PEBRA trial - Peer-Educator-coordinated vs nurse-coordinated ART refill for adolescents and young adults living with HIV in Lesotho – a cluster randomized clinical trial

 

Background

Despite tremendous progress in controlling the HIV epidemic in sub-Saharan Africa, HIV-related mortality continues to increase among adolescents and young people living with HIV (AYPLHIV). Globally, sub-Saharan Africa accounts for 85% of the AYPLHIV. Overall outcomes along the HIV care...

Ongoing
01.12.2018 - 30.11.2020
Clinical Trial
International AIDS Society (IAS) / Collaborative Initiative for Paediatric HIV Education and Research (CIPHER)
Clinical Research Unit
Alain Amstutz , Niklaus Labhardt
SESOTHO trial - SESOTHO trial (“Switch Either near Suppression Or THOusand”) – switch to second-line versus WHO-guided standard of care for unsuppressed patients on first-line ART with viremia below 1000 copies/mL: a multicenter, open-label, randomized clinical trial

 

Background

The World Health Organization (WHO) recommends viral load (VL) measurement as the preferred monitoring strategy for HIV-infected individuals on antiretroviral therapy (ART) in resource-limited settings. The new WHO guidelines 2016 continue to define virologic failure as two consecutive...

Ongoing
01.12.2017 -
Clinical Trial, PhD project
Clinical Research Unit
Niklaus Labhardt , Alain Amstutz
VIBRA trial (GET ON project) – Effect of village-based refill of ART following home-based same-day ART initiation vs clinic-based ART refill on viral suppression among individuals living with HIV: a cluster-randomized clinical trial in rural Lesotho

The VIBRA trial is linked to another trial, the HOSENG trial, together they constitute the GET ON (GETing tOwards Ninety) research project.

     

  • The VIBRA trial (VIllage-Based Refill of ART) is a cluster-randomized clinical trial conducted in two districts in Lesotho, southern Africa. Clusters (i.e.,...

Ongoing
01.12.2017 -
Clinical Trial, PhD project
Swiss National and Science Foundation (SNSF) / Programme r4d , Swiss National and Science Foundation (SNSF) / Career Eccellenza , Swiss National and Science Foundation (SNSF) / Career MD-PhD programme
Clinical Research Unit
Niklaus Labhardt , Alain Amstutz , Tracy Glass