Activity > Services

Bioactives

Drug discovery for tropical diseases is one of the research foci of the Swiss TPH. We have developed a wide range of in vitro assays and in vivo models to identify novel chemical hits and to guide hit-to-lead development. Our credo is to always test against the relevant pathogen species and stage, rather than using surrogate models. The success of this approach is illustrated by the fact that several of the therapies that are currently undergoing clinical testing have been developed with the help of our drug discovery platform. Breakthroughs that were achieved in collaboration with the Swiss TPH include novel treatments for Buruli ulcer, human African trypanosomiasis, malaria and soil-transmitted helminths.

Bacteria
Mycobacterium ulcerans                 in vitro assaysin vivo assays
Protozoa
Babesia divergensin vitro assays
Babesia microtiin vivo assays
Entamoeba histolyticain vitro assays
Giardia intestinalisin vitro assays
Leishmania donovaniin vitro assays
Leishmania infantumin vitro assays
Plasmodium falciparum
in vitro assaysin vivo assays
Plasmodium berghei
ex vivoin vivo assays
Trypanosoma brucei brucei
in vitro assaysin vivo assays
Trypanosoma brucei rhodesiense
in vitro assaysin vivo assays
Trypanosoma brucei gambiense
in vitro assaysin vivo assays
Trypanosoma congolense
in vitro assaysin vivo assays
Trypanosoma cruzi
in vitro assays
Trypanosoma evansi
in vitro assaysin vivo assays
Trypanosoma vivax
ex vivo assaysin vivo assays
Helminths
Ancylostoma ceylanicum
in vitro assaysin vivo assays
Echinostoma caproni
in vitro assaysin vivo assays
Fasciola hepatica
in vitro assaysin vivo assays
Heligmosomoides polygyrus          
in vitro assaysin vivo assays
Necator americanus
in vitro assaysin vivo assays
Schistosoma mansoni
in vitro assaysin vivo assays
Schistosoma haematobium
in vitro assaysin vivo assays
Trichuris muris
in vitro assaysin vivo assays
Divers
several cell lines of Cytotox           
in vitro assays                        

We rear a range of mosquito colonies and undertake bioassays in our Arthropod Testing Facility.

Aedes aegypti
Anopheles gambiae s.s.
Anopheles stephensi
Culex quinquefasciatus
Ornithodoros moubata

Contacts

Blood stages of Plasmodium falciparum
Egg of S. mansoni
T. b. rhodesiense between red blood cells
Aedes aegypti