ELAPSE - Effects of Low-Level Air Pollution: A study in Europe

ELAPSE (Effects of Low-Level Air Pollution: A Study in Europe) is a Europe-wide collaboration in a research project Mortality and morbidity effects of long-term exposure to low-level PM2.5, Black Carbon, NO2 and O3: an analysis of European cohorts. The Project addresses the issue of health effects at low air pollution levels by performing targeted analyses of all-cause and cause-specific mortality and morbidity endpoints within selected cohorts of the ESCAPE study with detailed individual data (~380,000 subjects) and in seven very large European administrative cohorts (> 35 million subjects). The analysis focuses on the pollutants PM2.5 (fine particles with an aerodynamic diameter of less than 2.5 μm), nitrogen dioxide (NO2), and ozone (O3), but also exploits the rich monitoring data of black carbon (BC) available from the ESCAPE study with high spatial resolution. Exposure assessment characterizes fine-scale intra-urban as well as between-urban air pollution contrasts using novel combinations of land use regression and dispersion models, routine monitoring data, and satellite observations.

Hvidtfeldt U.A, Chen J, Andersen Z.J, Atkinson R, Bauwelinck M, Bellander T, Brandt J, Brunekreef B, Cesaroni G, Concin H, Fecht D, Forastiere F, van Gils C.H, Gulliver J, Hertel O, Hoek G, Hoffmann B, de Hoogh K, Janssen N, Jorgensen J.T, Katsouyanni K, Jockel K.H, Ketzel M, Klompmaker J.O, Lang A, Leander K, Liu S, Ljungman P.L.S, Magnusson P.K.E, Mehta A.J, Nagel G, Oftedal B, Pershagen G, Peter R.S, Peters A, Renzi M, Rizzuto D, Rodopoulou S, Samoli E, Schwarze P.E, Severi G, Sigsgaard T, Stafoggia M, Strak M, Vienneau D, Weinmayr G, Wolf K, Raaschou-Nielsen O. Long-term exposure to fine particle elemental components and lung cancer incidence in the ELAPSE pooled cohort. Environ Res. 2020;193:110568. DOI: 10.1016/j.envres.2020.110568

Bauwelinck M, Chen J, de Hoogh K, Katsouyanni K, Rodopoulou S, Samoli E, Andersen Z.J, Atkinson R, Casas L, Deboosere P, Demoury C, Janssen N, Klompmaker J.O, Lefebvre W, Mehta A.J, Nawrot T.S, Oftedal B, Renzi M, Stafoggia M, Strak M, Vandenheede H, Vanpoucke C, Van Nieuwenhuyse A, Vienneau D, Brunekreef B, Hoek G. Variability in the association between long-term exposure to ambient air pollution and mortality by exposure assessment method and covariate adjustment: a census-based country-wide cohort study. Sci Total Environ. 2021;804:150091. DOI: 10.1016/j.scitotenv.2021.150091

Brunekreef B, Strak M, Chen J, Andersen Z.J, Atkinson R, Bauwelinck M, Bellander T, Boutron M.C, Brandt J, Carey I, Cesaroni G, Forastiere F, Fecht D, Gulliver J, Hertel O, Hoffmann B, de Hoogh K, Houthuijs D, Hvidfeldt U, Janssen N, Jørgensen J, Katsouyanni K, Ketzel M, Klompmaker J, Krog N.H, Lui S, Ljungman P, Mehta A, Nagel G, Oftedal B, Pershagen G, Peters A, Raaschou-Nielsen O, Renzi M, Rodopoulou S, Samoli E, Schwarze P, Sigsgaard T, Stafoggia M, Vienneau D, Weinmayr G, Wolf K, Hoek G. Mortality and morbidity effects of long-term exposure to low-level PM2.5, BC, NO2, and O3: an analysis of European cohorts in the ELAPSE project. Boston, MA: Health Effects Institut, 2021

Chen J, Rodopoulou S, de Hoogh K, Strak M, Andersen Z.J, Atkinson R, Bauwelinck M, Bellander T, Brandt J, Cesaroni G, Concin H, Fecht D, Forastiere F, Gulliver J, Hertel O, Hoffmann B, Hvidtfeldt U.A, Janssen N.A.H, Jockel K.H, Jorgensen J, Katsouyanni K, Ketzel M, Klompmaker J.O, Lager A, Leander K, Liu S, Ljungman P, MacDonald C.J, Magnusson P.K.E, Mehta A, Nagel G, Oftedal B, Pershagen G, Peters A, Raaschou-Nielsen O, Renzi M, Rizzuto D, Samoli E, van der Schouw Y.T, Schramm S, Schwarze P, Sigsgaard T, Sorensen M, Stafoggia M, Tjonneland A, Vienneau D, Weinmayr G, Wolf K, Brunekreef B, Hoek G. Long-term exposure to fine particle elemental components and natural and cause-specific mortality-a pooled analysis of eight European cohorts within the ELAPSE project. Environ Health Perspect. 2021;129(4):47009. DOI: 10.1289/EHP8368

Liu S, Jørgensen J.T, Ljungman P, Pershagen G, Bellander T, Leander K, Magnusson P.K.E, Rizzuto D, Hvidtfeldt U.A, Raaschou-Nielsen O, Wolf K, Hoffman B, Brunekreef B, Strak M, Chen J, Mehta A, Atkinson R.W, Bauwelinck M, Varraso R, Boutron-Ruault M.C, Brandt J, Cesaroni G, Forastiere F, Fecht D, Gulliver J, Hertel O, de Hoogh K, Janssen N.A.H, Katsouyanni K, Ketzel M, Klompmaker J.O, Nagel G, Oftedal B, Peters A, Tjønneland A, Rodopoulou S.P, Samoli E, Bekkevold T, Sigsgaard T, Stafoggia M, Vienneau D, Weinmayr G, Hoek G, Andersen Z.J. Long-term exposure to low-level air pollution and incidence of chronic obstructive pulmonary disease: the ELAPSE project. Environ Int. 2021;146:106267. DOI: 10.1016/j.envint.2020.106267

Liu S, Jørgensen J.T, Ljungman P, Pershagen G, Bellander T, Leander K, Magnusson P.K.E, Rizzuto D, Hvidtfeldt U.A, Raaschou-Nielsen O, Wolf K, Hoffmann B, Brunekreef B, Strak M, Chen J, Mehta A, Atkinson R.W, Bauwelinck M, Varraso R, Boutron-Ruault M.C, Brandt J, Cesaroni G, Forastiere F, Fecht D, Gulliver J, Hertel O, de Hoogh K, Janssen N.A.H, Katsouyanni K, Ketzel M, Klompmaker J.O, Nagel G, Oftedal B, Peters A, Tjønneland A, Rodopoulou S.P, Samoli E, Kristoffersen D.T, Sigsgaard T, Stafoggia M, Vienneau D, Weinmayr G, Hoek G, Andersen Z.J. Long-term exposure to low-level air pollution and incidence of asthma: the ELAPSE project. Eur Respir J. 2021;57(6):2003099. DOI: 10.1183/13993003.030992020

Samoli E, Rodopoulou S, Hvidtfeldt U.A, Wolf K, Stafoggia M, Brunekreef B, Strak M, Chen J, Andersen Z.J, Atkinson R, Bauwelinck M, Bellander T, Brandt J, Cesaroni G, Forastiere F, Fecht D, Gulliver J, Hertel O, Hoffmann B, de Hoogh K, Janssen N.A.H, Ketzel M, Klompmaker J.O, Liu S, Ljungman P, Nagel G, Oftedal B, Pershagen G, Peters A, Raaschou-Nielsen O, Renzi M, Kristoffersen D.T, Severi G, Sigsgaard T, Vienneau D, Weinmayr G, Hoek G, Katsouyanni K. Modeling multi-level survival data in multi-center epidemiological cohort studies: applications from the ELAPSE project. Environ Int. 2021;147:106371. DOI: 10.1016/j.envint.2020.106371

So R, Chen J, Mehta A.J, Liu S, Strak M, Wolf K, Hvidtfeldt U.A, Rodopoulou S, Stafoggia M, Klompmaker J.O, Samoli E, Raaschou-Nielsen O, Atkinson R, Bauwelinck M, Bellander T, Boutron-Ruault M.C, Brandt J, Brunekreef B, Cesaroni G, Concin H, Forastiere F, van Gils C.H, Gulliver J, Hertel O, Hoffmann B, de Hoogh K, Janssen N, Lim Y.H, Westendorp R, Jorgensen J.T, Katsouyanni K, Ketzel M, Lager A, Lang A, Ljungman P.L, Magnusson P.K.E, Nagel G, Simonsen M.K, Pershagen G, Peter R.S, Peters A, Renzi M, Rizzuto D, Sigsgaard T, Vienneau D, Weinmayr G, Severi G, Fecht D, Tjonneland A, Leander K, Hoek G, Andersen Z.J. Long-term exposure to air pollution and liver cancer incidence in six European cohorts. Int J Cancer. 2021;149(11):1887-1897. DOI: 10.1002/ijc.33743

Strak M, Weinmayr G, Rodopoulou S, Chen J, de Hoogh K, Andersen Z.J, Atkinson R, Bauwelinck M, Bekkevold T, Bellander T, Boutron-Ruault M.C, Brandt J, Cesaroni G, Concin H, Fecht D, Forastiere F, Gulliver J, Hertel O, Hoffmann B, Hvidtfeldt U.A, Janssen N.A.H, Jockel K.H, Jorgensen J.T, Ketzel M, Klompmaker J.O, Lager A, Leander K, Liu S, Ljungman P, Magnusson P.K.E, Mehta A.J, Nagel G, Oftedal B, Pershagen G, Peters A, Raaschou-Nielsen O, Renzi M, Rizzuto D, van der Schouw Y.T, Schramm S, Severi G, Sigsgaard T, Sorensen M, Stafoggia M, Tjonneland A, Verschuren W.M.M, Vienneau D, Wolf K, Katsouyanni K, Brunekreef B, Hoek G, Samoli E. Long term exposure to low level air pollution and mortality in eight European cohorts within the ELAPSE project: pooled analysis. BMJ. 2021;374:n1904. DOI: 10.1136/bmj.n1904

Wolf K, Hoffmann B, Andersen Z.J, Atkinson R.W, Bauwelinck M, Bellander T, Brandt J, Brunekreef B, Cesaroni G, Chen J, de Faire U, de Hoogh K, Fecht D, Forastiere F, Gulliver J, Hertel O, Hvidtfeldt U.A, Janssen N.A.H, Jorgensen J.T, Katsouyanni K, Ketzel M, Klompmaker J.O, Lager A, Liu S, MacDonald C.J, Magnusson P.K.E, Mehta A.J, Nagel G, Oftedal B, Pedersen N.L, Pershagen G, Raaschou-Nielsen O, Renzi M, Rizzuto D, Rodopoulou S, Samoli E, van der Schouw Y.T, Schramm S, Schwarze P, Sigsgaard T, Sorensen M, Stafoggia M, Strak M, Tjonneland A, Verschuren W.M.M, Vienneau D, Weinmayr G, Hoek G, Peters A, Ljungman P.L.S. Long-term exposure to low-level ambient air pollution and incidence of stroke and coronary heart disease: a pooled analysis of six European cohorts within the ELAPSE project. Lancet Planet Health. 2021;5(9):e620-e632. DOI: 10.1016/S2542-5196(21)00195-9

Chen J, de Hoogh K, Gulliver J, Hoffmann B, Hertel O, Ketzel M, Weinmayr G, Bauwelinck M, van Donkelaar A, Hvidtfeldt U.A, Atkinson R, Janssen N.A.H, Martin R.V, Samoli E, Andersen Z.J, Oftedal B.M, Stafoggia M, Bellander T, Strak M, Wolf K, Vienneau D, Brunekreef B, Hoek G. Development of Europe-wide models for particle elemental composition using supervised linear regression and random forest. Environ Sci Technol. 2020;54(24):15698-15709. DOI: 10.1021/acs.est.0c06595

Rodopoulou S, Stafoggia M, Chen J, de Hoogh K, Bauwelinck M, Mehta A.J, Klompmaker J.O, Oftedal B, Vienneau D, Janssen N.A.H, Strak M, Andersen Z.J, Renzi M, Cesaroni G, Nordheim C.F, Bekkevold T, Atkinson R, Forastiere F, Katsouyanni K, Brunekreef B, Samoli E, Hoek G. Long-term exposure to fine particle elemental components and mortality in Europe: results from six European administrative cohorts within the ELAPSE project. Sci Total Environ. 2022;809:152205. DOI: 10.1016/j.scitotenv.2021.152205

Hvidtfeldt U.A, Severi G, Andersen Z.J, Atkinson R, Bauwelinck M, Bellander T, Boutron-Ruault M.C, Brandt J, Brunekreef B, Cesaroni G, Chen J, Concin H, Forastiere F, van Gils C.H, Gulliver J, Hertel O, Hoek G, Hoffmann B, de Hoogh K, Janssen N, Jockel K.H, Jorgensen J.T, Katsouyanni K, Ketzel M, Klompmaker J.O, Krog N.H, Lang A, Leander K, Liu S, Ljungman P.L.S, Magnusson P.K.E, Mehta A.J, Nagel G, Oftedal B, Pershagen G, Peter R.S, Peters A, Renzi M, Rizzuto D, Rodopoulou S, Samoli E, Schwarze P.E, Sigsgaard T, Simonsen M.K, Stafoggia M, Strak M, Vienneau D, Weinmayr G, Wolf K, Raaschou-Nielsen O, Fecht D. Long-term low-level ambient air pollution exposure and risk of lung cancer - a pooled analysis of 7 European cohorts. Environ Int. 2020;146:106249. DOI: 10.1016/j.envint.2020.106249

Chen J, de Hoogh K, Gulliver J, Hoffmann B, Hertel O, Ketzel M, Bauwelinck M, van Donkelaar A, Hvidtfeldt U.A, Katsouyanni K, Janssen N.A.H, Martin R.V, Samoli E, Schwartz P.E, Stafoggia M, Bellander T, Strak M, Wolf K, Vienneau D, Vermeulen R, Brunekreef B, Hoek G. A comparison of linear regression, regularization, and machine learning algorithms to develop Europe-wide spatial models of fine particles and nitrogen dioxide. Environ Int. 2019;130:104934. DOI: 10.1016/j.envint.2019.104934

de Hoogh K, Chen J, Gulliver J, Hoffmann B, Hertel O, Ketzel M, Bauwelinck M, van Donkelaar A, Hvidtfeldt U.A, Katsouyanni K, Klompmaker J, Martin R.V, Samoli E, Schwartz P.E, Stafoggia M, Bellander T, Strak M, Wolf K, Vienneau D, Brunekreef B, Hoek G. Spatial PM2.5, NO2, O3 and BC models for Western Europe - evaluation of spatiotemporal stability. Environ Int. 2018;120:81-92. DOI: 10.1016/j.envint.2018.07.036

Contact

Kees de Hoogh

Kees de Hoogh, PD, PhD
Scientific Project Leader

+41612848749
c.dehooghswisstph.ch

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