Borel N, Sauer-Durand A.M, Hartel M, Kuratli J, Vaupel P, Scherr N, Pluschke G. wIRA: hyperthermia as a treatment option for intracellular bacteria, with special focus on Chlamydiae and Mycobacteria. Int J Hyperthermia. 2020;37:373-383. DOI: 10.1080/02656736.2020.1751312

2020
Journal Article
PubMed (32319834)
Link

Röltgen K, Pluschke G, Spencer J.S, Brennan P.J, Avanzi C. The immunology of other mycobacteria: M. ulcerans, M. leprae. Semin Immunopathol. 2020(in press). DOI: 10.1007/s00281-020-00790-4

2020
Journal Article
PubMed (32100087)

Tamborrini M, Hauser J, Schäfer A, Amacker M, Favuzza P, Kyungtak K, Fleury S, Pluschke G. Vaccination with virosomally formulated recombinant CyRPA elicits protective antibodies against Plasmodium falciparum parasites in preclinical in vitro and in vivo models. Vaccines. 2020;5:9. DOI: 10.1038/s41541-020-0158-9

2020
Journal Article
PubMed (32025340)
Link

Gehringer M, Mäder P, Gersbach P, Pfeiffer B, Scherr N, Dangy J.P, Pluschke G, Altmann K.H. Configurationally stabilized analogs of M. ulcerans exotoxins mycolactones A and B reveal the importance of side chain geometry for mycolactone virulence. Org Lett. 2019;21(15):5853-5857. DOI: 10.1021/acs.orglett.9b01947

2019
Journal Article
PubMed (31295000)

Guenin-Macé L, Ruf M.T, Pluschke G, Demangel C. Mycolactone: more than just a cytotoxin. In: Pluschke G,Röltgen K, eds. Buruli ulcer: , 117-134. Cham: Springer, 2019. DOI: 10.1007/978-3-030-11114-4_7

2019
Book Section
Link

Piazena H, Müller W, Pendl W, von Ah S, Cap V.H, Hug P.J, Sidler X, Pluschke G, Vaupel P. Thermal field formation during wIRA-hyperthermia: temperature measurements in skin and subcutis of piglets as a basis for thermotherapy of superficial tumors and local skin infections caused by thermosensitive microbial pathogens. Int J Hyperthermia. 2019;36(1):938-952. DOI: 10.1080/02656736.2019.1655594

2019
Journal Article
PubMed (31535588)
Link

Pluschke G,Röltgen K, eds. Buruli ulcer: Mycobacterium ulcerans disease. Cham: Springer, 2019. DOI: 10.1007/978-3-030-11114-4

2019
Edited Book
Link

Röltgen K, Cruz I, Ndung'u J.M, Pluschke G. Laboratory diagnosis of Buruli ulcer: challenges and future perspectives. In: Pluschke G,Röltgen K, eds. Buruli ulcer: , 183-202. Cham: Springer, 2019. DOI: 10.1007/978-3-030-11114-4_10

2019
Book Section
Link

Röltgen K, Pluschke G. Buruli ulcer: history and disease burden. In: Pluschke G,Röltgen K, eds. Buruli ulcer: , 1-42. Cham: Springer, 2019. DOI: 10.1007/978-3-030-11114-4_1

2019
Book Section
Link

Scherr N, Pluschke G. Buruli ulcer. In: Swinney D.C,Pollastri M.P, eds. Neglected tropical diseases: drug discovery and development, 327-347: Wiley, 2019

2019
Book Section

Tabah E.N, Johnson C.R, Degnonvi H, Pluschke G, Röltgen K. Buruli ulcer in Africa. In: Pluschke G,Röltgen K, eds. Buruli ulcer: , 43-60. Cham: Springer, 2019. DOI: 10.1007/978-3-030-11114-4_2

2019
Book Section
Link

Ispasanie E, Micoli F, Lamelas A, Keller D, Berti F, De Riccio R, Di Benedettoi R, Rondini S, Pluschke G. Spontaneous point mutations in the capsule synthesis locus leading to structural and functional changes of the capsule in serogroup A meningococcal populations. Virulence. 2018;9(1):1138-1149. DOI: 10.1080/21505594.2018.1467710

2018
Journal Article
PubMed (30067453)
Link

Lamelas A, Hamid A.M, Dangy J.P, Hauser J, Jud M, Röltgen K, Hodgson A, Junghanss T, Harris S.R, Parkhill J, Bentley S.D, Pluschke G. Loss of genomic diversity in a Neisseria meningitidis clone through a colonization bottleneck. Genome Biol Evol. 2018;10(8):2102-2109. DOI: 10.1093/gbe/evy152

2018
Journal Article
PubMed (30060167)

Pinho-Nascimento C.A, Bratschi M.W, Höfer R, Soares C.C, Warryn L, Pecerska J, Minyem J.C, Paixão I.C.N.P, Baroni de Moraes M.T, Um Boock A, Niel C, Pluschke G, Röltgen K. Transmission of hepatitis B and D viruses in an African rural community. mSystems. 2018;3(5):e00120-18. DOI: 10.1128/mSystems.00120-18

2018
Journal Article
PubMed (30246145)
Link

Röltgen K, Rose N, Ruggieri A, Warryn L, Scherr N, Pinho-Nascimento C.A, Tamborrini M, Jaenisch T, Pluschke G. Development of dengue virus serotype-specific NS1 capture assays for the rapid and highly sensitive identification of the infecting serotype in human sera. J Immunol. 2018;200(200):3857-3866. DOI: 10.4049/jimmunol.1701790

2018
Journal Article
PubMed (29661824)

Scherr N, Bieri R, Thomas S.S, Chauffour A, Kalia N.P, Schneide P, Ruf M.T, Lamelas A, Manimekalai M.S.S, Grüber G, Ishii N, Suzuki K, Tanner M, Moraski G.C, Miller M.J, Witschel M, Jarlier V, Pluschke G, Pethe K. Targeting the Mycobacterium ulcerans cytochrome bc1:aa3 for the treatment of Buruli ulcer. Nat Commun. 2018;9:5370. DOI: 10.1038/s41467-018-07804-8

2018
Journal Article
PubMed (30560872)
Link

Tabah E.N, Nsagha D.S, Bissek A.Z, Njamnshi T.N, Njih I.N, Pluschke G, Njamnshi A.K. Community knowledge, perceptions and attitudes regarding leprosy in rural Cameroon: the case of Ekondotiti and Mbonge health districts in the south-west region. PLoS Negl Trop Dis. 2018;12(2):e0006233. DOI: 10.1371/journal.pntd.0006233

2018
Journal Article
PubMed (29432474)
Link

Addison N.O, Pfau S, Koka E, Aboagye S.Y, Kpeli G, Pluschke G, Yeboah-Manu D, Junghanss T. Assessing and managing wounds of Buruli ulcer patients at the primary and secondary health care levels in Ghana. PLoS Negl Trop Dis. 2017;11(2):e0005331. DOI: 10.1371/journal.pntd.0005331

2017
Journal Article
PubMed (28245242)
Link

Bibert S, Bratschi M.W, Aboagye S.Y, Collinet E, Scherr N, Yeboah-Manu D, Beuret C, Pluschke G, Bochud P.Y. Susceptibility to Mycobacterium ulcerans disease (Buruli ulcer) is associated with IFNG and iNOS gene polymorphisms. Front Microbiol. 2017;8:1903. DOI: 10.3389/fmicb.2017.01903

2017
Journal Article
PubMed (29046669)

Bieri R, Scherr N, Ruf M.T, Dangy J.P, Gersbach P, Gehringer M, Altmann K.H, Pluschke G. The macrolide toxin mycolactone promotes bim-dependent apoptosis in Buruli ulcer through inhibition of mTOR. ACS Chem Biol. 2017;12(5):1297-1307. DOI: 10.1021/acschembio.7b00053

2017
Journal Article
PubMed (28294596)

Cornick J.E, Bishop Ö.T, Yalcin F, Kiran A.M, Kumwenda B, Chaguza C, Govindpershad S, Ousmane S, Senghore M, du Plessis M, Pluschke G, Ebruke C, McGee L, Sigauque B, Collard J.M, Bentley S.D, Kadioglu A, Antonio M, Von Gottberg A, French N, Klugman K.P, Heyderman R.S, Alderson M, Everett D.B, PAGe Consortium. The global distribution and diversity of protein vaccine candidate antigens in the highly virulent Streptococcus pneumoniae serotype 1. Vaccine. 2017;35(6):972-980. DOI: 10.1016/j.vaccine.2016.12.037

2017
Journal Article
PubMed (28081968)

Favuzza P, Guffart E, Tamborrini M, Scherer B, Dreyer A.M, Rufer A.C, Erny J, Hoernschemeyer J, Thoma R, Schmid G, Gsell B, Lamelas A, Benz J, Joseph C, Matile H, Pluschke G, Rudolph M.G. Structure of the malaria vaccine candidate antigen CyRPA and its complex with a parasite invasion inhibitory antibody. Elife. 2017;6:e20383. DOI: 10.7554/eLife.20383

2017
Journal Article
PubMed (28195038)

Kpeli G, Buultjens A.H, Giulieri S, Owusu-Mireku E, Aboagye S.Y, Baines S.L, Seemann T, Bulach D, Goncalves da Silva A, Monk I.R, Howden B.P, Pluschke G, Yeboah-Manu D, Stinear T. Genomic analysis of ST88 community-acquired methicillin resistant Staphylococcus aureus in Ghana. PeerJ. 2017;5:e3047. DOI: 10.7717/peerj.3047

2017
Journal Article
PubMed (28265515)

Lamelas A, Hauser J, Dangy J.P, Hamid A.M, Roltgen K, Abdul Sater M.R, Hodgson A, Sie A, Junghanss T, Harris S.R, Parkhill J, Bentley S.D, Pluschke G. Emergence and genomic diversification of a virulent serogroup W:ST-2881(CC175) Neisseria meningitidis clone in the African meningitis belt. Microb Genom. 2017;3(8):e000120. DOI: 10.1099/mgen.0.000120

2017
Journal Article
PubMed (29026659)
Link

N'krumah R.T.A.S, Kroné B, Cissé G, Tanner M, Utzinger J, Pluschke G, Tiembré I. Characteristics and epidemiological profile of Buruli ulcer in the district of Tiassalé, south Côte d’Ivoire. Acta Trop. 2017;175:138-144. DOI: 10.1016/j.actatropica.2016.12.023

2017
Journal Article
PubMed (28034768)

Owusu E, Newman M.J, Akumwena A, Bannerman E, Pluschke G. Evaluating decontamination protocols for the isolation of Mycobacterium ulcerans from swabs. BMC Microbiol. 2017;17:2. DOI: 10.1186/s12866-016-0918-x

2017
Journal Article
PubMed (28056807)
Link

Röltgen K, Pluschke G, Johnson P.D.R, Fyfe J. Mycobacterium ulcerans DNA in bandicoot excreta in Buruli ulcer-endemic area, Northern Queensland, Australia. Emerg Infect Dis. 2017;23(12):2042-2045. DOI: 10.3201/eid2312.170780

2017
Journal Article
PubMed (29148373)
Link

Ruf M.T, Andreoli A, Vujic G, Itin P, Pluschke G, Schmid P. Exudate collection using wound sponges - an easy, non-invasive and reliable method to explore protease activities in ulcers. Wound Repair Regen. 2017;25(2):320-326. DOI: 10.1111/wrr.12517

2017
Journal Article
PubMed (28370804)

Ruf M.T, Steffen C, Bolz M, Schmid P, Pluschke G. Infiltrating leukocytes surround early Buruli ulcer lesions, but are unable to reach the mycolactone producing mycobacteria. Virulence. 2017;8(8):1918-1926. DOI: 10.1080/21505594.2017.1370530

2017
Journal Article
PubMed (28873327)

Ampah K.A, Asare P, Binnah D.D, Maccaulley S, Opare W, Röltgen K, Pluschke G, Yeboah-Manu D. Burden and historical trend of Buruli ulcer prevalence in selected communities along the Offin River of Ghana. PLoS Negl Trop Dis. 2016;10(4):e0004603. DOI: 10.1371/journal.pntd.0004603

2016
Journal Article
PubMed (27078028)
Link

Ampah K.A, Nickel B, Asare P, Ross A, De-Graft D, Kerber S, Spallek R, Singh M, Pluschke G, Yeboah-Manu D, Röltgen K. A sero-epidemiological approach to explore transmission of Mycobacterium ulcerans. PLoS Negl Trop Dis. 2016;10:e0004387. DOI: 10.1371/journal.pntd.0004387

2016
Journal Article
PubMed (26808978)
Link

Ampah K.A, Pinho-Nascimento C.A, Kerber S, Asare P, De-Graft D, Adu-Nti F, Paixao I.C, Niel C, Yeboah-Manu D, Pluschke G, Röltgen K. Limited genetic diversity of hepatitis B virus in the general population of the Offin River valley in Ghana. PLoS One. 2016;11(6):e0156864. DOI: 10.1371/journal.pone.0156864

2016
Journal Article
PubMed (27271290)
Link

Bénard A, Sala C, Pluschke G. Mycobacterium ulcerans mouse model refinement for pre-clinical profiling of vaccine candidates. PLoS One. 2016;11(11):e0167059. DOI: 10.1371/journal.pone.0167059

2016
Journal Article
PubMed (27893778)
Link

Bieri R, Bolz M, Ruf M.T, Pluschke G. Interferon-gamma is a crucial activator of early host immune defense against Mycobacterium ulcerans infection in mice. PLoS Negl Trop Dis. 2016;10(2):e0004450. DOI: 10.1371/journal.pntd.0004450

2016
Journal Article
PubMed (26863011)
Link

Bolz M, Bénard A, Dreyer A.M, Kerber S, Vettiger A, Oehlmann W, Singh M, Duthie M.S, Pluschke G. Vaccination with the surface proteins MUL_2232 and MUL_3720 of Mycobacterium ulcerans induces antibodies but fails to provide protection against Buruli ulcer. PLoS Negl Trop Dis. 2016;10(2):e0004431. DOI: 10.1371/journal.pntd.0004431

2016
Journal Article
PubMed (26849213)
Link

Bolz M, Ruggli N, Borel N, Pluschke G, Ruf M.T. Local cellular immune responses and pathogenesis of Buruli ulcer lesions in the experimental Mycobacterium ulcerans pig infection model. PLoS Negl Trop Dis. 2016;10(4):e0004678. DOI: 10.1371/journal.pntd.0004678

2016
Journal Article
PubMed (27128097)
Link

Chaguza C, Cornick J.E, Harris S.R, Andam C.P, Bricio-Moreno L, Yang M, Yalcin F, Ousmane S, Govindpersad S, Senghore M, Ebruke C, Du Plessis M, Kiran A.M, Pluschke G, Sigauque B, McGee L, Klugman K.P, Turner P, Corander J, Parkhill J, Collard J.M, Antonio M, von Gottberg A, Heyderman R.S, French N, Kadioglu A, Hanage W.P, Everett D.B, Bentley S.D, PAGe Consortium. Understanding pneumococcal serotype 1 biology through population genomic analysis. BMC Infect Dis. 2016;16:649. DOI: 10.1186/s12879-016-1987-z

2016
Journal Article
PubMed (27821148)
Link

Dangy J.P, Scherr N, Gersbach P, Hug M.N, Bieri R, Bomio C, Li J, Huber S, Altmann K.H, Pluschke G. Antibody-mediated neutralization of the exotoxin mycolactone, the main virulence factor produced by Mycobacterium ulcerans. PLoS Negl Trop Dis. 2016;10(6):e0004808. DOI: 10.1371/journal.pntd.0004808

2016
Journal Article
PubMed (27351976)
Link

Favuzza P, Blaser S, Dreyer A.M, Riccio G, Tamborrini M, Thoma R, Matile H, Pluschke G. Generation of Plasmodium falciparum parasite-inhibitory antibodies by immunization with recombinantly-expressed CyRPA. Malar J. 2016;15:161. DOI: 101.1186/s12936-016-1213-x

2016
Journal Article
PubMed (26979066)
Link

Kpeli G, Darko Otchere I, Lamelas A, Buultjens A.L, Bulach D, Baines S.L, Seemann T, Giulieri S, Nakobu Z, Aboagye S.Y, Owusu-Mireku E, Pluschke G, Stinear T.P, Yeboah-Manu D. Possible healthcare-associated transmission as a cause of secondary infection and population structure of Staphylococcus aureus isolates from two wound treatment centres in Ghana. New Microbes New Infect. 2016;13:92-101. DOI: 10.1016/j.nmni.2016.07.001

2016
Journal Article
PubMed (27547406)