588-017-0014-7