Unit | Molecular Diagnostics

The unit develops new tools for diagnosing parasitic diseases and for genotyping parasite strains and species. New diagnostic tests are applied to population-wide studies in endemic areas. Successful research products are transferred to the field and used for molecular monitoring of disease interventions. They are also used for individual diagnosis in patients referred to Swiss TPH. The scientific tasks of the service side are shaped in close collaboration with the medical personnel from the Swiss TPH Medical Department.

Our Focus

The unit's projects focus on malaria, Leishmania and HIV. We aim to develop novel laboratory tests and strategies for analysing epidemiological data. A major aim is to support malaria eliminiation efforts in our partner countries and to provide the knowledge-base for planning and choosing effective control strategies.

Almeida A.C.G et al. High proportions of asymptomatic and submicroscopic Plasmodium vivax infections in a peri-urban area of low transmission in the Brazilian Amazon. Parasit Vectors. 2018;11:194. DOI: 10.1186/s13071-018-2787-7

Bande G. Molecular diagnostics point of care test for non-malarial fevers. Basel: Swiss Tropical and Public Health Institute, 2018. MSc Thesis

Gruenberg M et al. Plasmodium vivax molecular diagnostics in community surveys: pitfalls and solutions. Malar J. 2018;17:55. DOI: 10.1186/s12936-018-2201-0

Holzschuh A. Development of stage-specific detection assays for P.malariae and P.ovale gametocytes and development of a P.vivax assay targeting multi-copy genomic sequences. Basel: Swiss Tropical and Public Health Institute, 2018. MSc

Lerch A. Methods for analysis of deep sequencing data from mixtures of Plasmodium falciparum clones or stage-specific transcriptomes. Basel: Univ. Basel, 2018. PhD Thesis, University of Basel, Faculty of Science