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2021
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McCartney D.L, Min J.L, Richmond R.C, Lu A.T, Sobczyk M.K, Davies G, Broer L, Guo X, Jeong A, Jung J, Kasela S, Katrinli S, Kuo P.L, Matias-Garcia P.R, Mishra P.P, Nygaard M, Palviainen T, Patki A, Raffield L.M, Ratliff S.M, Richardson T.G, Robinson O, Soerensen M, Sun D, Tsai P.C, van der Zee M.D, Walker R.M, Wang X, Wang Y, Xia R, Xu Z, Yao J, Zhao W, Correa A, Boerwinkle E, Dugue P.A, Durda P, Elliott H.R, Gieger C, Genetics of DNA Methylation Consortium, de Geus E.J.C, Harris S.E, Hemani G, Imboden M, Kahonen M, Kardia S.L.R, Kresovich J.K, Li S, Lunetta K.L, Mangino M, Mason D, McIntosh A.M, Mengel-From J, Moore A.Z, Murabito J.M, NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium, Ollikainen M, Pankow J.S, Pedersen N.L, Peters A, Polidoro S, Porteous D.J, Raitakari O, Rich S.S, Sandler D.P, Sillanpaa E, Smith A.K, Southey M.C, Strauch K, Tiwari H, Tanaka T, Tillin T, Uitterlinden A.G, Van Den Berg D.J, van Dongen J, Wilson J.G, Wright J, Yet I, Arnett D, Bandinelli S, Bell J.T, Binder A.M, Boomsma D.I, Chen W, Christensen K, Conneely K.N, Elliott P, Ferrucci L, Fornage M, Hagg S, Hayward C, Irvin M, Kaprio J, Lawlor D.A, Lehtimaki T, Lohoff F.W, Milani L, Milne R.L, Probst-Hensch N, Reiner A.P, Ritz B, Rotter J.I, Smith J.A, Taylor J.A, van Meurs J.B.J, Vineis P, Waldenberger M, Deary I.J, Relton C.L, Horvath S, Marioni R.E. Genome-wide association studies identify 137 genetic loci for DNA methylation biomarkers of aging. Genome Biol. 2021;22:194. (TOPMed). DOI: 10.1186/s13059-021-02398-9

2021
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Probst-Hensch N, Jeong A, Stolz D, Pons M, Soccal P.M, Bettschart R, Jarvis D, Holloway J.W, Kronenberg F, Imboden M, Schindler C, Lovison G.F. Causal effects of body mass index on airflow obstruction and forced mid-expiratory flow: a mendelian randomization study taking interactions and age-specific instruments into consideration toward a life course perspective. Front Public Health. 2021;9:584955. DOI: 10.3389/fpubh.2021.584955

2021
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van Nunen E, Hoek G, Tsai M.Y, Probst-Hensch N, Imboden M, Jeong A, Naccarati A, Tarallo S, Raffaele D, Nieuwenhuijsen M, Vlaanderen J, Gulliver J, Amaral A.F.S, Vineis P, Vermeulen R. Short-term personal and outdoor exposure to ultrafine and fine particulate air pollution in association with blood pressure and lung function in healthy adults. Environ Res. 2021;194:110579. DOI: 10.1016/j.envres.2020.110579

2021
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Accordini S, Calciano L, Marcon A, Pesce G, Anto J.M, Beckmeyer-Borowko A.B, Carsin A.E, Corsico A.G, Imboden M, Janson C, Keidel D, Locatelli F, Svanes C, Burney P.G.J, Jarvis D, Probst-Hensch N.M, Minelli C. Incidence trends of airflow obstruction among European adults without asthma: a 20-year cohort study. Sci Rep. 2020;10:3452. DOI: 10.1038/s41598-020-60478-5

2020
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Aebi N.J, Bringolf-Isler B, Schaffner E, Caviezel S, Imboden M, Probst-Hensch N. Patterns of cross-sectional and predictive physical activity in Swiss adults aged 52+: results from the SAPALDIA cohort. Swiss Med Wkly. 2020;150:w20266. DOI: 10.4414/smw.2020.20266

2020
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Amaral A.F.S, Imboden M, Wielscher M, Rezwan F.I, Minelli C, Garcia-Aymerich J, Peralta G.P, Auvinen J, Jeong A, Schaffner E, Beckmeyer-Borowko A, Holloway J.W, Jarvelin M.R, Probst-Hensch N.M, Jarvis D.L, ALEC consortium. Role of DNA methylation in the association of lung function with body mass index: a two-step epigenetic Mendelian randomisation study. BMC Pulm Med. 2020;20:171. DOI: 10.1186/s12890-020-01212-9

2020
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Carsin A.E, Keidel D, Fuertes E, Imboden M, Weyler J, Nowak D, Heinrich J, Pascual Erquicia S, Martinez-Moratalla J, Huerta I, Sanchez J.L, Schaffner E, Caviezel S, Beckmeyer-Borowko A, Raherison C, Pin I, Demoly P, Leynaert B, Cerveri I, Squillacioti G, Accordini S, Gislason T, Svanes C, Toren K, Forsberg B, Janson C, Jogi R, Emtner M, Gomez Real F, Jarvis D, Guerra S, Dharmage S.C, Probst-Hensch N, Garcia-Aymerich J. Regular physical activity levels and incidence of restrictive spirometry pattern: a longitudinal analysis of two population-based cohorts. Am J Epidemiol. 2020;89(12):1521-1528. DOI: 10.1093/aje/kwaa087

2020
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Cerletti P, Eze I.C, Schaffner E, Foraster M, Vienneau D, Cajochen C, Wunderli J.M, Röösli M, Stolz D, Pons M, Imboden M, Probst-Hensch N. The independent association of source-specific transportation noise exposure, noise annoyance and noise sensitivity with health-related quality of life. Environ Int. 2020;143:105960. DOI: 10.1016/j.envint.2020.105960

2020
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Cerletti P, Keidel D, Imboden M, Schindler C, Probst-Hensch N. The modifying role of physical activity in the cross-sectional and longitudinal association of health-related quality of life with physiological functioning-based latent classes and metabolic syndrome. Health Qual Life Outcomes. 2020;18:345. DOI: 10.1186/s12955-020-01557-z

2020
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Demetz E, Tymoszuk P, Hilbe R, Volani C, Haschka D, Heim C, Auer K, Lener D, Zeiger L.B, Pfeifhofer-Obermair C, Boehm A, Obermair G.J, Ablinger C, Coassin S, Lamina C, Kager J, Petzer V, Asshoff M, Schroll A, Nairz M, Dichtl S, Seifert M, von Raffay L, Fischer C, Barros-Pinkelnig M, Brigo N, Valente de Souza L, Sopper S, Hirsch J, Graber M, Gollmann-Tepekoylu C, Holfeld J, Halper J, Macheiner S, Gostner J, Vogel G.F, Pechlaner R, Moser P, Imboden M, Marques-Vidal P, Probst-Hensch N.M, Meiselbach H, Strauch K, Peters A, Paulweber B, Willeit J, Kiechl S, Kronenberg F, Theurl I, Tancevski I, Weiss G. The haemochromatosis gene Hfe and Kupffer cells control LDL cholesterol homeostasis and impact on atherosclerosis development. Eur Heart J. 2020;41(40):3949-3959. DOI: 10.1093/eurheartj/ehaa140

2020
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Eze I.C, Foraster M, Schaffner E, Vienneau D, Pieren R, Imboden M, Wunderli J.M, Cajochen C, Brink M, Röösli M, Probst-Hensch N. Incidence of depression in relation to transportation noise exposure and noise annoyance in the SAPALDIA study. Environ Int. 2020;144:106014. DOI: 10.1016/j.envint.2020.106014

2020
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Eze I.C, Jeong A, Schaffner E, Rezwan F.I, Ghantous A, Foraster M, Vienneau D, Kronenberg F, Herceg Z, Vineis P, Brink M, Wunderli J.M, Schindler C, Cajochen C, Röösli M, Holloway J.W, Imboden M, Probst-Hensch N. Genome-wide DNA methylation in peripheral blood and long-term exposure to source-specific transportation noise and air pollution: the SAPALDIA study. Environ Health Perspect. 2020;128(6):67003. DOI: 10.1289/EHP6174

2020
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Fawcett K.A, Obeidat M, Melbourne C, Shrine N, Guyatt A.L, John C, Luan J, Richmond A, Moksnes M.R, Granell R, Weiss S, Imboden M, May-Wilson S, Hysi P, Boutin T.S, Portas L, Flexeder C, Harris S.E, Wang C.A, Lyytikainen L.P, Palviainen T, Foong R.E, Keidel D, Minelli C, Langenberg C, Bosse Y, Van den Berge M, Sin D.D, Hao K, Campbell A, Porteous D, Padmanabhan S, Smith B.H, Evans D.M, Ring S, Langhammer A, Hveem K, Willer C, Ewert R, Stubbe B, Pirastu N, Klaric L, Joshi P.K, Patasova K, Massimo M, Polasek O, Starr J.M, Karrasch S, Strauch K, Meitinger T, Rudan I, Rantanen T, Pietilainen K, Kahonen M, Raitakari O.T, Hall G.L, Sly P.D, Pennell C.E, Kaprio J, Lehtimaki T, Vitart V, Deary I.J, Jarvis D, Wilson J.F, Spector T, Probst-Hensch N, Wareham N.J, Volzke H, Henderson J, Strachan D.P, Brumpton B.M, Hayward C, Hall I.P, Tobin M.D, Wain L.V. Variants associated with HHIP expression have sex-differential effects on lung function. Wellcome Open Res. 2020;5:111. DOI: 10.12688/wellcomeopenres.15846.1

2020
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Hoang T.T, Sikdar S, Xu C.J, Lee M.K, Cardwell J, Forno E, Imboden M, Jeong A, Madore A.M, Qi C, Wang T, Bennett B.D, Ward J.M, Parks C.G, Beane-Freeman L.E, King D, Motsinger-Reif A, Umbach D.M, Wyss A.B, Schwartz D.A, Celedon J.C, Laprise C, Ober C, Probst-Hensch N, Yang I.V, Koppelman G.H, London S.J. Epigenome-wide association study of DNA methylation and adult asthma in the agricultural lung health study. Eur Respir J. 2020;56(3). DOI: 10.1183/13993003.00217-2020

2020
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Mancini F.R, Laine J.E, Tarallo S, Vlaanderen J, Vermeulen R, van Nunen E, Hoek G, Probst-Hensch N, Imboden M, Jeong A, Gulliver J, Chadeau-Hyam M, Nieuwenhuijsen M, de Kok T.M, Piepers J, Krauskopf J, Kleinjans J.C.S, Vineis P, Naccarati A. microRNA expression profiles and personal monitoring of exposure to particulate matter. Environ Pollut. 2020;263(Pt B):114392. DOI: 10.1016/j.envpol.2020.114392

2020
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Rezwan F.I, Imboden M, Amaral A.F.S, Wielscher M, Jeong A, Triebner K, Real F.G, Jarvelin M.R, Jarvis D, Probst-Hensch N.M, Holloway J.W. Association of adult lung function with accelerated biological aging. Aging. 2020;12(1):518-542. DOI: 10.18632/aging.102639

2020
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Schmidt J.C, Vogt S, Imboden M, Schaffner E, Grize L, Zemp E, Probst-Hensch N, Zitzmann N.U. Dental and periodontal health in a Swiss population-based sample of older adults: a cross-sectional study. Eur J Oral Sci. 2020;128:508-517. DOI: 10.1111/eos.12738

2020
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van Nunen E, Vermeulen R, Tsai M.Y, Probst-Hensch N, Ineichen A, Imboden M, Naccarati A, Tarallo S, Raffaele D, Ranzi A, Nieuwenhuijsen M, Jarvis D, Amaral A.F, Vlaanderen J, Meliefste K, Brunekreef B, Vineis P, Gulliver J, Hoek G. Associations between modeled residential outdoor and measured personal exposure to ultrafine particles in four European study areas. Atmos Environ. 2020;226:117353. DOI: 10.1016/j.atmosenv.2020.117353

2020
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West E.A, Anker D, Amati R, Richard A, Wisniak A, Butty A, Albanese E, Bochud M, Chiolero A, Crivelli L, Cullati S, d'Acremont V, Epure A.M, Fehr J, Flahault A, Fornerod L, Frank I, Frei A, Michel G, Gonseth S, Guessous I, Imboden M, Kahlert C.R, Kaufmann L, Kohler P, Mösli N, Paris D, Probst-Hensch N, Rodondi N, Stringhini S, Vermes T, Vollrath F, Puhan M.A, Corona Immunitas Research Group. Corona immunitas: study protocol of a nationwide program of SARS-CoV-2 seroprevalence and seroepidemiologic studies in Switzerland. Int J Public Health. 2020;65:1529–1548. DOI: 10.1007/s00038-020-01494-0

2020
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Carsin A.E, Fuertes E, Schaffner E, Jarvis D, Antó J.M, Heinrich J, Bellisario V, Svanes C, Keidel D, Imboden M, Weyler J, Nowak D, Martinez-Moratalla J, Gullón J.A, Sanchez Ramos J.L, Caviezel S, Beckmeyer-Borowko A, Raherison C, Pin I, Demoly P, Cerveri I, Accordini S, Gislason T, Toren K, Forsberg B, Janson C, Jogi R, Emtner M, Gómez Real F, Raza W, Leynaert B, Pascual S, Guerra S, Dharmage S.C, Probst-Hensch N, Garcia-Aymerich J. Restrictive spirometry pattern is associated with low physical activity levels. A population based international study. Respir Med. 2019;146:116-123. DOI: 10.1016/j.rmed.2018.11.017

2019
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Eze I.C, Essé C, Bassa F.K, Koné S, Acka F, Schindler C, Imboden M, Laubhouet-Koffi V, Kouassi D, N'Goran E.K, Utzinger J, Bonfoh B, Probst-Hensch N. Asymptomatic Plasmodium infection and glycemic control in adults: results from a population-based survey in south-central Côte d'Ivoire. Diabetes Res Clin Pract. 2019;156:107845. DOI: 10.1016/j.diabres.2019.107845

2019
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Imboden M, Wielscher M, Rezwan F.I, Amaral A.F.S, Schaffner E, Jeong A, Beckmeyer-Borowko A, Harris S.E, Starr J.M, Deary I.J, Flexeder C, Waldenberger M, Peters A, Schulz H, Chen S, Sunny S.K, Karmaus W.J.J, Jiang Y, Erhart G, Kronenberg F, Arathimos R, Sharp G.C, Henderson A.J, Fu Y, Piirilä P, Pietiläinen K.H, Ollikainen M, Johansson A, Gyllensten U, de Vries M, van der Plaat D.A, de Jong K, Boezen H.M, Hall I.P, Tobin M.D, Jarvelin M.R, Holloway J.W, Jarvis D, Probst-Hensch N.M. Epigenome-wide association study of lung function level and its change. Eur Respir J. 2019;54:1900457. DOI: 10.1183/13993003.00457-2019

2019
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Jeong A, Imboden M, Ghantous A, Novoloaca A, Carsin A.E, Kogevinas M, Schindler C, Lovison G, Herceg Z, Cuenin C, Vermeulen R, Jarvis D, Amaral A.F.S, Kronenberg F, Vineis P, Probst-Hensch N. DNA methylation in inflammatory pathways modifies the association between BMI and adult-onset non-atopic asthma. Int J Environ Res Public Health. 2019;16(4):600. DOI: 10.3390/ijerph16040600

2019
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Meier-Girard D, Delgado-Eckert E, Schaffner E, Schindler C, Künzli N, Adam M, Pichot V, Kronenberg F, Imboden M, Frey U, Probst-Hensch N. Association of long-term exposure to traffic-related PM10 with heart rate variability and heart rate dynamics in healthy subjects. Environ Int. 2019;125:107-116. DOI: 10.1016/j.envint.2019.01.031

2019
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Mostafavi N, Jeong A, Vlaanderen J, Imboden M, Vineis P, Jarvis D, Kogevinas M, Probst-Hensch N, Vermeulen R. The mediating effect of immune markers on the association between ambient air pollution and adult-onset asthma. Sci Rep. 2019;9:8818. DOI: 10.1038/s41598-019-45327-4

2019
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Sakornsakolpat P, Prokopenko D, Lamontagne M, Reeve N.F, Guyatt A.L, Jackson V.E, Shrine N, Qiao D, Bartz T.M, Kim D.K, Lee M.K, Latourelle J.C, Li X, Morrow J.D, Obeidat M, Wyss A.B, Bakke P, Barr R.G, Beaty T.H, Belinsky S.A, Brusselle G.G, Crapo J.D, de Jong K, DeMeo D.L, Fingerlin T.E, Gharib S.A, Gulsvik A, Hall I.P, Hokanson J.E, Kim W.J, Lomas D.A, London S.J, Meyers D.A, O'Connor G.T, Rennard S.I, Schwartz D.A, Sliwinski P, Sparrow D, Strachan D.P, Tal-Singer R, Tesfaigzi Y, Vestbo J, Vonk J.M, Yim J.J, Zhou X, Bosse Y, Manichaikul A, Lahousse L, Silverman E.K, Boezen H.M, Wain L.V, Tobin M.D, Hobbs B.D, Cho M.H, SpiroMeta Consortium, International COPD Genetics Consortium. Genetic landscape of chronic obstructive pulmonary disease identifies heterogeneous cell-type and phenotype associations. Nat Genet. 2019;51(3):494-505. DOI: 10.1038/s41588-018-0342-2

2019
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Shrine N, Guyatt A.L, Erzurumluoglu A.M, Jackson V.E, Hobbs B.D, Melbourne C.A, Batini C, Fawcett K.A, Song K, Sakornsakolpat P, Li X, Boxall R, Reeve N.F, Obeidat M, Zhao J.H, Wielscher M, Understanding Society Scientific Group, Weiss S, Kentistou K.A, Cook J.P, Sun B.B, Zhou J, Hui J, Karrasch S, Imboden M, Harris S.E, Marten J, Enroth S, Kerr S.M, Surakka I, Vitart V, Lehtimäki T, Allen R.J, Bakke P.S, Beaty T.H, Bleecker E.R, Bossé Y, Brandsma C.A, Chen Z, Crapo J.D, Danesh J, DeMeo D.L, Dudbridge F, Ewert R, Gieger C, Gulsvik A, Hansell A.L, Hao K, Hoffman J.D, Hokanson J.E, Homuth G, Joshi P.K, Joubert P, Langenberg C, Li X, Li L, Lin K, Lind L, Locantore N, Luan J, Mahajan A, Maranville J.C, Murray A, Nickle D.C, Packer R, Parker M.M, Paynton M.L, Porteous D.J, Prokopenko D, Qiao D, Rawal R, Runz H, Sayers I, Sin D.D, Smith B.H, Soler Artigas M, Sparrow D, Tal-Singer R, Timmers Prhj, Van den Berge M, Whittaker J.C, Woodruff P.G, Yerges-Armstrong L.M, Troyanskaya O.G, Raitakari O.T, Kähönen M, Polašek O, Gyllensten U, Rudan I, Deary I.J, Probst-Hensch N.M, Schulz H, James A.L, Wilson J.F, Stubbe B, Zeggini E, Jarvelin M.R, Wareham N, Silverman E.K, Hayward C, Morris A.P, Butterworth A.S, Scott R.A, Walters R.G, Meyers D.A, Cho M.H, Strachan D.P, Hall I.P, Tobin M.D, Wain L.V. New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries. Nat Genet. 2019;51(3):481-493. DOI: 10.1038/s41588-018-0321-7

2019
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Shrine N, Guyatt A.L, Erzurumluoglu A.M, Jackson V.E, Hobbs B.D, Melbourne C.A, Batini C, Fawcett K.A, Song K, Sakornsakolpat P, Li X, Boxall R, Reeve N.F, Obeidat M, Zhao J.H, Wielscher M, Understanding Society Scientific Group, Weiss S, Kentistou K.A, Cook J.P, Sun B.B, Zhou J, Hui J, Karrasch S, Imboden M, Harris S.E, Marten J, Enroth S, Kerr S.M, Surakka I, Vitart V, Lehtimaki T, Allen R.J, Bakke P.S, Beaty T.H, Bleecker E.R, Bosse Y, Brandsma C.A, Chen Z, Crapo J.D, Danesh J, DeMeo D.L, Dudbridge F, Ewert R, Gieger C, Gulsvik A, Hansell A.L, Hao K, Hoffman J.D, Hokanson J.E, Homuth G, Joshi P.K, Joubert P, Langenberg C, Li X, Li L, Lin K, Lind L, Locantore N, Luan J, Mahajan A, Maranville J.C, Murray A, Nickle D.C, Packer R, Parker M.M, Paynton M.L, Porteous D.J, Prokopenko D, Qiao D, Rawal R, Runz H, Sayers I, Sin D.D, Smith B.H, Artigas M.S, Sparrow D, Tal-Singer R, Timmers Prhj, Van den Berge M, Whittaker J.C, Woodruff P.G, Yerges-Armstrong L.M, Troyanskaya O.G, Raitakari O.T, Kahonen M, Polasek O, Gyllensten U, Rudan I, Deary I.J, Probst-Hensch N.M, Schulz H, James A.L, Wilson J.F, Stubbe B, Zeggini E, Jarvelin M.R, Wareham N, Silverman E.K, Hayward C, Morris A.P, Butterworth A.S, Scott R.A, Walters R.G, Meyers D.A, Cho M.H, Strachan D.P, Hall I.P, Tobin M.D, Wain L.V. Author correction: New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries. Nat Genet. 2019;51:1067-1068. DOI: 10.1038/s41588-019-0438-3

2019
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Accordini S, Calciano L, Marcon A, Pesce G, Anto J, Beckmeyer-Borowko A, Corsico A, Imboden M, Janson C, Keidel D, Locatelli F, Svanes C, Jarvis D, Probst-Hensch N, Minelli C. Incidence of airflow obstruction over 20 years in Europe. Eur Respir J, 2018;52(Suppl. 62):PA2267. DOI: 10.1183/13993003.congress-2018.PA2267

2018
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Amaral A.F.S, Imboden M, Wielscher M, Rezwan F.I, Minelli C, Garcia-Aymerich J, Peralta G.P, Auvinen J, Jeong A, Schaffner E, Beckmeyer-Borowko A, Holloway J.W, Jarvelin M.R, Probst-Hensch N, Jarvis D.L. Body mass index and lung function: a two-step epigenetic Mendelian randomization study. Eur Respir J, 2018;52(Suppl. 62):PA1276. DOI: 10.1183/13993003.congress-2018.PA1276

2018
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Beckmeyer-Borowko A, Imboden M, Rezwan F.I, Wielscher M, Amaral A.F.S, Jeong A, Schaffner E, Auvinen J, Sebert S, Karhunen V, Bettschart R, Turk A, Pons M, Stolz D, Kronenberg F, Arathimos R, Sharp G.C, Relton C, Henderson A.J, Jarvelin M.R, Jarvis D, Holloway J.W, Probst-Hensch N.M. SERPINA1 methylation and lung function in tobacco-smoke exposed European children and adults: a meta-analysis of ALEC population-based cohorts. Respir Res. 2018;19(1):156. DOI: 10.1186/s12931-018-0850-8

2018
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Carsin A.E, Keidel D, Fuertes E, Imboden M, Weyler J, Nowak D, Heinrich J, Urrutia I, Martinez-Moratalla J, Caviezel S, Beckmeyer-Borowko A, Raherison C, Pin I, Demoly P, Leynaert B, Cerveri I, Bono R, Accordini S, Amaral A, Gislason T, Svanes C, Toren K, Forsberg B, Janson C, Dharmage S, Jogi R, Anto J, Probst-Hensch N, Garcia-Aymerich J. Physical activity and incidence of restrictive spirometry pattern in adults. Eur Respir J, 2018;52(Suppl. 62):PA5289. DOI: 10.1183/13993003.congress-2018.PA5289

2018
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Curjuric I, Imboden M, Bettschart R, Caviezel S, Dratva J, Pons M, Rothe T, Schmidt-Trucksäss A, Stolz D, Thun G.A, Eckardstein A.V, Kronenberg F, Ferrarotti I, Probst-Hensch N.M. Alpha-1 antitrypsin deficiency: from the lung to the heart?. Atherosclerosis. 2018;270:166-172. DOI: 10.1016/j.atherosclerosis.2018.01.042

2018
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Demenais F, Margaritte-Jeannin P, Barnes K.C, Cookson W.O.C, Altmuller J, Ang W, Barr R.G, Beaty T.H, Becker A.B, Beilby J, Bisgaard H, Bjornsdottir U.S, Bleecker E, Bonnelykke K, Boomsma D.I, Bouzigon E, Brightling C.E, Brossard M, Brusselle G.G, Burchard E, Burkart K.M, Bush A, Chan-Yeung M, Chung K.F, Couto Alves A, Curtin J.A, Custovic A, Daley D, de Jongste J.C, Del-Rio-Navarro B.E, Donohue K.M, Duijts L, Eng C, Eriksson J.G, Farrall M, Fedorova Y, Feenstra B, Ferreira M.A, Freidin M.B, Gajdos Z, Gauderman J, Gehring U, Geller F, Genuneit J, Gharib S.A, Gilliland F, Granell R, Graves P.E, Gudbjartsson D.F, Haahtela T, Heckbert S.R, Heederik D, Heinrich J, Heliovaara M, Henderson J, Himes B.E, Hirose H, Hirschhorn J.N, Hofman A, Holt P, Hottenga J, Hudson T.J, Hui J, Imboden M, Ivanov V, Jaddoe V.W.V, James A, Janson C, Jarvelin M.R, Jarvis D, Jones G, Jonsdottir I, Jousilahti P, Kabesch M, Kahonen M, Kantor D.B, Karunas A.S, Khusnutdinova E, Koppelman G.H, Kozyrskyj A.L, Kreiner E, Kubo M, Kumar R, Kumar A, Kuokkanen M, Lahousse L, Laitinen T, Laprise C, Lathrop M, Lau S, Lee Y.A, Lehtimaki T, Letort S, Levin A.M, Li G, Liang L, Loehr L.R, London S.J, Loth D.W, Manichaikul A, Marenholz I, Martinez F.J, Matheson M.C, Mathias R.A, Matsumoto K, Mbarek H, McArdle W.L, Melbye M, Melen E, Meyers D, Michel S, Mohamdi H, Musk A.W, Myers R.A, Nieuwenhuis M.A.E, Noguchi E, O'Connor G.T, Ogorodova L.M, Palmer C.D, Palotie A, Park J.E, Pennell C.E, Pershagen G, Polonikov A, Postma D.S, Probst-Hensch N, Puzyrev V.P, Raby B.A, Raitakari O.T, Ramasamy A, Rich S.S, Robertson C.F, Romieu I, Salam M.T, Salomaa V, Schlunssen V, Scott R, Selivanova P.A, Sigsgaard T, Simpson A, Siroux V, Smith L.J, Solodilova M, Standl M, Stefansson K, Strachan D.P, Stricker B.H, Takahashi A, Thompson P.J, Thorleifsson G, Thorsteinsdottir U, Tiesler C.M.T, Torgerson D.G, Tsunoda T, Uitterlinden A.G, Van der Valk R.J.P, Vaysse A, Vedantam S, Von Berg A, Von Mutius E, Vonk J.M, Waage J, Wareham N.J, Weiss S.T, White W.B, Wickman M, Widen E, Willemsen G, Williams L.K, Wouters I.M, Yang J.J, Zhao J.H, Moffatt M.F, Ober C, Nicolae D.L, Australian Asthma Genetics Consortium Collaborators. Multiancestry association study identifies new asthma risk loci that colocalize with immune-cell enhancer marks. Nat Genet. 2018;50:42-53. (AAGC). DOI: 10.1038/s41588-017-0014-7

2018
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Gulliver J, Morley D, Dunster C, McCrea A, Van Nunen E, Tsai M, Probst-Hensch N, Eeftens M, Imboden M, Ducret-Stich R, Naccarati A, Cirachi M, Vermeulen, Vineis P, Hoek G, Kelly F.J. Land use regression models for the oxidative potential of fine particles (PM2.5) in five European areas. Environ Res. 2018;160:247-255. DOI: 10.1016/j.envres.2017.10.002

2018
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Htun N.S.N, Odermatt P, Paboriboune P, Sayasone S, Vongsakid M, Phimolsarn-Nusith V, Tran X.D, Ounnavong P.S, Andriama-Hefasoa N, Senvanpan N.D, Homsana A, Lianosay B, Xayavong D, Robinson D.R, Bounsavath P, Prasayasith P.P, Syphan S.D, Lu Y.X, Thilakoun K, Xaiyaphet X.S, Vongngakesone P.T, Eze I.C, Imboden M, Sripa B, Reinharz D, Probst-Hensch N. Association between helminth infections and diabetes mellitus in adults from the Lao People's Democratic Republic: a cross-sectional study. Infect Dis Poverty. 2018;7:105. DOI: 10.1186/s40249-018-0488-2

2018
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Jackson V.E, Latourelle J.C, Wain L.V, Smith A.V, Grove M.L, Bartz T.M, Obeidat M, Province M.A, Gao W, Qaiser B, Porteous D.J, Cassano P.A, Ahluwalia T.S, Grarup N, Li J, Altmaier E, Marten J, Harris S.E, Manichaikul A, Pottinger T.D, Li-Gao R, Lind-Thomsen A, Mahajan A, Lahousse L, Imboden M, Teumer A, Prins B, Lyytikainen L.P, Eiriksdottir G, Franceschini N, Sitlani C.M, Brody J.A, Bosse Y, Timens W, Kraja A, Loukola A, Tang W, Liu Y, Bork-Jensen J, Justesen J.M, Linneberg A, Lange L.A, Rawal R, Karrasch S, Huffman J.E, Smith B.H, Davies G, Burkart K.M, Mychaleckyj J.C, Bonten T.N, Enroth S, Lind L, Brusselle G.G, Kumar A, Stubbe B, Understanding Society Scientific Group, Kahonen M, Wyss A.B, Psaty B.M, Heckbert S.R, Hao K, Rantanen T, Kritchevsky S.B, Lohman K, Skaaby T, Pisinger C, Hansen T, Schulz H, Polasek O, Campbell A, Starr J.M, Rich S.S, Mook-Kanamori D.O, Johansson A, Ingelsson E, Uitterlinden A.G, Weiss S, Raitakari O.T, Gudnason V, North K.E, Gharib S.A, Sin D.D, Taylor K.D, O'Connor G.T, Kaprio J, Harris T.B, Pederson O, Vestergaard H, Wilson J.G, Strauch K, Hayward C, Kerr S, Deary I.J, Barr R.G, de Mutsert R, Gyllensten U, Morris A.P, Ikram M.A, Probst-Hensch N, Glaser S, Zeggini E, Lehtimaki T, Strachan D.P, Dupuis J, Morrison A.C, Hall I.P, Tobin M.D, London S.J. Meta-analysis of exome array data identifies six novel genetic loci for lung function. Wellcome Open Res. 2018;3:4. DOI: 10.12688/wellcomeopenres.12583.3

2018
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Jeong A, Fiorito G, Keski-Rahkonen P, Imboden M, Kiss A, Robinot N, Gmuender H, Vlaandere J, Vermeulen R, Kyrtopoulos S, Herceg Z, Ghantous A, Lovison G, Galassi C, Ranzi A, Krogh V, Grioni S, Agnoli C, Sacerdote C, Mostafavi N, Naccarati A, Scalbert A, Vineis P, Probst-Hensch N, EXPOsOMICS Consortium. Perturbation of metabolic pathways mediates the association of air pollutants with asthma and cardiovascular diseases. Environ Int. 2018;119:334-345. DOI: 10.1016/j.envint.2018.06.025

2018
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Marcon A, Locatelli F, Keidel D, Beckmeyer-Borowko A.B, Cerveri I, Dharmage S.C, Fuertes E, Garcia-Aymerich J, Heinrich J, Imboden M, Janson C, Johannessen A, Leynaert B, Pascual Erquicia S, Pesce G, Schaffner E, Svanes C, Urrutia I, Jarvis D, Probst-Hensch N.M, Accordini S, Ageing Lungs in European Cohorts study. Airway responsiveness to methacholine and incidence of COPD: an international prospective cohort study. Thorax. 2018;73(9):825-832. DOI: 10.1136/thoraxjnl-2017-211289

2018
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Mostafavi N, Vermeulen R, Ghantous A, Hoek G, Probst-Hensch N, Herceg Z, Tarallo S, Naccarati A, Kleinjans J.C.S, Imboden M, Jeong A, Morley D, Amaral A.F.S, Van Nunen E, Gulliver J, Chadeau-Hyam M, Vineis P, Vlaanderen J. Acute changes in DNA methylation in relation to 24 h personal air pollution exposure measurements: a panel study in four European countries. Environ Int. 2018;120:11-21. DOI: 10.1016/j.envint.2018.07.026

2018
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Veil R, Mohamdi H, Granell R, Ege M, Freidin M.B, Imboden M, James A, Jarvis D, Khusnutdinova E.K, Laprise C, Margaritte-Jeannin P, Ogorodova L.O, Sarnowski C, Marie-Helene, Henderson D.A.J, Karunas A.S, Von Mutius E, Probst-Hensch N.M, Leynaert B, Demenais F, Bouzigon E. Influence of gene-by-sex interaction on time-to-asthma onset: a large-scale genome-wide meta-analysis. Eur Respir J, 2018;52(Suppl. 62):OA2190. DOI: 10.1183/13993003.congress-2018.OA2190

2018
Conference Paper

Vonk J.M, Nieuwenhuis M.A.E, Dijk F.N, Boudier A, Siroux V, Bouzigon E, Probst-Hensch N, Imboden M, Keidel D, Sin D, Bossé Y, Hao K, van den Berge M, Faiz A, Koppelman G.H, Postma D.S. Novel genes and insights in complete asthma remission: a genome-wide association study on clinical and complete asthma remission. Clin Exp Allergy. 2018;48(10):1286-1296. DOI: 10.1111/cea.13181

2018
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Waage J, Standl M, Curtin J.A, Jessen L.E, Thorsen J, Tian C, Schoettler N, Me Research Team, AAGC collaborators, Flores C, Abdellaoui A, Ahluwalia T.S, Alves A.C, Amaral A.F.S, Anto J.M, Arnold A, Barreto-Luis A, Baurecht H, van Beijsterveldt C.E.M, Bleecker E.R, Bonas-Guarch S, Boomsma D.I, Brix S, Bunyavanich S, Burchard E.G, Chen Z, Curjuric I, Custovic A, den Dekker H.T, Dharmage S.C, Dmitrieva J, Duijts L, Ege M.J, Gauderman W.J, Georges M, Gieger C, Gilliland F, Granell R, Gui H, Hansen T, Heinrich J, Henderson J, Hernandez-Pacheco N, Holt P, Imboden M, Jaddoe V.W.V, Jarvelin M.R, Jarvis D.L, Jensen K.K, Jonsdottir I, Kabesch M, Kaprio J, Kumar A, Lee Y.A, Levin A.M, Li X, Lorenzo-Diaz F, Melen E, Mercader J.M, Meyers D.A, Myers R, Nicolae D.L, Nohr E.A, Palviainen T, Paternoster L, Pennell C.E, Pershagen G, Pino-Yanes M, Probst-Hensch N.M, Ruschendorf F, Simpson A, Stefansson K, Sunyer J, Sveinbjornsson G, Thiering E, Thompson P.J, Torrent M, Torrents D, Tung J.Y, Wang C.A, Weidinger S, Weiss S, Willemsen G, Williams L.K, Ober C, Hinds D.A, Ferreira M.A, Bisgaard H, Strachan D.P, Bonnelykke K. Genome-wide association and HLA fine-mapping studies identify risk loci and genetic pathways underlying allergic rhinitis [Letter]. Nat Genet. 2018;50(8):1072-1080. DOI: 10.1038/s41588-018-0157-1

2018
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Waage J, Standl M, Curtin J.A, Jessen L.E, Thorsen J, Tian C, Schoettler N, Me Research Team, AAGC collaborators, Flores C, Abdellaoui A, Ahluwalia T.S, Alves A.C, Amaral A.F.S, Anto J.M, Arnold A, Barreto-Luis A, Baurecht H, van Beijsterveldt C.E.M, Bleecker E.R, Bonas-Guarch S, Boomsma D.I, Brix S, Bunyavanich S, Burchard E.G, Chen Z, Curjuric I, Custovic A, den Dekker H.T, Dharmage S.C, Dmitrieva J, Duijts L, Ege M.J, Gauderman W.J, Georges M, Gieger C, Gilliland F, Granell R, Gui H, Hansen T, Heinrich J, Henderson J, Hernandez-Pacheco N, Holt P, Imboden M, Jaddoe V.W.V, Jarvelin M.R, Jarvis D.L, Jensen K.K, Jonsdottir I, Kabesch M, Kaprio J, Kumar A, Lee Y.A, Levin A.M, Li X, Lorenzo-Diaz F, Melen E, Mercader J.M, Meyers D.A, Myers R, Nicolae D.L, Nohr E.A, Palviainen T, Paternoster L, Pennell C.E, Pershagen G, Pino-Yanes M, Probst-Hensch N.M, Ruschendorf F, Simpson A, Stefansson K, Sunyer J, Sveinbjornsson G, Thiering E, Thompson P.J, Torrent M, Torrents D, Tung J.Y, Wang C.A, Weidinger S, Weiss S, Willemsen G, Williams L.K, Ober C, Hinds D.A, Ferreira M.A, Bisgaard H, Strachan D.P, Bonnelykke K. Author correction: Genome-wide association and HLA fine-mapping studies identify risk loci and genetic pathways underlying allergic rhinitis (Nature Genetics, (2018), 50, 8, (1072-1080), 10.1038/s41588-018-0157-1). Nat Genet. 2018;50(9):1343. DOI: 10.1038/s41588-018-0197-6

2018
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Adam M, Imboden M, Schaffner E, Boes E, Kronenberg F, Pons M, Bettschart R, Barthelemy J.C, Schindler C, Probst-Hensch N. The adverse impact of obesity on heart rate variability is modified by a NFE2L2 gene variant: the SAPALDIA Cohort. Int J Cardiol. 2017;228:341-346. DOI: 10.1016/j.ijcard.2016.11.049

2017
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De Jong K, Vonk J.M, Imboden M, Lahousse L, Hofman A, Brusselle G.G, Probst-Hensch N.M, Postma D.S, Boezen H.M. Genes and pathways underlying susceptibility to impaired lung function in the context of environmental tobacco smoke exposure. Respir Res. 2017;18:142. DOI: 10.1186/s12931-017-0625-7

2017
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Eze I.C, Esse C, Bassa F.K, Koné S, Acka F, Yao L, Imboden M, Jaeger F.N, Schindler C, Dosso M, Laubhouet-Koffi V, Kouassi D, N'Goran E.K, Utzinger J, Bonfoh B, Probst-Hensch N. Côte d'Ivoire Dual Burden of Disease (CoDuBu): study protocol to investigate the co-occurrence of chronic infections and noncommunicable diseases in rural settings of epidemiological transition. JMIR Res Protoc. 2017;6(10):e210. DOI: 10.2196/resprot.8599

2017
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Eze I.C, Foraster M, Schaffner E, Vienneau D, Héritier H, Rudzik F, Thiesse L, Pieren R, Imboden M, von Eckardstein A, Schindler C, Brink M, Cajochen C, Wunderli J.M, Röösli M, Probst-Hensch N. Long-term exposure to transportation noise and air pollution in relation to incident diabetes in the SAPALDIA study. Int J Epidemiol. 2017;46(4):1115-1125. DOI: 10.1093/ije/dyx020

2017
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Eze I.C, Imboden M, Foraster M, Schaffner E, Kumar A, Vienneau D, Héritier H, Rudzik F, Thiesse L, Pieren R, von Eckardstein A, Schindler C, Brink M, Wunderli J.M, Cajochen C, Röösli M, Probst-Hensch N. Exposure to night-time traffic noise, melatonin-regulating gene variants and change in glycemia in adults. Int J Environ Res Public Health. 2017;14(12):E1492. DOI: 10.3390/ijerph14121492

2017
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Gorski M, van der Most P.J, Teumer A, Chu A.Y, Li M, Mijatovic V, Nolte I.M, Cocca M, Taliun D, Gomez F, Li Y, Tayo B, Tin A, Feitosa M.F, Aspelund T, Attia J, Biffar R, Bochud M, Boerwinkle E, Borecki I, Bottinger E.P, Chen M.H, Chouraki V, Ciullo M, Coresh J, Cornelis M.C, Curhan G.C, Adamo A.P, Dehghan A, Dengler L, Ding J, Eiriksdottir G, Endlich K, Enroth S, Esko T, Franco O.H, Gasparini P, Gieger C, Girotto G, Gottesman O, Gudnason V, Gyllensten U, Hancock S.J, Harris T.B, Helmer C, Hollerer S, Hofer E, Hofman A, Holliday E.G, Homuth G, Hu F.B, Huth C, Hutri-Kahonen N, Hwang S.J, Imboden M, Johansson A, Kahonen M, Konig W, Kramer H, Kramer B.K, Kumar A, Kutalik Z, Lambert J.C, Launer L.J, Lehtimaki T, Borst M.H, Navis G, Swertz M, Liu Y, Lohman K, Loos R.J.F, Lu Y, Lyytikainen L.P, McEvoy M.A, Meisinger C, Meitinger T, Metspalu A, Metzger M, Mihailov E, Mitchell P, Nauck M, Oldehinkel A.J, Olden M, Wjh Penninx B, Pistis G, Pramstaller P.P, Probst-Hensch N, Raitakari O.T, Rettig R, Ridker P.M, Rivadeneira F, Robino A, Rosas S.E, Ruderfer D, Ruggiero D, Saba Y, Sala C, Schmidt H, Schmid R, Scott R.J, Sedaghat S, Smith A.V, Sorice R, Stengel B, Stracke S, Strauch K, Toniolo D, Uitterlinden A.G, Ulivi S, Viikari J.S, Volker U, Vollenweider P, Volzke H, Vuckovic D, Waldenberger M, Wang J.J, Yang Q, Chasman D.I, Tromp G, Snieder H, Heid I.M, Fox C.S, Kottgen A, Pattaro C, Boger C.A, Fuchsberger C. Corrigendum: 1000 Genomes-based meta-analysis identifies 10 novel loci for kidney function. Sci Rep. 2017;7:46835. DOI: 10.1038/srep46835

2017
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Gorski M, van der Most P.J, Teumer A, Chu A.Y, Li M, Mijatovic V, Nolte I.M, Cocca M, Taliun D, Gomez F, Li Y, Tayo B, Tin A, Feitosa M.F, Aspelund T, Attia J, Biffar R, Bochud M, Boerwinkle E, Borecki I, Bottinger E.P, Chen M.H, Chouraki V, Ciullo M, Coresh J, Cornelis M.C, Curhan G.C, d'Adamo A.P, Dehghan A, Dengler L, Ding J, Eiriksdottir G, Endlich K, Enroth S, Esko T, Franco O.H, Gasparini P, Gieger C, Girotto G, Gottesman O, Gudnason V, Gyllensten U, Hancock S.J, Harris T.B, Helmer C, Hollerer S, Hofer E, Hofman A, Holliday E.G, Homuth G, Hu F.B, Huth C, Hutri-Kahonen N, Hwang S.J, Imboden M, Johansson A, Kahonen M, Konig W, Kramer H, Kramer B.K, Kumar A, Kutalik Z, Lambert J.C, Launer L.J, Lehtimaki T, de Borst M, Navis G, Swertz M, Liu Y, Lohman K, Loos R.J.F, Lu Y, Lyytikainen L.P, McEvoy M.A, Meisinger C, Meitinger T, Metspalu A, Metzger M, Mihailov E, Mitchell P, Nauck M, Oldehinkel A.J, Olden M, Wjh Penninx B, Pistis G, Pramstaller P.P, Probst-Hensch N, Raitakari O.T, Rettig R, Ridker P.M, Rivadeneira F, Robino A, Rosas S.E, Ruderfer D, Ruggiero D, Saba Y, Sala C, Schmidt H, Schmid R, Scott R.J, Sedaghat S, Smith A.V, Sorice R, Stengel B, Stracke S, Strauch K, Toniolo D, Uitterlinden A.G, Ulivi S, Viikari J.S, Volker U, Vollenweider P, Volzke H, Vuckovic D, Waldenberger M, Jin Wang J, Yang Q, Chasman D.I, Tromp G, Snieder H, Heid I.M, Fox C.S, Kottgen A, Pattaro C, Boger C.A, Fuchsberger C. 1000 Genomes-based meta-analysis identifies 10 novel loci for kidney function. Sci Rep. 2017;7:45040. DOI: 10.1038/srep45040

2017
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Jeong A, Imboden M, Hansen S, Zemp E, Bridevaux P.O, Lovison G, Schindler C, Probst-Hensch N. Heterogeneity of obesity-asthma association disentangled by latent class analysis, the SAPALDIA cohort. Respir Med. 2017;125:25-32. DOI: 10.1016/j.rmed.2017.02.014

2017
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Li M, Li Y, Weeks O, Mijatovic V, Teumer A, Huffman J.E, Tromp G, Fuchsberger C, Gorski M, Lyytikainen L.P, Nutile T, Sedaghat S, Sorice R, Tin A, Yang Q, Ahluwalia T.S, Arking D.E, Bihlmeyer N.A, Boger C.A, Carroll R.J, Chasman D.I, Cornelis M.C, Dehghan A, Faul J.D, Feitosa M.F, Gambaro G, Gasparini P, Giulianini F, Heid I, Huang J, Imboden M, Jackson A.U, Jeff J, Jhun M.A, Katz R, Kifley A, Kilpelainen T.O, Kumar A, Laakso M, Li-Gao R, Lohman K, Lu Y, Magi R, Malerba G, Mihailov E, Mohlke K.L, Mook-Kanamori D.O, Robino A, Ruderfer D, Salvi E, Schick U.M, Schulz C.A, Smith A.V, Smith J.A, Traglia M, Yerges-Armstrong L.M, Zhao W, Goodarzi M.O, Kraja A.T, Liu C, Wessel J, Charge Glycemic-T2D Working Group, Charge Blood Pressure Working Group, Boerwinkle E, Borecki I.B, Bork-Jensen J, Bottinger E.P, Braga D, Brandslund I, Brody J.A, Campbell A, Carey D.J, Christensen C, Coresh J, Crook E, Curhan G.C, Cusi D, de Boer I.H, de Vries A.P, Denny J.C, Devuyst O, Dreisbach A.W, Endlich K, Esko T, Franco O.H, Fulop T, Gerhard G.S, Glumer C, Gottesman O, Grarup N, Gudnason V, Harris T.B, Hayward C, Hocking L, Hofman A, Hu F.B, Husemoen L.L, Jackson R.D, Jorgensen T, Jorgensen M.E, Kahonen M, Kardia S.L, Konig W, Kooperberg C, Kriebel J, Launer L.J, Lauritzen T, Lehtimaki T, Levy D, Linksted P, Linneberg A, Liu Y, Loos R.J, Lupo A, Meisinger C, Melander O, Metspalu A, Mitchell P, Nauck M, Nurnberg P, Orho-Melander M, Parsa A, Pedersen O, Peters A, Peters U, Polasek O, Porteous D, Probst-Hensch N.M, Psaty B.M, Qi L, Raitakari O.T, Reiner A.P, Rettig R, Ridker P.M, Rivadeneira F, Rossouw J.E, Schmidt F, Siscovick D, Soranzo N, Strauch K, Toniolo D, Turner S.T, Uitterlinden A.G, Ulivi S, Velayutham D, Volker U, Volzke H, Waldenberger M, Wang J.J, Weir D.R, Witte D, Kuivaniemi H, Fox C.S, Franceschini N, Goessling W, Kottgen A, Chu A.Y. SOS2 and ACP1 loci identified through large-scale exome chip analysis regulate kidney development and function. J Am Soc Nephrol. 2017;28(3):981-994. DOI: 10.1681/ASN.2016020131

2017
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Machin M, Amaral A.F, Wielscher M, Rezwan F.I, Imboden M, Jarvelin M.R, Adcock I.M, Probst-Hensch N, Holloway J.W, Jarvis D.L. Systematic review of lung function and COPD with peripheral blood DNA methylation in population based studies. BMC Pulm Med. 2017;17:54. DOI: 10.1186/s12890-017-0397-3

2017
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Rava M, Ahmed I, Kogevinas M, Le Moual N, Bouzigon E, Curjuric I, Dizier M.H, Dumas O, Gonzalez J.R, Imboden M, Mehta A.J, Tubert-Bitter P, Zock J.P, Jarvis D, Probst-Hensch N.M, Demenais F, Nadif R. Genes interacting with occupational exposures to low molecular weight agents and irritants on adult-onset asthma in three European studies. Environ Health Perspect. 2017;125(2):207-214. DOI: 10.1289/EHP376

2017
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van Nunen E, Vermeulen R, Tsai M.Y, Probst-Hensch N, Ineichen A, Davey M, Imboden M, Ducret-Stich R, Naccarati A, Raffaele D, Ranzi A, Ivaldi C, Galassi C, Nieuwenhuijsen M, Curto A, Donaire-Gonzalez D, Cirach M, Chatzi L, Kampouri M, Vlaanderen J, Meliefste K, Buijtenhuijs D, Brunekreef B, Morley D, Vineis P, Gulliver J, Hoek G. Land use regression models for ultrafine particles in six European areas. Environ Sci Technol. 2017;51(6):3336-3345. DOI: 10.1021/acs.est.6b05920

2017
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Vonk J.M, Scholtens S, Postma D.S, Moffatt M.F, Jarvis D, Ramasamy A, Wjst M, Omenaas E.R, Bouzigon E, Demenais F, Nadif R, Siroux V, Polonikov A.V, Solodilova M, Ivanov V.P, Curjuric I, Imboden M, Kumar A, Probst-Hensch N, Ogorodova L.M, Puzyrev V.P, Bragina E.Y, Freidin M.B, Nolte I.M, Farrall A.M, Cookson W.O, Strachan D.P, Koppelman G.H, Boezen H.M. Adult onset asthma and interaction between genes and active tobacco smoking: the GABRIEL consortium. PLoS One. 2017;12(3):e0172716. DOI: 10.1371/journal.pone.0172716

2017
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Wain L.V, Shrine N, Artigas M.S, Erzurumluoglu A.M, Noyvert B, Bossini-Castillo L, Obeidat M, Henry A.P, Portelli M.A, Hall R.J, Billington C.K, Rimington T.L, Fenech A.G, John C, Blake T, Jackson V.E, Allen R.J, Prins B.P, Understanding Society Scientific Group, Campbell A, Porteous D.J, Jarvelin M.R, Wielscher M, James A.L, Hui J, Wareham N.J, Zhao J.H, Wilson J.F, Joshi P.K, Stubbe B, Rawal R, Schulz H, Imboden M, Probst-Hensch N.M, Karrasch S, Gieger C, Deary I.J, Harris S.E, Marten J, Rudan I, Enroth S, Gyllensten U, Kerr S.M, Polasek O, Kahonen M, Surakka I, Vitart V, Hayward C, Lehtimaki T, Raitakari O.T, Evans D.M, Henderson A.J, Pennell C.E, Wang C.A, Sly P.D, Wan E.S, Busch R, Hobbs B.D, Litonjua A.A, Sparrow D.W, Gulsvik A, Bakke P.S, Crapo J.D, Beaty T.H, Hansel N.N, Mathias R.A, Ruczinski I, Barnes K.C, Bosse Y, Joubert P, van den Berge M, Brandsma C.A, Pare P.D, Sin D.D, Nickle D.C, Hao K, Gottesman O, Dewey F.E, Bruse S.E, Carey D.J, Kirchner H.L, Geisinger-Regeneron Discov EHR Collaboration, Jonsson S, Thorleifsson G, Jonsdottir I, Gislason T, Stefansson K, Schurmann C, Nadkarni G, Bottinger E.P, Loos R.J, Walters R.G, Chen Z, Millwood I.Y, Vaucher J, Kurmi O.P, Li L, Hansell A.L, Brightling C, Zeggini E, Cho M.H, Silverman E.K, Sayers I, Trynka G, Morris A.P, Strachan D.P, Hall I.P, Tobin M.D. Genome-wide association analyses for lung function and chronic obstructive pulmonary disease identify new loci and potential druggable targets. Nat Genet. 2017;49(3):416-425. DOI: 10.1038/ng.3787

2017
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Walther D, Curjuric I, Dratva J, Schaffner E, Quinto C, Schmidt-Trucksäss A, Eze I.C, Burdet L, Pons M, Gerbase M, Imboden M, Schindler C, Probst-Hensch N. Hypertension, diabetes and lifestyle in the long-term - results from a Swiss population-based cohort. Prev Med. 2017;97:56-61. DOI: 10.1016/j.ypmed.2016.12.016

2017
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Abramson M.J, Schindler C, Schikowski T, Bircher A.J, Burdet L, Gerbase M.W, Imboden M, Rochat T, Schmid-Grendelmeier P, Turk A.J, Zemp E, Künzli N, Probst-Hensch N. Rhinitis in Swiss adults is associated with asthma and early life factors, but not second hand tobacco smoke or obesity. Allergol Int. 2016;65(2):192-198. DOI: 10.1016/j.alit.2015.11.004

2016
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Boillat-Blanco N, Bovet P, Ramaiya K.L, Mganga M, Minja L.T, Saleh L, Imboden M, Schindler C, Gagneux S, Daubenberger C, Reither K, Probst-Hensch N. Association between tuberculosis, diabetes and 25 hydroxyvitamin D in Tanzania: a longitudinal case control study. BMC Infect Dis. 2016;16:626. DOI: 10.1186/s12879-016-1960-x

2016
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Curjuric I, Imboden M, Bridevaux P.O, Gerbase M.W, Haun M, Keidel D, Kumar A, Pons M, Rochat T, Schikowski T, Schindler C, von Eckardstein A, Kronenberg F, Probst-Hensch N.M. Common SIRT1 variants modify the effect of abdominal adipose tissue on aging-related lung function decline. Age (Dordr). 2016;38(3):52. DOI: 10.1007/s11357-016-9917-y

2016
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Eze I.C, Imboden M, Kumar A, Adam M, Von Eckardstein A, Stolz D, Gerbase M.W, Künzli N, Turk A, Schindler C, Kronenberg F, Probst-Hensch N. A common functional variant on the pro-inflammatory Interleukin-6 gene may modify the association between long-term PM10 exposure and diabetes. Environ Health. 2016;15:39. DOI: 10.1186/s12940-016-0120-5

2016
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Eze I.C, Imboden M, Kumar A, Von Eckardstein A, Stolz D, Gerbase M.W, Künzli N, Pons M, Kronenberg F, Schindler C, Probst-Hensch N. Air pollution and diabetes association: modification by type 2 diabetes genetic risk score. Environ Int. 2016;94:263-271. DOI: 10.1016/j.envint.2016.04.032

2016
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Pattaro C, Teumer A, Gorski M, Chu A.Y, Li M, Mijatovic V, Garnaas M, Tin A, Sorice R, Li Y, Taliun D, Olden M, Foster M, Yang Q, Chen M.H, Pers T.H, Johnson A.D, Ko Y.A, Fuchsberger C, Tayo B, Nalls M, Feitosa M.F, Isaacs A, Dehghan A, D'Adamo P, Adeyemo A, Dieffenbach A.K, Zonderman A.B, Nolte I.M, van der Most P.J, Wright A.F, Shuldiner A.R, Morrison A.C, Hofman A, Smith A.V, Dreisbach A.W, Franke A, Uitterlinden A.G, Metspalu A, Tonjes A, Lupo A, Robino A, Johansson A, Demirkan A, Kollerits B, Freedman B.I, Ponte B, Oostra B.A, Paulweber B, Kramer B.K, Mitchell B.D, Buckley B.M, Peralta C.A, Hayward C, Helmer C, Rotimi C.N, Shaffer C.M, Muller C, Sala C, van Duijn C.M, Saint-Pierre A, Ackermann D, Shriner D, Ruggiero D, Toniolo D, Lu Y, Cusi D, Czamara D, Ellinghaus D, Siscovick D.S, Ruderfer D, Gieger C, Grallert H, Rochtchina E, Atkinson E.J, Holliday E.G, Boerwinkle E, Salvi E, Bottinger E.P, Murgia F, Rivadeneira F, Ernst F, Kronenberg F, Hu F.B, Navis G.J, Curhan G.C, Ehret G.B, Homuth G, Coassin S, Thun G.A, Pistis G, Gambaro G, Malerba G, Montgomery G.W, Eiriksdottir G, Jacobs G, Li G, Wichmann H.E, Campbell H, Schmidt H, Wallaschofski H, Volzke H, Brenner H, Kroemer H.K, Kramer H, Lin H, Mateo Leach I, Ford I, Guessous I, Rudan I, Prokopenko I, Borecki I, Heid I.M, Kolcic I, Persico I, Jukema J.W, Wilson J.F, Felix J.F, Divers J, Lambert J.C, Stafford J.M, Gaspoz J.M, Smith J.A, Faul J.D, Wang J.J, Ding J, Hirschhorn J.N, Attia J, Whitfield J.B, Chalmers J, Viikari J, Coresh J, Denny J.C, Karjalainen J, Fernandes J.K, Endlich K, Butterbach K, Keene K.L, Lohman K, Portas L, Launer L.J, Lyytikainen L.P, Yengo L, Franke L, Ferrucci L, Rose L.M, Kedenko L, Rao M, Struchalin M, Kleber M.E, Cavalieri M, Haun M, Cornelis M.C, Ciullo M, Pirastu M, de Andrade M, McEvoy M.A, Woodward M, Adam M, Cocca M, Nauck M, Imboden M, Waldenberger M, Pruijm M, Metzger M, Stumvoll M, Evans M.K, Sale M.M, Kahonen M, Boban M, Bochud M, Rheinberger M, Verweij N, Bouatia-Naji N, Martin N.G, Hastie N, Probst-Hensch N, Soranzo N, Devuyst O, Raitakari O, Gottesman O, Franco O.H, Polasek O, Gasparini P, Munroe P.B, Ridker P.M, Mitchell P, Muntner P, Meisinger C, Smit J.H, Kovacs P, Wild P.S, Froguel P, Rettig R, Magi R, Biffar R, Schmid R, Middelberg R.P, Carroll R.J, Penninx B.W, Scott R.J, Katz R, Sedaghat S, Wild S.H, Kardia S.L, Ulivi S, Hwang S.J, Enroth S, Kloiber S, Trompet S, Stengel B, Hancock S.J, Turner S.T, Rosas S.E, Stracke S, Harris T.B, Zeller T, Zemunik T, Lehtimaki T, Illig T, Aspelund T, Nikopensius T, Esko T, Tanaka T, Gyllensten U, Volker U, Emilsson V, Vitart V, Aalto V, Gudnason V, Chouraki V, Chen W.M, Igl W, Marz W, Koenig W, Lieb W, Loos R.J, Liu Y, Snieder H, Pramstaller P.P, Parsa A, O'Connell J.R, Susztak K, Hamet P, Tremblay J, de Boer I.H, Boger C.A, Goessling W, Chasman D.I, Kottgen A, Kao W.H, Fox C.S. Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function. Nat Commun. 2016;7:10023. DOI: 10.1038/ncomms10023

2016
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PubMed (26831199)

Sarnowski C, Sugier P.E, Granell R, Jarvis D, Dizier M.H, Ege M, Imboden M, Laprise C, Khusnutdinova E.K, Freidin M.B, Cookson W.O.C, Moffatt M, Lathop M, Siroux V, Ogorodova L.M, Karunas A.S, James A, Probst-Hensch N.M, von Erika M, Pin I, Kogevinas M, Henderson A.J, Demenais F, Bouzigon E. Identification of a new locus at 16q12 associated with time-to-asthma onset. J Allergy Clin Immunol. 2016;138(4):1071-1080. DOI: 10.1016/j.jaci.2016.03.018

2016
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PubMed (27130862)

Artigas M.S, Wain L.V, Miller S, Kheirallah A.K, Huffman J.E, Ntalla I, Shrine N, Obeidat M, Trochet H, McArdle W.L, Alves A.C, Hui J, Zhao J.H, Joshi P.K, Teumer A, Albrecht E, Imboden M, Rawal R, Lopez L.M, Marten J, Enroth S, Surakka I, Polasek O, Lyytikäinen L.P, Granell R, Hysi P.G, Flexeder C, Mahajan A, Beilby J, Bosse Y, Brandsma C.A, Campbell H, Gieger C, Glaser S, Gonzalez J.R, Grallert H, Hammond C.J, Harris S.E, Hartikainen A.L, Heliövaara M, Henderson J, Hocking L, Horikoshi M, Hutri-Kähönen N, Ingelsson E, Johansson A, Kemp J.P, Kolcic I, Kumar A, Lind L, Melen E, Musk A.W, Navarro P, Nickle D.C, Padmanabhan S, Raitakari O.T, Ried J.S, Ripatti S, Schulz H, Scott R.A, Sin D.D, Starr J.M, Vinuela A, Völzke H, Wild S.H, Wright A.F, Zemunik T, Jarvis D.L, Spector T.D, Evans D.M, Lehtimaki T, Vitart V, Kähönen M, Gyllensten U, Rudan I, Deary I.J, Karrasch S, Probst-Hensch N.M, Heinrich J, Stubbe B, Wilson J.F, Wareham N.J, James A.L, Morris A.P, Jarvelin M.R, Hayward C, Sayers I, Strachan D.P, Hall I.P, Tobin M.D. Sixteen new lung function signals identified through 1000 Genomes Project reference panel imputation. Nat Commun. 2015;6:8658. DOI: 10.1038/ncomms9658

2015
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PubMed (26635082)

Eze I.C, Imboden M, Kumar A, Von Eckardstein A, Stolz D, Gerbase M.W, Künzli N, Rochat T, Kronenberg F, Schindler C, Probst-Hensch N. Modification of ambient air pollution and diabetes association by type 2 diabetes genetic risk score of 48 variants. Trop Med Int Health, 2015;20(Suppl. 1):127-128

2015
Conference Paper

Eze I.C, Schaffner E, Foraster M, Imboden M, Von Eckardstein A, Gerbase M.W, Rothe T, Rochat T, Künzli N, Schindler C, Probst-Hensch N. Long-term exposure to ambient air pollution and metabolic syndrome in adults. PLoS One. 2015;10(6):e0130337. DOI: 10.1371/journal.pone.0130337

2015
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Gharib S.A, Loth D.W, Soler Artigas M, Birkland T.P, Wilk J.B, Wain L.V, Brody J, Obeidat M, Hancock D.B, Tang W, Rawal R, Boezen H.M, Imboden M, Huffman J.E, Lahousse L, Alves A.C, Manichaikul A, Hui J, Morrison A.C, Ramasamy A, Smith A.V, Gudnason V, Surakka I, Vitart V, Evans D.M, Strachan D.P, Deary I.J, Hofman A, Glaser S, Wilson J.F, North K.E, Zhao J.H, Heckbert S.R, Jarvis D.L, Probst-Hensch N, Schulz H, Barr R.G, Jarvelin M.R, O'Connor G.T, Kähönen M, Cassano P.A, Hysi P.G, Dupuis J, Hayward C, Psaty B.M, Hall I.P, Parks W.C, Tobin M.D, London S.J. Integrative pathway genomics of lung function and airflow obstruction. Hum Mol Genet. 2015;24(23):6836-6848. DOI: 10.1093/hmg/ddv378

2015
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PubMed (26395457)

Guerra S, Halonen M, Vasquez M.M, Spangenberg A, Stern D.A, Morgan W.J, Wright A.L, Lavi I, Tarès L, Carsin A.E, Dobano C, Barreiro E, Zock J.P, Martínez-Moratalla J, Urrutia I, Sunyer J, Keidel D, Imboden M, Probst-Hensch N, Hallberg J, Melén E, Wickman M, Bousquet J, Belgrave D.C.M. Relation between circulating CC16 concentrations, lung function, and development of chronic obstructive pulmonary disease across the lifespan: a prospective study. Lancet Respir Med. 2015;3(8):613-620. DOI: 10.1016/S2213-2600(15)00196-4

2015
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PubMed (26159408)

Hampel R, Peters A, Beelen R, Brunekreef B, Cyrys J, de Faire U, de Hoogh K, Fuks K, Hoffmann B, Huls A, Imboden M, Jedynska A, Kooter I, König W, Künzli N, Leander K, Magnussen P, Mannisto S, Penell J, Pershagen G, Phuleria H, Probst-Hensch N, Pundt N, Schaffner E, Schikowski T, Sugiri D, Tittanen P, Tsai M.Y, Wang M, Wolf K, Lanki T. Long-term effects of elemental composition of particulate matter on inflammatory blood markers in European cohorts. Environ Int. 2015;82:76-84. DOI: 10.1016/j.envint.2015.05.008

2015
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PubMed (26057255)

Imboden M, Kumar A, Curjuric I, Adam M, Thun G.A, Haun M, Tsai M.Y, Pons M, Bettschart R, Turk A, Rochat T, Künzli N, Schindler C, Kronenberg F, Probst-Hensch N.M. Modification of the association between PM10 and lung function decline by cadherin 13 polymorphisms in the SAPALDIA cohort: a genome-wide interaction analysis. Environ Health Perspect. 2015;123(1):72-79. DOI: 10.1289/ehp.1307398

2015
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Jeong A, Imboden M, Schindler C, Probst-Hensch N. Heterogeneity of obesity-asthma association disentangled by latent class analysis. Trop Med Int Health, 2015;20(Suppl. 1):59. Abstracts of the 9th European Congress on Tropical Medicine and International Health, 6-10 September 2015, Basel, Switzerland

2015
Conference Paper

Lanki T, Hampel R, Tiittanen P, Andrich S, Beelen R, Brunekreef B, Dratva J, de Faire U, Fuks K.B, Hoffman B, Imboden M, Jousilahti P, Koenig W, Mahabadi A.A, Künzli N, Pedersen N.L, Penell J, Pershagen G, Probst-Hensch N.M, Schaffner E, Schindler C, Sugiri D, Swart W.J, Tsai M.Y, Turunen A.W, Weinmayr G, Wolf K, Yli-Tuomi T, Peters A. Air pollution from road traffic and systemic inflammation in adults: a cross-sectional analysis in the European ESCAPE project. Environ Health Perspect. 2015;123(8):785-791. DOI: 10.1289/ehp.1408224

2015
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PubMed (25816055)
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Adam M, Imboden M, Boes E, Schaffner E, Künzli N, Phuleria H.C, Kronenberg F, Gaspoz J.M, Carballo D, Probst-Hensch N. Modifying effect of a common polymorphism in the interleukin-6 promoter on the relationship between long-term exposure to traffic-related particulate matter and heart rate variability. PLoS One. 2014;9(8):e104978. DOI: 10.1371/journal.pone.0104978

2014
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PubMed (25133672)
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Curjuric I, Imboden M, Adam M, Bettschart R.W, Gerbase M.W, Künzli N, Rochat T, Rohrer L, Rothe T.B, Schwartz J, Stolz D, Tschopp J.M, Von Eckardstein A, Kronenberg F, Probst-Hensch N.M. Serum bilirubin is associated with lung function in a Swiss general population sample. Eur Respir J. 2014;43(5):1278-1288. DOI: 10.1183/09031936.00055813

2014
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PubMed (24177000)

Eze I.C, Schaffner E, Fischer E, Schikowski T, Adam M, Imboden M, Tsai M, Carballo D, Von Eckardstein A, Künzli N, Schindler C, Probst-Hensch N. Long-term air pollution exposure and diabetes in a population-based Swiss cohort. Environ Int. 2014;70:95-105. DOI: 10.1016/j.envint.2014.05.014

2014
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PubMed (24912113)

Mehta A.J, Thun G.A, Imboden M, Ferrarotti I, Keidel D, Künzli N, Kromhout H, Miedinger D, Phuleria H, Rochat T, Russi E.W, Schindler C, Schwartz J, Vermeulen R, Luisetti M, Probst-Hensch N. Interactions between SERPINA1 PiMZ genotype, occupational exposure and lung function decline. Occup Environ Med. 2014;71(4):234-240. DOI: 10.1136/oemed-2013-101592

2014
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PubMed (24213563)