ARQ_2021 - Kinase Inhibitors for Adjunct Antibiotic Treatment of Tuberculosis

Tuberculosis (TB) encompasses pulmonary and extra-pulmonary infections by the deadly obligate human pathogen Mycobacterium tuberculosis (MTB). Upon exposure to infectious aerosols, host immune responses build up multi-cellular structures called granulomas that aim to encapsulate the bacteria at the...

Ongoing
01.09.2020 - 31.08.2021
Research project
Novartis Foundation for medical-biological research
Tuberculosis Research Unit, Tuberculosis Immunology
Damien Portevin
SNF_TzExVivoGran - Human in vitro granulomas to dissect tuberculosis protective immune traits and assess drug candidates for tailored adjunct host-directed therapy

Taking advantage of a unique collection of human clinical specimens and our established in vitro granuloma model, we aim to gain important knowledge on some of the intrinsic differential immune traits that defines a protective response against MTB. We will demonstrate that in vitro granulomas...

Ongoing
01.01.2020 - 31.12.2024
Research project
Tuberculosis Immunology
Damien Portevin
Host-pathogen genomic interactions and their phenotypic impact in human tuberculosis

Tuberculosis (TB) is still a major health problem worldwide. Every year, 1.7 million people die from this infectious disease caused by the bacterium Mycobacterium tuberculosis (Mtb). Although TB is often fatal when untreated, the course of the disease differs enormously in people infected with Mtb....

Ongoing
01.12.2017 - 31.12.2021
Research project
Tuberculosis Research Unit
Sébastien Gagneux , Damien Portevin
Ongoing
01.02.2015 - 31.01.2017
Research project
AERAS Global TB Vaccine Foundation
Clinical Immunology
Damien Portevin