Swiss TPH is carrying out simulations of the public health impact of the RTS,S malaria vaccine, with the support of PATH-MVI. The work involves simulation of the impact of adding vaccines in the context of improved control, considering various vaccine profiles and deployment strategies. The work focusses on the likely impact in low income countries in sub-Saharan Africa, taking into account contextual factors such as the distributions of malaria transmission intensities. Vaccine profiles are based on field data from Phase III trials of RTS,S. The work also involves cost-effectiveness analysis, budget impact analyses. Swiss TPH participates in model-validation exercises and comparisons of model results with those of other groups simulating RTS,S impact.