Malaria importée: des médicaments tourjours plus efficaces et plus sûrs? (Publications)
South-East Asia, this phenomenon has no practical implications for travelers with uncomplicated malaria. The combination of artemether-lumefantrine is still very effective and safe, be it for P. falciparum [...] administration of artesunate has allowed to significantly reducing case fatality rate of severe malaria patients when compared to quinine treatment in endemic areas. Artesunate is also recommended in travelers
Naturally acquired immune responses to <em>P. vivax</em> merozoite surface protein 3alpha and merozoite surface protein 9 are associated with reduced... (Publications)
is the most geographically widespread human malaria parasite. Cohort studies in Papua New Guinea have identified a rapid onset of immunity against vivax-malaria in children living in highly endemic areas [...] and Merozoite Surface Protein 9 (PvMSP9) were measured and related to prospective risk of P. vivax malaria during 16 months of active follow-up. Overall, there was a low prevalence of antibodies to PvMSP3alpha [...] PvMSP9 N-terminus (aIRR = 0.68, p = 0.035) were associated with protection...
Malaria Policy Advisory Committee to the WHO: conclusions and recommendations of March 2013 meeting (Publications)
resource allocation for malaria control; malaria surveillance and the need for a surveillance, monitoring and evaluation Technical Expert Group; criteria and classification related to malaria elimination; the [...] Suriname; the outcomes from a consultation on non-malaria febrile illness; the outcomes from the second meeting of the Evidence Review Group on malaria burden estimation; an update on the review of the [...] Guidelines for the Treatment of Malaria; an update regarding progress on the...
Organellar proteomics reveals hundreds of novel nuclear proteins in the malaria parasite <em>Plasmodium falciparum</em> (Publications)
BACKGROUND: The post-genomic era of malaria research provided unprecedented insights into the biology of Plasmodium parasites. Due to the large evolutionary distance to model eukaryotes, however, we lack [...] serve as an important platform for dissecting general and parasite-specific nuclear processes in malaria parasites. Moreover, as the first nuclear proteome characterized in any protist organism, it will
Correct dosing of artemether-lumefantrine for management of uncomplicated malaria in rural Tanzania: do facility and patient characteristics matter? (Publications)
requires a strict dosing schedule that follows the drugs' pharmacokinetic properties. The quality of malaria case management was assessed in two areas in rural Tanzania, to ascertain patient characteristics [...] and facility-specific factors that influence correct dosing of AL for management of uncomplicated malaria. METHODS: Exit interviews were conducted with patients attending health facilities for initial illness [...] facilities were inventoried for capacity and availability of medical...
Health worker factors associated with prescribing of artemisinin combination therapy for uncomplicated malaria in rural Tanzania (Publications)
uncomplicated malaria defined as prescription of artemisinin-based combination therapy (ACT) for patients with fever and Plasmodium falciparum asexual infection based on blood slide or malaria rapid diagnostic [...] patients with uncomplicated malaria who were seen in a health facility with ACT in stock, and 71 health workers practicing in 30 health facilities. Overall, 58% of malaria patients were correctly treated [...] with correct ACT prescription for uncomplicated malaria. Targeted...
Effective autodissemination of pyriproxyfen to breeding sites by the exophilic malaria vector <em>Anopheles arabiensis</em> in semi-field settings in... (Publications)
autodissemination of PPF to breeding habitats by malaria vectors. These findings highlight the potential for this technique for outdoor control of malaria vectors and call for the testing of this technique [...] BACKGROUND: Malaria vector control strategies that target adult female mosquitoes are challenged by the emergence of insecticide resistance and behavioural resilience. Conventional larviciding is restricted