Babanezhad Harikandei K, Salehi P, Ebrahimi S.N, Bararjanian M, Kaiser M, Al-Harrasi A. Synthesis, in-vitro antiprotozoal activity and molecular docking study of isothiocyanate derivatives. Bioorg Med Chem. 2020;28(1):115185. DOI: 10.1016/j.bmc.2019.115185

2020
Journal Article
PubMed (31784198)

Chung J.H, Tang A.H, Geraghty K, Corcilius L, Kaiser M, Payne R.J. Total synthesis and antitrypanosomal activity of janadolide and simplified analogues. Org Lett. 2020(in press). DOI: 10.1021/acs.orglett.0c00840

2020
Journal Item
PubMed (32251602)

Dawidowski M, Kalel V.C, Napolitano V, Fino R, Schorpp K, Emmanouilidis L, Lenhart D, Ostertag M, Kaiser M, Kolonko M, Tippler B, Schliebs W, Dubin G, Mäser P, Tetko I.V, Hadian K, Plettenburg O, Erdmann R, Sattler M, Popowicz G.M. Structure-activity relationship in pyrazolo[4,3-c]pyridines, first inhibitors of PEX14-PEX5 protein-protein interaction with trypanocidal activity. J Med Chem. 2020;63(2):847-879. DOI: 10.1021/acs.jmedchem.9b01876

2020
Journal Article
PubMed (31860309)

Fesser A.F, Braissant O, Olmo F, Kelly J.M, Mäser P, Kaiser M. Non-invasive monitoring of drug action: a new live in vitro assay design for Chagas' disease drug discovery. PLoS Negl Trop Dis. 2020;14(7):e0008487. DOI: 10.1371/journal.pntd.0008487

2020
Journal Article
PubMed (32716934)
Link

Greve H.L, Kaiser M, Schmidt T.J. Investigation of antiplasmodial effects of terpenoid compounds isolated from myrrh. Planta Med. 2020;86(9):643-654. DOI: 10.1055/a-1157-9463

2020
Journal Article
PubMed (32365391)

Hagen J.P, Darner G, Anderson S, Higgins K, Leas D.A, Mitra A, Mashinson V, Wol T, Vera-Esquivel C, Belter B, Cal M, Kaiser M, Wallick A, Warner R.C, Davis P.H. Activity of diphenyl ether benzyl amines against Human African Trypanosomiasis. Bioorg Chem. 2020;97:103590. DOI: 10.1016/j.bioorg.2020.103590

2020
Journal Article
PubMed (32179269)

Harrison J.R, Sarkar S, Hampton S, Riley J, Stojanovski L, Sahlberg C, Appelqvist P, Erath J, Mathan V, Rodriguez A, Kaiser M, Pacanowska D.G, Read K.D, Johansson N.G, Gilbert I.H. Discovery and optimization of a compound series active against Trypanosoma cruzi, the causative agent of chagas disease. J Med Chem. 2020;63(6):3066-3089. DOI: 10.1021/acs.jmedchem.9b01852

2020
Journal Article
PubMed (32134269)

Kaiser M, Mäser P. In vitro drug efficacy testing against Trypanosoma brucei. In: Michels P.A.M,Ginger M.L,Zilberstein D, eds. Trypanosomatids: methods and protocols. 2116, 781-789. New York: Springer, 2020. DOI: 10.1007/978-1-0716-0294-2_46

2020
Book Section
PubMed (32221955)

Mahmoud A.B, Danton O, Kaiser M, Han S, Moreno A, Abd Algaffar S, Khalid S, Oh W.K, Hamburger M, Mäser P. Lignans, amides, and saponins from Haplophyllum tuberculatum and their antiprotozoal activity. Molecules. 2020;25(12):2825. DOI: 10.3390/molecules25122825

2020
Journal Article
PubMed (32575379)
Link

Mahmoud A.B, Mäser P, Kaiser M, Hamburger M, Khalid S. Mining sudanese medicinal plants for antiprotozoal agents. Front Pharmacol. 2020;11:865. DOI: 10.3389/fphar.2020.00865

2020
Journal Article
PubMed (32581814)
Link

Ponzi S, Bresciani A, Kaiser M, Nardi V, Nizi E, Ontoria J.M, Pace P, Paonessa G, Summa V, Harper S. Discovery of 4-((1-(1H-imidazol-2-yl)alkoxy)methyl)pyridines as a new class of Trypanosoma cruzi growth inhibitors. Bioorg Med Chem Lett. 2020;30(8):127052. DOI: 10.1016/j.bmcl.2020.127052

2020
Journal Article
PubMed (32113841)

Rao S.P.S, Lakshminarayana S.B, Jiricek J, Kaiser M, Ritchie R, Myburgh E, Supek F, Tuntland T, Nagle A, Molteni V, Maser P, Mottram J.C, Barrett M.P, Diagana T.T. Anti-trypanosomal proteasome inhibitors cure hemolymphatic and meningoencephalic murine infection models of african trypanosomiasis. Trop Med Infect Dis. 2020;5:28. DOI: 10.3390/tropicalmed5010028

2020
Journal Article
PubMed (32079320)
Link

Saldivia M, Fang E, Ma X, Myburgh E, Carnielli JBT, Bower-Lepts C, Brown E, Ritchie R, Lakshminarayana SB, Chen YL, Patra D, Ornelas E, Koh HXY, Williams SL, Supek F, Paape D, McCulloch R, Kaiser M, Barrett MP, Jiricek J, Diagana TT, Mottram JC, Rao SPS. Targeting the trypanosome kinetochore with CLK1 protein kinase inhibitors. Nat Microbiol. 2020(in press). DOI: 10.1038/s41564-020-0745-6

2020
Journal Article
PubMed (32661312)

Tasdemir D, MacIntosh A.J.J, Stergiou P, Kaiser M, Mansour N.R, Bickle Q, Huffman M.A. Antiprotozoal and antihelminthic properties of plants ingested by wild Japanese macaques (Macaca fuscata yakui) in Yakushima Island. J Ethnopharmacol. 2020;247:112270. DOI: 10.1016/j.jep.2019.112270

2020
Journal Article
PubMed (31589965)

Wang X, Cal M, Kaiser M, Buckner F.S, Lepesheva G.I, Sanford A.G, Wallick A.I, Davis P.H, Vennerstrom J.L. A new chemotype with promise against Trypanosoma cruzi. Bioorg Med Chem Lett. 2020;30:126778. DOI: 10.1016/j.bmcl.2019.126778

2020
Journal Article
PubMed (31706668)

Zadali R, Nejad Ebrahimi S, Tofighi Z, Es-Haghi A, Hamburger M, Kaiser M, D' Ambola M, De Tommasi N, Hadjiakhoondi A. Antiprotozoal activity of diterpenoids isolated from Zhumeria majdae- absolute configuration by circular dichroism. Daru. 2020(in press). DOI: 10.1007/s40199-020-00345-w

2020
Journal Article
PubMed (32394309)

Zhao L, Vo T.D, Kaiser M, Bode H.B. Phototemtide A, a cyclic lipopeptide heterologously expressed from Photorhabdus temperata Meg1, shows selective antiprotozoal activity. Chembiochem. 2020;21(9):1288-1292. DOI: 10.1002/cbic.201900665

2020
Journal Item
PubMed (31814269)

Babanezhad Harikandei K, Salehi P, Ebrahimi S.N, Bararjanian M, Kaiser M, Khavasi H.R, Al-Harrasi A. N-substituted noscapine derivatives as new antiprotozoal agents: synthesis, antiparasitic activity and molecular docking study. Bioorg Chem. 2019;91:103116. DOI: 10.1016/j.bioorg.2019.103116

2019
Journal Article
PubMed (31377384)

De Gasparo R, Halgas O, Harangozo D, Kaiser M, Pai E.F, Krauth-Siegel R.L, Diederich F. Targeting a large active site: structure-based design of nanomolar inhibitors of Trypanosoma brucei trypanothione reductase. Chem Eur J. 2019;25(49):11416-11421. DOI: 10.1002/chem.201901664

2019
Journal Article
PubMed (31407832)

Fayez S, Li J, Feineis D, Ake Assi L, Kaiser M, Brun R, Anany M.A, Wajant H, Bringmann G. A near-complete series of four atropisomeric jozimine A2-Type naphthylisoquinoline dimers with antiplasmodial and cytotoxic activities and related alkaloids from Ancistrocladus abbreviatus. J Nat Prod. 2019;82(11):3033-3046. DOI: 10.1021/acs.jnatprod.9b00589

2019
Journal Article
PubMed (31642313)

Galkina A, Krause N, Lenz M, Daniliuc C.G, Kaiser M, Schmidt T.J. Antitrypanosomal activity of sesquiterpene lactones from Helianthus tuberosus L. including a new furanoheliangolide with an unusual structure. Molecules. 2019;24(6):1068. DOI: 10.3390/molecules24061068

2019
Journal Article
PubMed (30889936)
Link

Hochegger P, Faist J, Seebacher W, Saf R, Mäser P, Kaiser M, Weis R. Antiprotozoal activities of tetrazole-quinolines with aminopiperidine linker. Med Chem. 2019;15(4):409-416. DOI: 10.2174/1573406414666181015115101

2019
Journal Article
PubMed (30324885)

Hochegger P, Faist J, Seebacher W, Saf R, Mäser P, Kaiser M, Weis R. Synthesis and structure-activity relationships for new 6-fluoroquinoline derivatives with antiplasmodial activity. Bioorg Med Chem. 2019;27(10):2052-2065. DOI: 10.1016/j.bmc.2019.03.061

2019
Journal Article
PubMed (30962114)

Hoffelner M, Petritsch M, Ahmad S, Seebacher W, Dolensky J, Hochegger P, Kaiser M, Mäser P, Saf R, Weis R. New derivatives of 3-azabicyclo[3.2.2]nonanes and their antiprotozoal activities. Monatsh Chem. 2019;150(11):1959-1972. DOI: 10.1007/s00706-019-02509-0

2019
Journal Article

Kimani N.M, Backhaus S, Matasyoh J.C, Kaiser M, Herrmann F.C, Schmidt T.J, Langer K. Preparation of sesquiterpene lactone-loaded PLA nanoparticles and evaluation of their antitrypanosomal activity. Molecules. 2019;24(11):2110. DOI: 10.3390/molecules24112110

2019
Journal Article
PubMed (31167374)
Link

Mofidi Tabatabaei S, Nejad Ebrahimi S, Salehi P, Sonboli A, Tabefam M, Kaiser M, Hamburger M, Moridi Farimani M. Antiprotozoal germacranolide sesquiterpene lactones from Tanacetum sonbolii. Planta Med. 2019;85(5):424-430. DOI: 10.1055/a-0824-1294

2019
Journal Article
PubMed (30620946)

Mohsin N.U.A, Seebacher W, Hochegger P, Faist J, Saf R, Kaiser M, Mäser P, Weis R. Synthesis of new 1-benzyl tetrahydropyridin-4-ylidene piperidinium salts and their antiplasmodial and antitrypanosomal activities. Med Chem Res. 2019;28(5):742-753. DOI: 10.1007/s00044-019-02331-7

2019
Journal Article

Mufusama J.P, Feineis D, Mudodo V, Kaiser M, Brun R, Bringmann G. Antiprotozoal dimeric naphthylisoquinolines, mbandakamines B3 and B4, and related 5,80'-coupled monomeric alkaloids, ikelacongolines A–D, from a Congolese Ancistrocladus liana. RSC Adv. 2019;9(21):12034-12046. DOI: 10.1039/c9ra01784d

2019
Journal Article
Link

Pérez-Moreno G, Sánchez-Carrasco P, Ruiz-Pérez L.M, Johansson N.G, Muller S, Baragaña B, Hampton S.E, Gilbert I.H, Kaiser M, Sarkar S, Pandurangan T, Kumar V, Gonzalez-Pacanowska D. Validation of Plasmodium falciparum dUTPase as the target of 5'-tritylated deoxyuridine analogues with anti-malarial activity. Malar J. 2019;18:392. DOI: 10.1186/s12936-019-3025-2

2019
Journal Article
PubMed (31796083)
Link

Saccoliti F, Madia V.N, Tudino V, De Leo A, Pescatori L, Messore A, De Vita D, Scipione L, Brun R, Kaiser M, Mäser P, Calvet Alvarez C.M, Jennings G.K, Podust L.M, Pepe G, Cirilli R, Faggi C, Di Marco A, Battista M.R, Summa V, Costi R, Di Santo R. Design, synthesis, and biological evaluation of new 1-(Aryl-1H-pyrrolyl)(phenyl)methyl-1H-imidazole derivatives as antiprotozoal agents. J Med Chem. 2019;62(3):1330-1347. DOI: 10.1021/acs.jmedchem.8b01464

2019
Journal Article
PubMed (30615444)

Shi Y.N, Pusch S, Shi Y.M, Richter C, Macia-Vicente J.G, Schwalbe H, Kaiser M, Opatz T, Bode H.B. (+/-)-Alternarlactones A and B, two antiparasitic alternariol-like dimers from the fungus Alternaria alternata p1210 isolated from the halophyte Salicornia sp. J Org Chem. 2019;84(17):11203-11209. DOI: 10.1021/acs.joc.9b01229

2019
Journal Article
PubMed (31409073)

Smeilus T, Mousavizadeh F, Krieger J, Tu X, Kaiser M, Giannis A. Synthesis and biological investigation of (+)-3-hydroxymethylartemisinin. Beilstein J Org Chem. 2019;15:567-570. DOI: 10.3762/bjoc.15.51

2019
Journal Article
PubMed (30873241)
Link

Tasdemir D, Kaiser M, Demirci B, Demirci F, Baser K.H.C. Antiprotozoal activity of Turkish Origanum onites essential oil and its components. Molecules. 2019;24(23):4421. DOI: 10.3390/molecules24234421

2019
Journal Article
PubMed (31817023)
Link

Tshitenge D.T, Bruhn T, Feineis D, Mudogo V, Kaiser M, Brun R, Bringmann G. An unusually broad series of seven cyclombandakamines, bridged dimeric naphthylisoquinoline alkaloids from the Congolese liana Ancistrocladus ealaensis. Sci Rep. 2019;9:9812. DOI: 10.1038/s41598-019-46336-z

2019
Journal Article
PubMed (31285489)
Link

Tshitenge D.T, Bruhn T, Feineis D, Schmidt D, Mudogo V, Kaiser M, Brun R, Wurthner F, Awale S, Bringmann G. Ealamines A-H, a series of naphthylisoquinolines with the rare 7,8'-coupling site, from the Congolese liana Ancistrocladus ealaensis, targeting pancreatic cancer cells. J Nat Prod. 2019;82(11):3150-3164. DOI: 10.1021/acs.jnatprod.9b00755

2019
Journal Article
PubMed (31630523)
Link

Zhao L, Awori R.M, Kaiser M, Gross J, Opatz T, Bode H.B. Structure, biosynthesis, and bioactivity of photoditritide from Photorhabdus temperata Meg1. J Nat Prod. 2019;82(12):3499-3503. DOI: 10.1021/acs.jnatprod.9b00932

2019
Journal Article
PubMed (31799840)

Cretton S, Oyarzun A, Righi D, Sahib L, Kaiser M, Christen P, Fajardo V. A new antifungal and antiprotozoal bibenzyl derivative from Gavilea lutea. Nat Prod Res. 2018;32(6):695-701. DOI: 10.1080/14786419.2017.1338287

2018
Journal Article
PubMed (28595455)

De Gasparo R, Brodbeck-Persch E, Bryson S, Hentzen N.B, Kaiser M, Pai E.F, Krauth-Siegel R.L, Diederich F. Biological evaluation and x-ray co-crystal structures of cyclohexylpyrrolidine ligands for trypanothione reductase, an enzyme from the redox metabolism of trypanosoma. ChemMedChem. 2018;13(9):957-967. DOI: 10.1002/cmdc.201800067

2018
Journal Article
PubMed (29624890)

Ebiloma G.U, Ayuga T.D, Balogun E.O, Gil L.A, Donachie A, Kaiser M, Herraiz T, Inaoka D.K, Shiba T, Harada S, Kita K. Inhibition of trypanosome alternative oxidase without its N-terminal mitochondrial targeting signal (ΔMTS-TAO) by cationic and non-cationic 4-hydroxybenzoate and 4-alkoxybenzaldehyde derivatives active against T. brucei and T. congolense. Eur J Med Chem. 2018;150:385-402. DOI: 10.1016/j.ejmech.2018.02.075

2018
Journal Article
PubMed (29544150)

Farimani M.M, Khodaei B, Moradi H, Aliabadi A, Ebrahimi S.N, De Mieri M, Kaiser M, Hamburger M. Phytochemical study of Salvia leriifolia roots: rearranged abietane diterpenoids with antiprotozoal activity. J Nat Prod. 2018;81(6):1384-1390. DOI: 10.1021/acs.jnatprod.7b01019

2018
Journal Article
PubMed (29896963)