Meningitis

Meningococcal Meningitis: Clonal Waves of Colonisation and Disease in the Meningitis Belt of Sub-Saharan Africa

Bacterial meningitis is a medical emergency and remains one of the major health problems in Sub-Saharan Africa. The three most important agents are Neisseria meningitidis, Streptococcus pneumoniae, and Haemophilus influenzae. All three pathogens are common colonizers of the human nasopharynx, invasive disease is usually a rare event.

Our research

The bacterial meningitis project involves longitudinal studies of the molecular epidemiology of comparatively carriage and disease of N. meningititdis and S. pneumoniae. The studies are being carried out in Northern Ghana and Burkina Faso and aim to enhance the understanding of the dynamics of meningitis epidemics in the African Meningitis Belt. The results provide important background information for the evaluation and introduction of new conjugate vaccines against meningococcal and pneumococcal infections in Africa.

 

Day C.J, Poole J, Pluschke G, Jennings M.P. Investigation of Mycobacterium ulcerans glycan interactions using glycan array and surface plasmon resonance. In: Pluschke G,Röltgen K, eds. Mycobacterium ulcerans. Methods in Molecular Biology. 2387, 29-40. New York, NY: Humana, 2022. DOI: 10.1007/978-1-0716-1779-3_4

Pluschke G,Röltgen K, eds. Mycobacterium ulcerans: methods and protocols. New York, N: Humana Press, 2022. DOI: 10.1007/978-1-0716-1779-3

Pluschke G, Röltgen K. Overview: development of drugs against Mycobacterium ulcerans. In: Pluschke G,Röltgen K, eds. Mycobacterium ulcerans. Methods in Molecular Biology. 2387, 185-187. New York, NY: Humana, 2022. DOI: 10.1007/978-1-0716-1779-3_17

Röltgen K, Pluschke G. Overview: Mycobacterium ulcerans disease (buruli ulcer). In: Pluschke G,Röltgen K, eds. Mycobacterium ulcerans. Methods in Molecular Biology. 2387, 3-6. New York, NY: Humana, 2022. DOI: 10.1007/978-1-0716-1779-3_1

Röltgen K, Pluschke G. Overview: mycolactone , the macrolide toxin of Mycobacterium ulcerans. In: Pluschke G,Röltgen K, eds. Mycobacterium ulcerans. Methods in Molecular Biology. 2387, 105-108. New York, NY: Humana, 2022. DOI: 10.1007/978-1-0716-1779-3_11