Bosch F, Palmeirim M.S, Ali S.M, Ame S.M, Hattendorf J, Keiser J. Diagnosis of soil-transmitted helminths using the Kato-Katz technique: what is the influence of stirring, storage time and storage temperature on stool sample egg counts?. PLoS Negl Trop Dis. 2021;15:e0009032. DOI: 10.1371/journal.pntd.0009032

2021
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PubMed (33481808)
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Brussee J.M, Hiroshige N, Neodo A, Coulibaly J.T, Pfister M, Keiser J. Population pharmacokinetics and exposure-response analysis of tribendimidine to improve treatment for children with hookworm infection. Antimicrob Agents Chemother. 2021;65(2):e01778-20. DOI: 10.1128/AAC.01778-20

2021
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PubMed (33139293)

Brussee J.M, Neodo A, Schulz J.D, Coulibaly J.T, Pfister M, Keiser J. Pharmacometric analysis of tribendimidine mono- and combination therapies to achieve high cure rates in patients with hookworm infections. Antimicrob Agents Chemother. 2021;65(2):e00714-20. DOI: 10.1128/AAC.00714-20

2021
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PubMed (33139276)

Buchter V, Schneeberger P.H.H, Keiser J. Validation of a human-serum-based in vitro growth method for drug screening on juvenile development stages of Schistosoma mansoni. PLoS Negl Trop Dis. 2021;15(3):e0009313. DOI: 10.1371/journal.pntd.0009313

2021
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PubMed (33784302)
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Debbert S.L, Hintz M.J, Bell C.J, Earl K.R, Forsythe G.E, Häberli C, Keiser J. Activities of quinoxaline, nitroquinoxaline and [1,2,4]triazolo[4,3-a]quinoxaline analogs of MMV007204 against Schistosoma mansoni. Antimicrob Agents Chemother. 2021(in press). DOI: 10.1128/AAC.01370-20

2021
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PubMed (33257453)

Hofmann D, Sayasone S, Keiser J. Development and validation of an LC-MS/MS method for the quantification of the anthelmintic drug moxidectin in a volumetric absorptive microsample, blood, and plasma: application to a pharmacokinetic study of adults infected with Strongyloides stercor. J Chromatogr B Analyt Technol Biomed Life Sci. 2021;1166:122556. DOI: 10.1016/j.jchromb.2021.122556

2021
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PubMed (33535101)

Hofmann D, Sayasone S, Sengngam K, Chongvilay B, Hattendorf J, Keiser J. Efficacy and safety of ascending doses of moxidectin against Strongyloides stercoralis infections in adults: a randomised, parallel-group, single-blinded, placebo-controlled, dose-ranging, phase 2a trial. Lancet Infect Dis. 2021(in press). DOI: 10.1016/S1473-3099(20)30691-5

2021
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PubMed (33798487)

Jittamala P, Monteiro W, Smit M.R, Pedrique B, Specht S, Chaccour C.J, Dard C, Del Giudice P, Khieu V, Maruani A, Failoc-Rojas V.E, Saez-de-Ocariz M, Soriano-Arandes A, Piquero-Casals J, Faisant A, Brenier-Pinchart M.P, Wimmersberger D, Coulibaly J.T, Keiser J, Boralevi F, Sokana O, Marks M, Engelman D, Romani L, Steer A.C, von Seidlein L, White N.J, Harriss E, Stepniewska K, Humphreys G.S, Kennon K, Guerin P.J, Kobylinski K.C. A systematic review and an individual patient data meta-analysis of ivermectin use in children weighing less than fifteen kilograms: is it time to reconsider the current contraindication?. PLoS Negl Trop Dis. 2021;15(3):e0009144. DOI: 10.1371/journal.pntd.0009144

2021
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PubMed (33730099)
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Keiser J, Häberli C. Evaluation of commercially available anthelminthics in laboratory models of human intestinal nematode infections. ACS Infect Dis. 2021(in press). DOI: 10.1021/acsinfecdis.0c00719

2021
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PubMed (33410658)

Keller L, Hürlimann E, Patel C, Welsche S, Sayasone S, Ali S.M, Ame S.M, Coulibaly J.T, Keiser J. Insights gained from conductinga randomised controlled trial onIvermectin-albendazole against Trichuris trichiurain Côte d’Ivoire, Lao PDR and Pemba Island. Adv Parasitol. 2021;111:253-276. DOI: 10.1016/bs.apar.2020.11.001

2021
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PubMed (33482976)

Nguyen W, Lee E.F, Evangelista M, Lee M, Harris T.J, Colman P.M, Smith N.A, Williams L.B, Jarman K.E, Lowes K.N, Häberli C, Keiser J, Smith B.J, Fairlie W.D, Sleebs B.E. Optimization of benzothiazole and thiazole hydrazones as inhibitors of schistosome bcl-2a. ACS Infect Dis. 2021(in press). DOI: 10.1021/acsinfecdis.0c00700

2021
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PubMed (33523649)

Palmeirim M.S, Mrimi E.C, Minja E.G, Samson A.J, Keiser J. A cross-sectional survey on parasitic infections in schoolchildren in a rural Tanzanian community. Acta Trop. 2021;213:105737. DOI: 10.1016/j.actatropica.2020.105737

2021
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PubMed (33159895)

Partridge F.A, Bataille C.J.R, Forman R, Marriott A.E, Forde-Thomas J, Häberli C, Dinsdale R.L, O'Sullivan J.D.B, Willis N.J, Wynne G.M, Whiteland H, Archer J, Steven A, Keiser J, Turner J.D, Hoffmann K.F, Taylor M.J, Else K.J, Russell A.J, Sattelle D.B. Structural requirements for dihydrobenzoxazepinone anthelmintics: actions against medically important and model parasites: Trichuris muris, Brugia malayi, Heligmosomoides polygyrus, and Schistosoma mansoni. ACS Infect Dis. 2021(in press). DOI: 10.1021/acsinfecdis.1c00025

2021
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PubMed (33797218)

Patel C, Keller L, Welsche S, Hattendorf J, Sayasone S, Ali S.M, Ame S.M, Coulibaly J.T, Hurlimann E, Keiser J. Assessment of fecal calprotectin and fecal occult blood as point-of-care markers for soil-transmitted helminth attributable intestinal morbidity in a case-control substudy conducted in Cote d'Ivoire, Lao PDR and Pemba Island, Tanzania. EClinicalMedicine. 2021;32:100724. DOI: 10.1016/j.eclinm.2021.100724

2021
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PubMed (33554091)
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Sólveig Palmeirim M, Specht S, Scandale I, Gander-Meisterernst I, Chabicovsky M, Keiser J. Preclinical and clinical characteristics of the trichuricidal drug oxantel pamoate and clinical development plans: a review. Drugs. 2021(in press). DOI: 10.1007/s40265-021-01505-1

2021
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PubMed (33929716)
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Sy I, Margardt L, Ngbede E.O, Adah M.I, Yusuf S.T, Keiser J, Rehner J, Utzinger J, Poppert S, Becker S.L. Identification of adult Fasciola spp. using matrix-assisted laser/desorption ionization time-of-flight (MALDI-TOF) mass spectrometry. Microorganisms. 2021;9:82. DOI: 10.3390/microorganisms9010082

2021
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Barda B, Schindler C, Wampfler R, Ame S, Ali S.M, Keiser J. Comparison of real-time PCR and the Kato-Katz method for the diagnosis of soil-transmitted helminthiasis and assessment of cure in a randomized controlled trial. BMC Microbiol. 2020;20:298. DOI: 10.1186/s12866-020-01963-9

2020
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PubMed (33008301)
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Buchter V, Ong Y.C, Mouvet F, Ladaycia A, Lepeltier E, Rothlisberger U, Keiser J, Gasser G. Multidisciplinary preclinical investigations on three oxamniquine analogues as novel drug candidates for schistosomiasis. Chemistry. 2020;26:15232 –15241. DOI: 10.1002/chem.202002856

2020
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PubMed (32852116)

Buchter V, Priotti J, Leonardi D, Lamas M.C, Keiser J. Activity of novel oral formulations of albendazole and mebendazole against Heligmosomoides polygyrus in vitro and in vivo. J Pharm Sci. 2020;109(5):1819-1826. DOI: 10.1016/j.xphs.2020.02.002

2020
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PubMed (32070702)

Buchter V, Priotti J, Leonardi D, Lamas M.C, Keiser J. Preparation, physicochemical characterization and in vitro and in vivo activity against Heligmosomoides polygyrus of novel oral formulations of albendazole and mebendazole. J Pharm Sci. 2020;109(5):1819-1826. DOI: 10.1016/j.xphs.2020.02.002

2020
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PubMed (32070702)

De Rycker M, Horn D, Aldridge B, Amewu R.K, Barry C.E, Buckner F.S, Cook S, Ferguson M.A.J, Gobeau N, Herrmann J, Herrling P, Hope W, Keiser J, Lafuente-Monasterio M.J, Leeson P.D, Leroy D, Manjunatha U.H, McCarthy J, Miles T.J, Mizrahi V, Moshynets O, Niles J, Overington J.P, Pottage J, Rao S.P.S, Read K.D, Ribeiro I, Silver L.L, Southern J, Spangenberg T, Sundar S, Taylor C, Van Voorhis W, White N.J, Wyllie S, Wyatt P.G, Gilbert I.H. Setting our sights on infectious diseases. ACS Infect Dis. 2020;6(1):3-13. DOI: 10.1021/acsinfecdis.9b00371

2020
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Else K.J, Keiser J, Holland C.V, Grencis R.K, Sattelle D.B, Fujiwara R.T, Bueno L.L, Asaolu S.O, Sowemimo O.A, Cooper P.J. Whipworm and roundworm infections. Nat Rev Dis Primers. 2020;6(1):44. DOI: 10.1038/s41572-020-0171-3

2020
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Keiser J, Koch V, Deckers A, Cheung H.T.A, Jung N, Brase S. Naturally occurring cardenolides affecting Schistosoma mansoni. ACS Infect Dis. 2020;6(7):1922-1927. DOI: 10.1021/acsinfecdis.0c00175

2020
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Keller L, Palmeirim M.S, Ame S.M, Ali S.M, Puchkov M, Huwyler J, Hattendorf J, Keiser J. Efficacy and safety of ascending dosages of moxidectin and moxidectin-albendazole against Trichuris trichiura in adolescents: a randomized controlled trial. Clin Infect Dis. 2020;70(6):1193-1201. DOI: 10.1093/cid/ciz326

2020
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PubMed (31044235)

Keller L, Patel C, Welsche S, Schindler T, Hürlimann E, Keiser J. Performance of the Kato-Katz method and real time polymerase chain reaction for the diagnosis of soil-transmitted helminthiasis in the framework of a randomised controlled trial: treatment efficacy and day-to-day variation. Parasit Vectors. 2020;13(1):517. DOI: 10.1186/s13071-020-04401-x

2020
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Levecke B, Cools P, Albonico M, Ame S, Angebault C, Ayana M, Behnke J.M, Bethony J.M, Cringoli G, Dana D, Guillard B, Viet Hoa N.T, Kang G, Kattula D, Keiser J, Kotze A.C, Matoso L.F, Maurelli M.P, McCarthy J.S, Mekonnen Z, Mirams G, Montresor A, Oliveira R.C, Periago M.V, Pinto S.A, Rinaldi L, Sayasone S, Sumo L, Tchuem-Tchuenté L.A, Cam Thach D.T, Thomas E, Zeynudin A, Verweij J.J, Vlaminck J, Vercruysse J. Identifying thresholds to classify moderate-to-heavy soil-transmitted helminth intensity infections for FECPAKG2, McMaster, Mini-FLOTAC and qPCR. PLoS Negl Trop Dis. 2020;14(7):e0008296. DOI: 10.1371/journal.pntd.0008296

2020
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Lin Y, Ong Y.C, Keller S, Karges J, Bouchene R, Manoury E, Blacque O, Müller J, Anghel N, Hemphill A, Häberli C, Taki A.C, Gasser R.B, Cariou K, Keiser J, Gasser G. Synthesis, characterization and antiparasitic activity of organometallic derivatives of the anthelmintic drug albendazole. Dalton Trans. 2020;49(20):6616-6626. DOI: 10.1039/d0dt01107j

2020
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Lombardo F.C, Ravaynia P.S, Modena M.M, Hierlemann A, Keiser J. Evaluation of human liver microtissues for drug screening on Schistosoma mansoni schistosomula. ACS Infect Dis. 2020(in press). DOI: 10.1021/acsinfecdis.0c00614

2020
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PubMed (33105989)

Moser W, Keiser J, Speich B, Sayasone S, Knopp S, Hattendorf J. One mean to rule them all? The arithmetic mean based egg reduction rate can be misleading when estimating anthelminthic drug efficacy in clinical trials. PLoS Negl Trop Dis. 2020;14(4):e0008185. DOI: 10.1371/journal.pntd.0008185

2020
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PubMed (32267856)
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Olliaro P.L, Coulibaly J.T, Garba A, Halleux C, Keiser J, King C.H, Mutapi F, N'Goran E.K, Raso G, Scherrer A.U, Sousa-Figueiredo J.C, Stete K, Utzinger J, Vaillant M.T. Efficacy and safety of single 40 mg/kg oral praziquantel in the treatment of schistosomiasis in preschool-age versus school-age children: an individual participant data meta-analysis. PLoS Negl Trop Dis. 2020;14(6):e0008277. DOI: 10.1371/journal.pntd.0008277

2020
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Palmeirim M.S, Bosch F, Ame S.M, Ali S.M, Hattendorf J, Keiser J. Efficacy, safety and acceptability of a new chewable formulationversusthe solid tablet of mebendazole against hookworm infections in children: an open-label, randomized controlled trial. EClinicalMedicine. 2020;27:100556. DOI: 10.1016/j.eclinm.2020.100556

2020
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PubMed (33150325)
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Palmeirim M.S, Ross A, Obrist B, Mohammed U.A, Ame S.M, Ali S.M, Keiser J. Informed consent procedure in a double blind randomized anthelminthic trial on Pemba Island, Tanzania: do pamphlet and information session increase caregivers knowledge?. BMC Med Ethics. 2020;21:1. DOI: 10.1186/s12910-019-0441-3

2020
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Patel C, Coulibaly J.T, Hofmann D, N'Gbesso Y, Hattendorf J, Keiser J. Efficacy and safety of albendazole in hookworm-infected preschool-aged children, school-aged children and adults in Côte d'Ivoire: a phase II randomized controlled dose-finding trial. Clin Infect Dis. 2020(in press). DOI: 10.1093/cid/ciaa989

2020
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Patel C, Coulibaly J.T, Schulz J.D, N'Gbesso Y, Hattendorf J, Keiser J. Efficacy and safety of ascending dosages of albendazole against Trichuris trichiura in preschool-aged children, school-aged children and adults: a multi-cohort randomized controlled trial. EClinicalMedicine. 2020;22:100335. DOI: 10.1016/j.eclinm.2020.100335

2020
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Probst A, Häberli C, Siegel D, Huang J, Vigneron S, Ta A.P, Skinner D.E, El-Sakkary N, Momper J.D, Gangoiti J, Dong Y, Vennerstrom J.L, Charman S.A, Caffrey C.R, Keiser J. Efficacy, metabolism and pharmacokinetics of Ro 15-5458, a forgotten schistosomicidal 9-acridanone hydrazone. J Antimicrob Chemother. 2020:dkaa247. DOI: 10.1093/jac/dkaa247

2020
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PubMed (32617557)

Ravaynia P.S, Lombardo F.C, Biendl S, Dupuch M.A, Keiser J, Hierlemann A, Modena M.M. Parallelized impedance-based platform for continuous dose-response characterization of antischistosomal drugs. Adv Biosyst. 2020;4(7):e1900304. DOI: 10.1002/adbi.201900304

2020
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PubMed (32510834)

Twumasi E.B, Akazue P.I, Kyeremeh K, Gwira T.M, Keiser J, Cho-Ngwa F, Flint A, Anibea B, Bonsu E.Y, Amewu R.K, Amoah L.E, Appiah-Opong R, Osei-Safo D. Antischistosomal, antionchocercal and antitrypanosomal potentials of some Ghanaian traditional medicines and their constituents. PLoS Negl Trop Dis. 2020;14(12):e0008919. DOI: 10.1371/journal.pntd.0008919

2020
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PubMed (33382717)
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Vlaminck J, Cools P, Albonico M, Ame S, Ayana M, Dana D, Keiser J, Matoso L.F, Montresor A, Mekonnen Z, Correa-Oliveira R, Pinto S.A, Sayasone S, Vercruysse J, Levecke B. An in-depth report of quality control on Kato-Katz and data entry in four clinical trials evaluating the efficacy of albendazole against soil-transmitted helminth infections. PLoS Negl Trop Dis. 2020;14(9):e0008625. DOI: 10.1371/journal.pntd.0008625

2020
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Vlaminck J, Cools P, Albonico M, Ame S, Chanthapaseuth T, Viengxay V, Do Trung D, Osei-Atweneboana M.Y, Asuming-Brempong E, Jahirul Karim M, Al Kawsar A, Keiser J, Khieu V, Faye B, Turate I, Mbonigaba J.B, Ruijeni N, Shema E, Lucianez A, Santiago Nicholls R, Jamsheed M, Mikhailova A, Montresor A, Mupfasoni D, Yajima A, Ngina Mwinzi P, Gilleard J, Prichard R.K, Verweij J.J, Vercruysse J, Levecke B. Piloting a surveillance system to monitor the global patterns of drug efficacy and the emergence of anthelmintic resistance in soil-transmitted helminth control programs: a Starworms study protocol. Gates Open Res. 2020;4:28. DOI: 10.12688/gatesopenres.13115.1

2020
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PubMed (32266328)
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Wagner-Hattler L, Quebatte G, Keiser J, Schoelkopf J, Schleputz C.M, Huwyler J, Puchkov M. Study of drug particle distributions within mini-tablets using synchrotron X-ray microtomography and superpixel image clustering. Int J Pharm. 2020;573:118827. DOI: 10.1016/j.ijpharm.2019.118827

2020
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PubMed (31756443)