Mathematical models to define new malaria immunotherapies and interventions to meet public health needs

Despite recent progress in fighting malaria, there remains a need for new antimalarial interventions to protect children and other vulnerable populations who experience the highest burden of malaria.

Developing new interventions is time-consuming and costly, and it is often unclear what the public...

Ongoing
01.02.2021 - 31.01.2024
Research project
Disease Modelling, Disease Modelling and Intervention Dynamics
Melissa Penny
Agent-based tracking of disease spread with dynamic models of travel behaviour in a pandemic

Epidemic models are essential tools to coordinate all aspects of the response to pandemics. Models can inform policy makers on strategies for vaccinations and testing, but also to trigger mitigation measure such as the ‘lockdowns’ used during the COVID-19 outbreak in Switzerland. Here, we propose to...

Ongoing
01.09.2020 - 31.08.2022
Research project
Swiss National Science Foundation (SNSF) / Programme NRP
Disease Modelling, Disease Modelling and Intervention Dynamics
Melissa Penny
MODCOVID - Using model-based evidence to optimise medical intervention profiles and disease management strategies for COVID-19 control

Background: Country governments have imposed strict spatial distancing and lockdown measures to reduce infection incidence and associated disease burden of coronavirus infectious disease (COVID- 19). As of April 7th, there is no proven medical or pharmaceutical tool to prevent or treat the disease....

Ongoing
01.06.2020 - 31.12.2022
Research project
Disease Modelling and Intervention Dynamics, Disease Modelling
Melissa Penny
Modeling support for BMGF Malaria Portfolio Analysis

In this project we provide modeling analysis and estimates of the public health impact of new innovations in the malaria product portfolio of the Bill & Melinda Gates Foundation and partners. This model-based evidence combined with costs and economic analysis supports strategic decisions for...

Ongoing
01.11.2018 - 31.12.2020
Research project
Disease Modelling, Disease Modelling and Intervention Dynamics
Melissa Penny
PATH malaria vaccine modelling

The malaria vaccine RTS,S is currently in Phase 4 studies and undergoing pilot implementation in 3 countries in Africa.  Supporting ongoing policy decisions by Gavi and MPAC/SAGE on RTS,S, model based estimates are required to take into account possible scenarios with other malaria interventions...

Ongoing
04.12.2017 - 31.03.2022
Research project
Disease Modelling, Disease Modelling and Intervention Dynamics
Melissa Penny
MMC elimination costing

The project will generate evidence on the trade-offs between cost and effectiveness of malaria elimination interventions. This includes surveillance and a range of targeted and focal malaria elimination interventions when added incrementally to current levels of routine malaria control and case...

Ongoing
01.12.2017 - 31.10.2020
Research project
Disease Modelling, Disease Modelling and Intervention Dynamics
Melissa Penny
SNF_FP_modelling - Multi-scale mathematical modelling of parasite, drug and vaccine interactions: optimising public health and disease elimination strategies

Tremendous progress has been made over the last decades in controlling malaria. From 2000 to 2015 scale-up of control and curative interventions enabled a 60% reduction in malaria death rates and a 40% reduction in rate of clinical disease. Despite these gains, we face significant challenges if we...

Ongoing
01.07.2017 - 31.07.2021
Research project
Disease Modelling, Disease Modelling and Intervention Dynamics
Melissa Penny
Developing a modelling framework for malaria transmission prevention tools

Following years of investment in strategies to control malaria, elimination is now being considered. But optimal delivery strategies and profiles for new tools for elimination differ from those of disease control. The efficacy profiles of new drugs, vaccines and vector control, along with how to...

Ongoing
01.05.2017 - 31.03.2018
Research project
Disease Modelling, Disease Modelling and Intervention Dynamics
Melissa Penny
RGS Model Drug Development - Modelling and simulation for drug development at Swiss TPH: clinical anthelminthic drug development and preclinical antimalarial development

This research project is aligned with priorities of the Swiss Tropical and Public Health Institute, namely integrating drug discovery and drug development with modeling. Aiming to strengthen capacity at the institute for model based research and development of existing and novel drugs we propose to...

Ongoing
01.01.2016 - 30.06.2017
Research project
Disease Modelling, Disease Modelling and Intervention Dynamics
Melissa Penny
RGS Effective coverage - Impact of systems failures in malaria service delivery in Africa

Malaria treatment provides individual benefits by curing infection and preventing progression to severe disease. Treatment also provides community-level benefits by reducing the infectious reservoir. However, across endemic countries treatment does not always lead to a complete parasitological cure,...

Ongoing
01.01.2016 - 31.12.2018
Research project
Disease Modelling and Intervention Dynamics, Disease Modelling
Melissa Penny