BRCCH EDCTP Outreach - Improving Access to SARS-CoV-2 Screening and Testing through Community-based COVID-19 Case-Finding and the Use of Digital Solutions in Lesotho and Zambia

In a collaboration between teams in Lesotho and Zambia, Dr Klaus Reither (Swiss Tropical and Public Health Institute, BRCCH) and Dr Kwame Shanaube (Zambart, EDCTP) will investigate the effects of community-led interventions, rapid point-of-care diagnostics and swab self-collection in mitigating the...

Ongoing
01.01.2021 - 31.12.2022
Evaluation project
Botnar Research Centre for Child Health (BRCCH)
Clinical Research Unit
Klaus Reither
ComBaCaL - Community-Based chronic disease Care Lesotho: A 5-year implementation research programme to tackle non-communicable diseases in rural Lesotho

Non-Communicable Diseases (NCDs) such as diabetes and high blood pressure are the number one cause of death and disability globally. More than 75% of premature NCD-related deaths occur in low- and middle-income countries. A programme mainly funded by the Swiss Agency for Development and Cooperation...

Ongoing
01.12.2020 - 31.12.2025
Clinical Trial, Evaluation project, PhD project, Research project, Teaching and training project
Swiss Agency for Development and Cooperation (SDC)
International HIV and Chronic Disease Care
Niklaus Labhardt , Alain Amstutz
PEBRA trial - Peer-Educator-coordinated vs nurse-coordinated ART refill for adolescents and young adults living with HIV in Lesotho – a cluster randomized clinical trial

 

Background

Despite tremendous progress in controlling the HIV epidemic in sub-Saharan Africa, HIV-related mortality continues to increase among adolescents and young people living with HIV (AYPLHIV). Globally, sub-Saharan Africa accounts for 85% of the AYPLHIV. Overall outcomes along the HIV care...

Ongoing
01.12.2018 - 30.11.2020
Clinical Trial
International AIDS Society (IAS) / Collaborative Initiative for Paediatric HIV Education and Research (CIPHER)
Clinical Research Unit
Alain Amstutz , Niklaus Labhardt
SESOTHO trial - Switch Either near Suppression Or THOusand – switch to second-line versus WHO-guided standard of care for unsuppressed patients on first-line ART with viremia below 1000 copies/mL: a multicenter, open-label, randomized clinical trial

Background

The World Health Organization (WHO) recommends viral load (VL) measurement as the preferred monitoring strategy for HIV-infected individuals on antiretroviral therapy (ART) in resource-limited settings. The 2016 WHO guidelines defined virologic failure as two consecutive VL ≥1000...

Ongoing
01.12.2017 - 31.12.2021
Clinical Trial, PhD project
Swiss National Science Foundation (SNSF) / Programme r4d , Swiss National Science Foundation (SNSF) / Career MD-PhD programme , Swiss National Science Foundation (SNSF) / Career Eccellenza
Clinical Research Unit
Niklaus Labhardt , Alain Amstutz
GET ON project: HOSENG trial - Home-based oral self-testing for absent and declining individuals during a door-to-door HIV testing campaign in rural Lesotho: The HOSENG cluster-randomised trial

Background

In sub-Saharan Africa, home-based HIV testing is validated and accepted, but coverage is low because household members are often absent during home-based testing campaigns. We aimed to measure the effect of secondary distribution of oral-fluid HIV self-tests during home-based testing in...

Ongoing
01.12.2017 - 31.12.2021
Clinical Trial, PhD project
Swiss National Science Foundation (SNSF) / Programme r4d , Swiss National Science Foundation (SNSF) / Career Eccellenza , International AIDS Society (IAS) / Collaborative Initiative for Paediatric HIV Education and Research (CIPHER) , Swiss National Science Foundation (SNSF) / Career MD-PhD programme
Clinical Research Unit
Alain Amstutz , Niklaus Labhardt , Tracy Glass
GET ON project: VIBRA trial - Effect of Offering ART refill through community health workers versus clinic-based follow-up after home-based same-day ART initiation in rural Lesotho: The VIBRA cluster-randomized clinical trial

Background

Community-based antiretroviral therapy (ART) dispensing by lay workers is an important differentiated service delivery model in sub-Sahara Africa. However, patients new in care are generally excluded from such models. Home-based same-day ART initiation is becoming widespread practice, but...

Ongoing
01.12.2017 - 31.12.2021
Clinical Trial, PhD project
Swiss National Science Foundation (SNSF) / Programme r4d , Swiss National Science Foundation (SNSF) / Career Eccellenza , Swiss National Science Foundation (SNSF) / Career MD-PhD programme
Clinical Research Unit
Niklaus Labhardt , Alain Amstutz , Tracy Glass