GIVE MOVE - Genotype-Informed Versus Empiric Management of VirEmia: A Randomised Clinical Trial

Background: HIV-1-positive children and adolescents receiving antiretroviral therapy (ART) suffer high rates of treatment failure, predominantly caused by poor adherence to therapy and/or viral drug resistance. While high-income countries routinely use genotypic resistance testing (GRT), this...

Ongoing
01.10.2019 - 30.09.2022
Clinical Trial, Intervention Study, Research project, PhD project
Clinical Research Unit
Jennifer Brown , Niklaus Labhardt
DO-REAL - Observational Assessment of the Nation-Wide Roll-Out of Dolutegravir in Lesotho (Dolutegravir in Real Life 'DO-REAL study')

Background: Dolutegravir (DTG) is a second-generation integrase strand transfer inhibitor with low side-effects and superior treatment outcomes for people living with HIV-1 when compared to other antiretroviral drugs currently in use in low-income countries. Though some cases have been described,...

Ongoing
01.01.2019 -
Observational study, PhD project, Research project
Swiss National and Science Foundation (SNSF) / Career Eccellenza
Clinical Research Unit
Jennifer Brown , Niklaus Labhardt