Medicinal chemistry optimization of antiplasmodial imidazopyridazine hits from high throughput screening of a softfocus kinase library: part 2 (Publications)
On the basis of our recent results on a novel series of imidazopyridazine-based antimalarials, we focused on identifying compounds with improved aqueous solubility and hERG profile while maintaining m
The determination of the species specificity of Leishmania antibodies in different groups of human sera (Publications)
Species-specificity of two serological tests has been compared: Indirect immunofluorescence test and C-ELISA using antigens prepared of 7 Leishmania species of various groups of human sera, including
Potential impact of air pollution on multiple sclerosis in Tehran, Iran (Publications)
Background: Multiple sclerosis (MS) incidence has dramatically increased in Tehran, Iran. The health impact of air pollution in Tehran underscores the attention to a possible association to this envir
Treatment of chloroquine-resistant malaria using pyrimethamine in combination with berberine, tetracycline or cotrimoxazole (Publications)
Two hundred and fifteen patients with chloroquine-resistant malaria were randomised into three groups. The first group of 82 patients were given pyrimethamine and berberine (berberine group), the seco
Antigenicity and immunogenicity of a novel <em>Plasmodium vivax</em> circumsporozoite derived synthetic vaccine construct (Publications)
BACKGROUND: The circumsporozoite (CS) protein is a major malaria sporozoite surface antigen currently being considered as vaccine candidate. Plasmodium vivax CS (PvCS) protein comprises a dimorphic ce