MATIAS - Treatment of Severe Malaria with Injectable Artesunate

Implementation Non-Controlled Longitudinal Observational Study to Support Artesunate Introduction in the Democratic Republic of the Congo (DRC)

In 2010, the AQUAMAT study demonstrated that, in children, the treatment of severe malaria with artesunate reduced the case fatality substantially. An overall reduction of 22.5 % of mortality in African children (< 15 years) was reported using injectable artesunate compared to injectable quinine for treatment of severe malaria caused by Plasmodium falciparum.

These results with high quality evidence led to a change in the WHO guidelines for the treatment of severe malaria in children and adults with in 2011. In early 2012, the Programme National de Lutte contre of Paludisme (PNLP) of the DRC decided to follow the WHO guidelines and changed the policy for the treatment of severe malaria. However, this process is a complex undertaking, requiring many operational and clinical adaptations. To support this process, need for on-site operational information and consequences of the switch from quinine to artesunate was noticed.

The MATIAS Study

The MATIAS study was conducted as collaboration between the Swiss TPH, the MMV (Medicines for Malaria Venture), the Kinshasa School of Public Health and several study sites in the Democratic Republic of the Congo. The project aimed to demonstrate through limited scope implementation studies how injectable artesunate may be progressively rolled out nationwide as the preferred treatment for severe malaria. Four components were evaluated to compare quinine to artesunate treatment: clinical assessment, time and motion study, feasibility and acceptability assessment and analysis of the financial cost. Due to reports concerning hemolytic anemias potentially related to the use of artesunate, measurements of hemoglobin were added.

Summarizing the results, this study provided a descriptive evidence of the greater operational simplicity and lower cost of injectable artesunate for the treatment of severe malaria. Combined with its higher efficacy, these findings are supporting the switch-over in the Democratic Republic of the Congo and elsewhere.


Walker T.M et al. A cluster of multidrug-resistant Mycobacterium tuberculosis among patients arriving in Europe from the Horn of Africa: a molecular epidemiological study. Lancet. 2018(in press). DOI: 10.1016/S1473-3099(18)30004-5

Cretton S et al. A new antifungal and antiprotozoal bibenzyl derivative from Gavilea lutea. Nat Prod Res. 2018;32(6):695-701. DOI: 10.1080/14786419.2017.1338287

Nguyen T.T.N, Schindler C, Dien T.M, Probst-Hensch N, Perez L, Künzli N. Acute effects of ambient air pollution on lower respiratory infections in Hanoi children: an eight-year time series study. Environ Int. 2018;110:139-148. DOI: 10.1016/j.envint.2017.10.024

Müller-Rompa S.E.K et al. An approach to the asthma-protective farm effect by geocoding: good farms and better farms. Pediatr Allergy Immunol. 2018(in press). DOI: 10.1111/pai.12861

Maia M.F et al. Attractive toxic sugar baits for controlling mosquitoes: a qualitative study in Bagamoyo, Tanzania. Malar J. 2018;17(1):22. DOI: 10.1186/s12936-018-2171-2