Unit | Molecular Diagnostics

The unit develops new tools for diagnosing parasitic diseases and for genotyping parasite strains and species. New diagnostic tests are applied to population-wide studies in endemic areas. Successful research products are transferred to the field and used for molecular monitoring of disease interventions. They are also used for individual diagnosis in patients referred to Swiss TPH. The scientific tasks of the service side are shaped in close collaboration with the medical personnel from the Swiss TPH Medical Department.

Our Focus

The unit's projects focus on malaria, Leishmania and HIV. We aim to develop novel laboratory tests and strategies for analysing epidemiological data. A major aim is to support malaria eliminiation efforts in our partner countries and to provide the knowledge-base for planning and choosing effective control strategies.

Ingrid Felger

Professor Ingrid Felger, PhD

Messerli C, Hofmann N.E, Beck H.P, Felger I. Critical evaluation of molecular monitoring in malaria drug efficacy trials and pitfalls of length-polymorphic markers. Antimicrob Agents Chemother. 2017;61(1):e01500-16. DOI: 10.1128/AAC.01500-16

Siqueira A.M et al. Fixed-dose artesunate-amodiaquine combination vs chloroquine for treatment of uncomplicated blood stage P. vivax infection in the Brazilian amazon: an open-label randomized, controlled trial. Clin Infect Dis. 2017;64(2):166-174. DOI: 10.1093/cid/ciw706

Tadesse F. G et al. The shape of the iceberg: quantification of submicroscopic Plasmodium falciparum and Plasmodium vivax parasitaemia and gametocytaemia in five low endemic settings in Ethiopia. Malar J. 2017;16:99. DOI: 10.1186/s12936-017-1749-4

Van der Auwera G et al. Comparison of Leishmania typing results obtained from 16 European clinical laboratories in 2014. Euro Surveill. 2016;21(49):30418. DOI: 10.2807/1560-7917.ES.2016.21.49.30418

Pett H et al. Comparison of molecular quantification of Plasmodium falciparum gametocytes by Pfs25 qRT-PCR and QT-NASBA in relation to mosquito infectivity. Malar J. 2016;15:539. DOI: 10.1186/s12936-016-1584-z