SAPALDIA program

The SAPALDIA cohort investigates since 1991 the effects of life style and environment on the chronic diseases and aging in adults of the Swiss general population. The SAPALDIA study participants have been recruited from 8 areas of Switzerland which differ by culture, language, geography, micro-climate, socio-demography and environmental exposures. The aim of baseline examination (Study on Air Pollution And Lung Disease In Adults, SAPALDIA) in 1991 was to identify and quantify the long-term effect of air pollution on the respiratory health of the adult general population in Switzerland. Ten years later, 83% of the 9561 original study participants agreed to a follow-up examination in 2002 (SAPALDIA2, n=8047).
At this follow-up the disease focus was expanded to also include cardiovascular and metabolic health. To investigate causal biologic mechanisms a systematic prospective collection of population-based blood samples was started and the SAPALDIA biobank was established. There have been a third and fourth follow-up inviting the same participants for additional data collection including detailed questionnaires, clinical examination and health measures (SAPALDIA3 in 2010 and SAPALDIA4 in 2017). SAPALDIA is one of the very few population-based adult longitudinal cohort studies in Europe examining the exposome cardio-respiratory disease, multi-morbidity, and also healthy aging. SAPALDIA can address environmental and health policy questions to guide evidence–based decisions in Switzerland and to improve quality of life of the aging Swiss population.

More Informtion under SAPALDIA

Endes S, Dratva J, Caviezel S, Schindler C, Künzli N, Probst-Hensch N, Gaspoz J.M, Rochat T, Schmidt-Trucksass A. Association of the cardio-ankle vascular index with age and sex in the SAPALDIA 3 cohort study. Artery Research, 2012;6(4):157

Jayet P.Y, Schindler C, Schwartz J, Künzli N, Zellweger J.P, Ackermann-Liebrich U, Leuenberger P. Passive smoking exposure among adults and the dynamics of respiratory symptoms in a prospective multicenter cohort study. Scand J Work Environ Health. 2005;31(6):465-473

Degens P, Baur X, Brandli O, Schindler C. Empfehlungen neuer Lungenfunktionssollwerte aus der SAPALDIA-Studie. Pneumologie. 2000;54(12):596-603. DOI: 10.1055/s-2000-9191

Ackermann-Liebrich U. Umwelt- und Gesundheitsforschung in der Schweiz: Ein Rückblick auf das nationale Forschungsprogramm 26A. Umweltmed Forsch Prax. 2000;5(1):45-51

Brink M, Schreckenberg D, Vienneau D, Cajochen C, Wunderli J.M, Probst-Hensch N, Röösli M. Effects of scale, question location, order of response alternatives, and season on self-reported noise annoyance using ICBEN scales: a field experiment. Int J Environ Res Public Health. 2016;13(11):1163. DOI: 10.3390/ijerph13111163

Triebner K, Matulonga B, Johannessen A, Suske S, Benediktsdottir B, Demoly P, Dharmage S.C, Franklin K.A, Garcia Aymerich J, Gullon Blanco J.A, Heinrich J, Holm M, Jarvis D, Jogi R, Lindberg E, Moratalla Rovira J.M, Muniozguren Agirre N, Pin I, Probst-Hensch N, Puggini L, Raherison C, Sanchez-Ramos J.L, Schlunssen V, Sunyer J, Svanes C, Hustad S, Leynaert B, Real F.G. Menopause is associated with accelerated lung function decline. Am J Respir Crit Care Med. 2017;195(8):1058-1065. DOI: 10.1164/rccm.201605-0968OC

Aeschbacher S, Bossard M, Ruperti Repilado F.J, Good N, Schoen T, Zimny M, Probst-Hensch N.M, Schmidt-Trucksass A, Risch M, Risch L, Conen D. Healthy lifestyle and heart rate variability in young adults. Eur J Prev Cardiol. 2016;23(10):1037-1044. DOI: 10.1177/2047487315623708

De Torres J.P, Casanova C, Celli B.R. Sex, forced expiratory volume in 1 s decline, body weight change and C-reactive protein in COPD patients. Eur Respir J. 2009;34(3):776. DOI: 10.1183/09031936.00051809

Rochat M.K, Laubender R.P, Kuster D, Braendli O, Moeller A, Mansmann U, Von Mutius E, Wildhaber J. Spirometry reference equations for central European populations from school age to old age. PLoS One. 2013;8(1):e52619. DOI: 10.1371/journal.pone.0052619

Wüthrich B. Epidemiologie IgE-vermittelter Allergien. Hautnah Schweiz. 1995(6):12-13

Lüthi J.C, Zellweger J.P, Grize L, Leuenberger P, Ackermann-Liebrich U, SAPALDIA Team. Étude du biais dû aux non-répondants dans une étude épidemiologique (SAPALDIA). Soz Präventivmed. 1997;42(2):85-94

Conen D, Adam M, Barthelemy J.C, Imboden M, Künzli N, Von Eckardstein A, Rochat T, Gaspoz J.M, Probst-Hensch N, Carballo D. Premature atrial contractions in the general population: prevalence and risk factors. Eur Heart J, 2012;33(Suppl. 1):40

Gorski M, van der Most P.J, Teumer A, Chu A.Y, Li M, Mijatovic V, Nolte I.M, Cocca M, Taliun D, Gomez F, Li Y, Tayo B, Tin A, Feitosa M.F, Aspelund T, Attia J, Biffar R, Bochud M, Boerwinkle E, Borecki I, Bottinger E.P, Chen M.H, Chouraki V, Ciullo M, Coresh J, Cornelis M.C, Curhan G.C, Adamo A.P, Dehghan A, Dengler L, Ding J, Eiriksdottir G, Endlich K, Enroth S, Esko T, Franco O.H, Gasparini P, Gieger C, Girotto G, Gottesman O, Gudnason V, Gyllensten U, Hancock S.J, Harris T.B, Helmer C, Hollerer S, Hofer E, Hofman A, Holliday E.G, Homuth G, Hu F.B, Huth C, Hutri-Kahonen N, Hwang S.J, Imboden M, Johansson A, Kahonen M, Konig W, Kramer H, Kramer B.K, Kumar A, Kutalik Z, Lambert J.C, Launer L.J, Lehtimaki T, Borst M.H, Navis G, Swertz M, Liu Y, Lohman K, Loos R.J.F, Lu Y, Lyytikainen L.P, McEvoy M.A, Meisinger C, Meitinger T, Metspalu A, Metzger M, Mihailov E, Mitchell P, Nauck M, Oldehinkel A.J, Olden M, Wjh Penninx B, Pistis G, Pramstaller P.P, Probst-Hensch N, Raitakari O.T, Rettig R, Ridker P.M, Rivadeneira F, Robino A, Rosas S.E, Ruderfer D, Ruggiero D, Saba Y, Sala C, Schmidt H, Schmid R, Scott R.J, Sedaghat S, Smith A.V, Sorice R, Stengel B, Stracke S, Strauch K, Toniolo D, Uitterlinden A.G, Ulivi S, Viikari J.S, Volker U, Vollenweider P, Volzke H, Vuckovic D, Waldenberger M, Wang J.J, Yang Q, Chasman D.I, Tromp G, Snieder H, Heid I.M, Fox C.S, Kottgen A, Pattaro C, Boger C.A, Fuchsberger C. Corrigendum: 1000 Genomes-based meta-analysis identifies 10 novel loci for kidney function. Sci Rep. 2017;7:46835. DOI: 10.1038/srep46835

Endes S, Schaffner E, Caviezel S, Dratva J, Wanner M, Martin B, Schindler C, Künzli N, Probst-Hensch N, Schmidt-Trucksäss A. Long-term change of physical activity towards a physically active lifestyle is associated with reduced arterial stiffness in elderly males: results of the SAPALDIA 3 cohort study. Eur Heart J, 2015;36:461

Steinemann N, Leonhäuser I.U, Probst-Hensch N, Grize L, Brombach C. Evaluation of a food frequency questionnaire to determine dietary intake in a large cohort: the SAPALDIA study. Aktuel Ernahrungsmed, 2012(3):P6_4. DOI: 10.1055/s-0032-1312542

Felber Dietrich D, Schwartz J, Schindler C, Gaspoz J.M, Barthelemy J.C, Tschopp J.M, Roche F, Von Eckardstein A, Brändli O, Leuenberger P, Gold D.R, Ackermann-Liebrich U, SAPALDIA Team. Effects of passive smoking on heart rate variability, heart rate and blood pressure: an observational study. Int J Epidemiol. 2007;8:521-529

Marcon A, Cerveri I, Wjst M, Antó J.M, Heinrich J, Janson C, Jarvis D, Leynaert B, Probst-Hensch N.M, Svanes C, Toren K, Burney P, de Marco R. Can an airway challenge test predict respiratory diseases? A population-based international study. J Allergy Clin Immunol. 2014;133(1):104-110. DOI: 10.1016/j.jaci.2013.03.040

Meyer U, Schindler C, Zahner L, Ernst D, Hebestreit H, van Mechelen W, Rocca H.P, Probst-Hensch N, Puder J.J, Kriemler S. Long-term effect of a school-based physical activity program (KISS) on fitness and adiposity in children: a cluster-randomized controlled trial. PLoS One. 2014;9(2):e87929. DOI: 10.1371/journal.pone.0087929

Schwager F, Bayer-Oglesby L, Hazenkamp von Arx M, Braun-Fahrländer C, Ackermann-Liebrich U. Analyse der NO2-Passivsammler Daten von SAPALDIA 2: Ermittlung von Aussenluft-Jahresmitteln. Basel: Institut für Sozial- und Präventivmedizin, 2005

Repapi E, Sayers I, Wain L.V, Burton P.R, Johnson T, Obeidat M, Zhao J.H, Ramasamy A, Zhai G, Vitart V, Huffman J.E, Igl W, Albrecht E, Deloukas P, Henderson J, Granell R, McArdle W.L, Rudnicka A.R, Barroso I, Loos R.J, Wareham N.J, Mustelin L, Rantanen T, Surakka I, Imboden M, Wichmann H.E, Grkovic I, Jankovic S, Zgaga L, Hartikainen A.L, Peltonen L, Gyllensten U, Johansson A, Zaboli G, Campbell H, Wild S.H, Wilson J.F, Glaser S, Homuth G, Volzke H, Mangino M, Soranzo N, Spector T.D, Polasek O, Rudan I, Wright A.F, Heliövaara M, Ripatti S, Pouta A, Naluai A.T, Olin A.C, Toren K, Cooper M.N, James A.L, Palmer L.J, Hingorani A.D, Wannamethee S.G, Whincup P.H, Smith G.D, Ebrahim S, McKeever T.M, Pavord I.D, MacLeod A.K, Morris A.D, Porteous D.J, Cooper C, Dennison E, Shaheen S, Karrasch S, Schnabel E, Schulz H, Grallert H, Bouatia-Naji N, Delplanque J, Froguel P, Blakey J.D, Britton J.R, Morris R.W, Holloway J.W, Lawlor D.A, Hui J, Nyberg F, Jarvelin M.R, Jackson C, Kahonen M, Kaprio J, Probst-Hensch N.M, Koch B, Hayward C, Evans D.M, Elliott P, Strachan D.P, Hall I.P, Tobin M.D. Genome-wide association study identifies five loci associated with lung function. Nat Genet. 2010;42(1):36-44. DOI: 10.1038/ng.501

Obeidat M, Wain L.V, Shrine N, Soler Artigas M, Repapi E, Burton P.R, Johnson T, Ramasamy A, Zhao J.H, Zhai G, Huffman J.E, Vitart V, Albrecht E, Igl W, Hartikainen A.L, Pouta A, Cadby G, Hui J, Palmer L.J, Hadley D, McArdle W.L, Rudnicka A.R, Barroso I, Loos R.J.F, Wareham N.J, Mangino M, Soranzo N, Spector T.D, Gläser S, Homuth G, Völzke H, Deloukas P, Granell R, Henderson J, Grkovic I, Jankovic S, Zgaga L, Polasek O, Rudan I, Wright A.F, Campbell H, Wild S.H, Wilson J.F, Heinrich J, Imboden M, Probst-Hensch N.M, Gyllensten U, Johansson A, Zaboli G, Mustelin L, Rantanen T, Surakka I, Kaprio J, Jarvelin M.R, Hayward C, Evans D.M, Koch B, Musk A.W, Elliott P, Strachan D.P, Tobin M.D, Sayers I, Hall I.P, SpiroMeta Consortium. A comprehensive evaluation of potential lung function associated genes in the SpiroMeta general population sample. PLoS One. 2011;6(5):e19382. DOI: 10.1371/journal.pone.0019382

Dratva J, Phuleria H.C, Foraster M, Gaspoz J.M, Keidel D, Künzli N, Liu S.L, Pons M, Zemp E, Gerbase M.W, Schindler C. Transportation noise and blood pressure in a population-based sample of adults. Environ Health Perspect. 2012;120(1):50-55. DOI: 10.1289/ehp.1103448

Schindler C, Ackermann-Liebrich U, Leuenberger P, Monn C, Rapp R, Bolognini G, Bongard J.P, Brändli O, Domenighetti G, Karrer W, Keller R, Medici T.G, Perruchoud A.P, Schoni M.H, Tschopp J.M, Villiger B, Zellweger J.P, SAPALDIA Team. Associations between lung function and estimated average exposure to NO2 in eight areas of Switzerland. Epidemiology. 1998;9(4):405-411

Wyler C, Braun-Fahrländer C, Künzli N, Schindler C, Ackermann-Liebrich U, Perruchoud A.P, Leuenberger P, Wüthrich B. Exposure to motor vehicle traffic and allergic sensitization. The Swiss Study on Air Pollution and Lung Diseases in Adults (SAPALDIA) Team. Epidemiology. 2000;11(4):450-456. DOI: 10.1097/00001648-200007000-00015

Sistek D, Tschopp J.M, Schindler C, Brutsche M, Ackermann-Liebrich U, Perruchoud A.P, Leuenberger P. Clinical diagnosis of current asthma: predictive value of respiratory symptoms in the SAPALDIA study. Swiss Study on Air Pollution and Lung Diseases in Adults. Eur Respir J. 2001;17(2):214-219. DOI: 10.1183/09031936.01.17202140

Bousleiman H, Chaturvedi M, Gschwandtner U, Hatz F, Schindler C, Zimmermann R, Fuhr P. Alpha 1/theta ratio from quantitative EEG (qEEG) as a reliable marker for mild cognitive impairment (MCI) in patients with Parkinson's disease (PD). Clin Neurophysiol, 2015;126(8):e150-e151

Boudier A, Curjuric I, Basagana X, Hazgui H, Anto J.M, Bousquet J, Bridevaux P.O, Dupuis-Lozeron E, Garcia-Aymerich J, Heinrich J, Janson C, Künzli N, Leynaert B, de Marco R, Rochat T, Schindler C, Varraso R, Pin I, Probst-Hensch N, Sunyer J, Kauffmann F, Siroux V. Ten-year follow-up of cluster-based asthma phenotypes in adults: a pooled analysis of three cohorts. Am J Respir Crit Care Med. 2013;188(5):550-560. DOI: 10.1164/rccm.201301-0156OC

Probst-Hensch N.M, Imboden M, Felber Dietrich D, Barthelemy J.C, Ackermann-Liebrich U, Berger W, Gaspoz J.M, Schwartz J. Glutathione S-transferase polymorphisms, passive smoking, obesity, and heart rate variability in nonsmokers. Environ Health Perspect. 2008;116(11):1494-1499

Zorzetto M, Russi E, Senn O, Imboden M, Ferrarotti I, Tinelli C, Campo I, Ottaviani S, Scabini R, Von Eckardstein A, Berger W, Brändli O, Rochat T, Luisetti M, Probst-Hensch N. SERPINA1 gene variants in individuals from the general population with reduced {alpha}1-antitrypsin concentrations. Clin Chem. 2008;54(8):1331-1338. DOI: 10.1373/clinchem.2007.102798

Teynor A, Caviezel S, Dratva J, Künzli N, Schmidt-Trucksass A. An automated, interactive analysis system for ultrasound sequences of the common carotid artery. Ultrasound Med Biol. 2012;38(8):1440-1450. DOI: 10.1016/j.ultrasmedbio.2012.03.015

Rochat T, Bridevaux P.O, Gerbase M, Probst-Hensch N, Künzli N. Quel est le rôle de la pollution atmosphérique dans l'asthme?. Rev Méd Suisse. 2012;8(363):2233-2238

Tschopp J.M, Sistek D, Schindler C, Leuenberger P, Perruchoud A.P, Wüthrich B, Brutsche M, Zellweger J.P, Karrer W, Brändli O. Current allergic asthma and rhinitis: diagnostic efficiency of three commonly used atopic markers (IgE, skin prick tests, and Phadiatop). Results from 8329 randomized adults from the SAPALDIA Study. Allergy. 1998;53(6):608-613

Wilk J.B, Shrine N.R, Loehr L.R, Zhao J.H, Manichaikul A, Lopez L.M, Smith A.V, Heckbert S.R, Smolonska J, Tang W, Loth D.W, Curjuric I, Hui J, Cho M.H, Latourelle J.C, Henry A.P, Aldrich M, Bakke P, Beaty T.H, Bentley A.R, Borecki I.B, Brusselle G.G, Burkart K.M, Chen T.H, Couper D, Crapo J.D, Davies G, Dupuis J, Franceschini N, Gulsvik A, Hancock D.B, Harris T.B, Hofman A, Imboden M, James A.L, Khaw K.T, Lahousse L, Launer L.J, Litonjua A, Liu Y, Lohman K.K, Lomas D.A, Lumley T, Marciante K.D, McArdle W.L, Meibohm B, Morrison A.C, Musk A.W, Myers R.H, North K.E, Postma D.S, Psaty B.M, Rich S.S, Rivadeneira F, Rochat T, Rotter J.I, Soler Artigas M, Starr J.M, Uitterlinden A.G, Wareham N.J, Wijmenga C, Zanen P, Province M.A, Silverman E.K, Deary I.J, Palmer L.J, Cassano P.A, Gudnason V, Barr R.G, Loos R.J, Strachan D.P, London S.J, Boezen H.M, Probst-Hensch N, Gharib S.A, Hall I.P, O'Connor G.T, Tobin M.D, Stricker B.H. Genome-wide association studies identify CHRNA5/3 and HTR4 in the development of airflow obstruction. Am J Respir Crit Care Med. 2012;186(7):622-632. DOI: 10.1164/rccm.201202-0366OC

Wüthrich B, Leuenberger P, Ackermann-Liebrich U, Schindler C, Karrer W, Künzli N, Brändli O, SAPALDIA Team. Atopische Sensibilisierung, Luftverschmutzung und respiratorische Erkrankungen in der Schweiz. Allergologie. 1999;22(5):267-274

Perez L, Rapp R, Künzli N. The year of the lung: outdoor air pollution and lung health. Swiss Med Wkly. 2010;140:w13129. DOI: 10.4414/smw.2010.13129

Schindler C, Künzli N, Bongard J.P, Leuenberger P, Karrer W, Rapp R, Monn C, Ackermann-Liebrich U. Short-term variation in air pollution and in average lung function among never-smokers. The Swiss Study on Air Pollution and Lung Diseases in Adults (SAPALDIA). Am J Respir Crit Care Med. 2001;163(2):356-361. DOI: 10.1164/ajrccm.163.2.9911116

Wüthrich B, Schindler C, Leuenberger P, Künzli N, Ackermann-Liebrich U, SAPALDIA Team. Prevalence of atopy and pollinosis in the adult population of Switzerland (SAPALDIA study). Int Arch Allergy Immunol. 1995;106(2):149-156

Wanner M, Probst-Hensch N, Kriemler S, Meier F, Bauman A, Martin B.W. What physical activity surveillance needs: validity of a single-item questionnaire. Br J Sports Med. 2014;48(21):1570-1576. DOI: 10.1136/bjsports-2012-092122

Leuenberger P. Passive Smoking Exposure in Adults and Chronic Respiratory Symptoms (SAPALDIA study) (Authors' response). Am J Respir Crit Care Med. 1996;153(1):462-463

Amaral A.F, Minelli C, Guerra S, Wjst M, Probst-Hensch N, Pin I, Svanes C, Janson C, Heinrich J, Jarvis D.L. The locus C11orf30 increases susceptibility to poly-sensitization. Allergy. 2015;70(3):328-333. DOI: 10.1111/all.12557

Hampel R, Peters A, Beelen R, Brunekreef B, Cyrys J, de Faire U, de Hoogh K, Fuks K, Hoffmann B, Huls A, Imboden M, Jedynska A, Kooter I, König W, Künzli N, Leander K, Magnussen P, Mannisto S, Penell J, Pershagen G, Phuleria H, Probst-Hensch N, Pundt N, Schaffner E, Schikowski T, Sugiri D, Tittanen P, Tsai M.Y, Wang M, Wolf K, Lanki T. Long-term effects of elemental composition of particulate matter on inflammatory blood markers in European cohorts. Environ Int. 2015;82:76-84. DOI: 10.1016/j.envint.2015.05.008

Wanner M, Probst-Hensch N, Kriemler S, Meier F, Autenrieth C, Martin B.W. Validation of the long international physical activity questionnaire: influence of age and language region. Prev Med Rep. 2016;3:250-256. DOI: 10.1016/j.pmedr.2016.03.003

de Hoogh K, Korek M, Vienneau D, Keuken M, Kukkonen J, Nieuwenhuijsen M.J, Badaloni C, Beelen R, Bolignano A, Cesaroni G, Pradas M.C, Cyrys J, Douros J, Eeftens M, Forastiere F, Forsberg B, Fuks K, Gehring U, Gryparis A, Gulliver J, Hansell A.L, Hoffmann B, Johansson C, Jonkers S, Kangas L, Katsouyanni K, Künzli N, Lanki T, Memmesheimer M, Moussiopoulos N, Modig L, Pershagen G, Probst-Hensch N, Schindler C, Schikowski T, Sugiri D, Teixido O, Tsai M.Y, Yli-Tuomi T, Brunekreef B, Hoek G, Bellander T. Comparing land use regression and dispersion modelling to assess residential exposure to ambient air pollution for epidemiological studies. Environ Int. 2014;73:382-392. DOI: 10.1016/j.envint.2014.08.011

Caviezel S, Dratva J, Schaffner E, Schindler C, Endes S, Autenrieth C.S, Wanner M, Martin B, de Groot E, Gaspoz J.M, Künzli N, Probst-Hensch N, Schmidt-Trucksäss A. Carotid stiffness and physical activity in elderly: a short report of the SAPALDIA 3 cohort study. PLoS One. 2015;10(6):e0128991. DOI: 10.1371/journal.pone.0128991

Endes S, Schaffner E, Caviezel S, Dratva J, Autenrieth C.S, Wanner M, Martin B, Stolz D, Pons M, Turk A, Bettschart R, Schindler C, Künzli N, Probst-Hensch N, Schmidt-Trucksäss A. Long-term physical activity is associated with reduced arterial stiffness in older adults: longitudinal results of the SAPALDIA cohort study. Age Ageing. 2016;45:110-115. DOI: 10.1093/ageing/afv172

Schikowski T, Adam M, Marcon A, Cai Y, Vierkötter A, Carsin A.E, Jacquemin B, Al Kanani Z, Beelen R, Birk M, Bridevaux P.O, Brunekeef B, Burney P, Cirach M, Cyrys J, de Hoogh K, de Marco R, de Nazelle A, Declercq C, Forsberg B, Hardy R, Heinrich J, Hoek G, Jarvis D, Keidel D, Kuh D, Kuhlbusch T, Migliore E, Mosler G, Nieuwenhuijsen M.J, Phuleria H, Rochat T, Schindler C, Villani S, Tsai M.Y, Zemp E, Hansell A, Kauffmann F, Sunyer J, Probst-Hensch N, Kramer U, Künzli N. Association of ambient air pollution with the prevalence and incidence of COPD. Eur Respir J. 2014;44(3):614-626. DOI: 10.1183/09031936.00132213

Meier R, Eeftens M, Aguilera I, Phuleria H.C, Ineichen A, Davey M, Ragettli M.S, Fierz M, Schindler C, Probst-Hensch N, Tsai M.Y, Künzli N. Ambient ultrafine particle levels at residential and reference sites in urban and rural Switzerland. Environ Sci Technol. 2015;49(5):2709-2715. DOI: 10.1021/es505246m

Thun G.A, Imboden M, Künzli N, Rochat T, Keidel D, Haun M, Schindler C, Kronenberg F, Probst-Hensch N.M. Follow-up on genome-wide main effects: do polymorphisms modify the air pollution effect on lung function decline in adults?. Environ Int. 2014;64:110-115. DOI: 10.1016/j.envint.2013.12.012

Dratva J, Probst-Hensch N, Schmidt-Trucksäss A, Caviezel S, de Groot E, Bettschart R, Saleh L, Gapoz J.M, Rothe T, Schindler C, Stolz D, Turk A, Rochat T, Künzli N, Zemp E. Atherogenesis in youth - early consequence of adolescent smoking. Atherosclerosis. 2013;230(2):304-309. DOI: 10.1016/j.atherosclerosis.2013.08.004

Wunderli J.M, Pieren R, Habermacher M, Vienneau D, Cajochen C, Probst-Hensch N, Röösli M, Brink M. Intermittency ratio: a metric reflecting short-term temporal variations of transportation noise exposure. J Expo Sci Environ Epidemiol. 2016;26(6):575-585. DOI: 10.1038/jes.2015.56

Amaral A.F, Newson R.B, Abramson M.J, Anto J.M, Bono R, Corsico A.G, de Marco R, Demoly P, Forsberg B, Gislason T, Heinrich J, Huerta I, Janson C, Jogi R, Kim J.L, Maldonado J, Martinez-Moratalla R.J, Neukirch C, Nowak D, Pin I, Probst-Hensch N, Raherison-Semjen C, Svanes C, Urrutia Landa I, Van Ree R, Versteeg S.A, Weyler J, Zock J.P, Burney P.G, Jarvis D.L. Changes in IgE sensitization and total IgE levels over 20 years of follow-up. J Allergy Clin Immunol. 2016;137(6):1788-1795.e9. DOI: 10.1016/j.jaci.2015.09.037

Ragettli M.S, Ducret-Stich R.E, Foraster M, Morelli X, Aguilera I, Basagaña X, Corradi E, Ineichen A, Tsai M.Y, Probst-Hensch N, Rivera M, Slama R, Künzli N, Phuleria H.C. Spatio-temporal variation of urban ultrafine particle number concentrations. Atmos Environ. 2014;96:275-283. DOI: 10.1016/j.atmosenv.2014.07.049

Ferrarotti I, Thun G.A, Probst-Hensch N.M, Luisetti M. alpha1-antitrypsin level and pheno/genotypes [Letter to the Editor]. Chest. 2013;144(5):1732-1733. DOI: 10.1378/chest.13-1464

Bridevaux P.O, Dupuis-Lozeron E, Schindler C, Keidel D, Gerbase M.W, Probst-Hensch N.M, Bettschart R, Burdet L, Pons M, Rothe T, Turk A, Stolz D, Tschopp J.M, Künzli N, Rochat T. Spirometer replacement and serial lung function measurements in population studies: results from the SAPALDIA study. Am J Epidemiol. 2015;181(10):752-761. DOI: 10.1093/aje/kwu352

Sarnowski C, Sugier P.E, Granell R, Jarvis D, Dizier M.H, Ege M, Imboden M, Laprise C, Khusnutdinova E.K, Freidin M.B, Cookson W.O.C, Moffatt M, Lathop M, Siroux V, Ogorodova L.M, Karunas A.S, James A, Probst-Hensch N.M, von Erika M, Pin I, Kogevinas M, Henderson A.J, Demenais F, Bouzigon E. Identification of a new locus at 16q12 associated with time-to-asthma onset. J Allergy Clin Immunol. 2016;138(4):1071-1080. DOI: 10.1016/j.jaci.2016.03.018

Künzli N. Forschung für Generationen. VSAO Journal. 2011;30(1):24-25

Vienneau D, Schindler C, Perez L, Probst-Hensch N, Röösli M. The relationship between transportation noise exposure and ischemic heart disease: a meta-analysis. Environ Res. 2015;138:372-380. DOI: 10.1016/j.envres.2015.02.023

Endes S, Schaffner E, Caviezel S, Dratva J, Autenrieth C.S, Wanner M, Martin B, Stolz D, Pons M, Turk A, Bettschart R, Schindler C, Künzli N, Probst-Hensch N, Schmidt-Trucksäss A. Physical activity is associated with lower arterial stiffness in older adults: results of the SAPALDIA 3 cohort study. Eur J Epidemiol. 2016;31(3):275-285. DOI: 10.1007/s10654-015-0076-8

Endes S, Caviezel S, Dratva J, Schaffner E, Schindler C, Rothe T, Rochat T, Künzli N, Probst-Hensch N, Schmidt-Trucksäss A. Reproducibility of oscillometrically measured arterial stiffness indices: results of the SAPALDIA 3 cohort study. Scand J Clin Lab Invest. 2015;75(2):170-176. DOI: 10.3109/00365513.2014.993692

Dratva J, Zemp Stutz E. Die Variabilität reproduktiver Charakteristika in der Schweiz. Ergebnisse der SAPALDIA-Studie. Gynäkologie. 2007;6:25-28

Ekström M, Schioler L, Gronseth R, Johannessen A, Svanes C, Leynaert B, Jarvis D, Gislason T, Demoly P, Probst-Hensch N, Pin I, Corsico A.G, Forsberg B, Heinrich J, Nowak D, Raherison-Semjen C, Dharmage S.C, Trucco G, Urrutia I, Martinez-Moratalla Rovira J, Sanchez-Ramos J.L, Janson C, Toren K. Absolute values of lung function explain the sex difference in breathlessness in the general population. Eur Respir J. 2017;49(5):1602047. DOI: 10.1183/13993003.02047-2016

Dratva J, Caviezel S, Schaffner E, Bettschart R, Künzli N, Schindler C, Schmidt-Trucksass A, Stolz D, Zemp E, Probst-Hensch N. Childhood infectious diseases and vascular health in adolescence - results from the SAPALDIA youth study. Trop Med Int Health, 2015;20(Suppl. 1):247. Abstracts of the 9th European Congress on Tropical Medicine and International Health, 6-10 September 2015, Basel, Switzerland

Caviezel S, Dratva J, Schaffner E, Schindler C, Künzli N, Gaspoz J.M, Rochat T, Probst-Hensch N, Schmidt-Trucksäss A. Association of current carotid elastic modulus and prior body mass index in elderly people - results from the SAPALDIA cohort study. Eur Heart J, 2013;34(Suppl. 1):144

Dratva J, Künzli N, Schmidt-Trucksass A, de Groot E, Bettschart R.B, Stolz D, Turk A, Gaspoz J.M, Probst-Hensch N, Zemp E. Cardiovascular risk profile and impact of adolescent smoking. Eur Heart J, 2012;33(Suppl. 1):202

Ayala-Bernal D, Probst-Hensch N, Künzli N, Perez L, Vicedo-Cabrera A, Stolz D, Rochat T, Schindler C. Patterns and determinants of longitudinal changes in smoking behaviour in Switzerland between 1991 and 2011: results from the SAPALDIA cohort. Trop Med Int Health, 2015;20(Suppl. 1):153-154. Abstracts of the 9th European Congress on Tropical Medicine and International Health, 6-10 September 2015, Basel, Switzerland

Imboden M, Thun G, Kumar A, Curjuric I, Ferrarotti I, Rochat T, Russi E.W, Luisetti M, Probst-Hensch N.M. Genomewide association with alpha1-antitrypsin blood levels in a subset of the SAPALDIA cohort study. Am J Respir Crit Care Med, 2011;183:A1755

Caviezel S, Dratva J, Schaffner E, Schindler C, Zemp Stutz E, Künzli N, Gaspoz J.M, Rochat T, Probst-Hensch N, Schmidt-Trucksäss A. Sex-specific associations between carotid distensibility and prior blood pressure categories - results from the SAPALDIA cohort. Artery Res, 2013;7(3-4):133

Humbert M, Probst-Hensch N. Marc Humbert discusses lung function and long-term air pollution exposure with Prof. Nicole Probst-Hensch. Eur Respir J. 2015;45(1):E49

Probst-Hensch N.M, Curjuric I, Bridevaux P.O, Künzli N, Schindler C, Rochat T. Authors' response. Thorax. 2011;66:268-269. DOI: 10.1136/thx.2010.148213

Pattaro C, Teumer A, Gorski M, Chu A.Y, Li M, Mijatovic V, Garnaas M, Tin A, Sorice R, Li Y, Taliun D, Olden M, Foster M, Yang Q, Chen M.H, Pers T.H, Johnson A.D, Ko Y.A, Fuchsberger C, Tayo B, Nalls M, Feitosa M.F, Isaacs A, Dehghan A, D'Adamo P, Adeyemo A, Dieffenbach A.K, Zonderman A.B, Nolte I.M, van der Most P.J, Wright A.F, Shuldiner A.R, Morrison A.C, Hofman A, Smith A.V, Dreisbach A.W, Franke A, Uitterlinden A.G, Metspalu A, Tonjes A, Lupo A, Robino A, Johansson A, Demirkan A, Kollerits B, Freedman B.I, Ponte B, Oostra B.A, Paulweber B, Kramer B.K, Mitchell B.D, Buckley B.M, Peralta C.A, Hayward C, Helmer C, Rotimi C.N, Shaffer C.M, Muller C, Sala C, van Duijn C.M, Saint-Pierre A, Ackermann D, Shriner D, Ruggiero D, Toniolo D, Lu Y, Cusi D, Czamara D, Ellinghaus D, Siscovick D.S, Ruderfer D, Gieger C, Grallert H, Rochtchina E, Atkinson E.J, Holliday E.G, Boerwinkle E, Salvi E, Bottinger E.P, Murgia F, Rivadeneira F, Ernst F, Kronenberg F, Hu F.B, Navis G.J, Curhan G.C, Ehret G.B, Homuth G, Coassin S, Thun G.A, Pistis G, Gambaro G, Malerba G, Montgomery G.W, Eiriksdottir G, Jacobs G, Li G, Wichmann H.E, Campbell H, Schmidt H, Wallaschofski H, Volzke H, Brenner H, Kroemer H.K, Kramer H, Lin H, Mateo Leach I, Ford I, Guessous I, Rudan I, Prokopenko I, Borecki I, Heid I.M, Kolcic I, Persico I, Jukema J.W, Wilson J.F, Felix J.F, Divers J, Lambert J.C, Stafford J.M, Gaspoz J.M, Smith J.A, Faul J.D, Wang J.J, Ding J, Hirschhorn J.N, Attia J, Whitfield J.B, Chalmers J, Viikari J, Coresh J, Denny J.C, Karjalainen J, Fernandes J.K, Endlich K, Butterbach K, Keene K.L, Lohman K, Portas L, Launer L.J, Lyytikainen L.P, Yengo L, Franke L, Ferrucci L, Rose L.M, Kedenko L, Rao M, Struchalin M, Kleber M.E, Cavalieri M, Haun M, Cornelis M.C, Ciullo M, Pirastu M, de Andrade M, McEvoy M.A, Woodward M, Adam M, Cocca M, Nauck M, Imboden M, Waldenberger M, Pruijm M, Metzger M, Stumvoll M, Evans M.K, Sale M.M, Kahonen M, Boban M, Bochud M, Rheinberger M, Verweij N, Bouatia-Naji N, Martin N.G, Hastie N, Probst-Hensch N, Soranzo N, Devuyst O, Raitakari O, Gottesman O, Franco O.H, Polasek O, Gasparini P, Munroe P.B, Ridker P.M, Mitchell P, Muntner P, Meisinger C, Smit J.H, Kovacs P, Wild P.S, Froguel P, Rettig R, Magi R, Biffar R, Schmid R, Middelberg R.P, Carroll R.J, Penninx B.W, Scott R.J, Katz R, Sedaghat S, Wild S.H, Kardia S.L, Ulivi S, Hwang S.J, Enroth S, Kloiber S, Trompet S, Stengel B, Hancock S.J, Turner S.T, Rosas S.E, Stracke S, Harris T.B, Zeller T, Zemunik T, Lehtimaki T, Illig T, Aspelund T, Nikopensius T, Esko T, Tanaka T, Gyllensten U, Volker U, Emilsson V, Vitart V, Aalto V, Gudnason V, Chouraki V, Chen W.M, Igl W, Marz W, Koenig W, Lieb W, Loos R.J, Liu Y, Snieder H, Pramstaller P.P, Parsa A, O'Connell J.R, Susztak K, Hamet P, Tremblay J, de Boer I.H, Boger C.A, Goessling W, Chasman D.I, Kottgen A, Kao W.H, Fox C.S. Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function. Nat Commun. 2016;7:10023. DOI: 10.1038/ncomms10023

Caviezel S, Dratva J, Schaffner E, Schindler C, Zemp Stutz E, de Groot E, Burdet L, Rothe T, Pons M, Gaspoz J.M, Rochat T, Künzli N, Probst-Hensch N, Schmidt-Trucksäss A. Sex-specific associations of cardiovascular risk factors with carotid stiffness - results from the SAPALDIA cohort study. Atherosclerosis. 2014;235(2):576-584. DOI: 10.1016/j.atherosclerosis.2014.05.963

Dratva J, Zemp E, Dharmage S.C, Accordini S, Burdet L, Gislason T, Heinrich J, Janson C, Jarvis D, de Marco R, Norbäck D, Pons M, Real F.G, Sunyer J, Villani S, Probst-Hensch N, Svanes C. Early life origins of lung ageing: early life exposures and lung function decline in adulthood in two European cohorts aged 28-73 years. PLoS One. 2016;11(1):e0145127. DOI: 10.1371/journal.pone.0145127

Scholtens S, Postma D.S, Moffatt M.F, Panasevich S, Granell R, Henderson A.J, Melen E, Nyberg F, Pershagen G, Jarvis D, Ramasamy A, Wjst M, Svanes C, Bouzigon E, Demenais F, Kauffmann F, Siroux V, von Mutius E, Ege M.J, Braun-Fahrländer C, Genuneit J, Brunekreef B, Smit H.A, Wijga A.H, Kerkhof M, Curjuric I, Imboden M, Thun G.A, Probst-Hensch N, Freidin M.B, Bragina E.I, Deev I.A, Puzyrev V.P, Daley D, Park J, Becker A, Chan-Yeung M, Kozyrskyj A.L, Pare P, Marenholn I, Lau S, Keil T, Lee Y.A, Kabesch M, Wijmenga C, Franke L, Nolte I.M, Vonk J, Kumar A, Farrall M, Cookson W.O, Strachan D.P, Koppelman G.H, Boezen H.M. Novel childhood asthma genes interact with in utero and early-life tobacco smoke exposure [Letter to the editor]. J Allergy Clin Immunol. 2014;133(3):885-888. DOI: 10.1016/j.jaci.2013.08.049

Eze I.C, Schaffner E, Foraster M, Imboden M, Von Eckardstein A, Gerbase M.W, Rothe T, Rochat T, Künzli N, Schindler C, Probst-Hensch N. Long-term exposure to ambient air pollution and metabolic syndrome in adults. PLoS One. 2015;10(6):e0130337. DOI: 10.1371/journal.pone.0130337

Dratva J, Schneider C, Schindler C, Stolz D, Gerbase M, Pons M, Bettschart R, Gaspoz J.M, Künzli N, Zemp E, Probst-Hensch N. Is there a differential impact of parity on blood pressure by age?. J Hypertens. 2014;32(11):2146-2151. DOI: 10.1097/HJH.0000000000000325

Abramson M.J, Schindler C, Schikowski T, Bircher A.J, Burdet L, Gerbase M.W, Imboden M, Rochat T, Schmid-Grendelmeier P, Turk A.J, Zemp E, Künzli N, Probst-Hensch N. Rhinitis in Swiss adults is associated with asthma and early life factors, but not second hand tobacco smoke or obesity. Allergol Int. 2016;65(2):192-198. DOI: 10.1016/j.alit.2015.11.004

Adam M, Imboden M, Boes E, Schaffner E, Künzli N, Phuleria H.C, Kronenberg F, Gaspoz J.M, Carballo D, Probst-Hensch N. Modifying effect of a common polymorphism in the interleukin-6 promoter on the relationship between long-term exposure to traffic-related particulate matter and heart rate variability. PLoS One. 2014;9(8):e104978. DOI: 10.1371/journal.pone.0104978

Eze I.C, Schaffner E, Fischer E, Schikowski T, Adam M, Imboden M, Tsai M, Carballo D, Von Eckardstein A, Künzli N, Schindler C, Probst-Hensch N. Long-term air pollution exposure and diabetes in a population-based Swiss cohort. Environ Int. 2014;70:95-105. DOI: 10.1016/j.envint.2014.05.014

Caviezel S, Dratva J, Schaffner E, Schindler C, Probst-Hensch N, Künzli N, Gaspoz J.M, Rochat T, Schmidt-Trucksass A. Association of carotide strain and prior of cardiovascular disease - results from the Swiss Air Pollution and Lung and Heart Disease in Adults Cohort Study (SAPALDIA3). Artery Research, 2012;6(4):151

Künzli N, Schwartz J, Stutz E.Z, Ackermann-Liebrich U, Leuenberger P. Association of environmental tobacco smoke at work and forced expiratory lung function among never smoking asthmatics and non-asthmatics. The SAPALDIA-Team. Swiss Study on Air Pollution and Lung Disease in Adults. Soz Präventivmed. 2000;45(5):208-217

Imboden M, Rochat T, Brutsche M, Schindler C, Downs S.H, Gerbase M.W, Berger W, Probst-Hensch N.M. Glutathione S-transferase genotype increases risk of progression from bronchial hyperresponsiveness to asthma in adults. Thorax. 2008;63(4):322-328

Imboden M, Schwartz J, Schindler C, Curjuric I, Berger W, Liu L.J.S, Russi E.W, Ackermann-Liebrich U, Rochat T, Probst-Hensch N.M. Decreased PM10 exposure attenuates age-related lung function decline: genetic variants in p53, p21, and CCND1 modify this effect. Environ Health Perspect. 2009;117(9):1420-1427

Hersberger M, Thun G.A, Imboden M, Brandstatter A, Waechter V, Summerer M, Schmid-Grendelmeier P, Bircher A, Rohrer L, Berger W, Russi E.W, Rochat T, Kronenberg F, Probst-Hensch N. Association of STR polymorphisms in CMA1 and IL-4 with asthma and atopy: the SAPALDIA cohort. Hum Immunol. 2010;71(11):1154-1160. DOI: 10.1016/j.humimm.2010.08.008

Graf N, Johansen P, Schindler C, Wüthrich B, Ackermann-Liebrich U, Gassner M, Kundig T.M, Senti G. Analysis of the relationship between pollinosis and date of birth in Switzerland. Int Arch Allergy Immunol. 2007;143(4):269-275

Gerbase M.W, Schindler C, Zellweger J.P, Künzli N, Downs S.H, Brändli O, Schwartz J, Frey M, Burdet L, Rochat T, Ackermann-Liebrich U, Leuenberger P. Respiratory effects of environmental tobacco exposure are enhanced by bronchial hyperreactivity. Am J Respir Crit Care Med. 2006;174(10):1125-1131

Felber Dietrich D, Ackermann-Liebrich U, Schindler C, Barthelemy J.C, Brandli O, Gold D.R, Knopfli B, Probst-Hensch N.M, Roche F, Tschopp J.M, Von Eckardstein A, Gaspoz J.M. Effect of physical activity on heart rate variability in normal weight, overweight and obese subjects: results from the SAPALDIA study. Eur J Appl Physiol. 2008;104(3):557-565

Felber Dietrich D, Gemperli A, Gaspoz J.M, Schindler C, Liu L.J, Gold D.R, Schwartz J, Rochat T, Barthelemy J.C, Pons M, Roche F, Probst-Hensch N.M, Bridevaux P.O, Gerbase M.W, Neu U, Ackermann-Liebrich U. Differences in heart rate variability associated with long-term exposure to NO2. Environ Health Perspect. 2008;116(10):1357-1361

Felber Dietrich D, Schindler C, Schwartz J, Barthelemy J.C, Tschopp J.M, Roche F, Von Eckardstein A, Brandli O, Leuenberger P, Gold D.R, Gaspoz J.M, Ackermann-Liebrich U. Heart rate variability in an ageing population and its association with lifestyle and cardiovascular risk factors: results of the SAPALDIA study. Europace. 2006;8(7):521-529

Imboden M, Downs S.H, Senn O, Matyas G, Brändli O, Russi E.W, Schindler C, Ackermann-Liebrich U, Berger W, Probst-Hensch N.M, SAPALDIA Team. Glutathione S-transferase genotypes modify lung function decline in the general population: SAPALDIA cohort study. Respir Res. 2007;8(1):2

Imboden M, Nieters A, Bircher A.J, Brutsche M, Becker N, Wjst M, Ackermann-Liebrich U, Berger W, Probst-Hensch N.M, SAPALDIA Team. Cytokine gene polymorphisms and atopic disease in two European cohorts. (ECRHS-Basel and SAPALDIA). Clin Mol Allergy. 2006;4(1):9

Künzli N, Ackermann-Liebrich U, Keller R, Perruchoud A.P, Schindler C, SAPALDIA Team. Variability of FVC and FEV1 due to technician, team, device and subject in an eight centre study. Eur Respir J. 1995;8(3):371-376

Künzli N, Ackermann-Liebrich U, Brändli O, Tschopp J.M, Schindler C, Leuenberger P. Clinically "small" effects of air pollution on FVC have a large public health impact. Swiss Study on Air Pollution and Lung Disease in Adults (SAPALDIA) - team. Eur Respir J. 2000;15(1):131-136

Künzli N. The SAPALDIA Study-no results?. Soz Präventivmed. 1997;42(3):131-132

Köttgen A, Albrecht E, Teumer A, Vitart V, Krumsiek J, Hundertmark C, Pistis G, Ruggiero D, O'Seaghdha C.M, Haller T, Yang Q, Tanaka T, Johnson A.D, Kutalik Z, Smith A.V, Shi J, Struchalin M, Middelberg R.P, Brown M.J, Gaffo A.L, Pirastu N, Li G, Hayward C, Zemunik T, Huffman J, Yengo L, Zhao J.H, Demirkan A, Feitosa M.F, Liu X, Malerba G, Lopez L.M, van der Harst P, Li X, Kleber M.E, Hicks A.A, Nolte I.M, Johansson A, Murgia F, Wild S.H, Bakker S.J, Peden J.F, Dehghan A, Steri M, Tenesa A, Lagou V, Salo P, Mangino M, Rose L.M, Lehtimaki T, Woodward O.M, Okada Y, Tin A, Muller C, Oldmeadow C, Putku M, Czamara D, Kraft P, Frogheri L, Thun G.A, Grotevendt A, Gislason G.K, Harris T.B, Launer L.J, McArdle P, Shuldiner A.R, Boerwinkle E, Coresh J, Schmidt H, Schallert M, Martin N.G, Montgomery G.W, Kubo M, Nakamura Y, Tanaka T, Munroe P.B, Samani N.J, Jacobs D.R. Jr, Liu K, D'Adamo P, Ulivi S, Rotter J.I, Psaty B.M, Vollenweider P, Waeber G, Campbell S, Devuyst O, Navarro P, Kolcic I, Hastie N, Balkau B, Froguel P, Esko T, Salumets A, Khaw K.T, Langenberg C, Wareham N.J, Isaacs A, Kraja A, Zhang Q, Wild P.S, Scott R.J, Holliday E.G, Org E, Viigimaa M, Bandinelli S, Metter J.E, Lupo A, Trabetti E, Sorice R, Doring A, Lattka E, Strauch K, Theis F, Waldenberger M, Wichmann H.E, Davies G, Gow A.J, Bruinenberg M, Stolk R.P, Kooner J.S, Zhang W, Winkelmann B.R, Boehm B.O, Lucae S, Penninx B.W, Smit J.H, Curhan G, Mudgal P, Plenge R.M, Portas L, Persico I, Kirin M, Wilson J.F, Mateo Leach I, van Gilst W.H, Goel A, Ongen H, Hofman A, Rivadeneira F, Uitterlinden A.G, Imboden M, Von Eckardstein A, Cucca F, Nagaraja R, Piras M.G, Nauck M, Schurmann C, Budde K, Ernst F, Farrington S.M, Theodoratou E, Prokopenko I, Stumvoll M, Jula A, Perola M, Salomaa V, Shin S.Y, Spector T.D, Sala C, Ridker P.M, Kahonen M, Viikari J, Hengstenberg C, Nelson C.P, Meschia J.F, Nalls M.A, Sharma P, Singleton A.B, Kamatani N, Zeller T, Burnier M, Attia J, Laan M, Klopp N, Hillege H.L, Kloiber S, Choi H, Pirastu M, Tore S, Probst-Hensch N.M, Volzke H, Gudnason V, Parsa A, Schmid R, Whitfield J.B, Fornage M, Gasparini P, Siscovick D.S, Polasek O, Campbell H, Rudan I, Bouatia-Naji N, Metspalu A, Loos R.J, van Duijn C.M, Borecki I.B, Ferrucci L, Gambaro G, Deary I.J, Wolffenbuttel B.H, Chambers J.C, Marz W, Pramstaller P.P, Snieder H, Gyllensten U, Wright A.F, Navis G, Watkins H, Witteman J.C, Sanna S, Schipf S, Dunlop M.G, Tonjes A, Ripatti S, Soranzo N, Toniolo D, Chasman D.I, Raitakari O, Kao W.H, Ciullo M, Fox C.S, Caulfield M, Bochud M, Gieger C. Genome-wide association analyses identify 18 new loci associated with serum urate concentrations. Nat Genet. 2013;45(2):145-154. DOI: 10.1038/ng.2500

Köttgen A, Pattaro C, Boger C.A, Fuchsberger C, Olden M, Glazer N.L, Parsa A, Gao X, Yang Q, Smith A.V, O'Connell J.R, Li M, Schmidt H, Tanaka T, Isaacs A, Ketkar S, Hwang S.J, Johnson A.D, Dehghan A, Teumer A, Pare G, Atkinson E.J, Zeller T, Lohman K, Cornelis M.C, Probst-Hensch N.M, Kronenberg F, Tonjes A, Hayward C, Aspelund T, Eiriksdottir G, Launer L.J, Harris T.B, Rampersaud E, Mitchell B.D, Arking D.E, Boerwinkle E, Struchalin M, Cavalieri M, Singleton A, Giallauria F, Metter J, de Boer I.H, Haritunians T, Lumley T, Siscovick D, Psaty B.M, Zillikens M.C, Oostra B.A, Feitosa M, Province M, de Andrade M, Turner S.T, Schillert A, Ziegler A, Wild P.S, Schnabel R.B, Wilde S, Munzel T.F, Leak T.S, Illig T, Klopp N, Meisinger C, Wichmann H.E, Koenig W, Zgaga L, Zemunik T, Kolcic I, Minelli C, Hu F.B, Johansson A, Igl W, Zaboli G, Wild S.H, Wright A.F, Campbell H, Ellinghaus D, Schreiber S, Aulchenko Y.S, Felix J.F, Rivadeneira F, Uitterlinden A.G, Hofman A, Imboden M, Nitsch D, Brandstatter A, Kollerits B, Kedenko L, Magi R, Stumvoll M, Kovacs P, Boban M, Campbell S, Endlich K, Volzke H, Kroemer H.K, Nauck M, Volker U, Polasek O, Vitart V, Badola S, Parker A.N, Ridker P.M, Kardia S.L, Blankenberg S, Liu Y, Curhan G.C, Franke A, Rochat T, Paulweber B, Prokopenko I, Wang W, Gudnason V, Shuldiner A.R, Coresh J, Schmid R, Ferrucci L, Shlipak M.G, van Duijn C.M, Borecki I, Kramer B.K, Rudan I, Gyllensten U, Wilson J.F, Witteman J.C, Pramstaller P.P, Rettig R, Hastie N, Chasman D.I, Kao W.H, Heid I.M, Fox C.S. New loci associated with kidney function and chronic kidney disease. Nat Genet. 2010;42(5):376-384. DOI: 10.1038/ng.568

Jayet P.Y, Schindler C, Künzli N, Zellweger J.P, Brändli O, Perruchoud A.P, Keller R, Schwartz J, Ackermann-Liebrich U, Leuenberger P. Reference values for methacholine reactivity (SAPALDIA study). Respir Res. 2005;6(1):131

Kaiser R, Schindler C, Künzli N, Ackermann-Liebrich U, Heeb D, Medici T.C, Zellweger J.P. Use of transition probabilities to estimate the effect of smoking on the duration of episodes of respiratory symptoms in diary data: the Swiss Study on Air Pollution and Lung Diseases in Adults (SAPALDIA). Am J Epidemiol. 1998;148(6):600-608

Imboden M, Nicod L, Nieters A, Glaus E, Matyas G, Bircher A.J, Ackermann-Liebrich U, Berger W, Probst-Hensch N.M. The common G-allele of interleukin-18 single-nucleotide polymorphism is a genetic risk factor for atopic asthma. The SAPALDIA Cohort Study. Clin Exp Allergy. 2006;36(2):211-218

Dratva J, Schindler C, Curjuric I, Stolz D, Macsali F, Gomez F.R, Zemp Stutz E. Perimenstrual increase in bronchial hyperreactivity in premenopausal women: results from the population-based SAPALDIA 2 cohort. J Allergy Clin Immunol. 2010;125(4):823-829. DOI: 10.1016/j.jaci.2009.12.938

Dratva J, Zemp Stutz E, Felber Dietrich D, Bridevaux P.O, Rochat T, Schindler C, Gerbase M.W. Impact of road traffic noise annoyance on health-related quality of life: results from a population-based study. Qual Life Res. 2010;19(1):37-46. DOI: 10.1007/s11136-009-9571-2

Dratva J, Breton C.V, Hodis H.N, Mack W.J, Salam M.T, Zemp E, Gilliland F, Künzli N, Avol E. Birth weight and carotid artery intima-media thickness. J Pediatr. 2013;162(5):906-911.e2. DOI: 10.1016/j.jpeds.2012.10.060

Beelen R, Hoek G, Vienneau D, Eeftens M, Dimakopoulou K, Pedeli X, Tsai M.Y, Künzli N, Schikowski T, Marco A, Eriksen K, Raaschou-Nielsen O, Stephanou E, Patelarou E, Lanki T, Yli-Tuomi T, Declercq C, Falq G, Stempfelet M, Birk M, Cyrys J, von Klot S, Nador G, Varro M.J, Dedele A, Grazuleviciene R, Mölter A, Lindley S, Madsen C, Cesaroni G, Ranzi A, Badaloni C, Hoffmann B, Nonnemacher M, Krämer U, Kuhlbusch T, Cirach M, de Nazelle A, Nieuwenhuijsen M, Bellander T, Korek M, Olsson D, Strömgren M, Dons E, Jerrett M, Fischer P, Wang M, Brunekreef B, de Hoogh K. Development of NO2 and NOx land use regression models for estimating air pollution exposure in 36 study areas in Europe - The ESCAPE project. Atmos Environ. 2013;72:10-23. DOI: 10.1016/j.atmosenv.2013.02.037

Bayer-Oglesby L, Schindler C, Hazenkamp-von Arx M.E, Braun-Fahrländer C, Keidel D, Rapp R, Künzli N, Brändli O, Burdet L, Liu L.J.S, Leuenberger P, Ackermann-Liebrich U. Living near main streets and respiratory symptoms in adults. Am J Epidemiol. 2006;164:1190-1198. DOI: 10.1093/aje/kwj338

Ackermann-Liebrich U, Leuenberger P, Schwartz J, Schindler C, Monn C, Bolognini G, Bongard J.P, Brändli O, Domenighetti G, Elsasser S, Grize L, Karrer W, Keller R, Keller-Wossidlo H, Künzli N, Martin B.W, Medici T.C, Perruchoud A.P, Schoni M.H, Tschopp J.M, Villiger B, Wüthrich B, Zellweger J.P, Zemp E, SAPALDIA Team. Lung function and long term exposure to air pollutants in Switzerland.. Am J Respir Crit Care Med. 1997;155(1):122-129

Ackermann-Liebrich U, Kuna-Dibbert B, Probst-Hensch N.M, Schindler C, Felber Dietrich D, Zemp Stutz E, Bayer-Oglesby L, Baum F, Brändli O, Brutsche M, Downs S.H, Keidel D, Gerbase M.W, Imboden M, Keller R, Knöpfli B, Künzli N, Nicod L, Pons M, Städele P, Tschopp J.M, Zellweger J.P, Leuenberger P. Follow-up of the Swiss Cohort Study on Air Pollution and Lung Diseases in Adults (SAPALDIA 2) 1991-2003: methods and characterization of participants. Soz Präventivmed. 2005;50(4):245-263

Ackermann-Liebrich U. Schweizer Studie "Luftverschmutzung und Atemwegserkrankungen bei Erwachsenen- SAPALDIA". Atemw Lungenkrkh. 1993;19(5):190-194

Enright P.L. GOLD stage 1 is crying wolf. Thorax. 2009;64(2):182-183

Ackermann-Liebrich U, Künzli N, Leuenberger P, SAPALDIA Team. Air pollution exposure and asthma - the Swiss Study on Air Pollution and Lung Diseases in Adults (SAPALDIA). In: Commission of the European Communities, ed. EC(cost) - East europe workshop on air pollution epidemiology, 88-94. Brussels: Office for Official Publications of the European Communities, 1992

Baum F, Bayer-Oglesby L, Hazenkamp-von Arx M, Ackermann-Liebrich U, Braun-Fahrländer C. Analyse der Luftschadstoffdaten 1990-2002 in den SAPALDIA- und SCARPOL-Regionen. Basel: Institut für Sozial- und Präventivmedizin, 2004

Brändli O, Schindler C, Künzli N, Keller R, Perruchoud A.P. Lung function in healthy never smoking adults: reference values and lower limits of normal of a Swiss population. Thorax. 1996;51(3):277-283. DOI: 10.1136/thx.51.3.277

Brutsche M.H, Downs S.H, Schindler C, Gerbase M.W, Schwartz J, Frey M, Russi E.W, Ackermann-Liebrich U, Leuenberger P, SAPALDIA Team. Bronchial hyperresponsiveness and the development of asthma and COPD in asysmptomatic individuals - SAPALDIA cohort study. Thorax. 2006;61(8):671-677

Danuser B, Weber C, Künzli N, Schindler C, Nowak D. Respiratory symptoms in Swiss farmers: an epidemiological study of risk factors. Am J Ind Med. 2001;39(4):410-418. DOI: 10.1002/ajim.1032

Canova C, Heinrich J, Anto J.M, Leynaert B, Smith M, Künzli N, Zock J.P, Janson C, Cerveri I, de Marco R, Toren K, Gislason T, Nowak D, Pin I, Wjst M, Manfreda J, Svanes C, Crane J, Abramson M, Burr M, Burney P, Jarvis D. The influence of sensitisation to pollens and moulds on seasonal variations in asthma attacks. Eur Respir J. 2013;42(4):935-945. DOI: 10.1183/09031936.00097412

Chinn S, Downs S.H, Anto J.M, Gerbase M.W, Leynaert B, de Marco R, Janson C, Jarvis D, Künzli N, Sunyer J, Svanes C, Zemp E, Ackermann-Liebrich U, Burney P. Incidence of asthma and net change in symptoms in relation to changes in obesity. Eur Respir J. 2006;28:763-771

Bridevaux P.O, Cornuz J, Gaspoz J.M, Burnand B, Ackermann-Liebrich U, Schindler C, Leuenberger P, Rochat T, Gerbase M.W. Secondhand Smoke and Health-Related Quality of Life in Never Smokers: Results From the SAPALDIA Cohort Study 2. Arch Intern Med. 2007;167(22):2516-2523. DOI: 10.1001/archinte.167.22.2516

Bridevaux P.O, Gerbase M.W, Probst-Hensch N.M, Schindler C, Gaspoz J.M, Rochat T. Long-term decline in lung function, utilisation of care and quality of life in modified GOLD stage 1 COPD. Thorax. 2008;63(9):768-774

Bridevaux P.O, Probst-Hensch N.M, Schindler C, Curjuric I, Felber Dietrich D, Braendli O, Brutsche M, Burdet L, Frey M, Gerbase M.W, Ackermann-Liebrich U, Pons M, Tschopp J.M, Rochat T, Russi E.W. Prevalence of airflow obstruction in smokers and never smokers in Switzerland. Eur Respir J. 2010;36(6):1259-1269. DOI: 10.1183/09031936.00004110

Bridevaux P.O, Gerbase M.W, Schindler C, Felber Dietrich D, Curjuric I, Dratva J, Ackermann-Liebrich U, Probst-Hensch N.M, Gaspoz J.M, Rochat T. Sex-specific effect of body weight gain on systemic inflammation in subjects with COPD: results from the SAPALDIA cohort study 2. Eur Respir J. 2009;34(2):332-339. DOI: 10.1183/09031936.00162608

Schwager F, Bulgheroni R. Black Smoke Analysen im Rahmen von SAPALDIA und SCARPOL : Praktikumsbericht. Basel: Institut für Sozial- und Präventivmedizin, 2003

Schwartz J, Schindler C, Zemp E, Perruchoud A.P, Zellweger J.P, Wüthrich B, Leuenberger P, Ackermann-Liebrich U, SAPALDIA Team. Predictors of methacholine responsiveness in a general population. Chest. 2002;122(3):812-820

Jacquemin B, Schikowski T, Carsin A.E, Hansell A, Krämer U, Sunyer J, Probst-Hensch N, Kauffmann F, Künzli N. The role of air pollution in adult-onset asthma: a review of the current evidence. Semin Respir Crit Care Med. 2012;33(6):606-609. DOI: 10.1055/s-0032-1325191

Eeftens M, Tsai M.Y, Ampe C, Anwander B, Beelen R, Bellander T, Cesaroni G, Cirach M, Cyrys J, de Hoogh K, de Nazelle A, de Vocht F, Declercq C, Dedele A, Eriksen K, Galassi C, Grauleviciene R, Grivas G, Heinrich J, Hoffmann B, Iakovides M, Ineichen A, Katsouyanni K, Korek M, Krämer U, Kuhlbusch T, Lanki T, Madsen C, Meliefste K, Mölter A, Mosler G, Nieuwenhuijsen M, Oldenwening M, Pennanen A, Probst-Hensch N, Quass U, Raaschou-Nielsen O, Ranzi A, Stephanou E, Sugiri D, Udvardy O, Vaskövi E, Weinmayr G, Brunekreef B, Hoek G. Spatial variation of PM2.5, PM10, PM2.5 absorbance and PMcoarse concentrations between and within 20 European study areas and the relationship with NO2 - results of the ESCAPE project. Atmos Environ. 2012;62:303-317. DOI: 10.1016/j.atmosenv.2012.08.038

Hancock D.B, Soler Artigas M, Gharib S.A, Henry A, Manichaikul A, Ramasamy A, Loth D.W, Imboden M, Koch B, McArdle W, Smith A.V, Smolonska J, Sood A, Tang W, Wilk J.B, Zhai G, Zhao J.H, Aschard H, Burkart K.M, Curjuric I, Eijgelsheim M, Elliott P, Gu X, Harris T.B, Janson C, Homuth G, Hysi P, Liu J.Z, Loehr L.R, Lohman K, Loos R, Manning A.K, Marciante K.D, Obeidat M, Postma D, Aldrich M, Brusselle G.G, Chen T.H, Eiriksdottir G, Franceschini N, Heinrich J, Rotter J.I, Wijmenga C, Williams O.D, Bentley A.R, Hofman A, Laurie C, Lumley T, Morrison A.C, Joubert B.R, Rivadeneira F, Couper D.J, Kritchevsky S.B, Liu Y, Wjst M, Wain L.V, Vonk J.M, Uitterlinden A, Rochat T, Rich S.S, Psaty B.M, O'Connor G.T, North K.E, Mirel D.B, Meibohm B, Launer L.J, Khaw K.T, Hartikainen A.L, Hammond C.J, Gläser S, Marchini J, Kraft P, Wareham N.J, Völzke H, Stricker B.H.C, Spector T.D, Probst-Hensch N.M, Jarvis D, Jarvelin M.R, Heckbert S.R, Gudnason V, Boezen H.M, Barr R.G, Cassano P.A, Strachan D.P, Fornage M, Hall I.P, Dupuis J, Tobin M.D, London S.J. Genome-wide joint meta-analysis of SNP and SNP-by-smoking interaction identifies novel loci for pulmonary function. PLoS Genet. 2012;8(12):e1003098. DOI: 10.1371/journal.pgen.1003098

Martin B.W, Ackermann-Liebrich U, Leuenberger P, Künzli N, Stutz E.Z, Keller R, Zellweger J.P, Wüthrich B, Monn C, Blaser K, Bolognini G, Bongard J.P, Brändli O, Braun P, Defila C, Domenighetti G, Grize L, Karrer W, Keller-Wossidlo H, Medici T.C, Peeters A, Perruchoud A.P, Schindler C, Schoeni M.H, Villiger B. SAPALDIA: methods and participation in the cross-sectional part of the Swiss Study on Air Pollution and Lung Diseases in Adults. Soz Präventivmed. 1997;42(2):67-84

Liu L.J.S, Tsai M.Y, Keidel D, Gemperli A, Ineichen A, Hazenkamp-von Arx M, Bayer-Oglesby L, Rochat T, Künzli N, Ackermann-Liebrich U, Straehl P, Schwartz J, Schindler C. Long-term exposure models for traffic related NO2 across geographically diverse areas over separate years. Atmos Environ. 2012;46:460-471. DOI: 10.1016/j.atmosenv.2011.09.021

Mehta A.J, Schindler C, Perez L, Probst-Hensch N, Schwartz J, Brändli O, Karrer W, Tschopp J.M, Rochat T, Künzli N. Acute respiratory health effects of urban air pollutants in adults with different patterns of underlying respiratory disease. Swiss Med Wkly. 2012;142:w13681. DOI: 10.4414/smw.2012.13681

Mehta A.J, Adam M, Schaffner E, Barthelemy J.C, Carballo D, Gaspoz J.M, Rochat T, Schindler C, Schwartz J, Zock J.P, Künzli N, Probst-Hensch N, SAPALDIA Team. Heart rate variability in association with frequent use of household sprays and scented products in SAPALDIA. Environ Health Perspect. 2012;120(7):958-964. DOI: 10.1289/ehp.1104567

Mehta A.J, Miedinger D, Keidel D, Bettschart R, Bircher A, Bridevaux P.O, Curjuric I, Kromhout H, Rochat T, Rothe T, Russi E.W, Schikowski T, Schindler C, Schwartz J, Turk A, Vermeulen R, Probst-Hensch N, Künzli N. Occupational exposure to dusts, gases and fumes and incidence of chronic obstructive pulmonary disease in the Swiss Cohort Study on Air Pollution and Lung and Heart Diseases in Adults. Am J Respir Crit Care Med. 2012;185(12):1292-1300. DOI: 10.1164/rccm.201110-1917OC

Olivieri M, Zock J.P, Accordini S, Heinrich J, Jarvis D, Künzli N, Anto J.M, Norback D, Svanes C, Verlato G. Risk factors for new-onset cat sensitization among adults: a population-based international cohort study. J Allergy Clin Immunol. 2012;129(2):420-425. DOI: 10.1016/j.jaci.2011.10.044

Cyrys J, Eeftens M, Heinrich J, Ampe C, Armengaud A, Beelen R, Bellander T, Beregszaszai T, Birk M, Cesaroni G, Cirach M, de Hoogh K, de Nazelle A, de Vocht F, Declercq C, Dedele A, Dimakopoulou K, Eriksen K, Galassi C, Grazuleviciene R, Grivas G, Gruzieva O, Hagenbjörk Gustafsson A, Hoffmann B, Iakovides M, Ineichen A, Krämer U, Lanki T, Lozano P, Madsen C, Meliefste K, Modig L, Mölter A, Mosler G, Nieuwenhuijsen M, Nonnemacher M, Oldenwening M, Peters A, Pontet S, Probst-Hensch N, Quass U, Raaschou-Nielsen O, Ranzi A, Sugiri D, Stephanou E.G, Taimisto P, Tsai M.Y, Vaskövi E, Villani S, Wang M, Brunekreef B, Hoek G. Variation of NO2 and NOx concentrations between and within 36 European study areas: results from the ESCAPE study. Atmos Environ. 2012;62:374-390. DOI: 10.1016/j.atmosenv.2012.07.080

Wanner M, Martin B.W, Meier F, Probst-Hensch N, Kriemler S. Effects of filter choice in GT3X accelerometer assessments of free-living activity. Med Sci Sports Exerc. 2013;45(1):170-177. DOI: 10.1249/MSS.0b013e31826c2cf1

Zemp E, Elsasser S, Schindler C, Künzli N, Perruchoud A.P, Domenighetti G, Medici T, Ackermann-Liebrich U, Leuenberger P, Monn C, Bolognini G, Bongard J.P, Brändli O, Karrer W, Keller R, Schoni M.H, Tschopp J.M, Villiger B, Zellweger J.P, SAPALDIA Team. Long-term ambient air pollution and respiratory symptoms in adults (SAPALDIA study). Am J Respir Crit Care Med. 1999;159(4 Pt 1):1257-1266

Wüthrich B, Schindler C, Medici T.C, Zellweger J.P, Leuenberger P, SAPALDIA Team. IgE levels, atopy markers and hay fever in relation to age, sex and smoking status in a normal adult Swiss population. Int Arch Allergy Immunol. 1996;111(4):396-402

Senn O, Russi E.W, Imboden M, Probst-Hensch N.M. alpha1-Antitrypsin deficiency and lung disease: risk modification by occupational and environmental inhalants. Eur Respir J. 2005;26(5):909-917

Zemp E, Schikowski T, Dratva J, Schindler C, Probst-Hensch N. Asthma and the menopause: a systematic review and meta-analysis. Maturitas. 2012;73(3):212-217. DOI: 10.1016/j.maturitas.2012.08.010

Thun G.A, Imboden M, Berger W, Rochat T, Probst-Hensch N.M. The association of a variant in the cell cycle control gene CCND1 and obesity on the development of asthma in the Swiss SAPALDIA study. J Asthma. 2013;50(2):147-154. DOI: 10.3109/02770903.2012.757776

Puhan M.A, Gaspoz J.M, Bridevaux P.O, Schindler C, Ackermann-Liebrich U, Rochat T, Gerbase M.W. Comparing a disease-specific and a generic health-related quality of life instrument in subjects with asthma from the general population. Health Qual Life Outcomes. 2008;6(1):15

Castro-Giner F, Kogevinas M, Imboden M, de Cid R, Jarvis D, Machler M, Berger W, Burney P, Franklin K.A, Gonzalez J.R, Heinrich J, Janson C, Omenaas E, Pin I, Rochat T, Sunyer J, Wjst M, Anto J.M, Estivill X, Probst-Hensch N.M. Joint effect of obesity and TNFA variability on asthma: two international cohort studies. Eur Respir J. 2009;33(5):1003-1009. DOI: 10.1183/09031936.00140608

Curjuric I, Imboden M, Nadif R, Kumar A, Schindler C, Haun M, Kronenberg F, Künzli N, Phuleria H, Postma D.S, Russi E.W, Rochat T, Demenais F, Probst-Hensch N.M. Different genes interact with particulate matter and tobacco smoke exposure in affecting lung function decline in the general population. PLoS One. 2012;7(7):e40175. DOI: 10.1371/journal.pone.0040175

Gerbase M.W, Keidel D, Imboden M, Gemperli A, Bircher A, Schmid-Grendelmeier P, Bridevaux P.O, Berger W, Schindler C, Rochat T, Probst-Hensch N. Effect modification of immunoglobulin E-mediated atopy and rhinitis by glutathione S-transferase genotypes in passive smokers. Clin Exp Allergy. 2011;41(11):1579-1586. DOI: 10.1111/j.1365-2222.2011.03807.x

Ferrarotti I, Thun G.A, Zorzetto M, Ottaviani S, Imboden M, Schindler C, Von Eckardstein A, Rohrer L, Rochat T, Russi E.W, Probst-Hensch N.M, Luisetti M. Serum levels and genotype distribution of alpha1-antitrypsin in the general population. Thorax. 2012;67(8):669-674. DOI: 10.1136/thoraxjnl-2011-201321

Mirabelli M.C, Zock J.P, Bircher A.J, Jarvis D, Keidel D, Kromhout H, Norback D, Olivieri M, Plana E, Radon K, Schindler C, Schmid-Grendelmeier P, Toren K, Villani S, Kogevinas M. Metalworking exposures and persistent skin symptoms in the ECRHS II and SAPALDIA 2 cohorts. Contact Dermatitis. 2009;60(5):256-263

Leuenberger P. Asthme bronchique et pollution atmosphérique. Méd Environ. 1995;53(2098):2597-2598

Leuenberger P, Ackermann-Liebrich U, Künzli N, Schindler C, Perruchoud A.P. SAPALDIA: passé, présent et avenir. Schweiz Med Wochenschr. 2000;130(8):291-297

Leuenberger P, SAPALDIA Team. Pollution de l'air en Suisse et maladies respiratoires chez l'adulte. Résultats préliminaires de la partie transversale de l'étude SAPALDIA. Praxis. 1995;84(40):1096-1100

Leuenberger P, Künzli N, Ackermann-Liebrich U, Schindler C, Bolognini G, Bongard J.P, Brändli O, Defila C, Domenighetti G, Karrer W, Keller R, Medici T, Monn C, Perruchoud A.P, Schoni M, Tschopp J.M, Villiger B, Wüthrich B, Zellweger J.P. Etude suisse sur la pollution de l'air et les maladies respiratoires chez l'adulte (SAPALDIA). Schweiz Med Wochenschr. 1998;128(5):150-161

Leuenberger P, Schwartz J, Ackermann-Liebrich U, Blaser K, Bolognini G, Bongard J.P, Brändli O, Braun P, Bron C, Brutsche M, Domenighetti G, Elsasser S, Guldimann P, Hollenstein C, Hufschmid P, Keller R, Keller-Wossidlo H, Künzli N, Lüthi J.C, Martin B.W, Medici T, Perruchoud A.P, Radaelli A, Schindler C, Schöni M.H, Solari G, Tschopp J.M, Villiger B, Wüthrich B, Zellweger J.P, Zemp Stutz E, SAPALDIA Team. Passive smoking exposure in adults and chronic respiratory symptoms (SAPALDIA Study). Am J Respir Crit Care Med. 1994;150(5 Pt 1):1222-1228

Leuenberger P, Schindler C, Schwartz J, Ackermann-Liebrich U, Tara D, Perruchoud A.P, Wüthrich B, Zellweger J.P, Blaser K, Bolognini G, Bongard J.P, Brändli O, Domenighetti G, Elsasser S, Grize L, Karrer W, Keller R, Künzli N, Medici T, Schoni M.H, Solari G, Tschopp J.M, Villiger B, Zemp E. Occupational exposure to inhalative irritants and methacholine responsiveness. Scand J Work Environ Health. 2000;26(2):146-152

Leuenberger P. Pollution de l'air et maladies respiratoires: la situation en Suisse. Trib Med Ticinese. 1992;57:696-697

Mélen E, Granell R, Kogevinas M, Strachan D, Gonzalez J.R, Wjst M, Jarvis D, Ege M, Braun-Fahrländer C, Genuneit J, Horak E, Bouzigon E, Demenais F, Kauffmann F, Siroux V, Michel S, von Berg A, Heinzmann A, Kabesch M, Probst-Hensch N.M, Curjuric I, Imboden M, Rochat T, Henderson J, Sterne J.A.C, McArdle W.L, Hui J, James A.L, Musk A.W, Palmer L.J, Becker A, Kozyrskyj A.L, Chan-Young M, Park J.E, Leung A, Daley D, Freidin M.B, Deev I.A, Ogorodova L.M, Puzyrev V.P, Celedón J.C, Brehm J.M, Cloutier M.M, Canino G, Acosta-Pérez E, Soto-Quiros M, Avila L, Bergström A, Magnusson J, Söderhäll C, Kull I, Scholtens S, Boezen H.M, Koppelman G.H, Wijga A.H, Marenholz I, Esparza-Gordillo J, Lau S, Lee Y.A, Standl M, Tiesler C.M.T, Flexeder C, Heinrich J, Myers R.A, Ober C, Nicolae D.L, Farrall M, Kumar A, Moffatt M.F, Cookson W.O.C.M, Lasky-Su J. Genome-wide association study of body mass index in 23,000 individuals with and without asthma. Clin Exp Allergy. 2013;43(4):463-474. DOI: 10.1111/cea.12054

Monn C, Brändli O, Schaeppi G, Schindler C, Ackermann-Liebrich U, Leuenberger P, SAPALDIA Team. Particulate matter < 10 pm (PM10) and total suspended particulates (TSP) in urban, rural and alpine air in Switzerland. Atmos Environ. 1995;29(19):2565-2573

Ritter M, Müller M.D, Tsai M.Y, Parlow E. Air pollution modeling over very complex terrain: An evaluation of WRF-Chem over Switzerland for two 1-year periods. Atmospheric Research. 2013;132-133:209-222. DOI: 10.1016/j.atmosres.2013.05.021

Wang M, Beelen R, Basagana X, Becker T, Cesaroni G, de Hoogh K, Dedele A, Declercq C, Dimakopoulou K, Eeftens M, Forastiere F, Galassi C, Grazuleviciene R, Hoffmann B, Heinrich J, Iakovides M, Künzli N, Korek M, Lindley S, Molter A, Mosler G, Madsen C, Nieuwenhuijsen M.J, Phuleria H, Pedeli X, Raaschou-Nielsen O, Ranzi A, Sugiri D, Stempfelet M, Tsai M.Y, Lanki T, Udvardy O, Varro M.J, Wolf K, Weinmayr G, Yli-Tuomi T, Hoek G, Brunekreef B. Evaluation of land use regression models for NO2 and particulate matter in 20 European study areas: the ESCAPE project. Environ Sci Technol. 2013;47(9):4357-4364. DOI: 10.1021/es305129t

Norbäck D, Zock J.P, Plana E, Heinrich J, Svanes C, Sunyer J, Künzli N, Villani S, Olivieri M, Soon A, Jarvis D. Mould and dampness in dwelling places, and onset of asthma: the population-based cohort ECRHS. Occup Environ Med. 2013;70(5):325-331. DOI: 10.1136/oemed-2012-100963

Schikowski T, Mills I.C, Anderson H.R, Cohen A, Hansell A, Kauffmann F, Kramer U, Marcon A, Perez L, Sunyer J, Probst-Hensch N, Künzli N. Ambient air pollution- a cause for COPD?. Eur Respir J. 2014;43(1):250-263. DOI: 10.1183/09031936.00100112

Ritter M, Müller M.D, Jorba O, Parlow E, Liu L.J.S. Impact of chemical and meteorological boundary and initial conditions on air quality modeling: WRF-Chem sensitivity evaluation for a European domain. Meteorol Atmos Phys. 2013;119(1-2):59-70. DOI: 10.1007/s00703-012-0222-8

Oglesby L, Künzli N, Monn C, Schindler C, Ackermann-Liebrich U, Leuenberger P. Validity of annoyance scores for estimation of long term air pollution exposure in epidemiologic studies: the Swiss Study on Air Pollution and Lung Diseases in Adults (SAPALDIA). Am J Epidemiol. 2000;152(1):75-83

Monn C, Brändli O, Schindler C, Ackermann-Liebrich U, Leuenberger P, SAPALDIA Team. Personal exposure to nitrogen dioxide in Switzerland. Sci Total Environ. 1998;215(3):243-251

Monn C. Staubförmige Verunreinigung der Luft. Allergologie. 1994;17(11):509-513

Liu L.J, Curjuric I, Keidel D, Heldstab J, Künzli N, Bayer-Oglesby L, Ackermann-Liebrich U, Schindler C. Characterization of source-specific air pollution exposure for a large population-based Swiss cohort (SAPALDIA). Environ Health Perspect. 2007;115(11):1638-1645

Parsa A, Fuchsberger C, Kottgen A, O'Seaghdha C.M, Pattaro C, de Andrade M, Chasman D.I, Teumer A, Endlich K, Olden M, Chen M.H, Tin A, Kim Y.J, Taliun D, Li M, Feitosa M, Gorski M, Yang Q, Hundertmark C, Foster M.C, Glazer N, Isaacs A, Rao M, Smith A.V, O'Connell J.R, Struchalin M, Tanaka T, Li G, Hwang S.J, Atkinson E.J, Lohman K, Cornelis M.C, Johansson A, Tonjes A, Dehghan A, Couraki V, Holliday E.G, Sorice R, Kutalik Z, Lehtimaki T, Esko T, Deshmukh H, Ulivi S, Chu A.Y, Murgia F, Trompet S, Imboden M, Kollerits B, Pistis G, Harris T.B, Launer L.J, Aspelund T, Eiriksdottir G, Mitchell B.D, Boerwinkle E, Schmidt H, Hofer E, Hu F, Demirkan A, Oostra B.A, Turner S.T, Ding J, Andrews J.S, Freedman B.I, Giulianini F, Koenig W, Illig T, Doring A, Wichmann H.E, Zgaga L, Zemunik T, Boban M, Minelli C, Wheeler H.E, Igl W, Zaboli G, Wild S.H, Wright A.F, Campbell H, Ellinghaus D, Nothlings U, Jacobs G, Biffar R, Ernst F, Homuth G, Kroemer H.K, Nauck M, Stracke S, Volker U, Volzke H, Kovacs P, Stumvoll M, Magi R, Hofman A, Uitterlinden A.G, Rivadeneira F, Aulchenko Y.S, Polasek O, Hastie N, Vitart V, Helmer C, Wang J.J, Stengel B, Ruggiero D, Bergmann S, Kahonen M, Viikari J, Nikopensius T, Province M, Colhoun H, Doney A, Robino A, Kramer B.K, Portas L, Ford I, Buckley B.M, Adam M, Thun G.A, Paulweber B, Haun M, Sala C, Mitchell P, Ciullo M, Vollenweider P, Raitakari O, Metspalu A, Palmer C, Gasparini P, Pirastu M, Jukema J.W, Probst-Hensch N.M, Kronenberg F, Toniolo D, Gudnason V, Shuldiner A.R, Coresh J, Schmid R, Ferrucci L, van Duijn C.M, Borecki I, Kardia S.L, Liu Y, Curhan G.C, Rudan I, Gyllensten U, Wilson J.F, Franke A, Pramstaller P.P, Rettig R, Prokopenko I, Witteman J, Hayward C, Ridker P.M, Bochud M, Heid I.M, Siscovick D.S, Fox C.S, Kao W.L, Boger C.A. Common variants in Mendelian kidney disease genes and their association with renal function. J Am Soc Nephrol. 2013;24(12):2105-2117. DOI: 10.1681/ASN.2012100983

Marcon A, Locatelli F, Keidel D, Beckmeyer-Borowko A.B, Cerveri I, Dharmage S.C, Fuertes E, Garcia-Aymerich J, Heinrich J, Imboden M, Janson C, Johannessen A, Leynaert B, Pascual Erquicia S, Pesce G, Schaffner E, Svanes C, Urrutia I, Jarvis D, Probst-Hensch N.M, Accordini S, Ageing Lungs in European Cohorts study. Airway responsiveness to methacholine and incidence of COPD: an international prospective cohort study. Thorax. 2018;73(9):825-832. DOI: 10.1136/thoraxjnl-2017-211289

Eze I.C, Imboden M, Foraster M, Schaffner E, Kumar A, Vienneau D, Héritier H, Rudzik F, Thiesse L, Pieren R, von Eckardstein A, Schindler C, Brink M, Wunderli J.M, Cajochen C, Röösli M, Probst-Hensch N. Exposure to night-time traffic noise, melatonin-regulating gene variants and change in glycemia in adults. Int J Environ Res Public Health. 2017;14(12):E1492. DOI: 10.3390/ijerph14121492

Fiorito G, Vlaanderen J, Polidoro S, Gulliver J, Galassi C, Ranzi A, Krogh V, Grioni S, Agnoli C, Sacerdote C, Panico S, Tsai M.Y, Probst-Hensch N, Hoek G, Herceg Z, Vermeulen R, Ghantous A, Vineis P, Naccarati A, EXPOsOMICS consortium. Oxidative stress and inflammation mediate the effect of air pollution on cardio- and cerebrovascular disease: a prospective study in nonsmokers. Environ Mol Mutagen. 2018;59(3):234-246. DOI: 10.1002/em.22153

Ayala-Bernal D, Probst-Hensch N, Rochat T, Bettschart R, Brandli O, Bridevaux P.O, Burdet L, Frey M, Gerbase M, Pons M, Rothe T, Stolz D, Tschopp J.M, Turk A, Künzli N, Schindler C. Factors associated with cessation of smoking among Swiss adults between 1991 and 2011: results from the SAPALDIA Cohort. Swiss Med Wkly. 2017;147:w14502. DOI: 10.4414/smw.2017.14502

Gulliver J, Morley D, Dunster C, McCrea A, Van Nunen E, Tsai M, Probst-Hensch N, Eeftens M, Imboden M, Ducret-Stich R, Naccarati A, Cirachi M, Vermeulen, Vineis P, Hoek G, Kelly F.J. Land use regression models for the oxidative potential of fine particles (PM2.5) in five European areas. Environ Res. 2018;160:247-255. DOI: 10.1016/j.envres.2017.10.002

Jarvis D, Newson R, Janson C, Corsico A, Heinrich J, Anto J.M, Abramson M.J, Kirsten A.M, Zock J.P, Bono R, Demoly P, Leynaert B, Raherison C, Pin I, Gislason T, Jogi R, Schlunssen V, Svanes C, Watkins J, Weyler J, Pereira-Vega A, Urrutia I, Gullon J.A, Forsberg B, Probst-Hensch N, Boezen H.M, Martinez-Moratalla Rovira J, Accordini S, de Marco R, Burney P. Prevalence of asthma-like symptoms with ageing. Thorax. 2018;73:37-48. DOI: 10.1136/thoraxjnl-2016-209596

Doiron D, de Hoogh K, Probst-Hensch N, Mbatchou S, Eeftens M, Cai Y, Schindler C, Fortier I, Hodgson S, Gaye A, Stolk R, Hansell A. Residential air pollution and associations with wheeze and shortness of breath in adults: a combined analysis of cross-sectional data from two large European cohorts. Environ Health Perspect. 2017;125(9):097025. DOI: 10.1289/EHP1353

Valkonen M, Täubel M, Pekkanen J, Tischer C, Rintala H, Zock J.P, Casas L, Probst-Hensch N, Forsberg B, Holm M, Janson C, Pin I, Gislason T, Jarvis D, Heinrich J, Hyvärinen A. Microbial characteristics in homes of asthmatic and non-asthmatic adults in the ECRHS cohort. Indoor Air. 2018;28:16-27. DOI: 10.1111/ina.12427

Foraster M, Eze I.C, Schaffner E, Vienneau D, Héritier H, Endes S, Rudzik F, Thiesse L, Pieren R, Schindler C, Schmidt-Trucksäss A, Brink M, Cajochen C, Marc Wunderli J, Röösli M, Probst-Hensch N. Exposure to road, railway, and aircraft noise and arterial stiffness in the SAPALDIA study: annual average noise levels and temporal noise characteristics. Environ Health Perspect. 2017;125(9):097004. DOI: 10.1289/EHP1136

Demenais F, Margaritte-Jeannin P, Barnes K.C, Cookson W.O.C, Altmuller J, Ang W, Barr R.G, Beaty T.H, Becker A.B, Beilby J, Bisgaard H, Bjornsdottir U.S, Bleecker E, Bonnelykke K, Boomsma D.I, Bouzigon E, Brightling C.E, Brossard M, Brusselle G.G, Burchard E, Burkart K.M, Bush A, Chan-Yeung M, Chung K.F, Couto Alves A, Curtin J.A, Custovic A, Daley D, de Jongste J.C, Del-Rio-Navarro B.E, Donohue K.M, Duijts L, Eng C, Eriksson J.G, Farrall M, Fedorova Y, Feenstra B, Ferreira M.A, Freidin M.B, Gajdos Z, Gauderman J, Gehring U, Geller F, Genuneit J, Gharib S.A, Gilliland F, Granell R, Graves P.E, Gudbjartsson D.F, Haahtela T, Heckbert S.R, Heederik D, Heinrich J, Heliovaara M, Henderson J, Himes B.E, Hirose H, Hirschhorn J.N, Hofman A, Holt P, Hottenga J, Hudson T.J, Hui J, Imboden M, Ivanov V, Jaddoe V.W.V, James A, Janson C, Jarvelin M.R, Jarvis D, Jones G, Jonsdottir I, Jousilahti P, Kabesch M, Kahonen M, Kantor D.B, Karunas A.S, Khusnutdinova E, Koppelman G.H, Kozyrskyj A.L, Kreiner E, Kubo M, Kumar R, Kumar A, Kuokkanen M, Lahousse L, Laitinen T, Laprise C, Lathrop M, Lau S, Lee Y.A, Lehtimaki T, Letort S, Levin A.M, Li G, Liang L, Loehr L.R, London S.J, Loth D.W, Manichaikul A, Marenholz I, Martinez F.J, Matheson M.C, Mathias R.A, Matsumoto K, Mbarek H, McArdle W.L, Melbye M, Melen E, Meyers D, Michel S, Mohamdi H, Musk A.W, Myers R.A, Nieuwenhuis M.A.E, Noguchi E, O'Connor G.T, Ogorodova L.M, Palmer C.D, Palotie A, Park J.E, Pennell C.E, Pershagen G, Polonikov A, Postma D.S, Probst-Hensch N, Puzyrev V.P, Raby B.A, Raitakari O.T, Ramasamy A, Rich S.S, Robertson C.F, Romieu I, Salam M.T, Salomaa V, Schlunssen V, Scott R, Selivanova P.A, Sigsgaard T, Simpson A, Siroux V, Smith L.J, Solodilova M, Standl M, Stefansson K, Strachan D.P, Stricker B.H, Takahashi A, Thompson P.J, Thorleifsson G, Thorsteinsdottir U, Tiesler C.M.T, Torgerson D.G, Tsunoda T, Uitterlinden A.G, Van der Valk R.J.P, Vaysse A, Vedantam S, Von Berg A, Von Mutius E, Vonk J.M, Waage J, Wareham N.J, Weiss S.T, White W.B, Wickman M, Widen E, Willemsen G, Williams L.K, Wouters I.M, Yang J.J, Zhao J.H, Moffatt M.F, Ober C, Nicolae D.L, Australian Asthma Genetics Consortium Collaborators. Multiancestry association study identifies new asthma risk loci that colocalize with immune-cell enhancer marks. Nat Genet. 2018;50:42-53. (AAGC). DOI: 10.1038/s41588-017-0014-7

Fuertes E, Carsin A.E, Anto J.M, Bono R, Corsico A.G, Demoly P, Gislason T, Gullon J.A, Janson C, Jarvis D, Heinrich J, Holm M, Leynaert B, Marcon A, Martinez-Moratalla J, Nowak D, Pascual Erquicia S, Probst-Hensch N.M, Raherison C, Raza W, Gomez Real F, Russell M, Sanchez-Ramos J.L, Weyler J, Garcia Aymerich J. Leisure-time vigorous physical activity is associated with better lung function: the prospective ECRHS study. Thorax. 2018;73(4):376-384. DOI: 10.1136/thoraxjnl-2017-210947

Rudzik F, Thiesse L, Pieren R, Wunderli J.M, Brink M, Foraster M, Héritier H, Eze I.C, Garbazza C, Vienneau D, Probst-Hensch N, Röösli M, Cajochen C. Sleep spindle characteristics and arousability from night-time transportation noise exposure in healthy young and older individuals. Sleep. 2018;41(7):zsy077. DOI: 10.1093/sleep/zsy077

Lytras T, Kogevinas M, Kromhout H, Carsin A.E, Anto J.M, Bentouhami H, Weyler J, Heinrich J, Nowak D, Urrutia I, Martinez-Moratalla J, Gullon J.A, Pereira-Vega A, Raherison-Semjen C, Pin I, Demoly P, Leynaert B, Villani S, Gislason T, Svanes C, Holm M, Forsberg B, Norback D, Mehta A.J, Probst-Hensch N, Benke G, Jogi R, Toren K, Sigsgaard T, Schlunssen V, Olivieri M, Blanc P.D, Vermeulen R, Garcia-Aymerich J, Jarvis D, Zock J.P. Occupational exposures and 20-year incidence of COPD: the European Community Respiratory Health Survey. Thorax. 2018;73(11):1008-1015. DOI: 10.1136/thoraxjnl-2017-211158

Héritier H, Vienneau D, Foraster M, Eze I.C, Schaffner E, Thiesse L, Ruzdik F, Habermacher M, Köpfli M, Pieren R, Schmidt-Trucksäss A, Brink M, Cajochen C, Wunderli J.M, Probst-Hensch N, Röösli M, SNC study group. Diurnal variability of transportation noise exposure and cardiovascular mortality: a nationwide cohort study from Switzerland. Int J Hyg Environ Health. 2018;221(3):556-563. DOI: 10.1016/j.ijheh.2018.02.005

Pekkanen J, Valkonen M, Taubel M, Tischer C, Leppanen H, Karkkainen P.M, Rintala H, Zock J.P, Casas L, Probst-Hensch N, Forsberg B, Holm M, Janson C, Pin I, Gislason T, Jarvis D, Heinrich J, Hyvarinen A. Indoor bacteria and asthma in adults: a multicentre case-control study within ECRHS II. Eur Respir J. 2018;51(2):1701241. DOI: 10.1183/13993003.01241-2017

Turner M.C, Vineis P, Seleiro E, Dijmarescu M, Balshaw D, Bertollini R, Chadeau-Hyam M, Gant T, Gulliver J, Jeong A, Kyrtopoulos S, Martuzzi M, Miller G.W, Nawrot T, Nieuwenhuijsen M, Phillips D.H, Probst-Hensch N, Samet J, Vermeulen R, Vlaanderen J, Vrijheid M, Wild C, Kogevinas M, EXPOsOMICS Consortium. EXPOsOMICS: final policy workshop and stakeholder consultation. BMC Public Health. 2018;18:260. DOI: 10.1186/s12889-018-5160-z

Dratva J, Caviezel S, Schaffner E, Stolz D, Rothe T, Künzli N, Schmidt-Trucksäss A, Zemp E, Probst-Hensch N. Is there a gender-specific association between asthma and carotid intima media thickness in Swiss adolescents?. Eur J Pediatr. 2018;177(5):699-707. DOI: 10.1007/s00431-018-3107-0

Curjuric I, Imboden M, Bettschart R, Caviezel S, Dratva J, Pons M, Rothe T, Schmidt-Trucksäss A, Stolz D, Thun G.A, Eckardstein A.V, Kronenberg F, Ferrarotti I, Probst-Hensch N.M. Alpha-1 antitrypsin deficiency: from the lung to the heart?. Atherosclerosis. 2018;270:166-172. DOI: 10.1016/j.atherosclerosis.2018.01.042

Schlatter F, Piquerez A, Habermacher M, Ragettli M.S, Röösli M, Brink M, Cajochen C, Probst-Hensch N, Foraster M, Wunderli J.M. Validation of large scale noise exposure modeling by long-term measurements. Noise Mapping. 2017;4:75-96. DOI: 10.1515/noise-2017-0006

Endes S, Schaffner E, Caviezel S, Dratva J, Stolz D, Schindler C, Künzli N, Schmidt-Trucksass A, Probst-Hensch N. Is physical activity a modifier of the association between air pollution and arterial stiffness in older adults: the SAPALDIA cohort study. Int J Hyg Environ Health. 2017;220(6):1030-1038. DOI: 10.1016/j.ijheh.2017.06.001

Eze I.C, Foraster M, Schaffner E, Vienneau D, Héritier H, Rudzik F, Thiesse L, Pieren R, Imboden M, von Eckardstein A, Schindler C, Brink M, Cajochen C, Wunderli J.M, Röösli M, Probst-Hensch N. Long-term exposure to transportation noise and air pollution in relation to incident diabetes in the SAPALDIA study. Int J Epidemiol. 2017;46(4):1115-1125. DOI: 10.1093/ije/dyx020

De Jong K, Vonk J.M, Imboden M, Lahousse L, Hofman A, Brusselle G.G, Probst-Hensch N.M, Postma D.S, Boezen H.M. Genes and pathways underlying susceptibility to impaired lung function in the context of environmental tobacco smoke exposure. Respir Res. 2017;18:142. DOI: 10.1186/s12931-017-0625-7

Wüthrich B, Schmid-Grendelmeier P, Schindler C, Imboden M, Bircher A, Zemp E, Probst-Hensch N, SAPALDIA Team. Prevalence of atopy and respiratory allergic diseases in the elderly SAPALDIA population. Int Arch Allergy Immunol. 2013;162(2):143-148. DOI: 10.1159/000351416

Thun G.A, Ferrarotti I, Imboden M, Rochat T, Gerbase M, Kronenberg F, Bridevaux P.O, Zemp E, Zorzetto M, Ottaviani S, Russi E.W, Luisetti M, Probst-Hensch N.M. SERPINA1 PiZ and PiS heterozygotes and lung function decline in the SAPALDIA cohort. PLoS One. 2012;7(8):e42728. DOI: 10.1371/journal.pone.0042728

Curjuric I, Zemp Stutz E, Dratva J, Ackermann-Liebrich U, Bridevaux P.O, Bettschart R.W, Brutsche M, Frey M, Gerbase M.W, Knöpfli B, Künzli N, Pons M, Schwartz J, Schindler C, Rochat T. Determinants of change in airway reactivity over 11 years in a population study (SAPALDIA). Eur Respir J. 2011;37:492-500. DOI: 10.1183/09031936.00188609

Walther D, Curjuric I, Dratva J, Schaffner E, Quinto C, Schmidt-Trucksäss A, Eze I.C, Burdet L, Pons M, Gerbase M, Imboden M, Schindler C, Probst-Hensch N. Hypertension, diabetes and lifestyle in the long-term - results from a Swiss population-based cohort. Prev Med. 2017;97:56-61. DOI: 10.1016/j.ypmed.2016.12.016

Eze I.C, Schaffner E, Zemp E, Von Eckardstein A, Turk A, Bettschart R, Schindler C, Probst-Hensch N. Environmental tobacco smoke exposure and diabetes in adult never-smokers. Environ Health. 2014;13:74. DOI: 10.1186/1476-069X-13-74

Downs S.H, Brändli O, Zellweger J.P, Schindler C, Künzli N, Gerbase M.W, Burdet L, Bettschart R, Zemp E, Frey M, Keller R, Tschopp J.M, Leuenberger P, Ackermann-Liebrich U. Accelerated decline in lung function in smoking women with airway obstruction: SAPALDIA 2 cohort study. Respir Res. 2005;6(1):45

Schindler C, Keidel D, Gerbase M.W, Zemp E, Bettschart R, Brändli O, Brutsche M.H, Burdet L, Karrer W, Knöpfli B, Pons M, Rapp R, Bayer-Oglesby L, Künzli N, Schwartz J, Liu L.J, Ackermann-Liebrich U, Rochat T. Improvements in PM10 exposure and reduced rates of respiratory symptoms in a cohort of Swiss adults (SAPALDIA). Am J Respir Crit Care Med. 2009;179(7):579-587. DOI: 10.1164/rccm.200803-388OC

Dratva J, Gomez Real F, Schindler C, Ackermann-Liebrich U, Gerbase M.W, Probst-Hensch N.M, Svanes C, Omenaas E.R, Neukirch F, Wjst M, Morabia A, Jarvis D, Leynaert B, Zemp E. Is age at menopause increasing across Europe? Results on age at menopause and determinants from two population-based studies. Menopause. 2009;16(2):385-394. DOI: 10.1097/gme.0b013e31818aefef

Senn O, Russi E.W, Schindler C, Imboden M, Von Eckardstein A, Brändli O, Zemp E, Ackermann-Liebrich U, Berger W, Rochat T, Luisetti M, Probst-Hensch N.M. Circulating alpha1-antitrypsin in the general population: determinants and association with lung function. Respir Res. 2008;9:35

Moffatt M.F, Gut I.G, Demenais F, Strachan D.P, Bouzigon E, Heath S, von Mutius E, Farrall M, Lathrop M, Cookson W.O, Imboden M, Liu L.J, Schindler C, Rochat T, Gerbase M, Curjuric I, Thun G.A, Probst-Hensch N, Braun-Fahrländer C. A large-scale, consortium-based genomewide association study of asthma. N Engl J Med. 2010;363(13):1211-1221. DOI: 10.1056/NEJMoa0906312

Fuks K.B, Weinmayr G, Foraster M, Dratva J, Hampel R, Houthuijs D, Oftedal B, Oudin A, Panasevich S, Penell J, Sommar J.N, Sorensen M, Tittanen P, Wolf K, Xun W.W, Aguilera I, Basagaña X, Beelen R, Bots M.L, Brunekreef B, Bueno-de-Mesquita H.B, Caracciolo B, Cirach M, de Faire U, de Nazelle A, Eeftens M, Elosua R, Erbel R, Forsberg B, Fratiglioni L, Gaspoz J.M, Hilding A, Jula A, Korek M, Krämer U, Künzli N, Lanki T, Leander K, Magnusson P.K, Marrugat J, Nieuwenhuijsen M.J, Östenson C.G, Pedersen N.L, Pershagen G, Phuleria H.C, Probst-Hensch N.M, Raaschou-Nielsen O, Schaffner E, Schikowski T, Schindler C, Schwarze P.E, Sogaard A.J, Sugiri D, Swart W.J, Tsai M.Y, Turunen A.W, Vineis P, Peters A, Hoffmann B. Arterial blood pressure and long-term exposure to traffic-related air pollution: an analysis in the European Study of Cohorts for Air Pollution Effects (ESCAPE). Environ Health Perspect. 2014;122(9):896-905. DOI: 10.1289/ehp.1307725

Ragettli M.S, Tsai M.Y, Braun-Fahrländer C, de Nazelle A, Schindler C, Ineichen A, Ducret-Stich R.E, Perez L, Probst-Hensch N, Künzli N, Phuleria H.C. Simulation of population-based commuter exposure to NO2 using different air pollution models. Int J Environ Res Public Health. 2014;11(5):5049-5068. DOI: 10.3390/ijerph110505049

Cai Y, Schikowski T, Adam M, Buschka A, Carsin A.E, Jacquemin B, Marcon A, Sanchez M, Vierkötter A, Al-Kanaani Z, Beelen R, Birk M, Brunekreef B, Cirach M, Clavel-Chapelon F, Declercq C, de Hoogh K, de Nazelle A, Ducret-Stich R.E, Ferretti V, Forsberg B, Gerbase M.W, Hardy R, Heinrich J, Hoek G, Jarvis D, Keidel D, Kuh D, Nieuwenhuijsen M.J, Ragettli M.S, Ranzi A, Rochat T, Schindler C, Sugiri D, Temam S, Tsai M.Y, Varraso R, Kauffmann F, Kramer U, Sunyer J, Künzli N, Probst-Hensch N, Hansell A.L. Cross-sectional associations between air pollution and chronic bronchitis: an ESCAPE meta-analysis across five cohorts. Thorax. 2014;69(11):1005-1014. DOI: 10.1136/thoraxjnl-2013-204352

Beelen R, Stafoggia M, Raaschou-Nielsen O, Andersen Z.J, Xun W.W, Katsouyanni K, Dimakopoulou K, Brunekreef B, Weinmayr G, Hoffmann B, Wolf K, Samoli E, Houthuijs D, Nieuwenhuijsen M, Oudin A, Forsberg B, Olsson D, Salomaa V, Lanki T, Yli-Tuomi T, Oftedal B, Aamodt G, Nafstad P, de Faire U, Pedersen N.L, Östenson C.G, Fratiglioni L, Penell J, Korek M, Pyko A, Eriksen K.T, Tjønneland A, Becker T, Eeftens M, Bots M, Meliefste K, Wang M, Bueno-de-Mesquita B, Sugiri D, Kramer U, Heinrich J, de Hoogh K, Key T, Peters A, Cyrys J, Concin H, Nagel G, Ineichen A, Schaffner E, Probst-Hensch N, Dratva J, Ducret-Stich R, Vilier A, Clavel-Chapelon F, Stempfelet M, Grioni S, Krogh V, Tsai M.Y, Marcon A, Ricceri F, Sacerdote C, Galassi C, Migliore E, Ranzi A, Cesaroni G, Badaloni C, Forastiere F, Tamayo I, Amiano P, Dorronsoro M, Katsoulis M, Trichopoulou A, Vineis P, Hoek G. Long-term exposure to air pollution and cardiovascular mortality: an analysis of 22 european cohorts. Epidemiology. 2014;25(3):368-378. DOI: 10.1097/EDE.0000000000000076

Guerra S, Carsin A.E, Keidel D, Sunyer J, Leynaert B, Janson C, Jarvis D, Stolz D, Rothe T, Pons M, Turk A, Anto J.M, Probst-Hensch N. Health-related quality of life and risk factors associated with spirometric restriction. Eur Respir J. 2017;49(5):1602096. DOI: 10.1183/13993003.02096-2016

Beelen R, Raaschou-Nielsen O, Stafoggia M, Andersen Z.J, Weinmayr G, Hoffmann B, Wolf K, Samoli E, Fischer P, Nieuwenhuijsen M, Vineis P, Xun W.W, Katsouyanni K, Dimakopoulou K, Oudin A, Forsberg B, Modig L, Havulinna A.S, Lanki T, Turunen A, Oftedal B, Nystad W, Nafstad P, de Faire U, Pedersen N.L, Östenson C.G, Fratiglioni L, Penell J, Korek M, Pershagen G, Eriksen K.T, Overvad K, Ellermann T, Eeftens M, Peeters P.H, Meliefste K, Wang M, Bueno-de-Mesquita B, Sugiri D, Krämer U, Heinrich J, de Hoogh K, Key T, Peters A, Hampel R, Concin H, Nagel G, Ineichen A, Schaffner E, Probst-Hensch N, Künzli N, Schindler C, Schikowski T, Adam M, Phuleria H, Vilier A, Clavel-Chapelon F, Declercq C, Grioni S, Krogh V, Tsai M.Y, Ricceri F, Sacerdote C, Galassi C, Migliore E, Ranzi A, Cesaroni G, Badaloni C, Forastiere F, Tamayo I, Amiano P, Dorronsoro M, Katsoulis M, Trichopoulou A, Brunekreef B, Hoek G. Effects of long-term exposure to air pollution on natural-cause mortality: an analysis of 22 European cohorts within the multicentre ESCAPE project. Lancet. 2014;383(9919):785-795. DOI: 10.1016/S0140-6736(13)62158-3

de Hoogh K, Wang M, Adam M, Badaloni C, Beelen R, Birk M, Cesaroni G, Cirach M, Declercq C, Dedele A, Dons E, de Nazelle A, Eeftens M, Eriksen K, Eriksson C, Fischer P, Grazuleviciene R, Gryparis A, Hoffmann B, Jerrett M, Katsouyanni K, Iakovides M, Lanki T, Lindley S, Madsen C, Molter A, Mosler G, Nador G, Nieuwenhuijsen M, Pershagen G, Peters A, Phuleria H, Probst-Hensch N, Raaschou-Nielsen O, Quass U, Ranzi A, Stephanou E, Sugiri D, Schwarze P, Tsai M.Y, Yli-Tuomi T, Varro M.J, Vienneau D, Weinmayr G, Brunekreef B, Hoek G. Development of land use regression models for particle composition in twenty study areas in Europe. Environ Sci Technol. 2013;47(11):5778-5786. DOI: 10.1021/es400156t

Eeftens M, Beelen R, de Hoogh K, Bellander T, Cesaroni G, Cirach M, Declercq C, Dedele A, Dons E, de Nazelle A, Dimakopoulou K, Eriksen K.T, Falq G, Fischer P, Galassi C, Grazuleviciene R, Heinrich J, Hoffmann B, Jerrett M, Keidel D, Korek M, Lankki T, Lindley S, Madsen C, Molter A, Nador G, Nieuwenhuijsen M.J, Nonnemacher M, Pedeli X, Raaschou-Nielsen O, Patelarou E, Quass U, Ranzi A, Schindler C, Stempfelet M, Stephanou E.G, Sugiri D, Tsai M, Yli-Tuomi T, Varro M.J, Vienneau D, von Klot S, Wolf K, Brunekreef B, Hoek G. Development of land use regression models for PM2.5, PM2.5 absorbance, PM10 and PMcoarse in 20 European study areas; results of the ESCAPE project. Environ Sci Technol. 2012;46(20):11195-11205. DOI: 10.1021/es301948k

Li M, Li Y, Weeks O, Mijatovic V, Teumer A, Huffman J.E, Tromp G, Fuchsberger C, Gorski M, Lyytikainen L.P, Nutile T, Sedaghat S, Sorice R, Tin A, Yang Q, Ahluwalia T.S, Arking D.E, Bihlmeyer N.A, Boger C.A, Carroll R.J, Chasman D.I, Cornelis M.C, Dehghan A, Faul J.D, Feitosa M.F, Gambaro G, Gasparini P, Giulianini F, Heid I, Huang J, Imboden M, Jackson A.U, Jeff J, Jhun M.A, Katz R, Kifley A, Kilpelainen T.O, Kumar A, Laakso M, Li-Gao R, Lohman K, Lu Y, Magi R, Malerba G, Mihailov E, Mohlke K.L, Mook-Kanamori D.O, Robino A, Ruderfer D, Salvi E, Schick U.M, Schulz C.A, Smith A.V, Smith J.A, Traglia M, Yerges-Armstrong L.M, Zhao W, Goodarzi M.O, Kraja A.T, Liu C, Wessel J, Charge Glycemic-T2D Working Group, Charge Blood Pressure Working Group, Boerwinkle E, Borecki I.B, Bork-Jensen J, Bottinger E.P, Braga D, Brandslund I, Brody J.A, Campbell A, Carey D.J, Christensen C, Coresh J, Crook E, Curhan G.C, Cusi D, de Boer I.H, de Vries A.P, Denny J.C, Devuyst O, Dreisbach A.W, Endlich K, Esko T, Franco O.H, Fulop T, Gerhard G.S, Glumer C, Gottesman O, Grarup N, Gudnason V, Harris T.B, Hayward C, Hocking L, Hofman A, Hu F.B, Husemoen L.L, Jackson R.D, Jorgensen T, Jorgensen M.E, Kahonen M, Kardia S.L, Konig W, Kooperberg C, Kriebel J, Launer L.J, Lauritzen T, Lehtimaki T, Levy D, Linksted P, Linneberg A, Liu Y, Loos R.J, Lupo A, Meisinger C, Melander O, Metspalu A, Mitchell P, Nauck M, Nurnberg P, Orho-Melander M, Parsa A, Pedersen O, Peters A, Peters U, Polasek O, Porteous D, Probst-Hensch N.M, Psaty B.M, Qi L, Raitakari O.T, Reiner A.P, Rettig R, Ridker P.M, Rivadeneira F, Rossouw J.E, Schmidt F, Siscovick D, Soranzo N, Strauch K, Toniolo D, Turner S.T, Uitterlinden A.G, Ulivi S, Velayutham D, Volker U, Volzke H, Waldenberger M, Wang J.J, Weir D.R, Witte D, Kuivaniemi H, Fox C.S, Franceschini N, Goessling W, Kottgen A, Chu A.Y. SOS2 and ACP1 loci identified through large-scale exome chip analysis regulate kidney development and function. J Am Soc Nephrol. 2017;28(3):981-994. DOI: 10.1681/ASN.2016020131

Marcon A, Marchetti P, Antó J.M, Cazzoletti L, Cerveri I, Corsico A, Ferreira D.S, Garcia-Aymerich J, Gislason D, Heinrich J, Jõgi R, Johannessen A, Leynaert B, Malinovschi A, Pin I, Probst-Hensch N, Weyler J, Janson C, Jarvis D, Accordini S, Ageing Lungs in European Cohorts (ALEC) study. Atopy modifies the association between inhaled corticosteroid use and lung function decline in patients with asthma. J Allergy Clin Immunol Pract. 2020;8(3):980-988 e10. DOI: 10.1016/j.jaip.2019.10.023

Olivieri M, Murgia N, Carsin A.E, Heinrich J, Benke G, Bono R, Corsico A.G, Demoly P, Forsberg B, Gislason T, Janson C, Jõgi R, Leynaert B, Martínez-Moratalla Rovira J, Norbäck D, Nowak D, Pascual S, Pin I, Probst-Hensch N, Raherison C, Sigsgaard T, Svanes C, Torén K, Urrutia I, Weyler J, Jarvis D, Zock J.P, Verlato G. Effects of smoking bans on passive smoking exposure at work and at home. The European Community Respiratory Health Survey. Indoor Air. 2019;29(4):670-679. DOI: 10.1111/ina.12556

Fiorito G, McCrory C, Robinson O, Carmeli C, Rosales C.O, Zhang Y, Colicino E, Dugué P.A, Artaud F, McKay G.J, Jeong A, Mishra P.P, Nøst T.H, Krogh V, Panico S, Sacerdote C, Tumino R, Palli D, Matullo G, Guarrera S, Gandini M, Bochud M, Dermitzakis E, Muka T, Schwartz J, Vokonas P.S, Just A, Hodge A.M, Giles G.G, Southey M.C, Hurme M.A, Young I, McKnight A.J, Kunze S, Waldenberger M, Peters A, Schwettmann L, Lund E, Baccarelli A, Milne R.L, Kenny R.A, Elbaz A, Brenner H, Kee F, Voortman T, Probst-Hensch N, Lehtimäki T, Elliot P, Stringhini S, Vineis P, Polidoro S, Bios Consortium, Lifepath consortium. Socioeconomic position, lifestyle habits and biomarkers of epigenetic aging: a multi-cohort analysis. Aging (Albany NY). 2019;11(7):2045-2070. DOI: 10.18632/aging.101900

Kutlar Joss M, Kappeler R, Probst-Hensch N, Künzli N. Luft und Gesundheit in der Schweiz und anderswo. Swiss Med Forum. 2019;19(1314):213-218. DOI: 10.4414/smf.2019.08079

Kutlar Joss M, Kappeler R, Probst-Hensch N, Künzli N. Air et santé en Suisse et ailleurs. Swiss Med Forum. 2019;19(1314):213-218. DOI: 10.4414/fms.2019.08079

Shrine N, Guyatt A.L, Erzurumluoglu A.M, Jackson V.E, Hobbs B.D, Melbourne C.A, Batini C, Fawcett K.A, Song K, Sakornsakolpat P, Li X, Boxall R, Reeve N.F, Obeidat M, Zhao J.H, Wielscher M, Understanding Society Scientific Group, Weiss S, Kentistou K.A, Cook J.P, Sun B.B, Zhou J, Hui J, Karrasch S, Imboden M, Harris S.E, Marten J, Enroth S, Kerr S.M, Surakka I, Vitart V, Lehtimäki T, Allen R.J, Bakke P.S, Beaty T.H, Bleecker E.R, Bossé Y, Brandsma C.A, Chen Z, Crapo J.D, Danesh J, DeMeo D.L, Dudbridge F, Ewert R, Gieger C, Gulsvik A, Hansell A.L, Hao K, Hoffman J.D, Hokanson J.E, Homuth G, Joshi P.K, Joubert P, Langenberg C, Li X, Li L, Lin K, Lind L, Locantore N, Luan J, Mahajan A, Maranville J.C, Murray A, Nickle D.C, Packer R, Parker M.M, Paynton M.L, Porteous D.J, Prokopenko D, Qiao D, Rawal R, Runz H, Sayers I, Sin D.D, Smith B.H, Soler Artigas M, Sparrow D, Tal-Singer R, Timmers Prhj, Van den Berge M, Whittaker J.C, Woodruff P.G, Yerges-Armstrong L.M, Troyanskaya O.G, Raitakari O.T, Kähönen M, Polašek O, Gyllensten U, Rudan I, Deary I.J, Probst-Hensch N.M, Schulz H, James A.L, Wilson J.F, Stubbe B, Zeggini E, Jarvelin M.R, Wareham N, Silverman E.K, Hayward C, Morris A.P, Butterworth A.S, Scott R.A, Walters R.G, Meyers D.A, Cho M.H, Strachan D.P, Hall I.P, Tobin M.D, Wain L.V. New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries. Nat Genet. 2019;51(3):481-493. DOI: 10.1038/s41588-018-0321-7

Donaire-Gonzalez D, Valentin A, van Nunen E, Curto A, Rodriguez A, Fernandez-Nieto M, Naccarati A, Tarallo S, Tsai M.Y, Probst-Hensch N, Vermeulen R, Hoek G, Vineis P, Gulliver J, Nieuwenhuijsen M.J. ExpoApp: an integrated system to assess multiple personal environmental exposures. Environ Int. 2019;126:494-503. DOI: 10.1016/j.envint.2019.02.054

Sakornsakolpat P, Prokopenko D, Lamontagne M, Reeve N.F, Guyatt A.L, Jackson V.E, Shrine N, Qiao D, Bartz T.M, Kim D.K, Lee M.K, Latourelle J.C, Li X, Morrow J.D, Obeidat M, Wyss A.B, Bakke P, Barr R.G, Beaty T.H, Belinsky S.A, Brusselle G.G, Crapo J.D, de Jong K, DeMeo D.L, Fingerlin T.E, Gharib S.A, Gulsvik A, Hall I.P, Hokanson J.E, Kim W.J, Lomas D.A, London S.J, Meyers D.A, O'Connor G.T, Rennard S.I, Schwartz D.A, Sliwinski P, Sparrow D, Strachan D.P, Tal-Singer R, Tesfaigzi Y, Vestbo J, Vonk J.M, Yim J.J, Zhou X, Bosse Y, Manichaikul A, Lahousse L, Silverman E.K, Boezen H.M, Wain L.V, Tobin M.D, Hobbs B.D, Cho M.H, SpiroMeta Consortium, International COPD Genetics Consortium. Genetic landscape of chronic obstructive pulmonary disease identifies heterogeneous cell-type and phenotype associations. Nat Genet. 2019;51(3):494-505. DOI: 10.1038/s41588-018-0342-2

Jeong A, Imboden M, Ghantous A, Novoloaca A, Carsin A.E, Kogevinas M, Schindler C, Lovison G, Herceg Z, Cuenin C, Vermeulen R, Jarvis D, Amaral A.F.S, Kronenberg F, Vineis P, Probst-Hensch N. DNA methylation in inflammatory pathways modifies the association between BMI and adult-onset non-atopic asthma. Int J Environ Res Public Health. 2019;16(4):600. DOI: 10.3390/ijerph16040600

Shrine N, Guyatt A.L, Erzurumluoglu A.M, Jackson V.E, Hobbs B.D, Melbourne C.A, Batini C, Fawcett K.A, Song K, Sakornsakolpat P, Li X, Boxall R, Reeve N.F, Obeidat M, Zhao J.H, Wielscher M, Understanding Society Scientific Group, Weiss S, Kentistou K.A, Cook J.P, Sun B.B, Zhou J, Hui J, Karrasch S, Imboden M, Harris S.E, Marten J, Enroth S, Kerr S.M, Surakka I, Vitart V, Lehtimaki T, Allen R.J, Bakke P.S, Beaty T.H, Bleecker E.R, Bosse Y, Brandsma C.A, Chen Z, Crapo J.D, Danesh J, DeMeo D.L, Dudbridge F, Ewert R, Gieger C, Gulsvik A, Hansell A.L, Hao K, Hoffman J.D, Hokanson J.E, Homuth G, Joshi P.K, Joubert P, Langenberg C, Li X, Li L, Lin K, Lind L, Locantore N, Luan J, Mahajan A, Maranville J.C, Murray A, Nickle D.C, Packer R, Parker M.M, Paynton M.L, Porteous D.J, Prokopenko D, Qiao D, Rawal R, Runz H, Sayers I, Sin D.D, Smith B.H, Artigas M.S, Sparrow D, Tal-Singer R, Timmers Prhj, Van den Berge M, Whittaker J.C, Woodruff P.G, Yerges-Armstrong L.M, Troyanskaya O.G, Raitakari O.T, Kahonen M, Polasek O, Gyllensten U, Rudan I, Deary I.J, Probst-Hensch N.M, Schulz H, James A.L, Wilson J.F, Stubbe B, Zeggini E, Jarvelin M.R, Wareham N, Silverman E.K, Hayward C, Morris A.P, Butterworth A.S, Scott R.A, Walters R.G, Meyers D.A, Cho M.H, Strachan D.P, Hall I.P, Tobin M.D, Wain L.V. Author correction: New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries. Nat Genet. 2019;51:1067-1068. DOI: 10.1038/s41588-019-0438-3

Imboden M, Wielscher M, Rezwan F.I, Amaral A.F.S, Schaffner E, Jeong A, Beckmeyer-Borowko A, Harris S.E, Starr J.M, Deary I.J, Flexeder C, Waldenberger M, Peters A, Schulz H, Chen S, Sunny S.K, Karmaus W.J.J, Jiang Y, Erhart G, Kronenberg F, Arathimos R, Sharp G.C, Henderson A.J, Fu Y, Piirilä P, Pietiläinen K.H, Ollikainen M, Johansson A, Gyllensten U, de Vries M, van der Plaat D.A, de Jong K, Boezen H.M, Hall I.P, Tobin M.D, Jarvelin M.R, Holloway J.W, Jarvis D, Probst-Hensch N.M. Epigenome-wide association study of lung function level and its change. Eur Respir J. 2019;54:1900457. DOI: 10.1183/13993003.00457-2019

Brink M, Schaffer B, Vienneau D, Pieren R, Foraster M, Eze I.C, Rudzik F, Thiesse L, Cajochen C, Probst-Hensch N, Röösli M, Wunderli J.M. Self-reported sleep disturbance from road, rail and aircraft noise: exposure-response relationships and effect modifiers in the SiRENE Study. Int J Environ Res Public Health. 2019;16(21):4186. DOI: 10.3390/ijerph16214186

Röösli M, Wunderli J.M, Brink M, Cajochen C, Probst-Hensch N. Bruit du trafic, mortalité cardiovasculaire, diabète, troubles du sommeil et nuisance: l'étude SiRENE. Swiss Med Forum. 2019;19(5-6):77-82. DOI: 10.4414/smf.2019.03433

Röösli M, Wunderli J.M, Brink M, Cajochen C, Probst-Hensch N. Die SiRENE-Studie: Verkehrslärm, kardiovaskuläre Sterblichkeit, Diabetes, Schlafstörung und Belästigung. Swiss Med Forum. 2019;19(5-6):77-82. DOI: 10.4414/smf.2019.03433

Doiron D, de Hoogh K, Probst-Hensch N, Fortier I, Cai Y, De Matteis S, Hansell A.L. Air pollution, lung function and COPD: results from the population-based UK Biobank study. Eur Respir J. 2019;54(1):1802140. DOI: 10.1183/13993003.02140-2018

Mostafavi N, Jeong A, Vlaanderen J, Imboden M, Vineis P, Jarvis D, Kogevinas M, Probst-Hensch N, Vermeulen R. The mediating effect of immune markers on the association between ambient air pollution and adult-onset asthma. Sci Rep. 2019;9:8818. DOI: 10.1038/s41598-019-45327-4

Peters A, Hoffmann B, Brunekreef B, Künzli N, Kutlar Joss M, Probst-Hensch N, Ritz B, Schulz H, Straif K, Wichmann E. Die Rolle der Luftschadstoffe für die Gesundheit: eine Expertise im Namen der Internationalen Gesellschaft für Umweltepidemiologie (ISEE) und der European Respiratory Society (ERS). Schweiz Ärzteztg. 2019;100(23-24):796-799

Peters A, Hoffmann B, Brunekreef B, Künzli N, Kutlar Joss M, Probst-Hensch N, Ritz B, Schulz H, Straif K, Wichmann E. Les effets des polluants atmosphériques sur la santé: un rapport d'expertise établi pour le compte de la Société internationale d'épidémiologie environnementale (ISEE) et de l'European Respiratory Society (ERS). Schweiz Ärzteztg. 2019;100(23-24):796-799

Keidel D, Anto J.M, Basagana X, Bono R, Burte E, Carsin A.E, Forsberg B, Fuertes E, Galobardes B, Heinrich J, de Hoogh K, Jarvis D, Künzli N, Leynaert B, Marcon A, Le Moual N, de Nazelle A, Schindler C, Siroux V, Stempfelet M, Sunyer J, Temam S, Tsai M.Y, Varraso R, Jacquemin B, Probst-Hensch N. The role of socioeconomic status in the association of lung function and air pollution-a pooled analysis of three adult ESCAPE cohorts. Int J Environ Res Public Health. 2019;16(11):1901. DOI: 10.3390/ijerph16111901

Flexeder C, Zock J.P, Jarvis D, Verlato G, Olivieri M, Benke G, Abramson M.J, Sigsgaard T, Svanes C, Torén K, Nowak D, Jogi R, Martinez-Moratalla J, Demoly P, Janson C, Gislason T, Bono R, Holm M, Franklin K.A, Garcia-Aymerich J, Siroux V, Leynaert B, Dorado Arenas S, Corsico A.G, Pereira-Vega A, Probst-Hensch N, Urrutia Landa I, Schulz H, Heinrich J. Second-hand smoke exposure in adulthood and lower respiratory health during 20 year follow up in the European Community Respiratory Health Survey. Respir Res. 2019;20:33. DOI: 10.1186/s12931-019-0996-z

Meier-Girard D, Delgado-Eckert E, Schaffner E, Schindler C, Künzli N, Adam M, Pichot V, Kronenberg F, Imboden M, Frey U, Probst-Hensch N. Association of long-term exposure to traffic-related PM10 with heart rate variability and heart rate dynamics in healthy subjects. Environ Int. 2019;125:107-116. DOI: 10.1016/j.envint.2019.01.031

Brink M, Schäffer B, Vienneau D, Foraster M, Pieren R, Eze I.C, Cajochen C, Probst-Hensch N, Röösli M, Wunderli J.M. A survey on exposure-response relationships for road, rail, and aircraft noise annoyance: differences between continuous and intermittent noise. Environ Int. 2019;125:277-290. DOI: 10.1016/j.envint.2019.01.043

Beckmeyer-Borowko A, Imboden M, Rezwan F.I, Wielscher M, Amaral A.F.S, Jeong A, Schaffner E, Auvinen J, Sebert S, Karhunen V, Bettschart R, Turk A, Pons M, Stolz D, Kronenberg F, Arathimos R, Sharp G.C, Relton C, Henderson A.J, Jarvelin M.R, Jarvis D, Holloway J.W, Probst-Hensch N.M. SERPINA1 methylation and lung function in tobacco-smoke exposed European children and adults: a meta-analysis of ALEC population-based cohorts. Respir Res. 2018;19(1):156. DOI: 10.1186/s12931-018-0850-8

Fuertes E, Markevych I, Jarvis D, Vienneau D, de Hoogh K, Antó J.M, Bowatte G, Bono R, Corsico A.G, Emtner M, Gislason D, Gullón J.A, Heinrich J, Henderson J, Holm M, Johannessen A, Leynaert B, Marcon A, Marchetti P, Martinez Moratella J, Pascual S, Probst-Hensch N, Sanchez-Ramos J.L, Siroux V, Sommar J, Weyler J, Künzli N, Jacquemin B, Garcia-Aymerich J. Residential air pollution does not modify the positive association between physical activity and lung function in current smokers in the ECRHS study. Environ Int. 2018;120:364-372. DOI: 10.1016/j.envint.2018.07.032

Mostafavi N, Vermeulen R, Ghantous A, Hoek G, Probst-Hensch N, Herceg Z, Tarallo S, Naccarati A, Kleinjans J.C.S, Imboden M, Jeong A, Morley D, Amaral A.F.S, Van Nunen E, Gulliver J, Chadeau-Hyam M, Vineis P, Vlaanderen J. Acute changes in DNA methylation in relation to 24 h personal air pollution exposure measurements: a panel study in four European countries. Environ Int. 2018;120:11-21. DOI: 10.1016/j.envint.2018.07.026

Thiesse L, Rudzik F, Spiegel K, Leproult R, Pieren R, Wunderli J.M, Foraster M, Héritier H, Eze I.C, Meyer M, Vienneau D, Brink M, Probst-Hensch N, Röösli M, Cajochen C. Adverse impact of nocturnal transportation noise on glucose regulation in healthy young adults: effect of different noise scenarios. Environ Int. 2018;121(1):1011-1023. DOI: 10.1016/j.envint.2018.05.036

Jeong A, Fiorito G, Keski-Rahkonen P, Imboden M, Kiss A, Robinot N, Gmuender H, Vlaandere J, Vermeulen R, Kyrtopoulos S, Herceg Z, Ghantous A, Lovison G, Galassi C, Ranzi A, Krogh V, Grioni S, Agnoli C, Sacerdote C, Mostafavi N, Naccarati A, Scalbert A, Vineis P, Probst-Hensch N, EXPOsOMICS Consortium. Perturbation of metabolic pathways mediates the association of air pollutants with asthma and cardiovascular diseases. Environ Int. 2018;119:334-345. DOI: 10.1016/j.envint.2018.06.025

Vonk J.M, Nieuwenhuis M.A.E, Dijk F.N, Boudier A, Siroux V, Bouzigon E, Probst-Hensch N, Imboden M, Keidel D, Sin D, Bossé Y, Hao K, van den Berge M, Faiz A, Koppelman G.H, Postma D.S. Novel genes and insights in complete asthma remission: a genome-wide association study on clinical and complete asthma remission. Clin Exp Allergy. 2018;48(10):1286-1296. DOI: 10.1111/cea.13181

Steinemann N, Grize L, Pons M, Rothe T, Stolz D, Turk A, Schindler C, Brombach C, Probst-Hensch N. Associations between dietary patterns and post-bronchodilation lung function in the SAPALDIA cohort. Respiration. 2018;95(6):454-463. DOI: 10.1159/000488148

Waage J, Standl M, Curtin J.A, Jessen L.E, Thorsen J, Tian C, Schoettler N, Me Research Team, AAGC collaborators, Flores C, Abdellaoui A, Ahluwalia T.S, Alves A.C, Amaral A.F.S, Anto J.M, Arnold A, Barreto-Luis A, Baurecht H, van Beijsterveldt C.E.M, Bleecker E.R, Bonas-Guarch S, Boomsma D.I, Brix S, Bunyavanich S, Burchard E.G, Chen Z, Curjuric I, Custovic A, den Dekker H.T, Dharmage S.C, Dmitrieva J, Duijts L, Ege M.J, Gauderman W.J, Georges M, Gieger C, Gilliland F, Granell R, Gui H, Hansen T, Heinrich J, Henderson J, Hernandez-Pacheco N, Holt P, Imboden M, Jaddoe V.W.V, Jarvelin M.R, Jarvis D.L, Jensen K.K, Jonsdottir I, Kabesch M, Kaprio J, Kumar A, Lee Y.A, Levin A.M, Li X, Lorenzo-Diaz F, Melen E, Mercader J.M, Meyers D.A, Myers R, Nicolae D.L, Nohr E.A, Palviainen T, Paternoster L, Pennell C.E, Pershagen G, Pino-Yanes M, Probst-Hensch N.M, Ruschendorf F, Simpson A, Stefansson K, Sunyer J, Sveinbjornsson G, Thiering E, Thompson P.J, Torrent M, Torrents D, Tung J.Y, Wang C.A, Weidinger S, Weiss S, Willemsen G, Williams L.K, Ober C, Hinds D.A, Ferreira M.A, Bisgaard H, Strachan D.P, Bonnelykke K. Author correction: Genome-wide association and HLA fine-mapping studies identify risk loci and genetic pathways underlying allergic rhinitis (Nature Genetics, (2018), 50, 8, (1072-1080), 10.1038/s41588-018-0157-1). Nat Genet. 2018;50(9):1343. DOI: 10.1038/s41588-018-0197-6

Jackson V.E, Latourelle J.C, Wain L.V, Smith A.V, Grove M.L, Bartz T.M, Obeidat M, Province M.A, Gao W, Qaiser B, Porteous D.J, Cassano P.A, Ahluwalia T.S, Grarup N, Li J, Altmaier E, Marten J, Harris S.E, Manichaikul A, Pottinger T.D, Li-Gao R, Lind-Thomsen A, Mahajan A, Lahousse L, Imboden M, Teumer A, Prins B, Lyytikainen L.P, Eiriksdottir G, Franceschini N, Sitlani C.M, Brody J.A, Bosse Y, Timens W, Kraja A, Loukola A, Tang W, Liu Y, Bork-Jensen J, Justesen J.M, Linneberg A, Lange L.A, Rawal R, Karrasch S, Huffman J.E, Smith B.H, Davies G, Burkart K.M, Mychaleckyj J.C, Bonten T.N, Enroth S, Lind L, Brusselle G.G, Kumar A, Stubbe B, Understanding Society Scientific Group, Kahonen M, Wyss A.B, Psaty B.M, Heckbert S.R, Hao K, Rantanen T, Kritchevsky S.B, Lohman K, Skaaby T, Pisinger C, Hansen T, Schulz H, Polasek O, Campbell A, Starr J.M, Rich S.S, Mook-Kanamori D.O, Johansson A, Ingelsson E, Uitterlinden A.G, Weiss S, Raitakari O.T, Gudnason V, North K.E, Gharib S.A, Sin D.D, Taylor K.D, O'Connor G.T, Kaprio J, Harris T.B, Pederson O, Vestergaard H, Wilson J.G, Strauch K, Hayward C, Kerr S, Deary I.J, Barr R.G, de Mutsert R, Gyllensten U, Morris A.P, Ikram M.A, Probst-Hensch N, Glaser S, Zeggini E, Lehtimaki T, Strachan D.P, Dupuis J, Morrison A.C, Hall I.P, Tobin M.D, London S.J. Meta-analysis of exome array data identifies six novel genetic loci for lung function. Wellcome Open Res. 2018;3:4. DOI: 10.12688/wellcomeopenres.12583.3

Hansen S, Zemp E, Bettschart R, Pons M, Rochat T, Jeong A, Keidel D, Schindler C, Probst-Hensch N. Gender differences in the association between life history of body silhouettes and asthma incidence: results from the SAPALDIA cohort study. Respir Med X. 2019;1:100001. DOI: 10.1016/j.yrmex.2019.100001

Lytras T, Kogevinas M, Kromhout H, Carsin A.E, Anto J.M, Bentouhami H, Weyler J, Heinrich J, Nowak D, Urrutia I, Martinez-Moratalla J, Gullon J.A, Vega A.P, Raherison Semjen C, Pin I, Demoly P, Leynaert B, Villani S, Gislason T, Svanes O, Holm M, Forsberg B, Norbäck D, Mehta A.J, Probst-Hensch N, Benke G, Jogi R, Toren K, Sigsgaard T, Schlünssen V, Olivieri M, Blanc P.D, Watkins J, Bono R, Buist A.S, Vermeulen R, Jarvis D, Zock J.P. Occupational exposures and incidence of chronic bronchitis and related symptoms over two decades: the European Community Respiratory Health Survey. Occup Environ Med. 2019;76(4):222-229. DOI: 10.1136/oemed-2018-105274

Carsin A.E, Fuertes E, Schaffner E, Jarvis D, Antó J.M, Heinrich J, Bellisario V, Svanes C, Keidel D, Imboden M, Weyler J, Nowak D, Martinez-Moratalla J, Gullón J.A, Sanchez Ramos J.L, Caviezel S, Beckmeyer-Borowko A, Raherison C, Pin I, Demoly P, Cerveri I, Accordini S, Gislason T, Toren K, Forsberg B, Janson C, Jogi R, Emtner M, Gómez Real F, Raza W, Leynaert B, Pascual S, Guerra S, Dharmage S.C, Probst-Hensch N, Garcia-Aymerich J. Restrictive spirometry pattern is associated with low physical activity levels. A population based international study. Respir Med. 2019;146:116-123. DOI: 10.1016/j.rmed.2018.11.017

Vienneau D, Héritier H, Foraster M, Eze I.C, Schaffner E, Thiesse L, Rudzik F, Habermacher M, Köpfli M, Pieren R, Brink M, Cajochen C, Wunderli J.M, Probst-Hensch N, Röösli M, SNC study Group. Façades, floors and maps – influence of exposure measurement error on the association between transportation noise and myocardial infarction. Environ Int. 2019;123:399-406. DOI: 10.1016/j.envint.2018.12.015

Triebner K, Accordini S, Calciano L, Johannessen A, Benediktsdóttir B, Bifulco E, Demoly P, Dharmage S.C, Franklin K.A, Garcia-Aymerich J, Gullon Blanco J.A, Heinrich J, Holm M, Jarvis D, Jögi R, Lindberg E, Martínez-Moratalla J, Muniozguren Agirre N, Pin I, Probst-Hensch N, Raherison C, Sánchez-Ramos J.L, Schlünssen V, Svanes C, Hustad S, Leynaert B, Gómez Real F. Exogenous female sex steroids may reduce lung ageing after menopause: a 20-year follow-up study of a general population sample (ECRHS). Maturitas. 2019;120:29-34. DOI: 10.1016/j.maturitas.2018.11.007

Héritier H, Vienneau D, Foraster M, Eze I.C, Schaffner E, de Hoogh K, Thiesse L, Rudzik F, Habermacher M, Köpfli M, Pieren R, Brink M, Cajochen C, Wunderli J.M, Probst-Hensch N, Röösli M. A systematic analysis of mutual effects of transportation noise and air pollution exposure on myocardial infarction mortality: a nationwide cohort study in Switzerland. Eur Heart J. 2019;40(7):598-603. DOI: 10.1093/eurheartj/ehy650

Foraster M, Eze I.C, Vienneau D, Schaffner E, Jeong A, Héritier H, Rudzik F, Thiesse L, Pieren R, Brink M, Cajochen C, Wunderli J.M, Röösli M, Probst-Hensch N. Long-term exposure to transportation noise and its association with adiposity markers and development of obesity. Environ Int. 2018;121(Pt 1):879-889. DOI: 10.1016/j.envint.2018.09.057

Eze I.C, Foraster M, Schaffner E, Vienneau D, Héritier H, Pieren R, Thiesse L, Rudzik F, Rothe T, Pons M, Bettschart R, Schindler C, Cajochen C, Wunderli J.M, Brink M, Röösli M, Probst-Hensch N. Transportation noise exposure, noise annoyance and respiratory health in adults: a repeated-measures study. Environ Int. 2018;121(Pt 1):741-750. DOI: 10.1016/j.envint.2018.10.006

Svanes Ø, Bertelsen R.J, Lygre S.H.L, Carsin A.E, Anto J.M, Forsberg B, Garcia-Garcia J.M, Gullón J.A, Heinrich J, Holm M, Kogevinas M, Urrutia I, Leynaert B, Moratalla J.M, Le Moual N, Lytras T, Norbäck D, Nowak D, Olivieri M, Pin I, Probst-Hensch N, Schlünssen V, Sigsgaard T, Skorge T.D, Villani S, Jarvis D, Zock J.P, Svanes C. Cleaning at home and at work in relation to lung function decline and airway obstruction. Am J Respir Crit Care Med. 2018;197(9):1157-1163. DOI: 10.1164/rccm.201706-1311OC

Gharib S.A, Loth D.W, Soler Artigas M, Birkland T.P, Wilk J.B, Wain L.V, Brody J, Obeidat M, Hancock D.B, Tang W, Rawal R, Boezen H.M, Imboden M, Huffman J.E, Lahousse L, Alves A.C, Manichaikul A, Hui J, Morrison A.C, Ramasamy A, Smith A.V, Gudnason V, Surakka I, Vitart V, Evans D.M, Strachan D.P, Deary I.J, Hofman A, Glaser S, Wilson J.F, North K.E, Zhao J.H, Heckbert S.R, Jarvis D.L, Probst-Hensch N, Schulz H, Barr R.G, Jarvelin M.R, O'Connor G.T, Kähönen M, Cassano P.A, Hysi P.G, Dupuis J, Hayward C, Psaty B.M, Hall I.P, Parks W.C, Tobin M.D, London S.J. Integrative pathway genomics of lung function and airflow obstruction. Hum Mol Genet. 2015;24(23):6836-6848. DOI: 10.1093/hmg/ddv378

Curjuric I, Imboden M, Schindler C, Downs S.H, Hersberger M, Liu L.J, Matyas G, Russi E.W, Schwartz J, Thun G.A, Postma D.S, Rochat T, Probst-Hensch N.M. HMOX1 and GST variants modify attenuation of FEF25-75% decline due to PM10 reduction. Eur Respir J. 2010;35(3):505-514. DOI: 10.1183/09031936.00044309

Guerra S, Halonen M, Vasquez M.M, Spangenberg A, Stern D.A, Morgan W.J, Wright A.L, Lavi I, Tarès L, Carsin A.E, Dobano C, Barreiro E, Zock J.P, Martínez-Moratalla J, Urrutia I, Sunyer J, Keidel D, Imboden M, Probst-Hensch N, Hallberg J, Melén E, Wickman M, Bousquet J, Belgrave D.C.M. Relation between circulating CC16 concentrations, lung function, and development of chronic obstructive pulmonary disease across the lifespan: a prospective study. Lancet Respir Med. 2015;3(8):613-620. DOI: 10.1016/S2213-2600(15)00196-4

Ackermann-Liebrich U, Schindler C, Frei P, Probst-Hensch N.M, Imboden M, Gemperli A, Rochat T, Schmid-Grendelmeier P, Bircher A.J. Sensitisation to Ambrosia in Switzerland: a public health threat on the wait. Swiss Med Wkly. 2009;139(5-6):70-75

Girard D, Delgado-Eckert E, Schaffner E, Häcki C, Adam M, Stern G.L, Kumar N, Felber DietrichD, Turk A, Pons M, Künzli N, Gaspoz J.M, Rochat T, Schindler C, Probst-Hensch N, Frey U. Long-term smoking cessation and heart rate dynamics in an aging healthy cohort: is it possible to fully recover?. Environ Res. 2015;143(Pt A):39-48. DOI: 10.1016/j.envres.2015.09.023

Alif S.M, Dharmage S.C, Bowatte G, Karahalios A, Benke G, Dennekamp M, Mehta A.J, Miedinger D, Künzli N, Probst-Hensch N, Matheson M.C. Occupational exposure and risk of chronic obstructive pulmonary disease: a systematic review and meta-analysis. Expert Rev Respir Med. 2016;10(8):861-872. DOI: 10.1080/17476348.2016.1190274

Brändli O, Schindler C, Leuenberger P, Baur X, Degens P, Künzli N, Perruchoud A.P. Re-estimated equations for 5th percentiles of lung function variables (Letter to editors). Thorax. 2000;55(2):173-174

Hansen S, Probst-Hensch N, Keidel D, Dratva J, Bettschart R, Pons M, Burdet L, Bridevaux P.O, Schikowski T, Schindler C, Rochat T, Zemp E. Gender differences in adult-onset asthma: results from the Swiss SAPALDIA cohort study. Eur Respir J. 2015;46(4):1011-1020. DOI: 10.1183/13993003.02278-2014

Artigas M.S, Loth D.W, Wain L.V, Gharib S.A, Obeidat M, Tang W, Zhai G, Zhao J.H, Smith A.V, Huffman J.E, Albrecht E, Jackson C.M, Evans D.M, Cadby G, Fornage M, Manichaikul A, Lopez L.M, Johnson T, Aldrich M.C, Aspelund T, Barroso I, Campbell H, Cassano P.A, Couper D.J, Eiriksdottir G, Franceschini N, Garcia M, Gieger C, Gislason G.K, Grkovic I, Hammond C.J, Hancock D.B, Harris T.B, Ramasamy A, Heckbert S.R, Heliovaara M, Homuth G, Hysi P.G, James A.L, Jankovic S, Joubert B.R, Karrasch S, Klopp N, Koch B, Kritchevsky S.B, Launer L.J, Liu Y, Loehr L.R, Lohman K, Loos R.J, Lumley T, Al Balushi K.A, Ang W.Q, Barr R.G, Beilby J, Blakey J.D, Boban M, Boraska V, Brisman J, Britton J.R, Brusselle G.G, Cooper C, Curjuric I, Dahgam S, Deary I.J, Ebrahim S, Eijgelsheim M, Francks C, Gaysina D, Granell R, Gu X, Hankinson J.L, Hardy R, Harris S.E, Henderson J, Henry A, Hingorani A.D, Hofman A, Holt P.G, Hui J, Hunter M.L, Imboden M, Jameson K.A, Kerr S.M, Kolcic I, Kronenberg F, Liu J.Z, Marchini J, McKeever T, Morris A.D, Olin A.C, Porteous D.J, Postma D.S, Rich S.S, Ring S.M, Rivadeneira F, Rochat T, Sayer A.A, Sayers I, Sly P.D, Smith G.D, Sood A, Starr J.M, Uitterlinden A.G, Vonk J.M, Wannamethee S.G, Whincup P.H, Wijmenga C, Williams O.D, Wong A, Mangino M, Marciante K.D, McArdle W.L, Meibohm B, Morrison A.C, North K.E, Omenaas E, Palmer L.J, Pietilainen K.H, Pin I, Pola Sbreve Ek O, Pouta A, Psaty B.M, Hartikainen A.L, Rantanen T, Ripatti S, Rotter J.I, Rudan I, Rudnicka A.R, Schulz H, Shin S.Y, Spector T.D, Surakka I, Vitart V, Volzke H, Wareham N.J, Warrington N.M, Wichmann H.E, Wild S.H, Wilk J.B, Wjst M, Wright A.F, Zgaga L, Zemunik T, Pennell C.E, Nyberg F, Kuh D, Holloway J.W, Boezen H.M, Lawlor D.A, Morris R.W, Probst-Hensch N, Kaprio J, Wilson J.F, Hayward C, Kahonen M, Heinrich J, Musk A.W, Jarvis D.L, Glaser S, Jarvelin M.R, Ch Stricker B.H, Elliott P, O'Connor G.T, Strachan D.P, London S.J, Hall I.P, Gudnason V, Tobin M.D. Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function. Nat Genet. 2011;43(11):1082-1090. DOI: 10.1038/ng.941

Leynaert B, Sunyer J, Garcia-Esteban R, Svanes C, Jarvis D, Cerveri I, Dratva J, Gislason T, Heinrich J, Janson C, Künzli N, de Marco R, Omenaas E, Raherison C, Gómez Real F, Wjst M, Zemp E, Zureik M, Burney P.G, Anto J.M, Neukirch F. Gender differences in prevalence, diagnosis and incidence of allergic and non-allergic asthma: a population-based cohort. Thorax. 2012;67(7):625-631. DOI: 10.1136/thoraxjnl-2011-201249

Probst-Hensch N.M, Curjuric I, Pierre-Olivier B, Ackermann-Liebrich U, Bettschart R.W, Brändli O, Brutsche M, Burdet L, Gerbase M.W, Knöpfli B, Künzli N, Pons M.G, Schindler C, Tschopp J.M, Rochat T, Russi E.W. Longitudinal change of prebronchodilator spirometric obstruction and health outcomes: results from the SAPALDIA cohort. Thorax. 2010;65(2):150-156. DOI: 10.1136/thx.2009.115063

Zemp E, Dratva J. Santé sexuelle: variabilités en Suisse et en Europe. Rev Méd Suisse. 2010;6(257):1433-1437

Curjuric I, Imboden M, Adam M, Bettschart R.W, Gerbase M.W, Künzli N, Rochat T, Rohrer L, Rothe T.B, Schwartz J, Stolz D, Tschopp J.M, Von Eckardstein A, Kronenberg F, Probst-Hensch N.M. Serum bilirubin is associated with lung function in a Swiss general population sample. Eur Respir J. 2014;43(5):1278-1288. DOI: 10.1183/09031936.00055813

Tsai M.Y, Hoek G, Eeftens M, de Hoogh K, Beelen R, Beregszaszai T, Cesaroni G, Cirach M, Cyrys J, de Nazelle A, de Vocht F, Ducret-Stich R, Eriksen K, Galassi C, Grazuleviciene R, Grazuleviciene T, Grivas G, Gryparis A, Heinrich J, Hoffmann B, Iakovides M, Keuken M, Krämer U, Künzli N, Lanki T, Madsen C, Meliefste K, Merritt A.S, Mölter A, Mosler G, Nieuwenhuijsen M.J, Pershagen G, Phuleria H, Quass U, Ranzi A, Schaffner E, Sokhi R, Stempfelet M, Stephanou E, Stempfelet M, Stephanou E, Sugiri D, Taimisto P, Tewis M, Udvardy O, Wang M, Brunekreef B. Spatial variation of PM elemental compositon between and within 20 European study areas - results of the ESCAPE project. Environ Int. 2015;84:181-192. DOI: 10.1016/j.envint.2015.04.015

Meier R, Eeftens M, Phuleria H.C, Ineichen A, Corradi E, Davey M, Fierz M, Ducret-Stich R.E, Aguilera I, Schindler C, Rochat T, Probst-Hensch N, Tsai M.Y, Künzli N. Differences in indoor versus outdoor concentrations of ultrafine particles, PM2.5, PMabsorbance and NO2 in Swiss homes. J Expo Sci Environ Epidemiol. 2015;25(5):499-505. DOI: 10.1038/jes.2015.3

Eze I.C, Imboden M, Kumar A, Von Eckardstein A, Stolz D, Gerbase M.W, Künzli N, Pons M, Kronenberg F, Schindler C, Probst-Hensch N. Air pollution and diabetes association: modification by type 2 diabetes genetic risk score. Environ Int. 2016;94:263-271. DOI: 10.1016/j.envint.2016.04.032

Imboden M, Probst-Hensch N.M. Biobanking across the phenome - at the center of chronic disease research. BMC Public Health. 2013;13:1094. DOI: 10.1186/1471-2458-13-1094

Chasman D.I, Fuchsberger C, Pattaro C, Teumer A, Boger C.A, Endlich K, Olden M, Chen M.H, Tin A, Taliun D, Li M, Gao X, Gorski M, Yang Q, Hundertmark C, Foster M.C, O'Seaghdha C.M, Glazer N, Isaacs A, Liu C.T, Smith A.V, O'Connell J.R, Struchalin M, Tanaka T, Li G, Johnson A.D, Gierman H.J, Feitosa M.F, Hwang S.J, Atkinson E.J, Lohman K, Cornelis M.C, Johansson A, Tonjes A, Dehghan A, Lambert J.C, Holliday E.G, Sorice R, Kutalik Z, Lehtimaki T, Esko T, Deshmukh H, Ulivi S, Chu A.Y, Murgia F, Trompet S, Imboden M, Coassin S, Pistis G, Harris T.B, Launer L.J, Aspelund T, Eiriksdottir G, Mitchell B.D, Boerwinkle E, Schmidt H, Cavalieri M, Rao M, Hu F, Demirkan A, Oostra B.A, de Andrade M, Turner S.T, Ding J, Andrews J.S, Freedman B.I, Giulianini F, Koenig W, Illig T, Meisinger C, Gieger C, Zgaga L, Zemunik T, Boban M, Minelli C, Wheeler H.E, Igl W, Zaboli G, Wild S.H, Wright A.F, Campbell H, Ellinghaus D, Nothlings U, Jacobs G, Biffar R, Ernst F, Homuth G, Kroemer H.K, Nauck M, Stracke S, Volker U, Volzke H, Kovacs P, Stumvoll M, Magi R, Hofman A, Uitterlinden A.G, Rivadeneira F, Aulchenko Y.S, Polasek O, Hastie N, Vitart V, Helmer C, Wang J.J, Stengel B, Ruggiero D, Bergmann S, Kahonen M, Viikari J, Nikopensius T, Province M, Ketkar S, Colhoun H, Doney A, Robino A, Kramer B.K, Portas L, Ford I, Buckley B.M, Adam M, Thun G.A, Paulweber B, Haun M, Sala C, Mitchell P, Ciullo M, Kim S.K, Vollenweider P, Raitakari O, Metspalu A, Palmer C, Gasparini P, Pirastu M, Jukema J.W, Probst-Hensch N.M, Kronenberg F, Toniolo D, Gudnason V, Shuldiner A.R, Coresh J, Schmid R, Ferrucci L, Siscovick D.S, van Duijn C.M, Borecki I.B, Kardia S.L, Liu Y, Curhan G.C, Rudan I, Gyllensten U, Wilson J.F, Franke A, Pramstaller P.P, Rettig R, Prokopenko I, Witteman J, Hayward C, Ridker P.M, Parsa A, Bochud M, Heid I.M, Kao W.L, Fox C.S, Kottgen A. Integration of genome-wide association studies with biological knowledge identifies six novel genes related to kidney function. Hum Mol Genet. 2012;21(24):5329-5343. DOI: 10.1093/hmg/dds369

Köttgen A, Glazer N.L, Dehghan A, Hwang S.J, Katz R, Li M, Yang Q, Gudnason V, Launer L.J, Harris T.B, Smith A.V, Arking D.E, Astor B.C, Boerwinkle E, Ehret G.B, Ruczinski I, Scharpf R.B, Chen Y.D, de Boer I.H, Haritunians T, Lumley T, Sarnak M, Siscovick D, Benjamin E.J, Levy D, Upadhyay A, Aulchenko Y.S, Hofman A, Rivadeneira F, Uitterlinden A.G, van Duijn C.M, Chasman D.I, Pare G, Ridker P.M, Kao W.H, Witteman J.C, Coresh J, Shlipak M.G, Fox C.S. Multiple loci associated with indices of renal function and chronic kidney disease. Nat Genet. 2009;41(6):712-717. DOI: 10.1038/ng.377

Caviezel S, Dratva J, Schaffner E, Teynor A, Baumstark M.W, Schindler C, de Groot E, Burdet L, Rothe T, Pons M, Gaspoz J.M, Rochat T, Künzli N, Probst-Hensch N, Schmidt-Trucksäss A. Variability and reproducibility of carotid structural and functional parameters assessed with transcutaneous ultrasound - results from the SAPALDIA cohort study. Atherosclerosis. 2013;231(2):448-455. DOI: 10.1016/j.atherosclerosis.2013.10.010

Gerbase M.W, Dupuis-Lozeron E, Schindler C, Keidel D, Bridevaux P.O, Kriemler S, Probst-Hensch N.M, Rochat T, Künzli N. Agreement between spirometers: a challenge in the follow-up of patients and populations?. Respiration. 2013;85(6):505-514. DOI: 10.1159/000346649

Eze I.C, Imboden M, Kumar A, Adam M, Von Eckardstein A, Stolz D, Gerbase M.W, Künzli N, Turk A, Schindler C, Kronenberg F, Probst-Hensch N. A common functional variant on the pro-inflammatory Interleukin-6 gene may modify the association between long-term PM10 exposure and diabetes. Environ Health. 2016;15:39. DOI: 10.1186/s12940-016-0120-5

Künzli N, Kuna-Dibbert B, Keidel D, Keller R, Brändli O, Schindler C, Schweinzer K.M, Leuenberger P, Ackermann-Liebrich U. Longitudinal validity of spirometers: a challenge in longitudinal studies. Swiss Med Wkly. 2005;135(33-34):503-508

Imboden M, Bouzigon E, Curjuric I, Ramasamy A, Kumar A, Hancock D.B, Wilk J.B, Vonk J.M, Thun G.A, Siroux V, Nadif R, Monier F, Gonzalez J.R, Wjst M, Heinrich J, Loehr L.R, Franceschini N, North K.E, Altmüller J, Koppelman G.H, Guerra S, Kronenberg F, Lathrop M, Moffatt M.F, O'Connor G.T, Strachan D.P, Postma D.S, London S.J, Schindler C, Kogevinas M, Kauffmann F, Jarvis D.L, Demenais F, Probst-Hensch N.M. Genome-wide association study of lung function decline in adults with and without asthma. J Allergy Clin Immunol. 2012;129(5):1218-1228. DOI: 10.1016/j.jaci.2012.01.074

Mehta A.J, Thun G.A, Imboden M, Ferrarotti I, Keidel D, Künzli N, Kromhout H, Miedinger D, Phuleria H, Rochat T, Russi E.W, Schindler C, Schwartz J, Vermeulen R, Luisetti M, Probst-Hensch N. Interactions between SERPINA1 PiMZ genotype, occupational exposure and lung function decline. Occup Environ Med. 2014;71(4):234-240. DOI: 10.1136/oemed-2013-101592

Gerbase M.W, Dratva J, Germond M, Tschopp J.M, Pépin J.L, Carballo D, Künzli N, Probst-Hensch N.M, Adam M, Zemp Stutz E, Roche F, Rochat T. Sleep fragmentation and sleep-disordered breathing in individuals living close to main roads: results from a population-based study. Sleep Med. 2014;15(3):322-328. DOI: 10.1016/j.sleep.2013.10.014

Amaral A.F, Ramasamy A, Castro-Giner F, Minelli C, Accordini S, Sorheim I.C, Pin I, Kogevinas M, Jogi R, Balding D.J, Norback D, Verlato G, Olivieri M, Probst-Hensch N, Janson C, Zock J.P, Heinrich J, Jarvis D.L. Interaction between gas cooking and GSTM1 null genotype in bronchial responsiveness: results from the European Community Respiratory Health Survey. Thorax. 2014;69(6):558-564. DOI: 10.1136/thoraxjnl-2013-204574

Smit L.A, Strachan D.P, Vermeulen R, de Bakker P.I, Demenais F, Dumas O, Carsin A.E, Cullinan P, Curjuric I, Ghosh R.E, Heederik D, Imboden M, Jarvis D, Lathrop M, Le Moual N, Mehta A, Miedinger D, Sigsgaard T, Siroux V, Vernez D, Zock J.P, Kauffmann F, Probst-Hensch N, Kogevinas M, Bouzigon E. Human leukocyte antigen class II variants and adult-onset asthma: does occupational allergen exposure play a role?. Eur Respir J. 2014;44(5):1234-1242. DOI: 10.1183/09031936.00068014

Meier R, Schindler C, Eeftens M, Aguilera I, Ducret-Stich R.E, Ineichen A, Davey M, Phuleria H.C, Probst-Hensch N, Tsai M.Y, Künzli N. Modeling indoor air pollution of outdoor origin in homes of SAPALDIA subjects in Switzerland. Environ Int. 2015;82:85-91. DOI: 10.1016/j.envint.2015.05.013

Smolonska J, Koppelman G.H, Wijmenga C, Vonk J.M, Zanen P, Bruinenberg M, Curjuric I, Imboden M, Thun G.A, Franke L, Probst-Hensch N.M, Nurnberg P, Riemersma R.A, van Schayck C.P, Loth D.W, Brusselle G.G, Stricker B.H, Hofman A, Uitterlinden A.G, Lahousse L, London S.J, Loehr L.R, Manichaikul A, Barr R.G, Donohue K.M, Rich S.S, Pare P, Bosse Y, Hao K, van den Berge M, Groen H.J, Lammers J.W, Mali W, Boezen H.M, Postma D.S. Common genes underlying asthma and COPD? Genome-wide analysis on the Dutch hypothesis. Eur Respir J. 2014;44(4):860-872. DOI: 10.1183/09031936.00001914

Adam M, Schikowski T, Carsin A.E, Cai Y, Jacquemin B, Sanchez M, Vierkötter A, Marcon A, Keidel D, Sugiri D, Al Kanani Z, Nadif R, Siroux V, Hardy R, Kuh D, Rochat T, Bridevaux P.O, Eeftens M, Tsai M.Y, Villani S, Phuleria H.C, Birk M, Cyrys J, Cirach M, de Nazelle A, Nieuwenhuijsen M.J, Forsberg B, de Hoogh K, Declerq C, Bono R, Piccioni P, Quass U, Heinrich J, Jarvis D, Pin I, Beelen R, Hoek G, Brunekreef B, Schindler C, Sunyer J, Kramer U, Kauffmann F, Hansell A.L, Künzli N, Probst-Hensch N. Adult lung function and long-term air pollution exposure. ESCAPE: a multicentre cohort study and meta-analysis. Eur Respir J. 2015;45(1):38-50. DOI: 10.1183/09031936.00130014

Thun G.A, Imboden M, Ferrarotti I, Kumar A, Obeidat M, Zorzetto M, Haun M, Curjuric I, Couto Alves A, Jackson V.E, Albrecht E, Ried J.S, Teumer A, Lopez L.M, Huffman J.E, Enroth S, Bosse Y, Hao K, Timens W, Gyllensten U, Polasek O, Wilson J.F, Rudan I, Hayward C, Sandford A.J, Deary I.J, Koch B, Reischl E, Schulz H, Hui J, James A.L, Rochat T, Russi E.W, Jarvelin M.R, Strachan D.P, Hall I.P, Tobin M.D, Dahl M, Fallgaard Nielsen S, Nordestgaard B.G, Kronenberg F, Luisetti M, Probst-Hensch N.M. Causal and synthetic associations of variants in the SERPINA gene cluster with alpha1-antitrypsin serum levels. PLoS Genet. 2013;9(8):e1003585. DOI: 10.1371/journal.pgen.1003585

Vienneau D, Perez L, Schindler C, Lieb C, Sommer C, Probst-Hensch N, Künzli N, Röösli M. Years of life lost and morbidity cases attributable to transportation noise and air pollution: a comparative health risk assessment for Switzerland in 2010. Int J Hyg Environ Health. 2015;218(6):514-521. DOI: 10.1016/j.ijheh.2015.05.003

Schikowski T, Schaffner E, Meier F, Phuleria H.C, Vierkötter A, Schindler C, Kriemler S, Zemp E, Kramer U, Bridevaux P.O, Rochat T, Schwartz J, Künzli N, Probst-Hensch N. Improved air quality and attenuated lung function decline: modification by obesity in the SAPALDIA cohort. Environ Health Perspect. 2013;121(9):1034-1039. DOI: 10.1289/ehp.1206145

Hegner H, Monn C, Stahel E, Leuenberger P, Ackermann-Liebrich U, Wanner H.U, SAPALDIA Team. Kleinräumige Verteilung von Stickstoffdioxid. Gesundheits- und Umwelttechnik. 1996;4:3-7

EArly Genetics and Lifecourse Epidemiology (EAGLE) Eczema Consortium, Australian Asthma Genetics Consortium(AAGC). Multi-ancestry genome-wide association study of 21,000 cases and 95,000 controls identifies new risk loci for atopic dermatitis. Nat Genet. 2015;47(12):1449-1456. DOI: 10.1038/ng.3424

Dratva J, Zemp E, Staedele P, Schindler C, Constanza M, Gerbase M.W, Probst-Hensch N, Rochat T, Ackermann-Liebrich U, SAPALDIA Team. Variability of reproductive history across the Swiss SAPALDIA cohort - Pattern and main determinants. Ann Hum Biol. 2007;34(4):437-453

Foraster M, Eze I.C, Vienneau D, Brink M, Cajochen C, Caviezel S, Héritier H, Schaffner E, Schindler C, Wanner M, Wunderli J.M, Röösli M, Probst-Hensch N. Long-term transportation noise annoyance is associated with subsequent lower levels of physical activity. Environ Int. 2016;91:341-349. DOI: 10.1016/j.envint.2016.03.011

Vineis P, Chadeau-Hyam M, Gmuender H, Gulliver J, Herceg Z, Kleinjans J, Kogevinas M, Kyrtopoulos S, Nieuwenhuijsen M, Phillips D, Probst-Hensch N, Scalbert A, Vermeulen R, Wild C.P. The exposome in practice: design of the EXPOsOMICS project. Int J Hyg Environ Health. 2017;220(2 Pt A):142-151. DOI: 10.1016/j.ijheh.2016.08.001

Tang W, Kowgier M, Loth D.W, Soler Artigas M, Joubert B.R, Hodge E, Gharib S.A, Smith A.V, Ruczinski I, Gudnason V, Mathias R.A, Harris T.B, Hansel N.N, Launer L.J, Barnes K.C, Hansen J.G, Albrecht E, Aldrich M.C, Allerhand M, Barr R.G, Brusselle G.G, Couper D.J, Curjuric I, Davies G, Deary I.J, Dupuis J, Fall T, Foy M, Franceschini N, Gao W, Glaser S, Gu X, Hancock D.B, Heinrich J, Hofman A, Imboden M, Ingelsson E, James A, Karrasch S, Koch B, Kritchevsky S.B, Kumar A, Lahousse L, Li G, Lind L, Lindgren C, Liu Y, Lohman K, Lumley T, McArdle W.L, Meibohm B, Morris A.P, Morrison A.C, Musk B, North K.E, Palmer L.J, Probst-Hensch N.M, Psaty B.M, Rivadeneira F, Rotter J.I, Schulz H, Smith L.J, Sood A, Starr J.M, Strachan D.P, Teumer A, Uitterlinden A.G, Völzke H, Voorman A, Wain L.V, Wells M.T, Wilk J.B, Williams O.D, Heckbert S.R, Stricker B.H, London S.J, Fornage M, Tobin M.D, O Connor G.T, Hall I.P, Cassano P.A. Large-scale genome-wide association studies and meta-analyses of longitudinal change in adult lung function. PLoS One. 2014;9(7):e100776. DOI: 10.1371/journal.pone.0100776

Dratva J, Caviezel S, Schaffner E, Zemp E, de Groot E, Schmidt-Trucksäss A, Bettschart R, Saleh L, Turk A, Gaspoz J.M, Carballo D, Künzli N, Probst-Hensch N. Early detection of subjects at risk for vascular remodelling - results from the Swiss population-based study SAPALDIA. Swiss Med Wkly. 2014;144:w14052. DOI: 10.4414/smw.2014.14052

Künzli N, Zemp Stutz E, Perruchoud A.P, Brändli O, Tschopp J.M, Bolognini G, Karrer W, Schindler C, Ackermann-Liebrich U, Leuenberger P. Peak flow variability in the SAPALDIA study and its validity in screening for asthma-related conditions. Am J Respir Crit Care Med. 1999;160(2):427-434

Vonk J.M, Scholtens S, Postma D.S, Moffatt M.F, Jarvis D, Ramasamy A, Wjst M, Omenaas E.R, Bouzigon E, Demenais F, Nadif R, Siroux V, Polonikov A.V, Solodilova M, Ivanov V.P, Curjuric I, Imboden M, Kumar A, Probst-Hensch N, Ogorodova L.M, Puzyrev V.P, Bragina E.Y, Freidin M.B, Nolte I.M, Farrall A.M, Cookson W.O, Strachan D.P, Koppelman G.H, Boezen H.M. Adult onset asthma and interaction between genes and active tobacco smoking: the GABRIEL consortium. PLoS One. 2017;12(3):e0172716. DOI: 10.1371/journal.pone.0172716

Adam M, Imboden M, Schaffner E, Boes E, Kronenberg F, Pons M, Bettschart R, Barthelemy J.C, Schindler C, Probst-Hensch N. The adverse impact of obesity on heart rate variability is modified by a NFE2L2 gene variant: the SAPALDIA Cohort. Int J Cardiol. 2017;228:341-346. DOI: 10.1016/j.ijcard.2016.11.049

Machin M, Amaral A.F, Wielscher M, Rezwan F.I, Imboden M, Jarvelin M.R, Adcock I.M, Probst-Hensch N, Holloway J.W, Jarvis D.L. Systematic review of lung function and COPD with peripheral blood DNA methylation in population based studies. BMC Pulm Med. 2017;17:54. DOI: 10.1186/s12890-017-0397-3

Wain L.V, Shrine N, Artigas M.S, Erzurumluoglu A.M, Noyvert B, Bossini-Castillo L, Obeidat M, Henry A.P, Portelli M.A, Hall R.J, Billington C.K, Rimington T.L, Fenech A.G, John C, Blake T, Jackson V.E, Allen R.J, Prins B.P, Understanding Society Scientific Group, Campbell A, Porteous D.J, Jarvelin M.R, Wielscher M, James A.L, Hui J, Wareham N.J, Zhao J.H, Wilson J.F, Joshi P.K, Stubbe B, Rawal R, Schulz H, Imboden M, Probst-Hensch N.M, Karrasch S, Gieger C, Deary I.J, Harris S.E, Marten J, Rudan I, Enroth S, Gyllensten U, Kerr S.M, Polasek O, Kahonen M, Surakka I, Vitart V, Hayward C, Lehtimaki T, Raitakari O.T, Evans D.M, Henderson A.J, Pennell C.E, Wang C.A, Sly P.D, Wan E.S, Busch R, Hobbs B.D, Litonjua A.A, Sparrow D.W, Gulsvik A, Bakke P.S, Crapo J.D, Beaty T.H, Hansel N.N, Mathias R.A, Ruczinski I, Barnes K.C, Bosse Y, Joubert P, van den Berge M, Brandsma C.A, Pare P.D, Sin D.D, Nickle D.C, Hao K, Gottesman O, Dewey F.E, Bruse S.E, Carey D.J, Kirchner H.L, Geisinger-Regeneron Discov EHR Collaboration, Jonsson S, Thorleifsson G, Jonsdottir I, Gislason T, Stefansson K, Schurmann C, Nadkarni G, Bottinger E.P, Loos R.J, Walters R.G, Chen Z, Millwood I.Y, Vaucher J, Kurmi O.P, Li L, Hansell A.L, Brightling C, Zeggini E, Cho M.H, Silverman E.K, Sayers I, Trynka G, Morris A.P, Strachan D.P, Hall I.P, Tobin M.D. Genome-wide association analyses for lung function and chronic obstructive pulmonary disease identify new loci and potential druggable targets. Nat Genet. 2017;49(3):416-425. DOI: 10.1038/ng.3787

Wanner M, Martin B.W, Autenrieth C.S, Schaffner E, Meier F, Brombach C, Stolz D, Bauman A, Rochat T, Schindler C, Kriemler S, Probst-Hensch N. Associations between domains of physical activity, sitting time, and different measures of overweight and obesity. Prev Med Rep. 2016;3:177-184. DOI: 10.1016/j.pmedr.2016.01.007

Héritier H, Vienneau D, Foraster M, Eze I.C, Schaffner E, Thiesse L, Rudzik F, Habermacher M, Köpfli M, Pieren R, Brink M, Cajochen C, Wunderli J.M, Probst-Hensch N, Röösli M, SNC Study Group. Transportation noise exposure and cardiovascular mortality: a nationwide cohort study from Switzerland. Eur J Epidemiol. 2017;32(4):307-315. DOI: 10.1007/s10654-017-0234-2

Beelen R, Hoek G, Raaschou-Nielsen O. Natural cause mortailty and long-term exposure to particle components: an analysis of 19 european cohorts within the multi-center ESCAPE project. Environ Health Perspect. 2015;123(6):525-533. DOI: 10.1289/ehp.1408095

van Nunen E, Vermeulen R, Tsai M.Y, Probst-Hensch N, Ineichen A, Davey M, Imboden M, Ducret-Stich R, Naccarati A, Raffaele D, Ranzi A, Ivaldi C, Galassi C, Nieuwenhuijsen M, Curto A, Donaire-Gonzalez D, Cirach M, Chatzi L, Kampouri M, Vlaanderen J, Meliefste K, Buijtenhuijs D, Brunekreef B, Morley D, Vineis P, Gulliver J, Hoek G. Land use regression models for ultrafine particles in six European areas. Environ Sci Technol. 2017;51(6):3336-3345. DOI: 10.1021/acs.est.6b05920

Jeong A, Imboden M, Hansen S, Zemp E, Bridevaux P.O, Lovison G, Schindler C, Probst-Hensch N. Heterogeneity of obesity-asthma association disentangled by latent class analysis, the SAPALDIA cohort. Respir Med. 2017;125:25-32. DOI: 10.1016/j.rmed.2017.02.014

Temam S, Burte E, Adam M, Antó J.M, Basagana X, Bousquet J, Carsin A.E, Galobardes B, Keidel D, Künzli N, Le Moual N, Sanchez M, Sunyer J, Bono R, Brunekreef B, Heinrich J, de Hoogh K, Jarvis D, Marcon A, Modig L, Nadif R, Nieuwenhuijsen M, Pin I, Siroux V, Stempfelet M, Tsai M, Probst-Hensch N. Socioeconomic position and outdoor nitrogen dioxide NO2 exposure in Western Europe: a multi-city analysis. Environ Int. 2017;101:117-124. DOI: 10.1016/j.envint.2016.12.026

Walther D, Curjuric I, Dratva J, Schaffner E, Quinto C, Rochat T, Gaspoz J.M, Burdet L, Bridevaux P.O, Pons M, Gerbase M.W, Schindler C, Probst-Hensch N. High blood pressure: prevalence and adherence to guidelines in a population-based cohort. Swiss Med Wkly. 2016;146:w14323. DOI: 10.4414/smw.2016.14323

Steinemann N, Grize L, Ziesemer K, Kauf P, Probst-Hensch N, Brombach C. Relative validation of a food frequency questionnaire to estimate food intake in an adult population. Food Nutr Res. 2017;61(1):1305193. DOI: 10.1080/16546628.2017.1305193

Nitsch D, Felber Dietrich D, Eckardstein A.V, Gaspoz J.M, Downs S.H, Leuenberger P, Tschopp J.M, Brandli O, Keller R, Gerbase M.W, Probst-Hensch N.M, Zemp Stutz E, Ackermann-Liebrich U, SAPALDIA Team. Prevalence of renal impairment and its association with cardiovascular risk factors in a general population: results of the Swiss SAPALDIA study. Nephrol Dial Transplant. 2006;21:935-944

Endes S, Caviezel S, Schaffner E, Dratva J, Schindler C, Künzli N, Bachler M, Wassertheurer S, Probst-Hensch N, Schmidt-Trucksäss A. Associations of novel and traditional vascular biomarkers of arterial stiffness: results of the SAPALDIA 3 cohort study. PLoS One. 2016;11(9):e0163844. DOI: 10.1371/journal.pone.0163844

Hansen S, Probst-Hensch N, Bettschart R, Pons M, Leynaert B, Gomez Real F, Rochat T, Dratva J, Schneider C, Keidel D, Schindler C, Zemp E. Early menarche and new onset of asthma: results from the SAPALDIA cohort study. Maturitas. 2017;101:57-63. DOI: 10.1016/j.maturitas.2017.04.012

Gorski M, van der Most P.J, Teumer A, Chu A.Y, Li M, Mijatovic V, Nolte I.M, Cocca M, Taliun D, Gomez F, Li Y, Tayo B, Tin A, Feitosa M.F, Aspelund T, Attia J, Biffar R, Bochud M, Boerwinkle E, Borecki I, Bottinger E.P, Chen M.H, Chouraki V, Ciullo M, Coresh J, Cornelis M.C, Curhan G.C, d'Adamo A.P, Dehghan A, Dengler L, Ding J, Eiriksdottir G, Endlich K, Enroth S, Esko T, Franco O.H, Gasparini P, Gieger C, Girotto G, Gottesman O, Gudnason V, Gyllensten U, Hancock S.J, Harris T.B, Helmer C, Hollerer S, Hofer E, Hofman A, Holliday E.G, Homuth G, Hu F.B, Huth C, Hutri-Kahonen N, Hwang S.J, Imboden M, Johansson A, Kahonen M, Konig W, Kramer H, Kramer B.K, Kumar A, Kutalik Z, Lambert J.C, Launer L.J, Lehtimaki T, de Borst M, Navis G, Swertz M, Liu Y, Lohman K, Loos R.J.F, Lu Y, Lyytikainen L.P, McEvoy M.A, Meisinger C, Meitinger T, Metspalu A, Metzger M, Mihailov E, Mitchell P, Nauck M, Oldehinkel A.J, Olden M, Wjh Penninx B, Pistis G, Pramstaller P.P, Probst-Hensch N, Raitakari O.T, Rettig R, Ridker P.M, Rivadeneira F, Robino A, Rosas S.E, Ruderfer D, Ruggiero D, Saba Y, Sala C, Schmidt H, Schmid R, Scott R.J, Sedaghat S, Smith A.V, Sorice R, Stengel B, Stracke S, Strauch K, Toniolo D, Uitterlinden A.G, Ulivi S, Viikari J.S, Volker U, Vollenweider P, Volzke H, Vuckovic D, Waldenberger M, Jin Wang J, Yang Q, Chasman D.I, Tromp G, Snieder H, Heid I.M, Fox C.S, Kottgen A, Pattaro C, Boger C.A, Fuchsberger C. 1000 Genomes-based meta-analysis identifies 10 novel loci for kidney function. Sci Rep. 2017;7:45040. DOI: 10.1038/srep45040

Rava M, Ahmed I, Kogevinas M, Le Moual N, Bouzigon E, Curjuric I, Dizier M.H, Dumas O, Gonzalez J.R, Imboden M, Mehta A.J, Tubert-Bitter P, Zock J.P, Jarvis D, Probst-Hensch N.M, Demenais F, Nadif R. Genes interacting with occupational exposures to low molecular weight agents and irritants on adult-onset asthma in three European studies. Environ Health Perspect. 2017;125(2):207-214. DOI: 10.1289/EHP376

Dratva J, Caviezel S, Schaffner E, Bettschart R, Künzli N, Schindler C, Schmidt-Trucksäss A, Stolz D, Zemp E, Probst-Hensch N. Infectious diseases are associated with carotid intima media thickness in adolescence. Atherosclerosis. 2015;243(2):609-615. DOI: 10.1016/j.atherosclerosis.2015.10.021

de Marco R, Marcon A, Rossi A, Anto J.M, Cerveri I, Gislason T, Heinrich J, Janson C, Jarvis D, Künzli N, Leynaert B, Probst-Hensch N, Svanes C, Wjst M, Burney P. Asthma, COPD and overlap syndrome: a longitudinal study in young European adults. Eur Respir J. 2015;46(3):671-679. DOI: 10.1183/09031936.00008615

Monn C, Alean-Kirkpatrick P, Künzli N, Defila C, Peeters A, Ackermann-Liebrich U, Leuenberger P, SAPALDIA Team. Air pollution, climate and pollen comparisons in urban, rural and alpine regions in Switzerland. Atmos Environ. 1999;33(15):2411-2416

Aguilera I, Dratva J, Caviezel S, Burdet L, de Groot E, Ducret-Stich R.E, Eeftens M, Keidel D, Meier R, Perez L, Rothe T, Schaffner E, Schmit-Trucksass A, Tsai M.Y, Schindler C, Künzli N, Probst-Hensch N. Particulate matter and subclinical atherosclerosis: associations between different particle sizes and sources with carotid intima-media thickness in the SAPALDIA study. Environ Health Perspect. 2016;124(11):1700-1706. DOI: 10.1289/EHP161

Eeftens M, Meier R, Schindler C, Aguilera I, Phuleria H, Ineichen A, Davey M, Ducret-Stich R, Keidel D, Probst-Hensch N, Künzli N, Tsai M.Y. Development of land use regression models for nitrogen dioxide, ultrafine particles, lung deposited surface area, and four other markers of particulate matter pollution in the Swiss SAPALDIA regions. Environ Health. 2016;15:53. DOI: 10.1186/s12940-016-0137-9

Downs S.H, Schindler C, Liu L.J, Keidel D, Bayer-Oglesby L, Brutsche M.H, Gerbase M.W, Keller R, Künzli N, Leuenberger P, Probst-Hensch N.M, Tschopp J.M, Zellweger J.P, Rochat T, Schwartz J, Ackermann-Liebrich U. Reduced exposure to PM10 and attenuated age-related decline in lung function. N Engl J Med. 2007;357(23):2338-2347. DOI: 10.1056/NEJMoa073625

Künzli N, Bridevaux P.O, Sally Liu L.J, Garcia-Esteban R, Schindler C, Gerbase M, Sunyer J, Keidel D, Rochat T. Traffic-related air pollution correlates with adult-onset asthma among never-smokers. Thorax. 2009;64(8):664-670

Siroux V, Gonzalez J.R, Bouzigon E, Curjuric I, Boudier A, Imboden M, Anto J.M, Gut I, Jarvis D, Lathrop M, Omenaas E.R, Pin I, Wjst M, Demenais F, Probst-Hensch N, Kogevinas M, Kauffmann F. Genetic heterogeneity of asthma phenotypes identified by a clustering approach. Eur Respir J. 2014;43(2):439-452. DOI: 10.1183/09031936.00032713

Ramasamy A, Curjuric I, Coin L.J, Kumar A, McArdle W.L, Imboden M, Leynaert B, Kogevinas M, Schmid-Grendelmeier P, Pekkanen J, Wjst M, Bircher A.J, Sovio U, Rochat T, Hartikainen A.L, Balding D.J, Jarvelin M.R, Probst-Hensch N, Strachan D.P, Jarvis D.L. A genome-wide meta-analysis of genetic variants associated with allergic rhinitis and grass sensitization and their interaction with birth order. J Allergy Clin Immunol. 2011;128(5):996-1005. DOI: 10.1016/j.jaci.2011.08.030

Aguilera I, Eeftens M, Meier R, Ducret-Stich R.E, Schindler C, Ineichen A, Phuleria H.C, Probst-Hensch N, Tsai M.Y, Künzli N. Land use regression models for crustal and traffic-related PM2.5 constituents in four areas of the SAPALDIA study. Environ Res. 2015;140:377-384. DOI: 10.1016/j.envres.2015.04.011.

Conen D, Adam M, Roche F, Barthelemy J.C, Felber Dietrich D, Imboden M, Künzli N, Von Eckardstein A, Regenass S, Hornemann T, Rochat T, Gaspoz J.M, Probst-Hensch N, Carballo D. Premature atrial contractions in the general population: frequency and risk factors. Circulation. 2012;126(19):2302-2308. DOI: 10.1161/CIRCULATIONAHA.112.112300

Curjuric I, Imboden M, Bridevaux P.O, Gerbase M.W, Haun M, Keidel D, Kumar A, Pons M, Rochat T, Schikowski T, Schindler C, von Eckardstein A, Kronenberg F, Probst-Hensch N.M. Common SIRT1 variants modify the effect of abdominal adipose tissue on aging-related lung function decline. Age (Dordr). 2016;38(3):52. DOI: 10.1007/s11357-016-9917-y

Bridevaux P.O, Gerbase M, Rochat T. Authors' reply to "Gold stage 1 is crying wolf" by PL Enright. Thorax. 2009;64:183

Imboden M, Kumar A, Curjuric I, Adam M, Thun G.A, Haun M, Tsai M.Y, Pons M, Bettschart R, Turk A, Rochat T, Künzli N, Schindler C, Kronenberg F, Probst-Hensch N.M. Modification of the association between PM10 and lung function decline by cadherin 13 polymorphisms in the SAPALDIA cohort: a genome-wide interaction analysis. Environ Health Perspect. 2015;123(1):72-79. DOI: 10.1289/ehp.1307398

Adam M, Felber Dietrich D, Schaffner E, Carballo D, Barthélémy J.C, Gaspoz J.M, Tsai M.Y, Rapp R, Phuleria H.C, Schindler C, Schwartz J, Künzli N, Probst-Hensch N.M. Long-term exposure to traffic-related PM10 and decreased heart rate variability: is the association restricted to subjects taking ACE inhibitors?. Environ Int. 2012;48:9-16. DOI: 10.1016/j.envint.2012.06.016

Jacquemin B, Siroux V, Sanchez M, Carsin A.E, Schikowski T, Adam M, Bellisario V, Buschka A, Bono R, Brunekreef B, Cai Y, Cirach M, Clavel-Chapelon F, Declercq C, de Marco R, de Nazelle A, Ducret-Stich R.E, Ferretti V.V, Gerbase M.W, Hardy R, Heinrich J, Janson C, Jarvis D, Al Kanaani Z, Keidel D, Kuh D, Le Moual N, Nieuwenhuijsen M.J, Marcon A, Modig L, Pin I, Rochat T, Schindler C, Sugiri D, Stempfelet M, Temam S, Tsai M.Y, Varraso R, Vienneau D, Vierkötter A, Hansell A.L, Kramer U, Probst-Hensch N.M, Sunyer J, Künzli N, Kauffmann F. Ambient air pollution and adult asthma incidence in six European cohorts (ESCAPE). Environ Health Perspect. 2015;123(6):613-621. DOI: 10.1289/ehp.1408206

Lanki T, Hampel R, Tiittanen P, Andrich S, Beelen R, Brunekreef B, Dratva J, de Faire U, Fuks K.B, Hoffman B, Imboden M, Jousilahti P, Koenig W, Mahabadi A.A, Künzli N, Pedersen N.L, Penell J, Pershagen G, Probst-Hensch N.M, Schaffner E, Schindler C, Sugiri D, Swart W.J, Tsai M.Y, Turunen A.W, Weinmayr G, Wolf K, Yli-Tuomi T, Peters A. Air pollution from road traffic and systemic inflammation in adults: a cross-sectional analysis in the European ESCAPE project. Environ Health Perspect. 2015;123(8):785-791. DOI: 10.1289/ehp.1408224

Eze I.C, Hemkens L.G, Bucher H.C, Hoffmann B, Schindler C, Künzli N, Schikowski T, Probst-Hensch N.M. Association between ambient air pollution and diabetes mellitus in Europe and North America: systematic review and meta-analysis. Environ Health Perspect. 2015;123(5):381-389. DOI: 10.1289/ehp.1307823

Karipidis I, Vienneau D, Habermacher M, Köpfli M, Brink M, Probst-Hensch N, Röösli M, Wunderli J.M. Reconstruction of historical noise exposure data for environmental epidemiology in Switzerland within the SiRENE project. Noise Mapping. 2014;1(1):3-14. DOI: 10.2478/noise-2014-0002

Wang M, Beelen R, Stafoggia M, Raaschou-Nielsen O, Andersen Z.J, Hoffmann B, Fischer P, Houthuijs D, Nieuwenhuijsen M, Weinmayr G, Vineis P, Xun W.W, Dimakopoulou K, Samoli E, Laatikainen T, Lanki T, Turunen A.W, Oftedal B, Schwarze P, Aamodt G, Penell J, de Faire U, Korek M, Leander K, Pershagen G, Pedersen N.L, Ostenson C.G, Fratiglioni L, Eriksen K.T, Sorensen M, Tjonneland A, Bueno-de-Mesquita B, Eeftens M, Bots M.L, Meliefste K, Kramer U, Heinrich J, Sugiri D, Key T, de Hoogh K, Wolf K, Peters A, Cyrys J, Jaensch A, Concin H, Nagel G, Tsai M.Y, Phuleria H, Ineichen A, Künzli N, Probst-Hensch N, Schaffner E, Vilier A, Clavel-Chapelon F, Declerq C, Ricceri F, Sacerdote C, Marcon A, Galassi C, Migliore E, Ranzi A, Cesaroni G, Badaloni C, Forastiere F, Katsoulis M, Trichopoulou A, Keuken M, Jedynska A, Kooter I.M, Kukkonen J, Sokhi R.S, Brunekreef B, Katsouyanni K, Hoek G. Long-term exposure to elemental constituents of particulate matter and cardiovascular mortality in 19 European cohorts: Results from the ESCAPE and TRANSPHORM projects. Environ Int. 2014;66:97-106. DOI: 10.1016/j.envint.2014.01.026

Pattaro C, Kottgen A, Teumer A, Garnaas M, Boger C.A, Fuchsberger C, Olden M, Chen M.H, Tin A, Taliun D, Li M, Gao X, Gorski M, Yang Q, Hundertmark C, Foster M.C, O'Seaghdha C.M, Glazer N, Isaacs A, Liu C.T, Smith A.V, O'Connell J.R, Struchalin M, Tanaka T, Li G, Johnson A.D, Gierman H.J, Feitosa M, Hwang S.J, Atkinson E.J, Lohman K, Cornelis M.C, Johansson A, Tonjes A, Dehghan A, Chouraki V, Holliday E.G, Sorice R, Kutalik Z, Lehtimaki T, Esko T, Deshmukh H, Ulivi S, Chu A.Y, Murgia F, Trompet S, Imboden M, Kollerits B, Pistis G, Harris T.B, Launer L.J, Aspelund T, Eiriksdottir G, Mitchell B.D, Boerwinkle E, Schmidt H, Cavalieri M, Rao M, Hu F.B, Demirkan A, Oostra B.A, de Andrade M, Turner S.T, Ding J, Andrews J.S, Freedman B.I, Koenig W, Illig T, Doring A, Wichmann H.E, Kolcic I, Zemunik T, Boban M, Minelli C, Wheeler H.E, Igl W, Zaboli G, Wild S.H, Wright A.F, Campbell H, Ellinghaus D, Nothlings U, Jacobs G, Biffar R, Endlich K, Ernst F, Homuth G, Kroemer H.K, Nauck M, Stracke S, Volker U, Volzke H, Kovacs P, Stumvoll M, Magi R, Hofman A, Uitterlinden A.G, Rivadeneira F, Aulchenko Y.S, Polasek O, Hastie N, Vitart V, Helmer C, Wang J.J, Ruggiero D, Bergmann S, Kahonen M, Viikari J, Nikopensius T, Province M, Ketkar S, Colhoun H, Doney A, Robino A, Giulianini F, Kramer B.K, Portas L, Ford I, Buckley B.M, Adam M, Thun G.A, Paulweber B, Haun M, Sala C, Metzger M, Mitchell P, Ciullo M, Kim S.K, Vollenweider P, Raitakari O, Metspalu A, Palmer C, Gasparini P, Pirastu M, Jukema J.W, Probst-Hensch N.M, Kronenberg F, Toniolo D, Gudnason V, Shuldiner A.R, Coresh J, Schmid R, Ferrucci L, Siscovick D.S, van Duijn C.M, Borecki I, Kardia S.L, Liu Y, Curhan G.C, Rudan I, Gyllensten U, Wilson J.F, Franke A, Pramstaller P.P, Rettig R, Prokopenko I, Witteman J.C, Hayward C, Ridker P, Parsa A, Bochud M, Heid I.M, Goessling W, Chasman D.I, Kao W.H, Fox C.S. Genome-wide association and functional follow-up reveals new loci for kidney function. PLoS Genet. 2012;8(3):e1002584. DOI: 10.1371/journal.pgen.1002584

Eeftens M, Phuleria H, Meier R, Aguilera I, Corradi E, Davey M, Ducret-Stich R, Fierz M, Gehrig R, Ineichen A, Keidel D, Probst-Hensch N, Ragettli M, Schindler C, Künzli N, Tsai M.Y. Spatial and temporal variability of ultrafine particles, NO2, PM2.5, PM2.5 absorbance, PM10 and PMcoarse in Swiss study areas. Atmos Environ. 2015;111:60-70. DOI: 10.1016/j.atmosenv.2015.03.031

Paternoster L, Standl M, Chen C.M, Ramasamy A, Bonnelykke K, Duijts L, Ferreira M.A, Alves A.C, Thyssen J.P, Albrecht E, Baurecht H, Feenstra B, Sleiman P.M, Hysi P, Warrington N.M, Curjuric I, Myhre R, Curtin J.A, Groen-Blokhuis M.M, Kerkhof M, Saaf A, Franke A, Ellinghaus D, Folster-Holst R, Dermitzakis E, Montgomery S.B, Prokisch H, Heim K, Hartikainen A.L, Pouta A, Pekkanen J, Blakemore A.I, Buxton J.L, Kaakinen M, Duffy D.L, Madden P.A, Heath A.C, Montgomery G.W, Thompson P.J, Matheson M.C, Le Souef P, Pourcain B.S, Smith G.D, Henderson J, Kemp J.P, Timpson N.J, Deloukas P, Ring S.M, Wichmann H.E, Muller-Nurasyid M, Novak N, Klopp N, Rodriguez E, McArdle W, Linneberg A, Menne T, Nohr E.A, Hofman A, Uitterlinden A.G, van Duijn C.M, Rivadeneira F, de Jongste J.C, van der Valk R.J, Wjst M, Jogi R, Geller F, Boyd H.A, Murray J.C, Kim C, Mentch F, March M, Mangino M, Spector T.D, Bataille V, Pennell C.E, Holt P.G, Sly P, Tiesler C.M, Thiering E, Illig T, Imboden M, Nystad W, Simpson A, Hottenga J.J, Postma D, Koppelman G.H, Smit H.A, Soderhall C, Chawes B, Kreiner-Moller E, Bisgaard H, Melen E, Boomsma D.I, Custovic A, Jacobsson B, Probst-Hensch N.M, Palmer L.J, Glass D, Hakonarson H, Melbye M, Jarvis D.L, Jaddoe V.W, Gieger C, Strachan D.P, Martin N.G, Jarvelin M.R, Heinrich J, Evans D.M, Weidinger S. Meta-analysis of genome-wide association studies identifies three new risk loci for atopic dermatitis. Nat Genet. 2012;44(2):187-192. DOI: 10.1038/ng.1017

Ackermann-Liebrich U. Alveolar macrophages carbon load: a marker of exposure? [Editorial]. Eur Respir J. 2012;40(5):1065-1066. DOI: 10.1183/09031936.00056412

Jarvis D, Minelli C, Adamson M, Portas L, Garcia-Aymerich J, Elfadaly F, Jarvelin M.R, Probst-Hensch N, Henderson J, Svanes C, Dharmage S. Developing a risk prediction tool for spirometrically defined copd in adults; experience from the ageing lungs in european cohorts project. Thorax, 2019;73(Suppl. 4):A163-A164. DOI: 10.1136/thorax-2018-212555.274

Rezwan F.I, Imboden M, Amaral A.F.S, Wielscher M, Jeong A, Triebner K, Real F.G, Jarvelin M.R, Jarvis D, Probst-Hensch N.M, Holloway J.W. Association of adult lung function with accelerated biological aging. Aging. 2020;12(1):518-542. DOI: 10.18632/aging.102639

Vineis P, Demetriou C.A, Probst-Hensch N. Long-term effects of air pollution: an exposome meet-in-the-middle approach. Int J Public Health. 2020;65(2):125-127. DOI: 10.1007/s00038-019-01329-7

Probst-Hensch N, Röösli M. Nicht übertragbare Krankheiten verstehen und verhindern mit Big Data und Exposom-Ansätzen. Leading Options. 2019;5:63-65

Peralta G.P, Marcon A, Carsin A.E, Abramson M.J, Accordini S, Amaral A.F, Anto J.M, Bowatte G, Burney P, Corsico A, Demoly P, Dharmage S, Forsberg B, Fuertes E, Garcia-Larsen V, Gislason T, Gullon J.A, Heinrich J, Holm M, Jarvis D.L, Janson C, Jogi R, Johannessen A, Leynaert B, Rovira J.M, Nowak D, Probst-Hensch N, Raherison C, Sánchez-Ramos J.L, Sigsgaard T, Siroux V, Squillacioti G, Urrutia I, Weyler J, Zock J.P, Garcia-Aymerich J. Body mass index and weight change are associated with adult lung function trajectories: the prospective ECRHS study. Thorax. 2020;75(4):313-320. DOI: 10.1136/thoraxjnl-2019-213880

Accordini S, Calciano L, Marcon A, Pesce G, Anto J.M, Beckmeyer-Borowko A.B, Carsin A.E, Corsico A.G, Imboden M, Janson C, Keidel D, Locatelli F, Svanes C, Burney P.G.J, Jarvis D, Probst-Hensch N.M, Minelli C. Incidence trends of airflow obstruction among European adults without asthma: a 20-year cohort study. Sci Rep. 2020;10:3452. DOI: 10.1038/s41598-020-60478-5

van Nunen E, Vermeulen R, Tsai M.Y, Probst-Hensch N, Ineichen A, Imboden M, Naccarati A, Tarallo S, Raffaele D, Ranzi A, Nieuwenhuijsen M, Jarvis D, Amaral A.F, Vlaanderen J, Meliefste K, Brunekreef B, Vineis P, Gulliver J, Hoek G. Associations between modeled residential outdoor and measured personal exposure to ultrafine particles in four European study areas. Atmos Environ. 2020;226:117353. DOI: 10.1016/j.atmosenv.2020.117353

Demetz E, Tymoszuk P, Hilbe R, Volani C, Haschka D, Heim C, Auer K, Lener D, Zeiger L.B, Pfeifhofer-Obermair C, Boehm A, Obermair G.J, Ablinger C, Coassin S, Lamina C, Kager J, Petzer V, Asshoff M, Schroll A, Nairz M, Dichtl S, Seifert M, von Raffay L, Fischer C, Barros-Pinkelnig M, Brigo N, Valente de Souza L, Sopper S, Hirsch J, Graber M, Gollmann-Tepekoylu C, Holfeld J, Halper J, Macheiner S, Gostner J, Vogel G.F, Pechlaner R, Moser P, Imboden M, Marques-Vidal P, Probst-Hensch N.M, Meiselbach H, Strauch K, Peters A, Paulweber B, Willeit J, Kiechl S, Kronenberg F, Theurl I, Tancevski I, Weiss G. The haemochromatosis gene Hfe and Kupffer cells control LDL cholesterol homeostasis and impact on atherosclerosis development. Eur Heart J. 2020;41(40):3949-3959. DOI: 10.1093/eurheartj/ehaa140

Hoang T.T, Sikdar S, Xu C.J, Lee M.K, Cardwell J, Forno E, Imboden M, Jeong A, Madore A.M, Qi C, Wang T, Bennett B.D, Ward J.M, Parks C.G, Beane-Freeman L.E, King D, Motsinger-Reif A, Umbach D.M, Wyss A.B, Schwartz D.A, Celedon J.C, Laprise C, Ober C, Probst-Hensch N, Yang I.V, Koppelman G.H, London S.J. Epigenome-wide association study of DNA methylation and adult asthma in the agricultural lung health study. Eur Respir J. 2020;56(3):2000217. DOI: 10.1183/13993003.00217-2020

Eze I.C, Jeong A, Schaffner E, Rezwan F.I, Ghantous A, Foraster M, Vienneau D, Kronenberg F, Herceg Z, Vineis P, Brink M, Wunderli J.M, Schindler C, Cajochen C, Röösli M, Holloway J.W, Imboden M, Probst-Hensch N. Genome-wide DNA methylation in peripheral blood and long-term exposure to source-specific transportation noise and air pollution: the SAPALDIA study. Environ Health Perspect. 2020;128(6):67003. DOI: 10.1289/EHP6174

Pesce G, Triebner K, van der Plaat D.A, Courbon D, Hustad S, Sigsgaard T, Nowak D, Heinrich J, Anto J.M, Dorado-Arenas S, Martinez-Moratalla J, Gullon-Blanco J.A, Sanchez-Ramos J.L, Raherison C, Pin I, Demoly P, Gislason T, Torén K, Forsberg B, Lindberg E, Zemp E, Jogi R, Probst-Hensch N, Dharmage S.C, Jarvis D, Garcia-Aymerich J, Marcon A, Gómez-Real F, Leynaert B. Low serum DHEA-S is associated with impaired lung function in women. EClinicalMedicine. 2020;23:100389. DOI: 10.1016/j.eclinm.2020.100389

Carsin A.E, Keidel D, Fuertes E, Imboden M, Weyler J, Nowak D, Heinrich J, Pascual Erquicia S, Martinez-Moratalla J, Huerta I, Sanchez J.L, Schaffner E, Caviezel S, Beckmeyer-Borowko A, Raherison C, Pin I, Demoly P, Leynaert B, Cerveri I, Squillacioti G, Accordini S, Gislason T, Svanes C, Toren K, Forsberg B, Janson C, Jogi R, Emtner M, Gomez Real F, Jarvis D, Guerra S, Dharmage S.C, Probst-Hensch N, Garcia-Aymerich J. Regular physical activity levels and incidence of restrictive spirometry pattern: a longitudinal analysis of two population-based cohorts. Am J Epidemiol. 2020;89(12):1521-1528. DOI: 10.1093/aje/kwaa087

Amaral A.F.S, Imboden M, Wielscher M, Rezwan F.I, Minelli C, Garcia-Aymerich J, Peralta G.P, Auvinen J, Jeong A, Schaffner E, Beckmeyer-Borowko A, Holloway J.W, Jarvelin M.R, Probst-Hensch N.M, Jarvis D.L, ALEC consortium. Role of DNA methylation in the association of lung function with body mass index: a two-step epigenetic Mendelian randomisation study. BMC Pulm Med. 2020;20:171. DOI: 10.1186/s12890-020-01212-9

Aebi N.J, Bringolf-Isler B, Schaffner E, Caviezel S, Imboden M, Probst-Hensch N. Patterns of cross-sectional and predictive physical activity in Swiss adults aged 52+: results from the SAPALDIA cohort. Swiss Med Wkly. 2020;150:w20266. DOI: 10.4414/smw.2020.20266

Cerletti P, Eze I.C, Schaffner E, Foraster M, Vienneau D, Cajochen C, Wunderli J.M, Röösli M, Stolz D, Pons M, Imboden M, Probst-Hensch N. The independent association of source-specific transportation noise exposure, noise annoyance and noise sensitivity with health-related quality of life. Environ Int. 2020;143:105960. DOI: 10.1016/j.envint.2020.105960

Probst-Hensch N. From genetic epidemiology to exposome and systems epidemiology. In: Patrinos G.P, ed. Applied genomics and public health: translational and applied genomics, 11-35. Cambridge, Massachusetts: Academic Press, 2020. DOI: 10.1016/B978-0-12-813695-9.00002-9

Eze I.C, Foraster M, Schaffner E, Vienneau D, Pieren R, Imboden M, Wunderli J.M, Cajochen C, Brink M, Röösli M, Probst-Hensch N. Incidence of depression in relation to transportation noise exposure and noise annoyance in the SAPALDIA study. Environ Int. 2020;144:106014. DOI: 10.1016/j.envint.2020.106014

Schmidt J.C, Vogt S, Imboden M, Schaffner E, Grize L, Zemp E, Probst-Hensch N, Zitzmann N.U. Dental and periodontal health in a Swiss population-based sample of older adults: a cross-sectional study. Eur J Oral Sci. 2020;128:508-517. DOI: 10.1111/eos.12738

Cerletti P, Keidel D, Imboden M, Schindler C, Probst-Hensch N. The modifying role of physical activity in the cross-sectional and longitudinal association of health-related quality of life with physiological functioning-based latent classes and metabolic syndrome. Health Qual Life Outcomes. 2020;18:345. DOI: 10.1186/s12955-020-01557-z

Lytras T, Beckmeyer-Borowko A, Kogevinas M, Kromhout H, Carsin A.E, Anto J.M, Bentouhami H, Weyler J, Heinrich J, Nowak D, Urrutia I, Martinez-Moratalla J, Gullon J.A, Pereira Vega A, Raherison Semjen C, Pin I, Demoly P, Leynaert B, Villani S, Gislason T, Svanes O, Holm M, Forsberg B, Norback D, Mehta A.J, Keidel D, Vernez D, Benke G, Jogi R, Toren K, Sigsgaard T, Schlunssen V, Olivieri M, Blanc P.D, Watkins J, Bono R, Squillacioti G, Buist A.S, Vermeulen R, Jarvis D, Probst-Hensch N, Zock J.P. Cumulative occupational exposures and lung function decline in two large general population cohorts. Ann Am Thorac Soc. 2021;18(2):238-246. DOI: 10.1513/AnnalsATS.202002-113OC

Probst-Hensch N, Röösli M. Auswirkungen von Lärmbelastung auf das kardiovaskuläre System. Hausarzt Praxis. 2020;15(11):13-16

van Nunen E, Hoek G, Tsai M.Y, Probst-Hensch N, Imboden M, Jeong A, Naccarati A, Tarallo S, Raffaele D, Nieuwenhuijsen M, Vlaanderen J, Gulliver J, Amaral A.F.S, Vineis P, Vermeulen R. Short-term personal and outdoor exposure to ultrafine and fine particulate air pollution in association with blood pressure and lung function in healthy adults. Environ Res. 2021;194:110579. DOI: 10.1016/j.envres.2020.110579

Fawcett K.A, Obeidat M, Melbourne C, Shrine N, Guyatt A.L, John C, Luan J, Richmond A, Moksnes M.R, Granell R, Weiss S, Imboden M, May-Wilson S, Hysi P, Boutin T.S, Portas L, Flexeder C, Harris S.E, Wang C.A, Lyytikainen L.P, Palviainen T, Foong R.E, Keidel D, Minelli C, Langenberg C, Bosse Y, Van den Berge M, Sin D.D, Hao K, Campbell A, Porteous D, Padmanabhan S, Smith B.H, Evans D.M, Ring S, Langhammer A, Hveem K, Willer C, Ewert R, Stubbe B, Pirastu N, Klaric L, Joshi P.K, Patasova K, Massimo M, Polasek O, Starr J.M, Karrasch S, Strauch K, Meitinger T, Rudan I, Rantanen T, Pietilainen K, Kahonen M, Raitakari O.T, Hall G.L, Sly P.D, Pennell C.E, Kaprio J, Lehtimaki T, Vitart V, Deary I.J, Jarvis D, Wilson J.F, Spector T, Probst-Hensch N, Wareham N.J, Volzke H, Henderson J, Strachan D.P, Brumpton B.M, Hayward C, Hall I.P, Tobin M.D, Wain L.V. Variants associated with HHIP expression have sex-differential effects on lung function. Wellcome Open Res. 2020;5:111. DOI: 10.12688/wellcomeopenres.15846.1

Cerletti P.A. Assessing multifactorial correlates of health-related quality of life in the general Swiss population. Basel: Univ. Basel, 2020. Faculty of Medicine. Doctoral Thesis, University of Basel, Faculty of Medicine DOI: 10.5451/unibas-ep79203

Marcon A, Locatelli F, Dharmage S.C, Svanes C, Heinrich J, Leynaert B, Burney P, Corsico A, Caliskan G, Calciano L, Gislason T, Janson C, Jarvis D, Jõgi R, Lytras T, Malinovschi A, Probst-Hensch N, Toren K, Casas L, Verlato G, Garcia-Aymerich J, Accordini S, Ageing Lungs in European Cohorts (ALEC) study. The coexistence of asthma and COPD: risk factors, clinical history and lung function trajectories. Eur Respir J. 2021;58(5):2004656. (ALEC). DOI: 10.1183/13993003.04656-2020

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