Unit | Tuberculosis Research

TB Research in the BSL3-Laboratory at Swiss TPH

The TB Research Unit conducts fundamental and translational research, focusing on the biology, immunology and genomic epidemiology of TB. The unit comprises two research groups that interact on a regular basis: The TB Ecology and Evolution Group explores the nature, cause and consequence of the genetic diversity in the Mycobacterium tuberculosis complex, particularly in the context of antibiotic resistance. This group combines experimental work in the laboratory and epidemiological investigation in the field with various population- and functional genomics approaches. The TB Immunology Group conducts in-depth clinical immunological studies to enhance our understanding of the host-pathogen interaction in TB, and for the development of novel diagnostics and host-directed interventions.


An important part of this work relies on our long-term partnerships with collaborators in TB-endemic countries. These include the Ifakara Health Institute in Tanzania, the Noguchi Memorial Institute for Medical Research in Ghana, and the National Centre for Tuberculosis and Lung Disease in Georgia.

Sébastien Gagneux

Sébastien Gagneux, Associate Professor, PhD

Coscolla M et al. Phylogenomics of Mycobacterium africanum reveals a new lineage and a complex evolutionary history. Microb Genom. 2021(in press). DOI: 10.1099/mgen.0.000477

Guimarães A.E.D.S et al. Evaluation of drug susceptibility profile of Mycobacterium tuberculosis Lineage 1 from Brazil based on whole genome sequencing and phenotypic methods. Mem Inst Oswaldo Cruz. 2021;115:e200520. DOI: 10.1590/0074-02760200520

Menardo F, Gagneux S, Freund F. Multiple merger genealogies in outbreaks of Mycobacterium tuberculosis. Mol Biol Evol. 2021;38(1):290-306. DOI: 10.1093/molbev/msaa179

Arbués A, Brees D, Chibout S.D, Fox T, Kammüller M, Portevin D. TNF-α antagonists differentially induce TGF-β1-dependent resuscitation of dormant-like Mycobacterium tuberculosis. PLoS Pathog. 2020;16(2):e1008312. DOI: 10.1371/journal.ppat.1008312

Arbués A, Kammüller M, Portevin D. Generating three-dimensional human granulomas in vitro to study Mycobacterium tuberculosis-host interaction. Bio Protoc. 2020;10(22):e3820. DOI: 10.21769/BioProtoc.3820