Brancucci N.M.B, De Niz M, Straub T.J, Ravel D, Sollelis L, Birren B.W, Voss T.S, Neafsey D.E, Marti M. Probing Plasmodium falciparum sexual commitment at the single-cell level. Wellcome Open Res. 2018;3:70. DOI: 10.12688/wellcomeopenres.14645.3

2018
Journal Article
PubMed (30320226)
Link

Filarsky M, Fraschka S.A, Niederwieser I, Brancucci N.M.B, Carrington E, Carrió E, Moes S, Jenoe P, Bartfai R, Voss T.S. GDV1 induces sexual commitment of malaria parasites by antagonizing HP1-dependent gene silencing. Science. 2018;359(6381):1259-1263. DOI: 10.1126/science.aan6042

2018
Journal Article
PubMed (29590075)

Fraschka S.A, Filarsky M, Hoo R, Niederwieser I, Yan Yam X, Brancucci N.M.B, Mohring F, Mushunje A.T, Huang X, Christensen P.R, Nosten F, Bozdech Z, Russell B, Moon R.W, Marti M, Preiser P.R, Bártfai R, Voss T.S. Comparative heterochromatin profiling reveals conserved and unique epigenome signatures linked to adaptation and development of malaria parasites. Cell Host Microbe. 2018;23(3):407-420 e8. DOI: 10.1016/j.chom.2018.01.008

2018
Journal Article
PubMed (29503181)
Link

Meerstein-Kessel L, Andolina C, Carrió E, Mahamar A, Sawa P, Diawara H, van de Vegte-Bolmer M, Stone W, Collins K.A, Schneider P, Dicko A, Drakeley C, Felger I, Voss T, Lanke K, Bousema T. A multiplex assay for the sensitive detection and quantification of male and female Plasmodium falciparum gametocytes. Malar J. 2018;17:441. DOI: 10.1186/s12936-018-2584-y

2018
Journal Article
PubMed (30497508)
Link

Zhu L, Tripathi J, Rocamora F.M, Miotto O, van der Pluijm R, Voss T.S, Mok S, Kwiatkowski D.P, Nosten F, Day N.P.J, White N.J, Dondorp A.M, Bozdech Z, Tracking Resistance to Artemisinin Collaboration I. The origins of malaria artemisinin resistance defined by a genetic and transcriptomic background. Nat Commun. 2018;9(1):5158. DOI: 10.1038/s41467-018-07588-x

2018
Journal Article
PubMed (30514877)
Link

Bertschi N.L, Toenhake C.G, Zou A, Niederwieser I, Henderson R, Moes S, Jenoe P, Parkinson J, Bartfai R, Voss T.S. Malaria parasites possess a telomere repeat-binding protein that shares ancestry with transcription factor IIIA. Nat Microbiol. 2017;2:17033. DOI: 10.1038/nmicrobiol.2017.33

2017
Journal Article
PubMed (28288093)

Brancucci N.M.B, Gerdt J.P, Wang C, De Niz M, Philip N, Adapa S.R, Zhang M, Hitz E, Niederwieser I, Boltryk S.D, Laffitte M.C, Clark M.A, Gruring C, Ravel D, Blancke Soares A, Demas A, Bopp S, Rubio-Ruiz B, Conejo-Garcia A, Wirth D.F, Gendaszewska-Darmach E, Duraisingh M.T, Adams J.H, Voss T.S, Waters A.P, Jiang R.H.Y, Clardy J, Marti M. Lysophosphatidylcholine regulates sexual stage differentiation in the human malaria parasite Plasmodium falciparum. Cell. 2017;171(7):1532-1544 e15. DOI: 10.1016/j.cell.2017.10.020

2017
Journal Article
PubMed (29129376)

Ngwa C.J, Kiesow M.J, Papst O, Orchard L.M, Filarsky M, Rosinski A.N, Voss T.S, Llinas M, Pradel G. Transcriptional profiling defines histone acetylation as a regulator of gene expression during human-to-mosquito transmission of the malaria parasite Plasmodium falciparum. Front Cell Infect Microbiol. 2017;7:320. DOI: 10.3389/fcimb.2017.00320

2017
Journal Article
PubMed (28791254)
Link

Josling G.A, Petter M, Oehring S.C, Gupta A.P, Dietz O, Wilson D.W, Schubert T, Langst G, Gilson P.R, Crabb B.S, Moes S, Jenoe P, Lim S.W, Brown G.V, Bozdech Z, Voss T.S, Duffy M.F. A Plasmodium falciparum bromodomain protein regulates invasion gene expression. Cell Host Microbe. 2015;17(6):741-751. DOI: 10.1016/j.chom.2015.05.009

2015
Journal Article
PubMed (26067602)

Pelle K.G, Oh K, Buchholz K, Narasimhan V, Joice R, Milner D.A, Brancucci N.M, Ma S, Voss T.S, Ketman K, Seydel K.B, Taylor T.E, Barteneva N.S, Huttenhower C, Marti M. Transcriptional profiling defines dynamics of parasite tissue sequestration during malaria infection. Genome Med. 2015;7:19. DOI: 10.1186/s13073-015-0133-7

2015
Journal Article
PubMed (25722744)

Brancucci N.M, Bertschi N.L, Zhu L, Niederwieser I, Chin W.H, Wampfler R, Freymond C, Rottmann M, Felger I, Bozdech Z, Voss T.S. Heterochromatin protein 1 secures survival and transmission of malaria parasites. Cell Host Microbe. 2014;16(2):165-176. DOI: 10.1016/j.chom.2014.07.004

2014
Journal Article
PubMed (25121746)

Brancucci N.M, Witmer K, Schmid C, Voss T.S. A var gene upstream element controls protein synthesis at the level of translation initiation in Plasmodium falciparum. PLoS One. 2014;9(6):e100183. DOI: 10.1371/journal.pone.0100183

2014
Journal Article
PubMed (24937593)
Link

Dietz O, Rusch S, Brand F, Mundwiler-Pachlatko E, Gaida A, Voss T, Beck H.P. Characterization of the small exported Plasmodium falciparum membrane protein SEMP1. PLoS One. 2014;9(7):e103272. DOI: 10.1371/journal.pone.0103272

2014
Journal Article
PubMed (25062022)
Link

Voss T.S, Bozdech Z, Bartfai R. Epigenetic memory takes center stage in the survival strategy of malaria parasites. Curr Opin Microbiol. 2014;20:88-95. DOI: 10.1016/j.mib.2014.05.007

2014
Journal Article
PubMed (24945736)

Brunner R, Ng C.L, Aissaoui H, Akabas M.H, Boss C, Brun R, Callaghan P.S, Corminboef O, Frame I.J, Heidmann B, Le Bihan A, Jenö P, Mattheis C, Moes S, Müller I.B, Paguio M, Roepe P.D, Siegrist R, Voss T, Welford R.W, Wittlin S, Fidock D.A, Binkert C. UV-triggered affinity-capture identifies interactions between the Plasmodium falciparum multidrug resistance protein 1 (PfMDR1) and antimalarial agents in live parasitized cells. J Biol Chem. 2013;288(31):22576-22583. DOI: 10.1074/jbc.M113.453159

2013
Journal Article
PubMed (23754276)

Brancucci N.M, Witmer K, Schmid C.D, Flueck C, Voss T.S. Identification of a cis-acting DNA-protein interaction implicated in singular var gene choice in Plasmodium falciparum. Cell Microbiol. 2012;14(12):1836-1848. DOI: 10.1111/cmi.12004

2012
Journal Article
PubMed (22891919)

Brunner R, Aissaoui H, Boss C, Bozdech Z, Brun R, Corminboeuf O, Delahaye S, Fischli C, Heidmann B, Kaiser M, Kamber J, Meyer S, Papastogiannidis P, Siegrist R, Voss T, Welford R, Wittlin S, Binkert C. Identification of a new chemical class of antimalarials. J Infect Dis. 2012;206(5):735-743. DOI: 10.1093/infdis/jis418

2012
Journal Article
PubMed (22732921)

Cortés A, Crowley V.M, Vaquero A, Voss T.S. A view on the role of epigenetics in the biology of malaria parasites. PLoS Pathog. 2012;8(12):e1002943. DOI: 10.1371/journal.ppat.1002943

2012
Journal Article
PubMed (23271963)
Link

Dreyer A.M, Matile H, Papastogiannidis P, Kamber J, Favuzza P, Voss T.S, Wittlin S, Pluschke G. Passive immunoprotection of Plasmodium falciparum-infected mice designates the CyRPA as candidate malaria vaccine antigen. J Immunol. 2012;188(12):6225-6237. DOI: 10.4049/jimmunol.1103177

2012
Journal Article
PubMed (22593616)

Hoeijmakers W.A, Flueck C, Françoijs K.J, Smits A.H, Wetzel J, Volz J.C, Cowman A.F, Voss T, Stunnenberg H.G, Bártfai R. Plasmodium falciparum centromeres display a unique epigenetic makeup and cluster prior to and during schizogony. Cell Microbiol. 2012;14(9):1391-1401. DOI: 10.1111/j.1462-5822.2012.01803.x

2012
Journal Article
PubMed (22507744)

Oehring S.C, Woodcroft B.J, Moes S, Wetzel J, Dietz O, Pulfer A, Dekiwadia C, Mäser P, Flück C, Witmer K, Brancucci N.M, Niederwieser I, Jenoe P, Ralph S.A, Voss T.S. Organellar proteomics reveals hundreds of novel nuclear proteins in the malaria parasite Plasmodium falciparum. Genome Biol. 2012;13(11):R108. DOI: 10.1186/gb-2012-13-11-r108

2012
Journal Article
PubMed (23181666)
Link

Witmer K, Schmid C.D, Brancucci N.M, Luah Y.H, Preiser P.R, Bozdech Z, Voss T.S. Analysis of subtelomeric virulence gene families in Plasmodium falciparum by comparative transcriptional profiling. Mol Microbiol. 2012;84(2):243-259. DOI: 10.1111/j.1365-2958.2012.08019.x

2012
Journal Article
PubMed (22435676)

Flueck C, Bartfai R, Niederwieser I, Witmer K, Alako B.T, Moes S, Bozdech Z, Jenoe P, Stunnenberg H.G, Voss T.S. A major role for the Plasmodium falciparum ApiAP2 protein PfSIP2 in chromosome end biology. PLoS Pathog. 2010;6(2):e1000784. DOI: 10.1371/journal.ppat.1000784

2010
Journal Article
PubMed (20195509)
Link

Flueck C, Bartfai R, Volz J, Niederwieser I, Salcedo-Amaya A.M, Alako B.T, Ehlgen F, Ralph S.A, Cowman A.F, Bozdech Z, Stunnenberg H.G, Voss T.S. Plasmodium falciparum heterochromatin protein 1 marks genomic loci linked to phenotypic variation of exported virulence factors. PLoS Pathog. 2009;5(9):e1000569. DOI: 10.1371/journal.ppat.1000569

2009
Journal Article
PubMed (19730695)
Link

Tonkin C.J, Carret C.K, Duraisingh M.T, Voss T.S, Ralph S.A, Hommel M, Duffy M.F, Silva L.M, Scherf A, Ivens A, Speed T.P, Beeson J.G, Cowman A.F. Sir2 paralogues cooperate to regulate virulence genes and antigenic variation in Plasmodium falciparum. PLoS Biol. 2009;7(4):e84. DOI: 10.1371/journal.pbio.1000084

2009
Journal Article
PubMed (19402747)
Link

Treeck M, Tamborrini M, Daubenberger C.A, Gilberger T.W, Voss T.S. Caught in action: mechanistic insights into antibody-mediated inhibition of Plasmodium merozoite invasion. Trends Parasitol. 2009;25(11):494-497. DOI: 10.1016/j.pt.2009.07.008

2009
Journal Article
PubMed (19734093)

Llinas M, Deitsch K.W, Voss T.S. Plasmodium gene regulation: far more to factor in. Trends Parasitol. 2008;24(12):551-556. DOI: 10.1016/j.pt.2008.08.010

2008
Journal Article
PubMed (18929512)

D'Ombrain M.C, Voss T.S, Maier A.G, Pearce J.A, Hansen D.S, Cowman A.F, Schofield L. Plasmodium falciparum erythrocyte membrane protein-1 specifically suppresses early production of host interferon-gamma. Cell Host Microbe. 2007;2(2):130-138. DOI: 10.1016/j.chom.2007.06.012

2007
Journal Article
PubMed (18005727)

Elliott S.R, Spurck T.P, Dodin J.M, Maier A.G, Voss T.S, Yosaatmadja F, Payne P.D, McFadden G.I, Cowman A.F, Rogerson S.J, Schofield L, Brown G.V. Inhibition of dendritic cell maturation by malaria is dose dependent and does not require Plasmodium falciparum erythrocyte membrane protein 1. Infect Immun. 2007;75(7):3621-3632. DOI: 10.1128/IAI.00095-07

2007
Journal Article
PubMed (17470539)

Voss T.S, Tonkin C.J, Marty A.J, Thompson J.K, Healer J, Crabb B.S, Cowman A.F. Alterations in local chromatin environment are involved in silencing and activation of subtelomeric var genes in Plasmodium falciparum. Mol Microbiol. 2007;66(1):139-150. DOI: 10.1111/j.1365-2958.2007.05899.x

2007
Journal Article
PubMed (17725559)

Marty A.J, Thompson J.K, Duffy M.F, Voss T.S, Cowman A.F, Crabb B.S. Evidence that Plasmodium falciparum chromosome end clusters are cross-linked by protein and are the sites of both virulence gene silencing and activation. Mol Microbiol. 2006;62(1):72-83. DOI: 10.1111/j.1365-2958.2006.05364.x

2006
Journal Article
PubMed (16942599)

Voss T.S, Healer J, Marty A.J, Duffy M.F, Thompson J.K, Beeson J.G, Reeder J.C, Crabb B.S, Cowman A.F. A var gene promoter controls allelic exclusion of virulence genes in Plasmodium falciparum malaria. Nature. 2006;439(7079):1004-1008. DOI: 10.1038/nature04407

2006
Journal Article
PubMed (16382237)

Duraisingh M.T, Voss T.S, Marty A.J, Duffy M.F, Good R.T, Thompson J.K, Freitas-Junior L.H, Scherf A, Crabb B.S, Cowman A.F. Heterochromatin silencing and locus repositioning linked to regulation of virulence genes in Plasmodium falciparum. Cell. 2005;121(1):13-24. DOI: 10.1016/j.cell.2005.01.036

2005
Journal Article
PubMed (15820675)

Voss T.S, Kaestli M, Vogel D, Bopp S, Beck H.P. Identification of nuclear proteins that differentially interact with Plasmodium falciparum var gene promoters. Mol Microbiol. 2003;48(6):1593-1607

2003
Journal Article
PubMed (12791141)

Voss T.S, Mini T, Jenoe P, Beck H.P. Plasmodium falciparum possesses a cell-cycle regulated short-type replication protein: a large subunit encodet by an unusual transcript. J Biol Chem. 2003;277(20):17493-17501

2003
Journal Article

Voss T. Extraction and purification of Plasmodium total RNA. Methods Mol Med. 2002;72:151-157. DOI: 10.1385/1-59259-271-6:151

2002
Journal Article
PubMed (12125112)

Voss Till S. Investigation of molecular mechanism underlying variant antigen gene expression in Plasmodium falciparum. Basel: Univ. Basel, 2002. PhD Thesis, University of Basel, Faculty of Science

2002
Thesis

Voss T.S, Thompson J.K, Waterkeyn J, Felger I, Weiss N, Cowman A.F, Beck H.P. Genomic distribution and functional characterisation of two distinct and conserved Plasmodium falciparum var gene 5' flanking sequences. Mol Biochem Parasitol. 2000;107(1):103-115

2000
Journal Article
PubMed (10717306)

Voss Till. Var genes located within subtelomeric region of Plasmodium falciparum chromosomes: analaysis of their genomic organisation and Identification of a conserved 5' flanking region [Diploma thesis]. Basel: Schweizerisches Tropeninstitut, 1997. Diploma

1997
Thesis