Effect of single nucleotide polymorphisms in cytochrome P450 isoenzyme and N-acetyltransferase-2 genes on the metabolism of artemisinin-based... (Publications)
first-line treatments with the current artemisinin derivatives and quinolines for uncomplicated malaria in specific populations. However, it cannot be ruled out that our results represent isolated findings
Consistently high estimates for the proportion of human exposure to malaria vector populations occurring indoors in rural Africa (Publications)
eated nets (ITNs) and indoor residual spraying (IRS) are highly effective tools for controlling malaria transmission in Africa because the most important vectors, from the Anopheles gambiae complex and
Cost-effectiveness of malaria intermittent preventive treatment in infants (IPTi) in Mozambique and the United Republic of Tanzania (Publications)
on the efficacy results of the intervention and on malaria incidence in the target population, an estimate was made of the number of clinical malaria episodes prevented. This number and an assumed cas [...] OBJECTIVE: To estimate the cost-effectiveness of malaria intermittent preventive treatment in infants (IPTi) using sulfadoxine-pyrimethamine (SP). METHODS: In two previous IPTi trials in Ifakara (United [...] costs, was then assessed on the basis of these figures. FINDINGS: The cost per...
Malaria: burden of disease (Publications)
large parts of the planet. The failed attempt to eradicate malaria gave way to the control policy that was followed by a huge resurgence of malaria during the late 70s and 80s. Together with the emergence [...] plasmodium species and Ross confirmed that they were transmitted by female anopheline mosquitoes, malaria remains a leading cause of morbidity and mortality worldwide. Although the areas where transmission [...] living at risk has grown to about 3 billion, and is expected to go on...
Malaria vaccines: a toy for travelers or a tool for eradication? (Publications)
efficacy of two candidate malaria vaccines in children living in malaria-endemic areas, namely RTS,S from the circumsporozoite protein that reduced infection and clinical malaria in Mozambique, and an asexual [...] visiting malaria-endemic areas, the usefulness of the first generation of malaria vaccine(s) will be limited, since the level of protection that is foreseen is unlikely to achieve that of malaria chemop [...] reduced parasite density in Papua New Guinea, allows one to believe that a m...