Project
3 available projects
PEBRA trial - Peer-Educator-coordinated vs nurse-coordinated ART refill for adolescents and young adults living with HIV in Lesotho – a cluster randomized clinical trial
Background
Despite tremendous progress in controlling the HIV epidemic in sub-Saharan Africa, HIV-related mortality continues to increase among adolescents and young people living with HIV (AYPLHIV). Globally, sub-Saharan Africa accounts for 85% of the AYPLHIV. Overall outcomes along the HIV care...
SESOTHO trial - SESOTHO trial (“Switch Either near Suppression Or THOusand”) – switch to second-line versus WHO-guided standard of care for unsuppressed patients on first-line ART with viremia below 1000 copies/mL: a multicenter, open-label, randomized clinical trial
Background
The World Health Organization (WHO) recommends viral load (VL) measurement as the preferred monitoring strategy for HIV-infected individuals on antiretroviral therapy (ART) in resource-limited settings. The new WHO guidelines 2016 continue to define virologic failure as two consecutive...
VIBRA trial (GET ON project) – Effect of village-based refill of ART following home-based same-day ART initiation vs clinic-based ART refill on viral suppression among individuals living with HIV: a cluster-randomized clinical trial in rural Lesotho
The VIBRA trial is linked to another trial, the HOSENG trial, together they constitute the GET ON (GETing tOwards Ninety) research project.
- The VIBRA trial (VIllage-Based Refill of ART) is a cluster-randomized clinical trial conducted in two districts in Lesotho, southern Africa. Clusters (i.e.,...