Manipulation of Human Immunity by Parasitic Worms

Approximately ten percent of the world's population is at risk of schistosomiasis, a neglected, tropical disease caused by species of the helminth Schistosoma. For the past 40 years, control of schistosomiasis has depended on the widespread use of a single drug, praziquantel. Despite its good...

01.12.2020 - 30.09.2021
Research project
Helminth Drug Development
Anna van Beek , Jennifer Keiser
HELP - Collaboration for innovation: Establishment of a pan-nematode drug development platform

To target helminth elimination, a drug research and development (R&D) pipeline is needed to provide new chemotherapeutics that effectively eliminate or sterilize adult worms, thus bringing about the paradigm shift necessary to reach the 2030 SDG goals on health.

Our consortium proposes to establish...

01.09.2019 - 31.08.2024
Research project, Clinical Trial
Helminth Drug Development
Jennifer Keiser
RGS Model Drug Development - Modelling and simulation for drug development at Swiss TPH: clinical anthelminthic drug development and preclinical antimalarial development

This research project is aligned with priorities of the Swiss Tropical and Public Health Institute, namely integrating drug discovery and drug development with modeling. Aiming to strengthen capacity at the institute for model based research and development of existing and novel drugs we propose to...

01.01.2016 - 30.06.2017
Research project
Disease Modelling, Disease Modelling and Intervention Dynamics
Melissa Penny
Pediatric Praziquantel Consortium - Pediatric Praziquantel Consortium: Development and appropriation of a palatable, safe and efficent Praziquantel formulation to treat preschool-aged children for Schistosomiasis.

Schistosomes, parasitic blood flukes, cause schistosomiasis, a chronic disease which can lead to anemia, severe damage of organs, reduced growth and, at worst, to death. Infection occurs if schistosomes larvae penetrate uncovered skin which is exposed to contaminated water. Therefore, this disease...

21.06.2012 - 30.06.2018
Long term service project
Clinical Operations
Eric Huber