Unit | Molecular Diagnostics

The unit develops new tools for diagnosing parasitic diseases and for genotyping parasite strains and species. New diagnostic tests are applied to population-wide studies in endemic areas. Successful research products are transferred to the field and used for molecular monitoring of disease interventions. They are also used for individual diagnosis in patients referred to Swiss TPH. The scientific tasks of the service side are shaped in close collaboration with the medical personnel from the Swiss TPH Medical Department.

Our Focus

The unit's projects focus on malaria, Leishmania and HIV. We aim to develop novel laboratory tests and strategies for analysing epidemiological data. A major aim is to support malaria eliminiation efforts in our partner countries and to provide the knowledge-base for planning and choosing effective control strategies.

Grossenbacher B. Molecular approaches for tracking residual malaria P. falciparum transmission in a close-to-elimination setting in Zanzibar. Basel: Swiss Tropical and Public Health Institute, 2019. MSc

Hofmann N.E et al. Diagnostic performance of conventional RDT and ultra-sensitive RDT for malaria diagnosis in febrile outpatients in Tanzania. J Infect Dis. 2019;219(9):1490-1498. DOI: 10.1093/infdis/jiy676

Jones S et al. Improving methods for analysing anti-malarial drug efficacy trials: molecular correction based on length-polymorphic markers msp-1, msp-2 and glurp. Antimicrob Agents Chemother. 2019(in press). DOI: 10.1128/AAC.00590-19

Lerch A et al. Longitudinal tracking and quantification of individual Plasmodium falciparum clones in complex infections. Sci Rep. 2019;9:3333. DOI: 10.1038/s41598-019-39656-7

Nguitragool W et al. Highly heterogeneous residual malaria risk in western Thailand. Int J Parasitol. 2019;49(6):455-462. DOI: 10.1016/j.ijpara.2019.01.004